Algorithmic trading has been there for a while, but still AI-agents in DeFi introduce new challenges in custody, key management, and fund access. This talk explores how to balance automation with security and control, covering policy and technical frameworks that enable AI agents to manage funds securely. The talk discusses risks, regulatory concerns, and solutions like smart contract proxies, approval mechanisms, multi-sig wallets and threshold signing. By bridging AI advancements with DeFi security, this session gives insights for builders, investors, and policymakers shaping the future of decentralized AI-driven finance.