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Drug and gene delivery vehicles are biocompatible devices that can carry therapeutic components in the body. Synthetic vehicles include block copolymers, liposomes, dendrimers, and magnetic nanoparticles. Block copolymers form micelles with hydrophobic cores that can encapsulate drugs. Liposomes are phospholipid vesicles that can encapsulate both hydrophilic and hydrophobic drugs. Dendrimers are nanoscale polymers that can be functionalized to target drugs. Magnetic nanoparticles can be used for drug delivery, hyperthermia cancer treatment, and as MRI contrast agents. These vehicles aim to improve drug bioavailability and targeting while decreasing toxicity.
Liposomes
Liposomes are microscopic phospholipid bubbles with a bilayered membrane structure that can be used to deliver drugs. Developments over the past 50 years have led to their use in clinical applications. Modifications like PEG coating and attaching ligands allow for long-circulating liposomes and targeted delivery to specific cells. New ligands under investigation include antibodies, folate, transferrin, and growth factors to target receptors overexpressed on tumor cells. pH-sensitive liposomes are also an area of focus to release drugs intracellularly.
Gene therapy and gene delivery systems
Genes carry hereditary information and encode proteins. Gene therapy aims to treat diseases by correcting defective genes through various approaches like inserting a normal gene or repairing an abnormal gene. Early research in the 1980s involved inserting human genes into bacteria. The first human gene therapy treated a girl for SCID in 1990 by inserting a normal gene into her white blood cells. Viral vectors like retroviruses and adenoviruses as well as non-viral methods can deliver genes, but all methods face challenges like short-lived effects, immune responses, and difficulties treating multi-gene disorders and diseases. While progress has been made, setbacks include a death in 1999 from an immune response and some children developing cancer from viral vectors.
Liposomes- A Novel Drug Delivery System
Liposomes are spherical vesicles made of phospholipid bilayers that can encapsulate hydrophilic or hydrophobic drugs. They range in size from 25nm to 5000nm. This document discusses the structure of liposomes and their components, including phospholipids and cholesterol. Various preparation methods are described, such as lipid film hydration, ethanol injection, and detergent removal. Liposomes offer advantages for drug delivery, such as the ability to encapsulate different drug types and provide controlled release. They can be classified based on structure, method of preparation, composition, and specialty type.
Liposome ppt
This document provides an overview of liposomes. It begins with an introduction describing liposomes as concentric bilayer vesicles composed mainly of phospholipids and cholesterol. It then covers the mechanism of liposome formation, classifications, biological fate, preparation methods, characterization techniques, advantages and disadvantages, and applications. Preparation methods discussed include physical dispersion, solvent dispersion, detergent solubilization, and various size reduction/increase techniques. Characterization includes assessing size, shape, lamellarity, surface charge, drug release, and encapsulation efficiency using tools like microscopy, NMR, and chromatography.
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McDonald's mission is to be its customers' favorite place and way to eat and drink. Its global strategy focuses on exceptional customer experience. It is committed to continuously improving operations and customer experience. McDonald's sees its competitive advantages as affordable prices, adherence to the fast food format, universal taste, and its large real estate holdings. It conducts segmentation, targeting and positioning as part of its marketing strategy.
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Recommended
Presentation
Drug and gene delivery vehicles are biocompatible devices that can carry therapeutic components in the body. Synthetic vehicles include block copolymers, liposomes, dendrimers, and magnetic nanoparticles. Block copolymers form micelles with hydrophobic cores that can encapsulate drugs. Liposomes are phospholipid vesicles that can encapsulate both hydrophilic and hydrophobic drugs. Dendrimers are nanoscale polymers that can be functionalized to target drugs. Magnetic nanoparticles can be used for drug delivery, hyperthermia cancer treatment, and as MRI contrast agents. These vehicles aim to improve drug bioavailability and targeting while decreasing toxicity.
Liposomes
Liposomes are microscopic phospholipid bubbles with a bilayered membrane structure that can be used to deliver drugs. Developments over the past 50 years have led to their use in clinical applications. Modifications like PEG coating and attaching ligands allow for long-circulating liposomes and targeted delivery to specific cells. New ligands under investigation include antibodies, folate, transferrin, and growth factors to target receptors overexpressed on tumor cells. pH-sensitive liposomes are also an area of focus to release drugs intracellularly.
Gene therapy and gene delivery systems
Genes carry hereditary information and encode proteins. Gene therapy aims to treat diseases by correcting defective genes through various approaches like inserting a normal gene or repairing an abnormal gene. Early research in the 1980s involved inserting human genes into bacteria. The first human gene therapy treated a girl for SCID in 1990 by inserting a normal gene into her white blood cells. Viral vectors like retroviruses and adenoviruses as well as non-viral methods can deliver genes, but all methods face challenges like short-lived effects, immune responses, and difficulties treating multi-gene disorders and diseases. While progress has been made, setbacks include a death in 1999 from an immune response and some children developing cancer from viral vectors.
Liposomes- A Novel Drug Delivery System
Liposomes are spherical vesicles made of phospholipid bilayers that can encapsulate hydrophilic or hydrophobic drugs. They range in size from 25nm to 5000nm. This document discusses the structure of liposomes and their components, including phospholipids and cholesterol. Various preparation methods are described, such as lipid film hydration, ethanol injection, and detergent removal. Liposomes offer advantages for drug delivery, such as the ability to encapsulate different drug types and provide controlled release. They can be classified based on structure, method of preparation, composition, and specialty type.
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This document provides an overview of liposomes. It begins with an introduction describing liposomes as concentric bilayer vesicles composed mainly of phospholipids and cholesterol. It then covers the mechanism of liposome formation, classifications, biological fate, preparation methods, characterization techniques, advantages and disadvantages, and applications. Preparation methods discussed include physical dispersion, solvent dispersion, detergent solubilization, and various size reduction/increase techniques. Characterization includes assessing size, shape, lamellarity, surface charge, drug release, and encapsulation efficiency using tools like microscopy, NMR, and chromatography.
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McDonald's mission is to be its customers' favorite place and way to eat and drink. Its global strategy focuses on exceptional customer experience. It is committed to continuously improving operations and customer experience. McDonald's sees its competitive advantages as affordable prices, adherence to the fast food format, universal taste, and its large real estate holdings. It conducts segmentation, targeting and positioning as part of its marketing strategy.
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Lehman Brothers was a major global investment bank that filed for bankruptcy in 2008 during the subprime mortgage crisis. It originated from a general store in Alabama in the mid-1800s and grew to become one of the largest investment banks in the world. However, its downfall was precipitated by the subprime mortgage crisis after it invested heavily in mortgage-backed securities and collateralized debt obligations composed of risky subprime loans. As borrowers began defaulting on these risky loans in large numbers, the value of these investments plunged, severely damaging Lehman Brothers' business and ultimately causing it to collapse.
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Penicillins in action...how do they work?
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Calcitonin poster
Template on Poster for:
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This document provides an overview and comparison of pharmaceutical companies Hoffman La Roche, Janssen, and Novartis. It begins with an introduction to Roche, including its founding, size, ownership, and subsidiaries. It then discusses Roche's board of directors and corporate governance practices. The document outlines Roche's business model, focusing on elements like personalization, partnerships, and revenue sources. It also summarizes Janssen's profile as a Johnson & Johnson subsidiary and highlights elements of its business model and demand planning practices. Key financial and SWOT analyses are presented for Roche.
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This document defines key financial terms used in the pharmaceutical industry such as sales, cost of goods sold, research and development expenses, selling and administrative expenses, taxes, depreciation, and operating income. It then describes the methods and selected companies used in an analysis of manufacturing costs in brand-name, generic, and biotech pharmaceutical companies. Key observations from the analysis include that generics have the highest cost of goods sold percentage while biotechs have the lowest, and that brand-name companies increased research and development expenditures as cost of goods sold decreased.
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Word-of-mouth marketing (WOMM) is when customers share their experiences and opinions about a company's products and services with others. It is a free and effective form of advertising. Netflix is an example of a company that utilizes WOMM through personal recommendations on social media. To encourage positive WOMM, companies should focus on exceeding customer expectations and providing opportunities for customer engagement. Monitoring both customer lifetime value and customer referral value can help companies optimize their WOMM strategy.
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For video: https://youtu.be/YCn2sX030As
A short explanation to Penicillin mechanism of action and how resistance develop.
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Calcitonin poster
Template on Poster for:
Calcitonin: new delivery systems through nasal route (challenges-advantages.)
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Sample paper for Drug Design Project using Accelrys Discovery Studio for preparing the protein & applying docking
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Opioid drugs like morphine produce their pharmacological effects like analgesia by acting on neuronal cell membrane receptors. Morphine was first isolated in 1804 and is used to treat dull constant pain. It causes side effects like euphoria, nausea, constipation and respiratory depression due to binding to mu, kappa and delta opioid receptors in the brain and spinal cord. Several morphine analogs were developed as drugs, including codeine, heroin, methadone, levorphanol, fentanyl, dipipanone, sufentanil and tapentadol, by modifying functional groups on morphine. These analogs have varying degrees of potency and side effect profiles compared to morphine.
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