Major functions of the gastrointestinal tract include digestion and absorption of food. Gastrointestinal disorders like peptic ulcer disease, constipation, and nausea and vomiting are treated with drugs. For constipation, laxatives are used including bulk forming, stool softeners, osmotic, and stimulant laxatives. Proton pump inhibitors are the most effective treatment for peptic ulcers by irreversibly inhibiting the H+/K+ ATPase pump. Triple therapy including a proton pump inhibitor, antibiotic, and misoprostol is used to eradicate Helicobacter pylori infections associated with peptic ulcers.
The document discusses drugs used to treat gastrointestinal disorders. It covers several topics:
1. It describes the major functions of the gastrointestinal tract and some common disorders like peptic ulcer disease, constipation, and nausea/vomiting.
2. It discusses different classes of laxatives used to treat constipation, including bulk-forming, stool softeners, osmotic, and stimulant laxatives.
3. It covers anti-emetic drugs for treating nausea/vomiting, including those that act on receptors in the chemoreceptor trigger zone and those that block vagal pathways.
These are local hormones called autacoids that are produced and act near their site of production. Key autacoids discussed include histamine, bradykinin, serotonin, prostaglandins, leukotrienes, thromboxanes, and platelet-activating factor. Histamine causes allergic reactions and is involved in gastric secretion. Bradykinin causes pain and inflammation. Prostaglandins regulate gastric acid secretion and platelet aggregation. Autacoids act through G-protein coupled receptors and are involved in processes like inflammation and smooth muscle contraction. H1 receptor antagonists and H2 receptor antagonists are used to treat allergic disorders and gastric acid conditions, respectively.
Antiemetics, Anti-Diarrheals and Drugs for Constipation and irritable bowel s...KuldeepKumar56017
This document discusses drugs used to treat gastrointestinal disorders like nausea, vomiting, diarrhea, constipation, and irritable bowel syndrome. It describes several classes of antiemetic, antidiarrheal, laxative drugs and their mechanisms of action. Specifically, it covers NK1 receptor antagonists like aprepitant for nausea, opioid drugs for diarrhea, various laxatives for constipation, and alosetron and antispasmodics for irritable bowel syndrome.
This document discusses various classes of anti-diarrheal drugs including opioid agonists like loperamide and diphenoxylate which inhibit intestinal motility, colloidal bismuth compounds like bismuth subsalicylate which coat the gastrointestinal tract, and bile salt-binding resins which bind excess bile acids in the intestine. It also covers octreotide, a synthetic somatostatin analogue, which reduces intestinal secretion and slows motility. Octreotide is used to treat diarrhea from conditions like carcinoid tumors, short bowel syndrome, or AIDS. All anti-diarrheal drugs have potential side effects and should not be used in cases of bloody diarrhea or high fever.
This document discusses drugs used to treat gastrointestinal disorders, focusing on those that reduce stomach acid. It describes the physiology of acid secretion and the roles of histamine, gastrin, and acetylcholine. It outlines the classes of drugs that work by reducing acidity, including H2 blockers like cimetidine and ranitidine, and proton pump inhibitors like omeprazole. The uses of these drugs in conditions like peptic ulcers, gastroesophageal reflux disease, and Zollinger-Ellison syndrome are covered. Proton pump inhibitors are highlighted as the most potent agents for inhibiting acid secretion.
This document summarizes different types of anti-diarrheal drugs, their mechanisms of action, pharmacokinetics, uses, and side effects. The main classes discussed are opioid agonists like loperamide, anticholinergics, alpha-2 adrenergic receptor agonists, and octreotide. Opioid agonists work by decreasing intestinal motility and secretions through mu and delta receptor activation. Anticholinergics decrease bowel motility and fluid absorption. Alpha-2 agonists inhibit fluid and electrolyte secretion and increase transit time. Octreotide is used for secretory diarrheas and inhibits the release of various hormones to produce anti-diarrheal effects.
The document discusses drugs used to treat gastrointestinal disorders. It covers several topics:
1. It describes the major functions of the gastrointestinal tract and some common disorders like peptic ulcer disease, constipation, and nausea/vomiting.
2. It discusses different classes of laxatives used to treat constipation, including bulk-forming, stool softeners, osmotic, and stimulant laxatives.
3. It covers anti-emetic drugs for treating nausea/vomiting, including those that act on receptors in the chemoreceptor trigger zone and those that block vagal pathways.
These are local hormones called autacoids that are produced and act near their site of production. Key autacoids discussed include histamine, bradykinin, serotonin, prostaglandins, leukotrienes, thromboxanes, and platelet-activating factor. Histamine causes allergic reactions and is involved in gastric secretion. Bradykinin causes pain and inflammation. Prostaglandins regulate gastric acid secretion and platelet aggregation. Autacoids act through G-protein coupled receptors and are involved in processes like inflammation and smooth muscle contraction. H1 receptor antagonists and H2 receptor antagonists are used to treat allergic disorders and gastric acid conditions, respectively.
Antiemetics, Anti-Diarrheals and Drugs for Constipation and irritable bowel s...KuldeepKumar56017
This document discusses drugs used to treat gastrointestinal disorders like nausea, vomiting, diarrhea, constipation, and irritable bowel syndrome. It describes several classes of antiemetic, antidiarrheal, laxative drugs and their mechanisms of action. Specifically, it covers NK1 receptor antagonists like aprepitant for nausea, opioid drugs for diarrhea, various laxatives for constipation, and alosetron and antispasmodics for irritable bowel syndrome.
This document discusses various classes of anti-diarrheal drugs including opioid agonists like loperamide and diphenoxylate which inhibit intestinal motility, colloidal bismuth compounds like bismuth subsalicylate which coat the gastrointestinal tract, and bile salt-binding resins which bind excess bile acids in the intestine. It also covers octreotide, a synthetic somatostatin analogue, which reduces intestinal secretion and slows motility. Octreotide is used to treat diarrhea from conditions like carcinoid tumors, short bowel syndrome, or AIDS. All anti-diarrheal drugs have potential side effects and should not be used in cases of bloody diarrhea or high fever.
This document discusses drugs used to treat gastrointestinal disorders, focusing on those that reduce stomach acid. It describes the physiology of acid secretion and the roles of histamine, gastrin, and acetylcholine. It outlines the classes of drugs that work by reducing acidity, including H2 blockers like cimetidine and ranitidine, and proton pump inhibitors like omeprazole. The uses of these drugs in conditions like peptic ulcers, gastroesophageal reflux disease, and Zollinger-Ellison syndrome are covered. Proton pump inhibitors are highlighted as the most potent agents for inhibiting acid secretion.
This document summarizes different types of anti-diarrheal drugs, their mechanisms of action, pharmacokinetics, uses, and side effects. The main classes discussed are opioid agonists like loperamide, anticholinergics, alpha-2 adrenergic receptor agonists, and octreotide. Opioid agonists work by decreasing intestinal motility and secretions through mu and delta receptor activation. Anticholinergics decrease bowel motility and fluid absorption. Alpha-2 agonists inhibit fluid and electrolyte secretion and increase transit time. Octreotide is used for secretory diarrheas and inhibits the release of various hormones to produce anti-diarrheal effects.
Presentation on Antacids and antiulcer drugs. Introduction to ulcers, classification of antiulcer drugs, their pharmacological actions, uses and adverse effects.
Group 5_ Year 3 Pharmacology 2023.pptxssuser504dda
This document discusses acid secretion disorder drugs and anti-emetic drugs. It begins by explaining the physiology of gastric acid secretion, which is regulated by gastrin, histamine, and acetylcholine. It then discusses acid secretion disorders like GERD, gastritis, and ulcers. The main drugs used for acid secretion disorders are outlined, including antacids, H2 receptor antagonists like ranitidine, and proton pump inhibitors like omeprazole. It provides details on their mechanisms of action, pharmacokinetics, uses and side effects. The document also briefly discusses anti-emetic drugs and the physiology of vomiting before concluding.
This document discusses antidiarrheal agents including opioid agonists like loperamide, bile salt-binding resins like cholestyramine, and octreotide. Opioid agonists increase colonic transit time through inhibition of nerves in the colon wall. Bile salt-binding resins bind excess bile salts in the colon that cause diarrhea. Octreotide is a synthetic somatostatin analogue that reduces intestinal secretion and slows motility, making it effective for treating diarrhea from various causes like short bowel syndrome or dumping syndrome. Potential side effects include changes in pancreatic function, gallbladder sludge, and alterations in blood sugar.
This document discusses drugs used to treat gastrointestinal tract disorders. It focuses on drugs for peptic ulcer disease, including proton pump inhibitors which irreversibly block acid production, and H2 receptor antagonists which reversibly compete with histamine. Proton pump inhibitors are more potent but H2 receptor antagonists adequately suppress nocturnal acid secretion. Cytoprotective drugs like misoprostol and sucralfate are also used. The document provides details on the physiology of acid secretion, mechanisms of action, pharmacokinetics, uses and side effects of these drug classes.
This document discusses drugs used to treat various gastrointestinal conditions. It describes several classes of antiemetic drugs that work through different mechanisms to prevent or relieve nausea and vomiting, including H1 antagonists, muscarinic receptor antagonists, dopamine antagonists, and 5HT3 antagonists. It also discusses the antiemetic metoclopramide and the prokinetic domperidone. Other sections cover prokinetic drugs, anti-spasmodics, anti-cholinergic drugs, laxatives (including their classifications and examples), and treatments for diarrhea like oral rehydration solutions and non-specific antidiarrheal drugs such as adsorbents and opiates.
This document summarizes drugs used to treat gastrointestinal disorders. It discusses drugs for peptic ulcers and GERD, including H2 blockers like ranitidine, proton pump inhibitors like omeprazole, and anti-H. pylori regimens. It also covers antacids, antiemetics, prokinetic drugs, and 5-HT3 antagonists used to treat nausea and vomiting. The mechanisms of action, uses, and side effects of these various drug classes are presented.
This document discusses the pathophysiology, treatment, and pharmacology of gout. It covers the following key points:
1) Gout is caused by the buildup of uric acid crystals in the joints due to high levels of uric acid in the blood. It discusses the biochemical pathway involved in uric acid production.
2) Treatment involves managing acute gout attacks with NSAIDs or colchicine, and lowering uric acid levels long-term with xanthine oxidase inhibitors like allopurinol and febuxostat, or uricosuric drugs like probenecid.
3) Colchicine provides rapid relief of gout attacks but has gastrointestinal side
DRUGS ACTING ON GI SYSTEM. pharmacology pptSuma Lakavath
This document provides an overview of gastrointestinal agents used to treat conditions affecting the GI tract, including antiemetics, antidiarrheals, and laxatives. It discusses the anatomy and functions of the GI tract and describes various causes of vomiting, diarrhea, and constipation. It then outlines eight categories of prescription antiemetics and their mechanisms and side effects. Nonpharmacologic approaches and over-the-counter antidiarrheal and laxative agents are also reviewed. The document provides detailed information on specific drugs used to treat GI issues.
This document discusses various classes of drugs used to treat gastrointestinal disorders. It describes the mechanisms of action, indications, examples, side effects and counseling points for histamine H2 receptor blockers, proton pump inhibitors, mucosal protectants, prostaglandins, antacids, antiemetics, antidiarrheals, laxatives and antispasmodics.
This document summarizes anti-ulcer drugs. It discusses the causes of ulcers including H. pylori infections and NSAID use. The main types of ulcers are described along with signs and symptoms. Treatment includes eradicating H. pylori, decreasing acid secretion through proton pump inhibitors or H2 receptor blockers, and protecting the stomach lining with drugs like misoprostol or sucralfate. Proton pump inhibitors are now the most potent way to decrease acid production and promote ulcer healing.
This document provides an overview of drugs acting on the gastrointestinal tract. It discusses the major parts of the GIT and disorders related to it like peptic ulcer and achlorhydria. It then covers the different classes of drugs used to treat GIT disorders like antiulcer drugs, drugs for achlorhydria, antiemetics, antidiarrheal agents, and laxatives. The mechanisms and examples of commonly used drugs from each class are described in detail.
This document summarizes drugs used to treat gastrointestinal disorders. It discusses antiemetics for vomiting, antidiarrheals for diarrhea, laxatives for constipation, and anti-ulcer drugs. It describes the causes and types of each condition and classifies the drugs by their mechanisms of action, including opiates, anticholinergics, antacids, H2 blockers, PPIs, pepsin inhibitors, and prostaglandin analogues. Common side effects are also outlined for each drug class.
Emetics, antiemetics and prokinetic agents.pptxsapnabohra2
The document discusses emetics and antiemetics. It describes the physiology of vomiting and pathophysiology of cytotoxic drug-induced vomiting. It discusses various emetics like apomorphine, ipecacuanha, and their mechanisms of action. It also discusses various classes of antiemetics like dopamine D2 antagonists, 5-HT3 antagonists, antimuscarinics, neuroleptics, neurokinin receptor antagonists and others. It provides details about specific drugs from these classes like ondansetron, metoclopramide, domperidone. It also discusses prokinetic agents that enhance gastrointestinal motility like metoclopramide, domperidone,
The document discusses drugs used to treat diarrhea and constipation. It describes the epidemiology of diarrhea and constipation and provides an overview of treatment approaches. It then focuses on specific drug classes used to treat diarrhea, including oral rehydration salts, antimotility agents, antisecretory agents, adsorbents, bacteria replacements, and antibiotics. It also briefly discusses drugs used to treat constipation, including bulk laxatives, stool softeners, saline/osmotic laxatives, stimulant laxatives, and lubricant laxatives.
This document discusses various drugs used to treat gastrointestinal conditions. It covers drugs that act on the gastrointestinal tract like antacids, H2 receptor blockers, proton pump inhibitors, cytoprotectants, antidiarrheals, and antibiotics for H. pylori eradication. It discusses their mechanisms of action, uses, and side effects. Laxatives are also covered, with classifications and mechanisms of different types.
This document discusses drugs acting on the gastrointestinal tract. It covers drugs used to treat peptic ulcer disease including H2 receptor antagonists that decrease acid secretion and proton pump inhibitors. It discusses antimicrobial therapy to eradicate Helicobacter pylori infections. Mucosal protective agents like sucralfate and antacids that neutralize acid are also mentioned. The document outlines drugs used to control chemotherapy-induced vomiting including 5-HT3 receptor antagonists, phenothiazines, and substituted benzamides. It provides details on metoclopramide and its mechanism as a prokinetic and antiemetic drug.
This document discusses various drugs that affect the gastrointestinal system. It covers drugs that affect GI secretions like antacids, H2 receptor blockers, proton pump inhibitors, mucosal protectants, and prostaglandin analogs. It also discusses laxatives, which are used to increase bowel movements, and are classified based on their mechanisms of action. Common side effects and nursing considerations are provided for each drug class.
Steroids are hormones that have wide-ranging effects in the body. Common types include mineralocorticoids like aldosterone, glucocorticoids like cortisol and prednisone, and androgens. They work by binding to intracellular receptors and acting as transcription factors to influence gene expression. Glucocorticoids are commonly prescribed for their anti-inflammatory and immunosuppressive effects to treat conditions like asthma, arthritis, and IBD. Their use can cause adverse effects like fluid retention, hypertension, immunosuppression, and HPA axis suppression requiring tapering of treatment. Dexamethasone and prednisone are potent synthetic glucocorticoids often used orally or parenterally
The document discusses strategies for a firm's growth, including internal and external strategies. Internal growth strategies involve expanding within the organization, such as market penetration, market development, product development, and diversification. External growth strategies involve expanding outside the organization through mergers, acquisitions, joint ventures, strategic alliances, franchising, and licensing agreements. Firms must develop growth strategies tailored to their own characteristics and operating environment to most effectively increase objectives, broaden customer reach, and reduce costs.
The document discusses health and human behavior. It defines key terms like health, determinants of health, and factors influencing human health behavior. It explains that health is influenced by behaviors and environmental factors. Behaviors are under individual control while environmental factors are not. The document also outlines different types of health behaviors like promotive, preventive, utilization, at-risk, illness, compliance and rehabilitation behaviors. It discusses factors that influence behaviors like predisposing factors (knowledge, attitudes), enabling factors (resources, skills) and reinforcing factors (social rewards). Approaches to behavior change like persuasion and informed decision making are also summarized.
Presentation on Antacids and antiulcer drugs. Introduction to ulcers, classification of antiulcer drugs, their pharmacological actions, uses and adverse effects.
Group 5_ Year 3 Pharmacology 2023.pptxssuser504dda
This document discusses acid secretion disorder drugs and anti-emetic drugs. It begins by explaining the physiology of gastric acid secretion, which is regulated by gastrin, histamine, and acetylcholine. It then discusses acid secretion disorders like GERD, gastritis, and ulcers. The main drugs used for acid secretion disorders are outlined, including antacids, H2 receptor antagonists like ranitidine, and proton pump inhibitors like omeprazole. It provides details on their mechanisms of action, pharmacokinetics, uses and side effects. The document also briefly discusses anti-emetic drugs and the physiology of vomiting before concluding.
This document discusses antidiarrheal agents including opioid agonists like loperamide, bile salt-binding resins like cholestyramine, and octreotide. Opioid agonists increase colonic transit time through inhibition of nerves in the colon wall. Bile salt-binding resins bind excess bile salts in the colon that cause diarrhea. Octreotide is a synthetic somatostatin analogue that reduces intestinal secretion and slows motility, making it effective for treating diarrhea from various causes like short bowel syndrome or dumping syndrome. Potential side effects include changes in pancreatic function, gallbladder sludge, and alterations in blood sugar.
This document discusses drugs used to treat gastrointestinal tract disorders. It focuses on drugs for peptic ulcer disease, including proton pump inhibitors which irreversibly block acid production, and H2 receptor antagonists which reversibly compete with histamine. Proton pump inhibitors are more potent but H2 receptor antagonists adequately suppress nocturnal acid secretion. Cytoprotective drugs like misoprostol and sucralfate are also used. The document provides details on the physiology of acid secretion, mechanisms of action, pharmacokinetics, uses and side effects of these drug classes.
This document discusses drugs used to treat various gastrointestinal conditions. It describes several classes of antiemetic drugs that work through different mechanisms to prevent or relieve nausea and vomiting, including H1 antagonists, muscarinic receptor antagonists, dopamine antagonists, and 5HT3 antagonists. It also discusses the antiemetic metoclopramide and the prokinetic domperidone. Other sections cover prokinetic drugs, anti-spasmodics, anti-cholinergic drugs, laxatives (including their classifications and examples), and treatments for diarrhea like oral rehydration solutions and non-specific antidiarrheal drugs such as adsorbents and opiates.
This document summarizes drugs used to treat gastrointestinal disorders. It discusses drugs for peptic ulcers and GERD, including H2 blockers like ranitidine, proton pump inhibitors like omeprazole, and anti-H. pylori regimens. It also covers antacids, antiemetics, prokinetic drugs, and 5-HT3 antagonists used to treat nausea and vomiting. The mechanisms of action, uses, and side effects of these various drug classes are presented.
This document discusses the pathophysiology, treatment, and pharmacology of gout. It covers the following key points:
1) Gout is caused by the buildup of uric acid crystals in the joints due to high levels of uric acid in the blood. It discusses the biochemical pathway involved in uric acid production.
2) Treatment involves managing acute gout attacks with NSAIDs or colchicine, and lowering uric acid levels long-term with xanthine oxidase inhibitors like allopurinol and febuxostat, or uricosuric drugs like probenecid.
3) Colchicine provides rapid relief of gout attacks but has gastrointestinal side
DRUGS ACTING ON GI SYSTEM. pharmacology pptSuma Lakavath
This document provides an overview of gastrointestinal agents used to treat conditions affecting the GI tract, including antiemetics, antidiarrheals, and laxatives. It discusses the anatomy and functions of the GI tract and describes various causes of vomiting, diarrhea, and constipation. It then outlines eight categories of prescription antiemetics and their mechanisms and side effects. Nonpharmacologic approaches and over-the-counter antidiarrheal and laxative agents are also reviewed. The document provides detailed information on specific drugs used to treat GI issues.
This document discusses various classes of drugs used to treat gastrointestinal disorders. It describes the mechanisms of action, indications, examples, side effects and counseling points for histamine H2 receptor blockers, proton pump inhibitors, mucosal protectants, prostaglandins, antacids, antiemetics, antidiarrheals, laxatives and antispasmodics.
This document summarizes anti-ulcer drugs. It discusses the causes of ulcers including H. pylori infections and NSAID use. The main types of ulcers are described along with signs and symptoms. Treatment includes eradicating H. pylori, decreasing acid secretion through proton pump inhibitors or H2 receptor blockers, and protecting the stomach lining with drugs like misoprostol or sucralfate. Proton pump inhibitors are now the most potent way to decrease acid production and promote ulcer healing.
This document provides an overview of drugs acting on the gastrointestinal tract. It discusses the major parts of the GIT and disorders related to it like peptic ulcer and achlorhydria. It then covers the different classes of drugs used to treat GIT disorders like antiulcer drugs, drugs for achlorhydria, antiemetics, antidiarrheal agents, and laxatives. The mechanisms and examples of commonly used drugs from each class are described in detail.
This document summarizes drugs used to treat gastrointestinal disorders. It discusses antiemetics for vomiting, antidiarrheals for diarrhea, laxatives for constipation, and anti-ulcer drugs. It describes the causes and types of each condition and classifies the drugs by their mechanisms of action, including opiates, anticholinergics, antacids, H2 blockers, PPIs, pepsin inhibitors, and prostaglandin analogues. Common side effects are also outlined for each drug class.
Emetics, antiemetics and prokinetic agents.pptxsapnabohra2
The document discusses emetics and antiemetics. It describes the physiology of vomiting and pathophysiology of cytotoxic drug-induced vomiting. It discusses various emetics like apomorphine, ipecacuanha, and their mechanisms of action. It also discusses various classes of antiemetics like dopamine D2 antagonists, 5-HT3 antagonists, antimuscarinics, neuroleptics, neurokinin receptor antagonists and others. It provides details about specific drugs from these classes like ondansetron, metoclopramide, domperidone. It also discusses prokinetic agents that enhance gastrointestinal motility like metoclopramide, domperidone,
The document discusses drugs used to treat diarrhea and constipation. It describes the epidemiology of diarrhea and constipation and provides an overview of treatment approaches. It then focuses on specific drug classes used to treat diarrhea, including oral rehydration salts, antimotility agents, antisecretory agents, adsorbents, bacteria replacements, and antibiotics. It also briefly discusses drugs used to treat constipation, including bulk laxatives, stool softeners, saline/osmotic laxatives, stimulant laxatives, and lubricant laxatives.
This document discusses various drugs used to treat gastrointestinal conditions. It covers drugs that act on the gastrointestinal tract like antacids, H2 receptor blockers, proton pump inhibitors, cytoprotectants, antidiarrheals, and antibiotics for H. pylori eradication. It discusses their mechanisms of action, uses, and side effects. Laxatives are also covered, with classifications and mechanisms of different types.
This document discusses drugs acting on the gastrointestinal tract. It covers drugs used to treat peptic ulcer disease including H2 receptor antagonists that decrease acid secretion and proton pump inhibitors. It discusses antimicrobial therapy to eradicate Helicobacter pylori infections. Mucosal protective agents like sucralfate and antacids that neutralize acid are also mentioned. The document outlines drugs used to control chemotherapy-induced vomiting including 5-HT3 receptor antagonists, phenothiazines, and substituted benzamides. It provides details on metoclopramide and its mechanism as a prokinetic and antiemetic drug.
This document discusses various drugs that affect the gastrointestinal system. It covers drugs that affect GI secretions like antacids, H2 receptor blockers, proton pump inhibitors, mucosal protectants, and prostaglandin analogs. It also discusses laxatives, which are used to increase bowel movements, and are classified based on their mechanisms of action. Common side effects and nursing considerations are provided for each drug class.
Steroids are hormones that have wide-ranging effects in the body. Common types include mineralocorticoids like aldosterone, glucocorticoids like cortisol and prednisone, and androgens. They work by binding to intracellular receptors and acting as transcription factors to influence gene expression. Glucocorticoids are commonly prescribed for their anti-inflammatory and immunosuppressive effects to treat conditions like asthma, arthritis, and IBD. Their use can cause adverse effects like fluid retention, hypertension, immunosuppression, and HPA axis suppression requiring tapering of treatment. Dexamethasone and prednisone are potent synthetic glucocorticoids often used orally or parenterally
The document discusses strategies for a firm's growth, including internal and external strategies. Internal growth strategies involve expanding within the organization, such as market penetration, market development, product development, and diversification. External growth strategies involve expanding outside the organization through mergers, acquisitions, joint ventures, strategic alliances, franchising, and licensing agreements. Firms must develop growth strategies tailored to their own characteristics and operating environment to most effectively increase objectives, broaden customer reach, and reduce costs.
The document discusses health and human behavior. It defines key terms like health, determinants of health, and factors influencing human health behavior. It explains that health is influenced by behaviors and environmental factors. Behaviors are under individual control while environmental factors are not. The document also outlines different types of health behaviors like promotive, preventive, utilization, at-risk, illness, compliance and rehabilitation behaviors. It discusses factors that influence behaviors like predisposing factors (knowledge, attitudes), enabling factors (resources, skills) and reinforcing factors (social rewards). Approaches to behavior change like persuasion and informed decision making are also summarized.
This document provides information on oncology nursing objectives and cancer pathophysiology. It defines key terms like neoplasia, tumors, and cancer. It describes the biological process of oncogenesis and carcinogenesis. It discusses cancer cell proliferation patterns and etiology factors like viruses, chemicals, genetics, diet, and hormones. It also covers cancer detection, diagnosis, staging, grading, and primary treatment methods including surgery, radiation therapy, and chemotherapy.
Chest trauma can be classified as either blunt or penetrating. Blunt chest trauma results from sudden compression or positive pressure to the chest wall from motor vehicle crashes, falls, or bicycle crashes. This can lead to hypoxemia from airway disruption, injury to the lung parenchyma or ribs, massive hemorrhage, collapsed lung, or pneumothorax. Rib fractures are the most common blunt chest injury and cause pain with breathing. Flail chest involves at least two fractures in two or more ribs, creating a floating segment that moves paradoxically with breathing and is associated with severe lung injury. Treatment for flail chest involves pain control, positive pressure ventilation, and sometimes surgical fixation of the fractures.
The document discusses various classes of antimicrobial drugs, including antibacterial agents. It describes the classification, mechanisms of action, spectra of activity, therapeutic uses and adverse effects of different classes of antibacterial drugs such as beta-lactam antibiotics (penicillins, cephalosporins, carbapenems), and their role in treatment and prevention of bacterial infections. It also addresses concepts of drug resistance and strategies to prevent emergence of resistance.
Carbohydrates can be classified as monosaccharides, oligosaccharides, or polysaccharides. Monosaccharides include glucose, fructose, and galactose. Oligosaccharides have 2-10 monosaccharide units linked together, while polysaccharides contain over 10 units and include starch, glycogen, cellulose. Carbohydrates provide energy and are important structural components. Their digestion and absorption provides glucose for cellular metabolism. Disorders like diabetes occur when insulin production or function is inadequate, leading to high blood glucose levels and metabolic disturbances.
The document discusses drugs that act on the autonomic nervous system. It introduces the two divisions of the autonomic nervous system - the sympathetic and parasympathetic nervous systems. The major transmitters of each system are described as acetylcholine, norepinephrine, and epinephrine. Cholinergic receptors, which mediate responses to acetylcholine, and adrenergic receptors, which mediate responses to norepinephrine and epinephrine, are defined. The locations and functions of these receptor subtypes are outlined. An overview of the autonomic nervous system and the roles of the sympathetic and parasympathetic systems are provided. The document goes on to describe various cholinergic and anticholinergic drugs
The document discusses drugs acting on the central nervous system (CNS). It first introduces that CNS drugs are used for both medical and non-medical purposes to act on the brain and spinal cord. It then discusses the major neurotransmitters of the CNS including noradrenaline, dopamine, serotonin, and acetylcholine. For each neurotransmitter, it briefly describes their physiological functions. The document also provides information on drugs used for Parkinson's disease, epilepsy, and schizophrenia, outlining their mechanisms of action, therapeutic uses, and common medications employed to treat each condition.
Lipids are a heterogeneous group of compounds that are insoluble in water but soluble in organic solvents. They serve important structural and energy storage functions. Lipids include fats, oils, waxes, phospholipids, and sterols. They undergo digestion in the small intestine by pancreatic lipases into fatty acids and monoacylglycerols. Fatty acids are transported to tissues for energy production or storage. Triglycerides in adipose tissue undergo lipolysis to release fatty acids into the bloodstream. In mitochondria, fatty acids undergo beta-oxidation in repeated cycles to produce acetyl-CoA for the TCA cycle or ketone body production.
Drugs used to treat pain, inflammation and gout can be categorized as non-steroidal anti-inflammatory drugs (NSAIDs) or steroidal anti-inflammatory drugs. NSAIDs such as aspirin, ibuprofen, and celecoxib work by inhibiting the COX enzyme and reducing prostaglandin production, providing analgesic, antipyretic, and anti-inflammatory effects with fewer side effects than traditional NSAIDs. They are used to treat conditions involving pain and inflammation. Potential adverse effects include gastrointestinal irritation and bleeding. Treatment for acute gout involves NSAIDs, colchicine, or glucocorticoids, while chronic treatment uses allopurinol, colchicine, or
Amino acids are the building blocks of proteins. They polymerize via peptide bonds to form protein structures. There are 20 standard amino acids, some of which are essential and must be obtained through diet. Proteins have primary, secondary, tertiary, and quaternary levels of structure which determine their shape and function. Digestion of proteins begins in the stomach through the actions of pepsin, rennin, and gastric acid. Further digestion occurs in the small intestine through aminopeptidases and other enzymes.
The document summarizes key aspects of gluconeogenesis and glycogenesis. Gluconeogenesis is the process by which glucose is generated from non-carbohydrate carbon substrates like lactate, glycerol, and amino acids in the liver. It is an energetically expensive process that bypasses three irreversible steps in glycolysis. Glycogenesis is the process of glycogen synthesis from glucose-6-phosphate in the liver and muscle. It involves the activation of glucose to UDP-glucose by UDP-glucose pyrophosphorylase and the transfer of glucose units to glycogen by glycogen synthase and branching enzyme to form the highly branched glycogen polymer.
This document discusses anti-fungal drugs. It begins by explaining that fungi are eukaryotic organisms that differ from bacteria in having a nucleus, cell wall composed of chitin, and cell membrane containing ergosterol. Fungal infections can be superficial, affecting the skin/nails, or systemic. The document then categorizes and describes several classes of anti-fungal drugs including polyenes like amphotericin B and nystatin, azoles like ketoconazole and fluconazole, flucytosine, and echinocandins like caspofungin. It provides details on the mechanism of action, pharmacokinetics, uses, and side effects of
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Aims to equip people who aspire to become leaders with good qualities,and with Christian values and morals as per Biblical teachings.The you who aspire to be leaders should first read and understand what the ambassador module for leadership says about leadership and marry that to what the bible says.Christians sh
2. Major function of GIT include;
Digestion and absorption of food,
In addition ,its endocrine system and neural network has an
integrative role
Major GIT disorders include PUD, constipation, nausea and
vomiting, etc…
Medicines for treating these gastrointestinal disorders
comprise some 8% of all prescriptions
10/11/2022 2
3. GIT cont’d
Drugs used for constipation;
LAXATIVES
• Used in the treatment of constipation, poison removal,
preparation of bowel for surgery and for removal of parasites
after anthelementics
• Classified by their major mechanism of action
1. BULK FORMING LAXATIVES
– Indigestible, hydrophilic Colloids that absorb water, forming a
bulky, emollient gel that distends colon & promotes peristalsis.
– Natural: psylium, methylcellulose
– Synthetic fiber: polycarbophil
– Bacterial digestion of the fiber in colon bloating and flatus
3
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4. GIT cont’d
2. STOOL SOFTNERS/SURFACTANT AGENTS
• Change surface tension of fluids in the bowel - this has an emulsifying effect on
feces, making them retain more water and hence softer - easier to pass out
• Glycerine suppositories.
• Docusate oral or enema
• Liquid paraffin
– Oily, liquid substance
– Not used anymore
• Absorbs the fat soluble vitamins in the gut, and therefore you
loose your fat soluble vitamins
4
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5. GIT cont’d
3. OSMOTIC LAXATIVES
• Soluble but not absorbable, resulting in increased stool liquidity
• treatment/prevention of acute/chronic constipation, respectively
• Nonabsorbable sugar: sorbitol & lactulose
♦ metabolized by colonic bacteria → severe flatus & cramp
• Nonabsorbable salt: magnesium oxide/ milk of magnesia
♦ hypermagnesemia in renal insufficient patient if used for
prolonged period
• High dose of osmotically active agents produce purgation within 1-
3hs
• Balanced polyethylene glycol: lavage solution containing PEG are
used for complete colonic cleansing prior to GI endoscopy
5
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6. GIT cont’d
4. STIMULANT LAXATIVES/ CATHARTICS
• Direct stimulation of the enteric nervous system and colonic fluid
and electrolyte secretion
• Long term: dependency & destruction of myenteric plexus; atony
• Useful in neurologically impaired and in bed bound patients in
long term care facility
• Anthraquinone derivatives
-Aloe, senna & cascara: bowel movement in 6-8hs after p.o.
- cause brown pigmentation of colon “melanosis coli”
• Caster oil: hydrolysed in small intestine to ricinoleic acid-irritant
that stimulates motility.
6
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7. GIT cont’d
TREATMENT OF DIARRHOEAS
• Therapeutic measures:
– treatment of fluid depletion, shock, and acidosis
– maintenance of nutrition
– drug therapy
• Rehydration
– Intravenous rehydration in severe fluid loss [10% body
weight]
– Oral rehydration if the fluid loss is mild
• Antimicrobials are of no use in diarrhea due to noninfective
causes
• Antimicrobials are useful only in severe disease
• Travellers diarrhea:mostly due to C.pylori, virus
[cotrimoxazole, norfloxacin, doxycycline, erythromycin]
7
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8. GIT cont’d
ANTI EMETICS
• Main area responsible for vomiting is the vomiting center
• It receives input from many areas:
– Chemoreceptor trigger zone -picks up circulating chemical
in the blood
– Vestibular apparatus
– vagal afferents from the gut
– Direct input from gut (reflex)
• Receptors involved in the emetic response
· On the CTZ: 5HT3, D2
· On the vagal afferents: 5HT3
· In the vomiting center: Muscarinic, H1 receptors
8
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10. GIT cont’d
• Drugs which causes nausea and vomiting
– Apomorphine (and Bromocriptine)
· Acts on the D2 receptor in the CTZ to
cause vomiting
– Cisplatin
· causes release of serotonin in the gut
10
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11. GIT cont’d
ANTI EMETIC DRUGS CHOICE
1. Motion Sickness
Promethazine
• H1 antagonist, antimuscarinic actions
• Used as a sedative in children
• Effective at preventing motion sickness (since the vestibular
afferents input in the vomiting center which has H1 and
Muscarinic receptors
• Not used for the driver [drowsy]
11
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12. Hyoscine (scopolamine)-anti-cholinergic.
Available as oral, subcutaneous, and transdermal
Can be used as a patch behind the ear
suppresses nerve traffic in neuronal pathway from vestibular
apparatus of inner ear to vomiting center
common side effects are dry mouth, blurred vision, drowsiness
more severe side effects include urinary retention,
constipation, and disorientation
10/11/2022 12
13. GIT cont’d
2. CTZ Mediated Vomiting
• Prochlorperazine
– phenothiazine, D2 antagonist
– Has no antipsychotic effects
– Useful as an antiemetic as well as for dizziness
– Has minor anticholinergic effects (it may work in motion
sickness, however, the above drugs are preferred)
– blocks D2 receptors elsewhere (e.g. substantia
nigra)cause extrapyramidal effects
– Chlorpromazine can also be used as an antiemetic,
although it tends to be very sedative
13
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14. GIT cont’d
• Metoclopromide
– D2 antagonist, weak 5HT3 antagonist
– Increases motility of the gut in the upper regions
– Useful because when someone is nauseous, there
is often gastric stasis
– helps absorption of drugs as it stimulates gastric
emptying
14
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15. GIT cont’d
3. Vomiting associated with vagal afferents (gut disorders,
heart, gut irritants - all stimulate the 5HT3 receptor on
the vagal afferents)
• Ondansetron
– Most effective drug available for suppressing nausea and vomiting caused
by cisplatin and other highly emetogenic anticancer drugs.
– 5HT3 antagonist
– Effective in patients receiving cancer chemotherapy (radiation or cisplatin
– stimulate the release of serotonin in the gut)
– Can also be used for CTZ nausea
15
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16. GIT cont’d
DRUGS FOR PEPTIC ULCER
• Ulcer: Breakdown of the protective mucosal
layer
– Common sites: Duodenum & Stomach
– Pain is due to:
· Acid acting on the erosion
· Increase in the motility of the gut, causing increased
intramural tension (antimotility agents decrease the pain)
16
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17. GIT cont’d
Causes of peptic ulcer
• Imbalance b/n protective and aggressive factors
• Defensive factors; mucus, bicarbonate, sub mucosal
blood flow and prostaglandins.
• Aggressive factors;
H. pylori
Excess HCL or pepsin secretion
Stress
NSAIDs
Alcohol, smoking, spicy foods etc
Treatment strategy;
decrease aggressive factors or increase defensive
factors
17
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20. Antacids
o Weak bases that neutralize acid
o Also inhibit formation of pepsin (As pepsinogen
converted to pepsin at acidic pH)
o Present day antacids :
Aluminium Hydroxide
Magnesium Hydroxide
o OTC drug for symptomatic relief of dyspepsia
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21. Duration of action :
o 30 min when taken in empty stomach
o 2 hrs when taken after a meal
o Side effects :
Al3+ antacids – constipation (As they relax gastric
smooth muscle & delay gastric emptying)
Mg2+ antacids – Osmotic diarrhoea .
In renal failure Al3+ antacid – Aluminium toxicity
&
Encephalopathy
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22. Drug interaction of antacids;
oAdsorb drugs and form insoluble complexes that are not absorbed .
Clinical importance :
o Interactions can be avoided by taking antacids 2 hrs before or after ingestion
of other drugs .
o rational to combine aluminium hydroxide and magnesium hydroxide in
antacid preparations
Combination provides a relatively fast and sustained
neutralising capacity .
(Magnesium Hydroxide – Rapidly acting
Aluminium Hydroxide - Slowly acting )
Combination preserves normal bowel function.
(Aluminium Hydroxide – constipation
Magnesium hydroxide – diarrhoea )
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23. 10/11/2022 23
Histamine H2 Receptor Antagonist
Reversible competitive inhibitors of H2 receptor
Highly selective, No action on H1 or H3 receptors
Very effective in inhibiting nocturnal acid secretion ( as
it depends largely on Histamine )
Modest impact on meal stimulated acid secretion (As it
depends on gastrin, acetyl choline and histamine)
25. H2 Blockers–Side effects & Interactions
Extremely safe drugs
Cimetidine inhibits CYP450 & increases conc. of Warfarin,
Theophylline, Phenytoin, Ethanol
CNS- Mental status change (confusion, agitation, hallucination)
in i.v. H2 antagonist
Endocrine effect: cimetidine inhibits binding of
dihydrotestosterone, inhibits metabolism of estradiol, increase
prolactin [gynecomasia, impotence in male; galactorrhea]
Cross the placenta &secreted into breast milk
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26. Drug interaction:
cimetidine interfere hepatic cytochrome P450 drug
metabolism pathways
warfarin,
theophylline,
phenytoin, lidocaine, quinidine, propranolol, TCAs,
several benzodiazepines,
CCBs, sulfonylureas, metronidazole, and ethanol
10/11/2022 26
27. Proton Pump Inhibitors (PPIs)
Most effective drugs in antiulcer therapy
Irreversible inhibitor of H+ K+ ATPase
Prodrugs requiring activation in acid environment
Weakly basic drugs & so accumulate in canaliculi of parietal cell
Activated in canaliculi & binds covalently to extracellular
domain of H+ K+ ATPase
Acid secretion resumes only after synthesis of new molecules
Since they require acid for activation - given 1 hr before meals
Other acid suppressing agents not coadministered
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31. Sucralfate;
Salt of sucrose complexed to sulfated aluminium
hydroxide
In acidic pH polymerises to viscous gel that adheres to
ulcer crater
Taken on empty stomach 1 hr. before meals
Concurrent antacids, H2 antagonist avoided
( as it needs acid for activation )
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32. Misoprostol;
PGE2 analogue
Modest acid inhibition
Stimulate mucus & bicarbonate secretion
Enhance mucusal blood flow
Approved for prevention of NSAID induced ulcer
Diarrhoea & cramping abd. pain – 20 %
Not so popular as P.P.I are more effective &
better tolerated
10/11/2022 32
33. PGE2 protects the stomach in a number of ways:
limits the amount of gastric acid being released
It increases mucous secretion
It increases blood flow to the stomach
· Side effects:
· Colic and diarrhoea
· Dangerous in pregnancy PGE2 contracts the uterus
10/11/2022 33
34. Colloidal Bismuth Compounds
Coats ulcer, stimulates mucus & bicarbonate secretion
Direct antimicrobial activity against H.pylori
May cause blackening of stools & tongue
Not used for long periods – bismuth toxicity
Available compounds :
Bismuth subsalicylate – in USA
Bismuth sobcitrate – in Europe
Bismuth dinitrate
10/11/2022 34
35. TREATMENT OF PUD CAUSED by H PYLORI
H pylori is a gram negative bacilli that colonize itself in acidic environment of
stomach.
Now generally considered to be a major cause of chronic gastritis.
Eradication of H. pylori infection promotes rapid & long-term healing of ulcers.
If a patient with PUD is positive for H Pylori, then it can be eradicated with a
1- or 2-week regimen of 'triple therapy'.
Triple theraoy comprises a PPI in combination with antibiotics amoxicillin or
metronidazole and clarithromycin.
In case of the 2-week regimen, bismuth-containing preparations are added.
10/11/2022 35
37. Summary of drugs for PUD
1. PUD only
First Line
Ranitidine, 150 mg P.O. BID OR 300 mg at bedtime for 4 – 6 weeks.
Alternatives
Cimetidine, 400 mg P.O. BID, with breakfast and at night, OR 800 mg
at night for 4 - 6 weeks.
OR
Famotidine, 40 mg, P.O. at night for 4 – 6 weeks.
OR
Omeprazole, 20 mg P.O. QD for 4 weeks (DU) or 8 weeks.
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38. 2. PUD associated with H. pylori
First Line
Amoxicillin, 1g, P.O. BID
PLUS
Clarithromycin, 500mg P.O. BID
PLUS
Omeprazole, 20mg P.O. BID (OR 40mg QD), all for 7 - 14 days.
Alternative
Clarithromycin, 500mg P.O. BID
PLUS
Metronidazole, 500mg, P.O. BID
PLUS
Omeprazole, 20mg P.O. BID OR 40mg QD for 7 - 14 days .
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