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NF + cells are F+ bacterial cells that contain a fertility factor (F factor) allowing them to transfer genetic material through conjugation, while Hfr cells have the F factor integrated into their chromosome, enabling them to transfer chromosomal genes during conjugation. This difference enhances genetic diversity as Hfr cells can introduce additional genetic variation through the exchange of chromosomal DNA with recipient cells, compared to NF + cells which primarily transfer the plasmid. Thus, Hfr cells contribute to higher rates of genetic recombination and diversity in bacterial populations.
