A empresa anunciou um novo produto para competir no mercado de smartphones. O novo aparelho tem câmera de alta resolução, bateria de longa duração e processador rápido a um preço acessível. A expectativa é que o lançamento ajude a empresa a aumentar sua participação no mercado.
A empresa de tecnologia anunciou um novo smartphone com câmera aprimorada, tela maior e bateria de longa duração por um preço acessível. O dispositivo tem como objetivo atrair mais consumidores em mercados emergentes com suas especificações equilibradas e preço baixo. Analistas esperam que as melhorias e o preço baixo impulsionem as vendas do novo aparelho.
La Unión Europea ha acordado un paquete de sanciones contra Rusia por su invasión de Ucrania. Las sanciones incluyen restricciones a las importaciones de bienes de Rusia, así como sanciones financieras contra bancos y funcionarios rusos. Los líderes de la UE esperan que estas medidas disuadan a Rusia de continuar su agresión militar contra Ucrania.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
A empresa anunciou um novo produto para competir no mercado de smartphones. O novo aparelho tem câmera de alta resolução, bateria de longa duração e processador rápido a um preço acessível. A expectativa é que o lançamento ajude a empresa a aumentar sua participação no mercado.
A empresa de tecnologia anunciou um novo smartphone com câmera aprimorada, tela maior e bateria de longa duração por um preço acessível. O dispositivo tem como objetivo atrair mais consumidores em mercados emergentes com suas especificações equilibradas e preço baixo. Analistas esperam que as melhorias e o preço baixo impulsionem as vendas do novo aparelho.
La Unión Europea ha acordado un paquete de sanciones contra Rusia por su invasión de Ucrania. Las sanciones incluyen restricciones a las importaciones de bienes de Rusia, así como sanciones financieras contra bancos y funcionarios rusos. Los líderes de la UE esperan que estas medidas disuadan a Rusia de continuar su agresión militar contra Ucrania.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help boost feelings of calmness, happiness and focus.
60 dias comigo dr. dukan - parte 1 (01 a 43)Vanessa Dias
A empresa de tecnologia anunciou um novo smartphone com câmera aprimorada, tela maior e bateria de longa duração por um preço acessível. O dispositivo tem como objetivo atrair mais consumidores em mercados emergentes com suas especificações equilibradas e preço baixo. Analistas esperam que as melhorias e o preço baixo impulsionem as vendas do novo aparelho.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise has also been shown to increase gray matter volume in the brain and reduce risks for conditions like Alzheimer's and dementia.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow, releases endorphins, and promotes changes in the brain which help regulate emotions and stress levels.
The document discusses the history and current state of climate change research. It notes that scientific consensus has formed around the occurrence of climate change due to human activity like fossil fuel burning. The document warns that climate change poses risks to natural and human systems and that limiting global warming requires substantial reductions in greenhouse gas emissions.
The document discusses the history and importance of chocolate in human civilization. It notes that chocolate originated in Mesoamerica over 3000 years ago and was prized by the Aztecs and Mayans for its taste. Cocoa beans were used as currency and their cultivation was tightly regulated. The Spanish brought cocoa beans back to Europe in the 16th century, starting chocolate's global spread and popularity as both a drink and candy.
Product type- Drug development - Departments of facility- Registration pathwa...Asmaa Khalil
In this video you will know the detailed information about:
🔸Departments of the manufacturing sites.
🔸Steps of drug product development.
🔸Regulatory Affairs department.
🔸Registration pathway.
🔸Product Type (Innovator "RLD" / Generic / Hybrid).
🔸All medicines must grant a Marketing Authorization (MA) in order to be placed on the market legally in the country.
🔸The ultimate purpose of marketing authorization is to ensure that safe, effective & high-quality medicines, as to protect public health.
https://youtu.be/edUEFt681iM
#asmaa_khalil_ctd
Different Export Prices of Medicinal Drugs.pdfAsmaa Khalil
The document discusses different price levels for drugs from factory to public. The EX-Factory price is the cost from the seller's factory. The wholesaler price is between the factory and pharmacies. The public or retail price is what pharmacies charge the public. It also defines CIF, FOB, and CFR pricing terms for exports, with CIF including cost, freight, and insurance, FOB including just cost, and CFR including cost and freight but not insurance. Export prices generally use CIF or FOB, rarely CFR.
60 dias comigo dr. dukan - parte 1 (01 a 43)Vanessa Dias
A empresa de tecnologia anunciou um novo smartphone com câmera aprimorada, tela maior e bateria de longa duração por um preço acessível. O dispositivo tem como objetivo atrair mais consumidores em mercados emergentes com suas especificações equilibradas e preço baixo. Analistas esperam que as melhorias e o preço baixo impulsionem as vendas do novo aparelho.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise has also been shown to increase gray matter volume in the brain and reduce risks for conditions like Alzheimer's and dementia.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow, releases endorphins, and promotes changes in the brain which help regulate emotions and stress levels.
The document discusses the history and current state of climate change research. It notes that scientific consensus has formed around the occurrence of climate change due to human activity like fossil fuel burning. The document warns that climate change poses risks to natural and human systems and that limiting global warming requires substantial reductions in greenhouse gas emissions.
The document discusses the history and importance of chocolate in human civilization. It notes that chocolate originated in Mesoamerica over 3000 years ago and was prized by the Aztecs and Mayans for its taste. Cocoa beans were used as currency and their cultivation was tightly regulated. The Spanish brought cocoa beans back to Europe in the 16th century, starting chocolate's global spread and popularity as both a drink and candy.
Product type- Drug development - Departments of facility- Registration pathwa...Asmaa Khalil
In this video you will know the detailed information about:
🔸Departments of the manufacturing sites.
🔸Steps of drug product development.
🔸Regulatory Affairs department.
🔸Registration pathway.
🔸Product Type (Innovator "RLD" / Generic / Hybrid).
🔸All medicines must grant a Marketing Authorization (MA) in order to be placed on the market legally in the country.
🔸The ultimate purpose of marketing authorization is to ensure that safe, effective & high-quality medicines, as to protect public health.
https://youtu.be/edUEFt681iM
#asmaa_khalil_ctd
Different Export Prices of Medicinal Drugs.pdfAsmaa Khalil
The document discusses different price levels for drugs from factory to public. The EX-Factory price is the cost from the seller's factory. The wholesaler price is between the factory and pharmacies. The public or retail price is what pharmacies charge the public. It also defines CIF, FOB, and CFR pricing terms for exports, with CIF including cost, freight, and insurance, FOB including just cost, and CFR including cost and freight but not insurance. Export prices generally use CIF or FOB, rarely CFR.
Global medicine regulatory authorities websites.pdfAsmaa Khalil
This document lists regulatory authorities' websites for medicines in various countries and regions. It includes 38 websites for countries in Africa and the Eastern Mediterranean, 21 websites for countries in Europe and European authorities, 19 websites for countries in the Americas, 36 websites for countries in Asia, and 11 websites for countries in Russia and the CIS region. The websites listed are mainly for countries' ministries of health and medicines regulatory authorities.
This document provides an overview of Gulf and European registration pathways for pharmaceutical products. It compares the registration processes and requirements between the Gulf Cooperation Council (GCC) countries and the European Union (EU). Specifically, it outlines the national and centralized registration options in GCC countries and EU, compares Module 1 requirements and chemistry, manufacturing and controls (CMC) data requirements between GCC and EU dossiers. It also provides timelines and performance targets for the different registration procedures in Saudi Food and Drug Authority (SFDA) and the EU.
The document provides tips for improving CVs and developing careers in the pharmaceutical field. It recommends including personal details, education, computer skills, training courses, and checking for spelling errors on CVs. It also lists various career opportunities for pharmacists and free online trainings from global organizations covering medicine, pharmaceutical industry topics, and good manufacturing practices. Contact details are provided for networking and sharing beneficial resources.
This document lists links to various ministries of health and medicine regulatory authority websites around the world, organized by region. It includes over 150 links to websites for countries in Africa, the Eastern Mediterranean, Asia, Europe, and the Americas. The websites provided are for organizations that regulate medicines and pharmaceutical products in their respective countries.
The document lists 17 new molecular entities approved by the FDA in 2022, including drugs to treat insomnia, eczema, hemolytic anemia, myelofibrosis, seizures, prostate cancer, vulvovaginal candidiasis, hypertrophic cardiomyopathy, Helicobacter pylori infection, type 2 diabetes mellitus, plaque psoriasis, polyneuropathy of hereditary transthyretin-mediated amyloidosis, hepatorenal syndrome, elevated intraocular pressure, amyotrophic lateral sclerosis, bile duct cancer, acute myeloid leukemia, non-small cell lung cancer, HIV-1 infection, and as a hyperpolarized contrast agent. Each drug is listed with its active ingredient
To formally attest to a signature on a document, a notary public will sign and stamp the document with their seal after verifying the identity of the signer. For countries that have signed the Hague Convention, only an apostille is needed, which is a certificate attached to the document by the Ministry of Foreign Affairs to authenticate the notary's seal. If the country is not part of the Hague Convention, the document must go through a process of legalization where each country's authorities further authenticate the document so it will be recognized as valid.
The document discusses various aspects of process validation including:
- The three stages of process validation: process design, process qualification, and continued process verification.
- Key definitions related to process validation including qualification, validation, and continued process verification.
- The importance of process validation in ensuring consistent quality and reducing risk.
- Key documents required for stage 1 process design including development reports and control strategy documents.
How to implement a successful regulatory due diligence.pdfAsmaa Khalil
How to implement a successful regulatory due diligence, in order to grant the DP MA license on a short time frame?, and What are the Formatting requirements for eCTD Publishing?
Introduction about CTD, NeeS & eCTD.pdfAsmaa Khalil
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like depression and anxiety.
The document discusses common conflicts and pains that can lead to delays in the drug registration process from a commercial point of view. It identifies several key challenges, including lacking a project plan, regulatory intelligence, and issues with CMC data for both drug substances and drug products. Specific problems are outlined, such as invalid certificates, missing documentation, and inconsistencies between dossier sections. Recommendations are provided on how to address these challenges to minimize timelines and cut costs in the registration process.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
This document summarizes the different types of marketing authorizations (MAs) in the European Union. There are national MAs granted by individual countries, as well as mutual recognition procedures (MRP), decentralized procedures (DCP), and centralized procedures (CP) which allow approval in multiple EU states. The MRP and DCP rely on one state conducting an initial assessment, while the CP provides a single approval valid across all EU states. Applications must demonstrate a positive benefit-risk assessment based on quality, safety, and efficacy considerations.
This document provides information about career opportunities for pharmacists and how to build a career. It discusses roles in various practice settings like community pharmacies, hospitals, and the pharmaceutical industry. It also mentions roles in government agencies, academia, and research. The document then provides tips for career development like obtaining additional education and skills through online courses from organizations like USP, WHO, and Uppsala Monitoring Centre. It emphasizes the importance of ongoing learning and lists social media and networking platforms like LinkedIn for connecting with others in the field.
This document provides information about career opportunities for pharmacists and how to build a career. It discusses roles in various practice settings like community pharmacy, hospitals, and industry. Industry roles include departments like quality assurance, production, and regulatory affairs. Other career paths include government agencies and academic/research. The document then provides suggestions for education and skills development like online courses from USP, WHO, and Uppsala Monitoring Centre on topics like GMP, pharmacovigilance, and COVID-19. It also recommends connecting on LinkedIn and Facebook for virtual meetings on career planning, entrepreneurship, and digital skills.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.