Examenes macroscópicas

1. Cilindroma nidos rodeados x una membrana hialina, cels grandes con nuclos
palidos en el centro y cels con nucleo obscuro en la periferia

3. LA MALFORMACIÓN ADENOMATOIDE QUÍSTICA
es una alteración pulmonar congénita poco frecuente (1 de 25 a 30 mil embarazos) representa el 25% de malformaciones pulmonares
congénitas y el 95% de las enfermedades quísticas pulmonares y consiste en una proliferación anormal de elementos
mesenquimales pulmonares, conteniendo epitelio respiratorio de los bronquiolos terminales con formación
de estructuras adenomatosas y quistes. Su presentación clínica es en la edad neonatal o primera infancia; el
diagnóstico prenatal de esta anomalía está seguido por un pronóstico bueno cuando no se presentan signos de "distress" fetal severo (. No tiene
predilección por sexo. Usualmente compromete un lóbulo pulmonar (inferior). Las paredes de las lesiones están constituidas por fibras elásticas
y músculo liso, pocas veces se identifica la presencia de glándulas mucosas y cartílagos .

4. • There is both cytoplasmic and nuclear
staining for S-100 protei

5. • Well-differentiated chondrosarcoma. The tumor
has a distinctly lobulated quality
The tumor retains a lobulated
appearance, but nuclear atypicality
is obvious.
Chondrosarcoma.

6. Mesenchymal chondrosarcoma:
shows an island of well-differentiated cartilage in the center

7. Mesenchymal chondrosarcoma
Cels claras
Hemangiopericytoma-like component

8. Siringoma
En mujeres adolescentes
Pápulas múltiples sobre los parpados y las mejillas
Esferulosis
colagena

9. Well-differentiated (Meyer’s type I) Sertoli–Leydig cell
tumor

10. • Poorly differentiated (Meyer’s type
III) Sertoli–Leydig cell tumo
• ntermediate (Meyer’s type II)
Sertoli–Leydig cell tumor

11. Células gigantes Café claro o café rojizo con trabeculas engrosadas.
Engrosamiento de corteza.
Areas de hemorragia
• Specimen from giant cell tumor of bone fixed in formalin
and embedded in paraffin, stained for acid phosphatase
(Duray’s technique)

12. Osteosarcoma
• Destructivo.
• Hemorrágico
• Necrótico
• Quistico

14. Osteosarcoma.
The malignant bone is more basophilic and has more irregular borders than the
preexisting bone trabeculae

15. Microscopic appearance of osteosarcoma showing characteristic basophilic thin
trabeculae of neoplastic bone with an appearance that is reminiscent of fungal hyphae

17. Juxtacortical osteosarcoma.
Moderately atypical spindle tumor cells grow between irregularly shaped bone trabeculae

18. NEVO DE SPITZ,
Ortoqueratosis 2)cels epiteliales o fusiformes,cuerpos de kamino y se distinguen
vertices entre cels malignas y queratinocitos

19. RETROPERITONEAL WELL-DIFFERENTIATED LIPOSARCOMA
(atypical lipomatous tumor) accompanied by foci of dedifferentiation, manifested by
the solid whitish areas

20. Quistes teca _luteinizantes
•
• En embarazos.
• En mola.
• Coriocarcioma.
• Son comunes en estas enfermedades.

21. CISTADENOCARCINOMA seroso (ovario)
areás de hemorragia y necrosis

22. DESPUES DE LA PUBERTAD.
FIBROMA.

23. • tecoma.
• 65%despues de la
menopausia,
• Rojo oloeoso la grasa
• Tincion de plata para
las fibras de
reticulina,

24. • Brenner.
• Se diferencian de los
fibromas o tecomas x q
TIENEN QUISTES
PEQUEÑITOS.
• Unilaterales.
• 40 años.
• Hiperestrogenismo.
• Sangrado.

25. BRENER MALIGNO

26. Sarcoma endometrial de bajo y alto grado
45 a. Vimentina es la regla.
CD10+/ H Caldesmon (–)
• Cels dispuestas
concentricamente alredededor
de las arterias espirales.

27. FILODES.
Areás de necrosis degeneracion quistica y hemorragia, foleas

30. SEMINOMA

31. Spermatocytic seminoma

32. ESTRONGILOIDES

33. Fig. 18.72 Embryonal carcinoma showing solid nodular , MAL DELIMITADO Y
PUNTEADO DE FOCOS DE hemorragia y necrosis siempre.
• Diferenciación temprana e
estructuras embrionarias .
• Las cels son + anaplasicas q
seminom,+ pleomorficas, y
muchos nucléolos.
. Ck 19,+ CD30 +(Ki.1) NUNCA
117 x eso se hace el dif con
seminoma

34. appearance of pure yolk sac tumor in
an infan, NO ES ENCAPSULADO

35. LEYDING benigno. COLOR CAFÉ pardo dorado
CARACTERISTICOS , EN CRIPTORQUIDIA, KLINERFELTER,
producen ESTROGENOS O ANDROGENOS o esteroides
•
Ginecomastia puede
ser 1 sintoma en
adultos.
• Precosidad sexual en
niños.
• 10%mets
• Citoplasmo-lipidos,
vacuolas, lipofuschina
• en 25% de los
tumores Cristaloides
REINKE en forma
baston

37. Fibrosis hepática congénita
(autosimico resecivo)
Los espacios portales estan unidos x
puentes fibrosos. Tractos portales
inmaduros, no hay inflamacion

39. Primary biliary cirrhosis, stage 3. The picture shows portal–portal septal fibrosis (septal
stage 3), portal inflammation with lymphoid aggregate, absence of interlobular bile duct
(ductopenia), and cholate stasis in periportal and periseptal parenchyma. (H&E

40. Enfermedad poliquistica autosomica renal, no tiene
caracteristicas embrionarias lo hace dif a displasia

44. Cambios minimos*IgM-C3 x lo regular la
inmofluoresencia es (-)

45. focal and segmental glomerulosclerosis. One of the glomeruli shows
segmental sclerosis, while the other appears unremarkable. Tubular atrophy
is also seen.IgM-C3

46. Glomerulonefritis membranosa(IgG-C3) Depositos granular pared capilar
Silver preparation showing spike formation along the thickened basement membrane

47. Early diffuse diabetic glomerulosclerosis showing a mild increase in mesangial
matrix and thickened capillary walls. The arteriole shows the typical hyaline
appearance of an insudative lesion.IgG

48. Glomerulus with prominent mesangial and vascular deposition
of amyloid, notese la ausencia de esclerosis y vasos q la
diferencian con Diabetes.

50. Type I membranoproliferative glomerulonephritis. There is an increase in
lobulation, diffuse mesangial hypercellularity, and thickening of the capillary
walls

51. Silver preparation showing marked increase in mesangial matrix
in the centrolobular areas with peripheral extension of the
mesangium producing a double contour pattern in the loops
IgG-C3

52. Mesangial enlargement with increase in
mesangial matrix and mesangial
hypercellularity in IgA nephropath

53. Acute postinfectious
glomerulonephritis with intracapillary
proliferation and crescent formation

55. LUPUS III(Necrosis focal)

56. LUPUS IV asas de alambre.Es la + + fte 30-65% de la bx

57. LP V

58. Fibrinoid necrosis involving two medium-sized arteries
in polyarteritis nodosa

61. Wilms’ tumor. A, Low-power microscopic view showing a
combination of blastema, stroma, epithelial tubular formation,
and immature glomerul

62. NEFROMA MESOBLASTICO

67. .121 Collecting duct carcinoma showing
branching tubules lined by cuboidal cells

73. Cryptococcus neoformans by their
mucicarmine-stained capsules

74. Toxoplasmosis. Minute, basophilic structures
representing bradyzoites fill a protozoal pseudocyst lying
among infiltrating lymphocytes, plasma cells, and
macrophage
BRADIZOITO

86. RETINOBLASTOMA

89. ASTROCITOMA
PILOCITO
Fibras de Rosental

90. LOBULO TEMPORAL. NINOS GRANDES ADULTOS
TEMPRANOPleomorphic xanthoastrocytoma. Spindle and giant
cells, including bizarre multinucleated forms, combine to give this relatively indolent neoplasm
a most disturbing appearance. Note hyaline, granular, and vacuolar cytoplasmic alterations, the
last attesting to lipid accumulation

91. Oligodendroglioma.
The bright signal abnormalities seen in this nonenhanced CT study of a large right cerebral oligodendroglioma
represent foci of intratumoral calcification. While evidenced by only a minority of oligodendroglial neoplasms,
linear or plate-like calcifications of this sort are most suggestive of the diagnosis

92. Granulosa cell tumor with an entirely cystic gross appearance

95. Renal cell carcinoma of papillary
type. Note the neutrophilic
infiltratio
Other gross appearances of renal cell carcinoma

97. Subependymal giant cell astrocytma
(MASA INTRAVENTRICULAR). 2-3 D.. features of tuberous
sclerosis..TRIADA(EPILEPSIA, REARDO MENTAL,
ADENOMA SEBASEO.

98. Choroid plexus papilloma. Note the characteristically bosselated surface of this surgically resected example. Deprived of
its blood supply, the tumor tissue loses its normally hyperemic appearance and may assume a tan or golden hue

99. Medulloblastoma. The classic medulloblastoma is a highly cellular neoplasm composed of diminutive,
undifferentiated-looking elements possessed of little definable cytoplasm and prone to nuclear moldin

100. Meningioma. The broad dural base depicted here is
characteristi

101. Menigioma sincitial
Tipo fibroblastico

102. Ependymoma. The cytoplasmic processes of ependymal tumor cells condense about blood vessels to form
pseudorosettes GLIOMA MAS FRECUENTE DEL CORDON ESPINAL. EN NIÑOS FOSA POSTERIOR (0-16) 30-40.
QX Y RX

103. >20 A.Ependymoma MIXOPAILAR. Characteristic of this entity is the huddling of
small tumor cells in an expansive fibrillar meshwork. Microcystic changes commonly round out
the histologic pictur, CONO MEDULAR Y COLA DE CABALLO. INCONTINENCIA URINARIA-FECAL

104. CORDOMA (SACROCOCCIGEO) CELS FISALIFERAS

108. Juvenile granulosa cell tumor. (B) the tumor cells are seen lack the coffee-
bean nuclei seen in the adult type

109. Juvenile granulosa cell tumor. The follicle-like spaces seen on low-power examination (A) are a common feature
of this neoplasm

111. Queratosis seborreica

112. Sx ewing.FEMUR-PELVIS 5-20A4 Gross appearance of Ewing’s sarcoma. It has a typical ill-defined quality, with
extensive involvement of medulla and cortex associated with elevation of periosteum

113. Ewing’s sarcoma of fibula. Growth is ill defined and accompanied by a prominent periosteal
reaction

114. Low- and high-power appearance of myxoid liposarcoma

116. Rosai–Dorfman disease. Low-power view showing massive distension of the sinuses by
the histiocytic infiltrate

117. Rosai–Dorfman disease.
• A, Oil red O stain showing abundant
neutral lipid in the cytoplasm of the
histiocytes
• Strong immunoreactivity of the sinus histiocytes for
S-100 protein in Rosai Dorfman disease

120. A and B, Lymph node involvement by Langerhans’ cell histiocytosis. A, The infiltrate
has a predominantly sinusal distributionB, High-power view showing mononuclear
and multinucleated Langerhans’ cells. There are also numerous eosinophils.

121. Immunoreactivity of the cells of Langerhans’ cell histiocytosis for
langerin

122. COLANGIOCARCINOMA MODERADAMENTE
DIFERENCIADO

123. Mantle cell lymphoma surrounding a small residual germinal
cente

124. Immunoreactivity for cyclin D1 in
mantle zone lymphom

126. Gross appearance of lymph nodes involved by non-Hodgkin’s lymphoma of
diffuse large B-cell type. The nodes are enlarged and show a homogeneous
tan cut surface

127. Medium and high-power views of diffuse large B-cell lymphoma of large
cleaved typ

129. Medium and high-power views of diffuse large B-cell lymphoma of immunoblastic typ

132. Sclerosing adenosis. MAMA B , Medium-power view. Note the spindle shape of the
proliferating cells in the center of the lobule and the fibrillary quality of the cytoplasm, indicative
of myoepithelial nature

133. Benign “perineurial invasion” in a breast lesion that had elsewhere the typical features of
sclerosing adenosi

134. Prototypical invasive ductal carcinom

136. Two views of low-grade phylloides tumor, showing cleft-like spaces and concentration of tumor cells beneath
the epithelium

137. Phylloides tumor with adipose tissue differentiation of the neoplastic stromal component

139. malignant mixed müllerian tumor of ovary. The neoplasms are large,
variegated, solid and cystic, with hemorrhagic and necrotic areas

140. , Malignant mixed müllerian tumor of ovary. The tumor shown in A is of the so-called
“homologous type,” whereas the others exhibit heterologous foci in the form of bone and
cartilage (B) or skeletal muscle (C

143. QUERATOSIS SEBOREICA
ACANTOSICA

155. Hiperplasia higado