Further Work

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salyouha

Health & Medicine Business

UV radiation, skin cancer and immune suppression The possible applications of this research Sophie Harris & Lisa Joseph

The evidence Walterscheid et al (2006) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

The story so far... ,[object Object],[object Object],[object Object],[object Object],[object Object]

The future ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Psoriasis ,[object Object],[object Object],[object Object],[object Object],[object Object]

Renal transplant recipients (RTRs) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Skin Type Reaction to sun exposure I Always burns, never tans II Usually burns, rarely tans III Seldom burns, gradually tans IV Rarely burns, tans easily V Very rarely burns, tans very easily (pigmented) VI Never burns, tans very easily (deeply pigmented)

Fair skin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Protection ,[object Object],[object Object],[object Object],[object Object]

Infection and UVR-induced immunosuppression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Human Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

UVR and the eye Norval M et al. 2007 ,[object Object],Tissue Acute effect Chronic effect Conjunctiva Photoconjunctivitis Chemosis (swelling) Pinguecula (local degeneration Dyskeratosis Intraepithelial neoplasia (e.g conjunctival scc’s) Cornea Photokeratitis Endothelial damage Reactivation of latent HSV Climatic droplet kaeratopathy Pterygium Endothelial changes Lens Anterior subcapsular opacities Age related cataract

Limitations of this approach ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What about the 5-HT 1 receptor? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Inducing immunosuppression as a therapeutic strategy ,[object Object],[object Object],[object Object],[object Object]

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