Statistical Process Control (SPC) is a critical methodology for quality control in semiconductor manufacturing that allows systematic process improvement through statistical analysis. SPC involves measuring process variables, stabilizing processes by reducing variations, monitoring for deviations using control charts, and improving processes based on insights. Implementing SPC in semiconductor manufacturing faces challenges due to complex chemical reactions and autocorrelation, but control models and advanced software help manufacturers better control processes and improve yields. SPC plays a vital role at every stage of semiconductor manufacturing and testing to enhance product quality and profitability.