This document summarizes the discovery of two important materials: plastics and penicillin. It describes how plastics were discovered by accident through Charles Goodyear's experiments with rubber and sulfur and John Wesley Hyatt's spilled bottle of collodion. It also recounts how Alexander Fleming discovered penicillin by accident when he noticed a mold growing in one of his dirty petri dishes that seemed to kill the surrounding bacteria, an observation which led to the identification of penicillin as an antibiotic. Both plastics and penicillin have gone on to have huge impacts despite originating from accidental discoveries.