Human Technopole is a proposed new research center in Milan, Italy that aims to:
1) Lead Italy to co-leadership in improving quality of life by ensuring better living conditions through scientific and technological developments.
2) Combine research excellence with strengthening Italy's healthcare industry to avoid "orphan" research.
3) Serve as a hub that strengthens Italy's existing university and research networks through interdisciplinary collaboration on topics like nutrition, sustainability, and ethics.
Innoteque 2016 was an event organized in Bucharest and Cluj between October 5-7, 2016 by Impact Hub and Recognos. Participants made a series of recommendations for building an ecosystem of innovation and entrepreneurship in Romania.
Innoteque 2016 was an event organized in Bucharest and Cluj between October 5-7, 2016 by Impact Hub and Recognos. Participants made a series of recommendations for building an ecosystem of innovation and entrepreneurship in Romania.
EUROPEAN INSTITUTE OF INNOVATION AND TECHNOLOGY: POLICY EXPERIMENTATION FOR P...Totti Könnölä
The Ministry of Economic Affairs and Employment, the Finnish Funding Agency for Innovation TEKES and the Finnish Innovation Fund SITRA organised in autumn 2016 an international workshop to compile international research data on developing ecosystems. Totti Könnölä, CEO of Insight Foresight Institute, presented the paper “Co-creating Pan-European Innovation Ecosystems: reflections from the EIT”.
Industrial Policy for New Growth Areas and
Entrepreneurial Ecosystems
Research workshop in Helsinki 28.-29. November 2016
Convenors: Timo Hämäläinen, Sitra and Antonio
Andreoni, SOAS University of London
Organizers: Sitra, Tekes & MEE
Invited lecture
10 European conferences for health entrepreneurs in 2019Sofie Staelraeve
There are many many conferences and events on health innovations all over the world. It might be a difficult job to find which one is specifically interesting for you.
I’ve selected 10 European health conferences (+ 1 extra) you should not miss as a health entrepreneur.
Slides from "Macro-Level Issues Facing the Research Infrastructure" section of the "Management Challenges in Research Infrastructures" module from the PARTHENOS Training Suite, https://training.parthenos-project.eu
Newsletter of Horizon 2020 and OECD Observatory of Public Sector Innovation | July 2016 | No. 1
News and Issues on Public Sector Innovation around the world and OPSI Horizon 2020 activities.
OPSI collects and analyses examples and shared experiences of public sector innovation to provide practical advice to countries on how to make innovations work.
STI Policy and Practices in Japan_Dr. Michiharu Nakamurascirexcenter
STI Policy and Practices in Japan_Dr. NAKAMURA Michiharu, Counselor to the President, Japan Science and Technology Agency_日中韓国際シンポジウム「3カ国からみるイノベーション政策の現状と展望」Japan-China-ROK Symposium "Current Issues and Expectations on Innovation Policy in Three Countries"_20161122
On 17th May in Alicante, the Interreg MED Programme organised a community building event entitled "We are MED - Going beyond thematic communities". The event was the occasion to work together on a common work methodology and last but not least build a strong Interreg MED community. https://interreg-med.eu/news-events/events/we-are-med/
Winning ITNs with RRI - Relevant sources and further readingJobenco
Here is some more background on the notion of Responsible Research and Innovation (RRI), how it has been operationalised in Horizon 2020 and how it can be relevant for writing MSCA ITN proposals. We have included the academic and policy background and concrete sources/best practices to inspire others to take it up in their proposal.
European Summit on Innovation for Active and Healthy AgeingRunwaySale
The report consolidates the discussions held throughout the 2-day event and is organised in a clear set of actions that we will explore jointly with interested stakeholders in the coming 18 months.
The final report includes possible measures to better convert innovation into economic growth and jobs, mobilize public and private investment, transform health and care systems to meet the needs of the ageing population, leverage technological breakthroughs and build a more inclusive "ageing society".
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
EUROPEAN INSTITUTE OF INNOVATION AND TECHNOLOGY: POLICY EXPERIMENTATION FOR P...Totti Könnölä
The Ministry of Economic Affairs and Employment, the Finnish Funding Agency for Innovation TEKES and the Finnish Innovation Fund SITRA organised in autumn 2016 an international workshop to compile international research data on developing ecosystems. Totti Könnölä, CEO of Insight Foresight Institute, presented the paper “Co-creating Pan-European Innovation Ecosystems: reflections from the EIT”.
Industrial Policy for New Growth Areas and
Entrepreneurial Ecosystems
Research workshop in Helsinki 28.-29. November 2016
Convenors: Timo Hämäläinen, Sitra and Antonio
Andreoni, SOAS University of London
Organizers: Sitra, Tekes & MEE
Invited lecture
10 European conferences for health entrepreneurs in 2019Sofie Staelraeve
There are many many conferences and events on health innovations all over the world. It might be a difficult job to find which one is specifically interesting for you.
I’ve selected 10 European health conferences (+ 1 extra) you should not miss as a health entrepreneur.
Slides from "Macro-Level Issues Facing the Research Infrastructure" section of the "Management Challenges in Research Infrastructures" module from the PARTHENOS Training Suite, https://training.parthenos-project.eu
Newsletter of Horizon 2020 and OECD Observatory of Public Sector Innovation | July 2016 | No. 1
News and Issues on Public Sector Innovation around the world and OPSI Horizon 2020 activities.
OPSI collects and analyses examples and shared experiences of public sector innovation to provide practical advice to countries on how to make innovations work.
STI Policy and Practices in Japan_Dr. Michiharu Nakamurascirexcenter
STI Policy and Practices in Japan_Dr. NAKAMURA Michiharu, Counselor to the President, Japan Science and Technology Agency_日中韓国際シンポジウム「3カ国からみるイノベーション政策の現状と展望」Japan-China-ROK Symposium "Current Issues and Expectations on Innovation Policy in Three Countries"_20161122
On 17th May in Alicante, the Interreg MED Programme organised a community building event entitled "We are MED - Going beyond thematic communities". The event was the occasion to work together on a common work methodology and last but not least build a strong Interreg MED community. https://interreg-med.eu/news-events/events/we-are-med/
Winning ITNs with RRI - Relevant sources and further readingJobenco
Here is some more background on the notion of Responsible Research and Innovation (RRI), how it has been operationalised in Horizon 2020 and how it can be relevant for writing MSCA ITN proposals. We have included the academic and policy background and concrete sources/best practices to inspire others to take it up in their proposal.
European Summit on Innovation for Active and Healthy AgeingRunwaySale
The report consolidates the discussions held throughout the 2-day event and is organised in a clear set of actions that we will explore jointly with interested stakeholders in the coming 18 months.
The final report includes possible measures to better convert innovation into economic growth and jobs, mobilize public and private investment, transform health and care systems to meet the needs of the ageing population, leverage technological breakthroughs and build a more inclusive "ageing society".
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Unveiling the Energy Potential of Marshmallow Deposits.pdf
Human Technopole presentation
1. Human Technopole Coordination Committee
Milan, 6th February 2017
HumanTechnopole
Italy 2040
The New Italian Research Center
in the EXPO Area in Milan
2. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Table of contents
1. Main trends and motivations
2. The investment in research
3. The HumanTechnopole project: general goals
4. Relevant comparative case-studies for HumanTechnopole
5. The HumanTechnopole project: the scientific structure
6. The HumanTechnopole project: the start-up phase
7. Appendices
2
3. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
1. Main trends and motivations
2040 trends: demography, engines of development, comparison
and competition among people
Cultural and governmental challenges
Science between method, the pleasure of discovery and the
related implications
A «new enterprise» in the healthcare sectors
The life science sector in Italy
3
4. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
2040 trends: demography, engines of
development, comparison and competition among
people
Engines of development: fertility rate, aging and population
Innovation as the «only» engine
Long-term protection of active population
Support arising from scientific developments
The future beyond «Guns, germs and steel».There is still
competition in science as a state of peace to defeat diseases
Emerging scientific areas
4
5. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Engines of development: fertility
rate, aging and population
World fertility rate 1960-2014
5
0
1
2
3
4
5
6
1960
1962
1964
1966
1968
1970
1972
1974
1976
1978
1980
1982
1984
1986
1988
1990
1992
1994
1996
1998
2000
2002
2004
2006
2008
2010
2012
2014
Source:TheWorld Bank data, last update 30th June 2016
6. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Energy
Transport
Sustainability
Nutrition
New industries
(industry 4.0)
Life sciences
6
Source: Horizon 2020
Emerging scientific areas
7. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Cultural and governmental challenges
Scientific development has always been associated with great
cultural and governmental challenges
Scientific progress cannot be only for few people
The most important aspect of scientific discoveries is the extension of
their benefits to everybody, thus becoming social achievements
We need to turn such discoveries into new «rights», hence
making public budgets more sustainable
«Good» behaviors are not prohibitions or impositions.They are
rather a natural consequence of good education
7
8. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Science between method, the pleasure of
discovery and the related implications
The value of science is connected to method, uprightness and
merit, but also to:
Altruism
Hope
Altruism and hope prevent new forms of scientism which,
although mitigated by history, hide egoism and egocentrism
8
9. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
A «new enterprise» in the healthcare sectors
It is crucial to combine a research institute with the
strengthening of the industry in health technologies
If excellence in research is not supported by industry, it risks
being an «orphan»: it produces knowledge that benefits other
Countries
Italy needs a new industry to be a leader in the field of quality
of life. It also needs a large amount of cross-fertilization
9
10. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The life sciences sector in Italy
Italy is among the leaders in the life-science industries.The Human
Technopole project will help the growth in a very competitive sector
10
24.8 13.9 10.5 8.7
PHARMACEUTICAL SECTOR
Production (€ Billion)
MEDICALTECHNOLOGIES SECTOR Sales (€ Billion)
Source: Biocat, report 2015 https://goo.gl/f7Ovs0
Source: Farmindustria, report 2016. Estimation 2015 https://goo.gl/SEdPz4
11. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
2. The investment in research
Global trends
Knowledge-driven economy and Lego innovation
The European goals
Lisbon 2000
The relaunch towards 2020
11
12. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Global trends – Knowledge-driven
economy and Lego innovation
In the XXI century, a significant part of the world economic
growth will be driven by a small number of “Knowledge
Economy Regions”
Regions with the right value chain (ingredients), the right
culture (forma mentis) and “forti individui” will perform best
Lego innovation: recombining knowledges, facing the wind by
making the mills work and not by building walls
12
13. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The European goals – Lisbon 2000 and the
relaunch towards 2020
According to theTreaty of Lisbon (2000), by 2020 3% of
GDP should be spent on research and development (vs. 1.9% in
Europe and 1.3% in Italy in 2015)
In 2020, 75% of the active population should work (vs. 72.5%
in Europe and 57% in Italy in 2015)
13
Source: Eurostat
14. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
3. The Human Technopole project
HumanTechnopole is a national cross-disciplinary research project
in Milan’s EXPO site.
Goals
Between training, research and industry
Key elements
A ‘Boston area’ for Italy
Infrastructure and Facilities
HumanTechnopole as a hub
Cluster
14
15. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The project aims to lead Italy towards the co-leadership in the field of
quality of life and to ensure better living conditions to all
The contribution to the existing initiatives is not only scientific and
technological, but also:
Educational in relation to prevention
Organizational in relation to diagnosis and care
Political in relation to its implications for social cohesion
Industrial in relation to technology transfer processes and the creation of a new
industry in healthcare
15
Human Technopole - Goals
16. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
HumanTechnopole with regards to the field of research combines
with Industry 4.0 projects and with the National Research Program
Research is a manifold activity and the related technologies are
pervasive
Understanding problems, and finding solutions, require a curiosity-
driven, often multidisciplinary, approach. Hence, various skills are
needed.
16
Human Technopole: between training, research
and industry (1/2)
17. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
It is possible to «catch up» with a 10-year long industrial
production.With this regard, the most innovative sectors – e.g. those
linked to ageing – can support our work
HumanTechnopole should also be the occasion for a cultural growth
connected to debates on ethic implications of new discoveries (the
human centrality and the need for a humanities/social sciences
approach)
17
Human Technopole: between training, research
and industry (2/2)
18. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Human Technopole and its key elements
HumanTechnopole will work with universities and the existing
research centers in order not to replicate but to strengthen the network
of research infrastructures
Special focus also on
Governance and scientific dissemination
Nutrition and sustainability
The so-called «third sector» and sociality
Ethical questions
18
19. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Human Technopole: a “Boston area” for Italy
The project aims to persuade the whole research system
Wealth tends to concentrate in some geographical areas, however
the idea of a balanced and widespread development cannot be
overlooked
The «bell tower» should be seen in terms of development for all
communities and of ceaseless dialogue
19
20. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Human Technopole: infrastructure and
facilities
Infrastructure indicates a crucial shared, long-term
good which is for common use
Facilities are tools whose aim is to facilitate the work
of those who already deal with the topics mentioned
above
20
21. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The Center should systematically act as a «last mile» and as a hub
The hub increases the value of universities and existing research centers
The hub should be based on interdisciplinarity as the starting point for
connecting and creating new knowledges.This is similar to the concept
of intermodality of transport systems
The hub should support the networking among research centers at
global level, thus helping and strengthening connections that already
exist among them at local level
21
Human Technopole: a hub
22. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI 22
Starting
year
Type of
Organization
Country Staff Sponsor
Annual Budget
(mln €)
m2
Human
Technopole**
2016/17 Foundation
Italy,
Milan
1,500 Government 140 30,000
Istituto Italiano
di Tecnologia (IIT)
2005/06 Foundation
Italy,
Genoa
1,470 Government 96 40,000
Weizmann
Institute
1934
Research
center***
Israel,
Rehovot
3,500 Government 338* 207,600
The Francis Crick
Institute
2007 Consortium
UK,
London
1,500
46%
Government
775 92,900
4. Relevant comparative case studies for
Human Technopole (1/2)
*Data 2013 **Targets of the project *** 29 km far fromTelAviv
Data for Istituto Italiano diTecnologia (IIT): https://www.iit.it/it/institute/facts-and-figures
Data forWeizmann Institute: https://www.weizmann.ac.il/Organic_Chemistry/Rafal/FF.pdf
Data for the FrancisCrick Institute: https://www.crick.ac.uk/media/310327/crick_institute_annual_review_2015-2016.pdf
23. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI 23
Starting
year
Type of
Organization
Country Staff Sponsor
Annual Budget
(mln €)
m2
Wellcome Trust
Sanger Institute
1993
Research
center
UK,
Cambridge
2,000
Mainly
Private
588 220,000
DZNE (Neurodeg
deseases)
2009
Research
center
Germany,
Bonn
900
90% Federal
10% State* 66**
38,000
4. Relevant comparative case studies for
Human Technopole (2/2)
Data forWellcomeTrust Sanger Institute: https://goo.gl/vmyWrT
Data for DZNE: https://goo.gl/Y5W3VH and https://www.dzne.de/en/research-institute-for-neurodegenerative-diseases.html
*90% from Federal Ministry of Education and Research and 10% from the respective federal states containing DZNE sites
** 5 years to go full speed
24. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
5. The Human Technopole project: the
scientific structure
The initial and approved scientific project will be composed of:
7 centers
3 facilities
24
25. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The 7 centers
C1: Onco Genomics Center
C2: Neuro Genomics Center
C3: Agri Food and Nutrition Genomics Center
C4: Data Science Center
C5: Computational Life Sciences Center
C6: Center for Analysis, Decisions, and Society
C7: Center for Smart Materials and Devices
25
26. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C1: Onco Genomics Center
Mission:To create a National Reference Center in Onco Genomics that will lay the
foundations to extend medical genomics’ current benefits to all Italian cancer patients
Areas of main development
RL1 Clinical Onco Genomics:
To improve disease prevention and treatment strategies by promoting screening
programs, innovative clinical trials and analytical computational tools
RL2 Fundamental Research in Onco Genomics:
To support continuous knowledge generation and innovation
RL3Technological Platforms:
To ensure the ongoing acquisition of the latest state-of-the-art genomics technologies
26
27. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C2: Neuro Genomics Center
Mission: To apply Precision Medicine to neurodegenerative diseases (Alzheimer’s
disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis)
Areas of main development
RL1 Neuro Genomics:
To establish a genomics-based stratification of patients with neurodegenerative diseases
RL2 Models & Mechanisms:
To identify selected classes of patients with a specific repertory of genomic mutations
RL3Translational Neuro Genomics:
To combine genomics-based diagnostics with new pharmacological treatments for
neurodegenerative diseases
27
28. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C3: Agri-Food and Nutrition Genomics Center
Mission: Better nutrition appears to be the main effective, cost-efficient prevention
strategy, particularly for chronic non-communicable diseases (NCDs)
Areas of main development
RL1 Crop Genomics and Biotechnology: To exploit new traits of potential agricultural
and nutritional interest
RL2:Functional and Systems Metagenomics and Metabolomics: To improve human
and plant health via directed intervention in the human microbiome
RL3 Food, Host, and Microbiota Interactions: To conduct functional studies on
immune modulation and nervous system activity
RL4 Personalized Nutrition: To investigate the human-genome-encoded determinants of
immune function, diet, and the metagenome to achieve the self-sustainability of health
28
29. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C4: Data Science Center
Mission: To develop a scientific framework to efficiently extract information from large
sets of heterogeneous data with the aim of generating structured knowledge
Areas of main development
RL1 Basic Issues in Data Science: Data managing, information modeling and retrieval, artificial
intelligence, machine learning, topological data analysis, data predictions, uncertainty modeling
RL2 Data-driven Genomics:To understand genome variations in relation to clinical data and how
they can be used in Personalized Medicine for cancer and neurodegenerative diseases
RL3 Data-driven Neuroscience: Topological data-handling methods for analyzing brain structure
RL4 Digital Epidemiology: Dynamics of health and disease distribution
RL5 Ethical Issues in Data Science: Privacy, security, data anonymization
29
30. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C5: Computational Life Sciences Center
Mission:To study disease-associated biological processes in order to discover innovative
and personalized therapies for cancer and neurodegenerative diseases
Areas of main development
RL1 Multiscale Modeling: To design nanoparticles and medical devices on the nanoscale,
and for modeling RNA
RL2 Bioinformatics:To handle, store, and categorize the huge amounts of data generated
by experimental groups
RL3 Software Development and HPC Optimization: To produce innovative software to
handle the large volumes of omics data
RL4 Computational Drug Discovery and Network Pharmacology:To decipher and
characterize new physio-pathological pathways using chemical biology approaches
30
31. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C6: Center for Analysis, Decisions, and Society
Mission:To develop original research at the intersection of computer science,
mathematics, statistics, artificial intelligence, and socioeconomic sciences, endowing
the HT with advanced data-handling tools and solutions
Areas of main development
RL1 HW&SW Conceptual Design: Hardware and software infrastructure research;
machine learning embryonic technologies
RL2 Information Processing: Data management, integration, and fusion; statistical
methods for complex and high dimensional data and data visualization
RL3 Modelling and Managing Socioeconomic Systems: Developing novel models
for the big data analysis of activities
RL4 Decisions and Policies: Sustaining the production of robust identifying
assumptions for causal analysis
31
32. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
C7: Center for Smart Materials and Devices
Mission: To develop material science and nanotechnologies for applications in food,
nutrition, health, and medicine
Areas of main development
RL1 Nanotechnology for Food and Human Health: to develop low-cost, high-
sensitivity assays for the rapid on-field testing of food and biological specimens
RL2 Smart Packaging: new smart packaging technologies for food
RL3Valorization of Natural Polymers, Food Residues, and Agricultural Residues:
to valorize food waste, agro-waste, pure natural fibers and polymers to develop easily
scalable methods for producing fully biocompatible and sustainable biomaterials and
plastics
RL4Water Cycle; RL5 Human Sensing: to develop novel nanotechnologies for water
analysis and purification
32
33. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The 3 facilities
F1: Central Genomics Facility
F2: Imaging Facility
F3: Data Storage and High-Performance Computing Facility
33
34. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
F1: Central Genomics Facility
The Central -Genomics Facility will gather the CommonTechnology-Development
Platforms common to OGN, NGC, and AFNGC and the high-throughput Next-
Generation Sequencing infrastructure for large population screenings
The F1 Facility will comprise specialized technological platforms run by dedicated
technologists (highly specialized technicians), and coordinated by teams of Principal
Investigators from the 3 centers.This structure will allow each technological platform
to be developed and adapted to meet the scientific needs of the OGC, NGC, and
AFNG
34
35. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
F2: Imaging Facility
To place the HumanTechnopole at the forefront of innovation in biomedical research,
a state-of-the-art cryo-EM infrastructure is needed.This infrastructure should be
available to a large group of structural biologists, who are already proficient in the
biochemistry relevant to sample preparation. At steady state, this Facility will comprise
labs for Electron DiffractionTomography and Electron Cryo-Tomography
35
36. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
F3: Data Storage and High-Performance
Computing Facility
This Facility will undertake joint endeavors in HPC and big data to create the basis
for a national infrastructure.These endeavors include i) designing an integrated
common sharing technology, ii) developing domain-oriented problem-solving
solutions intended to become benchmarks and standards, iii) facilitating efficient
access to databases of large volumes of structured and unstructured data, and iv)
creating workflow strategies to close the dramatic gap between the next-generation
informatics and computational tools and the ultimate goal of Personalized Medicine
This aim will be achieved by creating mirror sites of publicly available genomic data
and by enabling the electronic management of health records
36
37. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
6. The Human Technopole project: the start-up
phase
The start-up phase
Key facts after the Milan Universal Exposition in 2015
The Coordination Committee’s composition and tasks
The project structure of the Italian Institute of Technology (IIT)
The working groups of the Coordination Committee
Calendar for 2017 (6th February 2017)
37
38. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The start-up phase
The project will have a start-up phase lasting up to 2 years
(from September 2016) with the aim of:
1. Starting the set-up of the main infrastructure
2. Starting the collaboration network
3. Starting the recruitment of senior scientific staff, exclusively through
international calls
4. Organizing the core of HT administration offices
38
39. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Key facts after the Milan Universal Exposition
in 2015
1. Origin at governmental level (November 2015, after the Milan Universal Exposition)
2. Preparation of the scientific proposal by the IIT and University (from January to May 2016)
3. Project approval by international scientific referees (July 2016)
4. Government decree establishing the project structure within the IIT and the composition
of the Coordination Committee under the Government supervision (September 2016)
5. Formal appointment and first meeting of the Coordination Committee (29 November
2016)
6. ‘Stability law’ (December 2016): final long term funding of the project, request to the
Coordination Committee to write the Statute of the forthcoming HT legal entity (HT
Foundation) initially composed of the Ministry of Health, the Ministry of Education,
University and Research (MIUR) and the Ministry of Economy and Finance (MEF)
39
40. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Role Name
Chair and member appointed by MIUR* Prof. Stefano Paleari
Member appointed by MEF** Prof. Marco Simoni
IIT Director Prof. Roberto Cingolani
IIT Chairman Prof. Gabriele Galateri
Rector of Università di Milano Bicocca Prof. Cristina Messa
Rector of Politecnico di Milano Prof. Ferruccio Resta
Rector of Università Statale di Milano Prof. GianlucaVago
Chairman of Italian National Research Council (CNR) Prof. Massimo Inguscio
Chairman of National Institute of Health (ISS) Prof.Walter Ricciardi
International scientist
International scientist
International scientist
Prof. AlessandroVespignini (Northeastern University)
Prof. Munther A. Dahleh (MIT)
Prof. Martina C. Cornel (VU University Medical Center)
40
The Coordination Committee - Composition
* Ministero dell'Istruzione, dell'Universita e della Ricerca
** Ministero dell’Economia e delle Finanze
41. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The Coordination Committee - Tasks
41
Preparation of the Statute, which aims to:
Propose the name of the Foundation (it might be HumanTechnopole
again)
Propose the governance of the Foundation
Supervision of the start-up phase and coordination with the
project structure of IIT
42. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The project structure of IIT
42
IITwillmakeavailableaProjectStructureTeamtosupportthestartupphase
Administrative Project Structure (up to 16,5 FTE *)
Coordinator: Francesca Cagnoni
Scientific Project Structure
Coordinator: Fabio Pammolli
SELECTION OF
HT DIRECTOR
START UP OF THE
CENTRAL FACILITIES
JOINT LAB WITH
POLIMI
HUMAN RESOURCES
ADMINISTRATION
MANAGEMENT &
CONTROL
ICT
LEGAL
SECRETARIAT
* FTE = Full Time Equivalent
43. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The working groups of the Coordination Committee
Activity Coordinator Members
Statute of the
Foundation
Marco Simoni
Gabriele Galateri
Gianluca Vago
Masterplan Ferruccio Resta
Cristina Messa
Gianluca Vago
Performance indicators Massimo Inguscio
Walter Ricciardi
Martina C. Cornel
Alessandro Vespignini
Munther A. Dahleh
Selection criteria and
recruitment rules
Walter Ricciardi
Cristina Messa
Ferruccio Resta
Massimo Inguscio
Martina C. Cornel
Alessandro Vespignini
Munther A. Dahleh
43
44. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Calendar for 2017(6th February 2017)
February 2017: Call for selecting the HT Director General
March 2017: Committee Meeting
June 2017: Committee Meeting
September 2017: Call for selecting the HT Scientific Directors
January 2018: HT Foundation
44
46. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Table of contents
46
Appendix 1: the international comparison
Appendix 2: the Italian situation in the research sector by
number
47. Appendix 1
The international comparison
HumanTechnopole
Italy 2040
The New Italian Research Center
in the EXPO Area in Milan
48. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Cluster
Identifying the most active regions in the world:
- United States
SiliconValley and Boston area
- Asia and Middle East
Singapore, Hong Kong, Seoul andTel Aviv
- Europe
London, Cambridge, Heidelberg, Leuven, Amsterdam, Bonn
48
International comparison: the context and some
benchmarks
49. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Cluster – The value chain
Knowledge centers
Entrepreneurs and
behavior patterns
Liquidity
Financial markets
Infrastructures
Cluster policies
Presence of
international companies
Networks
Governments
Quality of life
49
Source: Gibbon, Sexian e Hinoul
50. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The importance of international comparison
The search for uniqueness is necessary. Uniqueness can be
achieved only through international comparison.The latter acts
as a «compass»
International comparison is fundamental. However, it should
not be conducted by adopting a «subaltern» approach and
attention should be paid to some elements revealing our country
specificity
50
51. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Most active regions in the world: United States
51
Italy California USA
Km2 (k) 301.3 423.9 9,834
Inhabitants (mln) 60.6 39.5 321.8
GDP per capita (k€)a 25.6 51 46
GERD per capita (€) 360b
2,168a
1,165
R&D FTE (% of total employment)e 1.1 n.a. 0.8
Patents (k)c 4.2 39.1e
36.9
Lombardy Silicon valley Massachusetts
Km2 (k) 23.8 4.8 27.3
Inhabitants (mln) 10 3 6.5
Inhabitants (%) 16.5a
7.6*c
2a
R&D FTE (% of total employment) 1.2e
n.a. n.a.
Patents (%) 21d
43e
19c
Milan San Francisco Boston
Km2 182 121 232
Inhabitants (mln) 1.3 0.8 0.6
Data 2016 a Data 2011 b Data 2015 c Data 2014 d Data 2012 e Data 2013
*San Jose metropolitan region Source: Eurostat, Us Patent andTrademark,
Bureau of EconomicAnalysis and National Center for Science and Engineering Statistics and Office
52. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Most active regions in the world: Asia and the
Middle East
52
Lombardy Singapore Hong Kong Israel South Korea
Km2 (k) 23.8 0.7 1.1 20.8 100.2
Inhabitants (mln) 10 5.5 7.3 8.5 50.6
GDP per capita (k€)a 33.9 49.7 32.8 31.5 22.6
GERD per capita (€) 464b
1,657c
366c
1,322c
904
R&D FTE (% of total employment) 1.2e
1.0c
0.7c
2.2c
1.6e
Patents (k) 0.9d
0.3c
0.1c
1.3c
6.4
Milan Tel Aviv Seoul
Km2 182 52 605
Inhabitants (mln) 1.3 0.4b
10.3
Data 2016
a Data 2011 c Data 2014
b Data 2015 d Data 2012 e Data 2013 Source: Eurostat,World Bank and Unesco
53. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
Most active regions in the world: Europe
53
Italy UK Belgium Germany Netherlands
Km2 (k) 301.3 242.5 30.5 357.0 41.5
Inhabitants (mln) 60.6 53.0 11.2 82.2 16.9
GDP per capitaa (k€) 25.6 29.6 34.5 33.3 35.9
GERD per capita (€)b 360 676 895 1,074 806
R&D FTE (% of total employment)e 1.1 1.3 1.5 1.5 1.5
Patents (k)c 4.2 5.4 1.5 20.7 3.5
Lombardy
Cambridge
shire
Flanders
Baden-
Württemberg
North
Holland
Km2 (k) 23.8 3.4 13.5 35.7 4.1
Inhabitants (mln) 10 0.7 6.5 10.8 2.8
Inhabitants (%) 16.5 1.4 57.6 13.1 16.3
R&D FTE (% of total employment)e 1.2 1.9 1.7 2.5 1.6
Patents (%)d 21 4 12 20 6
Milan London Cambridge Leuven Heidelberg Amsterdam
Km2 182 1.572 41 57 109 219
Inhabitants (mln) 1.3 8.7 0.1 0.1 0.2 0.8
Data 2016
*NUTS 1 (North East) Source: Eurostat
a Data 2011 b Data 2015 c Data 2014 d Data 2012 e Data 2013
54. Appendix 2
The Italian situation in the research sector by number
HumanTechnopole
Italy 2040
The New Italian Research Center
in the EXPO Area in Milan
55. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The Italian situation in the research sector by
numbers – The need to buck the trend
55
Source: Elaboration of MIUR andCINECA data
Data at 31st December of each year. *Academic staff 2016 at 4th November
* Research fellows: var. 2015-2013
Italy 2008 2009 2010 2011 2012 2013 2014 2015 2016*
Δ
(2008-
2016)
Δ %
Tenured academic staff 62,768 60,882 57,748 56,449 54,929 53,446 51,839 50,336 48,966 -13,802 -22.0%
Full Professors 18,929 17,880 15,854 15,242 14,522 13,890 13,263 12,867 12,689 -6,240 -33.0%
Associate Professors 18,256 17,567 16,955 16,611 16,143 15,810 17,541 20,037 19,814 1,558 8.5%
Assistant Professors 25,583 25,435 24,939 24,596 24,264 23,746 21,035 17,432 16,463 -9,120 -35.6%
Non-tenured academic staff 460 635 1,152 1,588 2,395 3,034 3,564 4,118 4,754 4,294
Art. 24 comma 3-a L. 240/10 3 148 1,118 1,972 2,611 2,971 3,234 3,234
Art. 24 comma 3-b L. 240/10 3 16 114 296 696 1,276 1,276
Art.1 comma 14 L. 230/05 460 635 1,149 1,437 1,261 948 657 451 244 -216 -47.0%
Total academic staff 63,238 61,534 58,937 58,080 57,384 56,604 55,602 54,750 54,007 -8,488 -13.4%
Research fellows na na na na na 16,002 15,511 13,940 13,606 -2,396 -15.0%
56. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI
The Italian situation in the research sector by
numbers – The number of researchers in a
comparative perspective
56
*A researcher is a professional engaged in the conception or creation of new knowledge, products, processes, methods and
systems, as well as in the management of the projects concerned (definition by Eurostat)
** Universities and research centers
Source: Eurostat and OECD data, year 2013
Total number of
researchers*
Total number of
HE researchers
Total number of
researchers per
1000 employed
UK 466,689 330,382 8.91
Germany 549,283 261,657 8.37
Spain 208,767 117,925 6.92
France 366,299 113,058 9.79
Italy 163,925 77,737** 4.77
57. HUMAN TECHNOPOLE PRESENTATION, 6TH FEBRUARY 2017STEFANO PALEARI 57
The Italian situation in the research sector by
numbers – R&D expenditure
Source: Eurostat
Total R&D expenditure
(€ per inhabitant)
R&D expenditure in the
HE sector (% GDP)
2008 2014 2008 2014
UK 523 590 0.43 0.43
Germany 809 1,045 0.43 0.51
Spain 322 276 0.35 0.35
France 642 727 0.41 0.46
Italy 324 367 0.35 0.39