6. The clinical question may require general background knowledge involving the who, what, when, where or why about a disease or disease process. Background questions are simple two-part questions about the basic facts of a disease. Look for answers to background questions in current, regularly updated electronic or print texts. Examples would be UpToDate, Clinical Evidence and ACP Medicine.

14. What Type of Question Do You Want to Ask? Clinical Map Checklist Differential Diagnosis Education Quality of Life Harm/Risk Diagnostic Tests Therapy Clinical Findings Manifestations of Disease Prevention Prognosis Cause/Etiology Cost-effectiveness

17. Evidence Pyramid From: Medical Research Library of Brooklyn

26. Evidence (Study Design) Appropriate for Question Types Matched to EBM Search Filters MEDLINE Search Filter Terms Study Design Type of Question Cohort Studies Follow-up Studies Prognosis Time Factors Morbidity Mortality Placebos Survival Analysis Disease Progression Recurrence Natural History Clinical Course Progression Observational Studies: Cohort Studies Case Control Studies Case Series Prognosis Sensitivity and Specificity Predictive Value of Tests Likelihood Functions Reproducibility of Results Cross-sectional Study: Consecutive sample design Diagnosis Double-blind Method Meta-analysis Random Allocation Clincial Trial Randomized Controlled Trial Placebo Random Systematic Reviews and Meta-Analyses Randomized Controlled Studies Therapy

27. MEDLINE Search Filter Terms Study Design Type of Question Randomized Controlled Trial Prevention and Control Mass Screening Sensitivity and Specificity Likelihood Functions Randomized Controlled Trials Screening Randomized Controlled Trial Prevention and Control Treatment Outcomes Clinical Trial Random Randomized Controlled Trials Prevention Case-control Studies Cohort Studies Cross-sectional Studies Risk Odds Ratio Causation Etiology or Aetiology Cohort Studies Case Control Studies Case Series Etiology/Harm

28. MEDLINE Search Filter Terms Study Design Type of Question McKinnell, I. and Elliott, J. (1997) The Cochrane Electronic Library: Self training guide and notes. R&D Directorate, NHS Executive Anglia and Oxford. Costs and Cost Analysis Cost-benefit Analysis Cost Control Cost Savings Cost of Illness Health Care Costs Drug Costs Hospital Costs Health Expenditures Quality Adjusted Life Year Randomized Controlled Trials Systematic Reviews Decision Analysis Model Economic Randomized Controlled Trial Practice Guidelines Outcomes Assessment (health care) Randomized Controlled Trials Quality Improvement