Developing a tool to help dog breeders predict genetic risks. Presentation in the Third Sector Stream at the OR Society's 2014 Conference OR56. Presented by Ian Seath & Sophie Carr.
The webinar was titled “Breed Health Improvement: finding the balance” and was a talk about approaches to breed health improvement and why every breed needs a health strategy.
Atul Butte's presentation to the Association of Medical School Pediatric Department Chairs #AMSPDC on March 3, 2018.
Some pre-publication data slides have been removed from this deck.
Developing a tool to help dog breeders predict genetic risks. Presentation in the Third Sector Stream at the OR Society's 2014 Conference OR56. Presented by Ian Seath & Sophie Carr.
The webinar was titled “Breed Health Improvement: finding the balance” and was a talk about approaches to breed health improvement and why every breed needs a health strategy.
Atul Butte's presentation to the Association of Medical School Pediatric Department Chairs #AMSPDC on March 3, 2018.
Some pre-publication data slides have been removed from this deck.
Philippa Robinson's presentation on dog health and welfare at BSAVA 2015Dog-ED
Many, if not most, canine health and welfare problems are linked to people, their behaviour and attitudes. And the issues surrounding such problems are far more complex than have been argued in recent years.
So said Philippa Robinson at the British Small Animals Veterinary Association’s recent congress, adding that ‘finger pointing’ was no longer helpful and blame counter-productive.
Colorectal Cancer Awareness Month may be behind us, but that doesn't mean our efforts to increase screening rates will slow down! Join Mary Doroshenk, MA, to learn about initiatives to increase colorectal cancer screening nationwide! In this webinar, designed for all those touched by colorectal cancer, Mary will discuss what 80% by 2018 is and how the effort is working. She will explain the role of survivors and caregivers and inspire you to participate in the effort.
This is a slideshow for a ten minute talk on system leadership challenges in health and social care, aimed at elected members as part of a "system challenges" workshop
"How Scientific Wellness will Drive The Future of Health" - Nathan Price (Pro...Hyper Wellbeing
"How Scientific Wellness will Drive The Future of Health" - Nathan Price (Professor, Institute of Systems Biology)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
This webinar will tell you what you need to know about clinical trials, their history, and help you prepare for a trial. If you’re currently considering participating in a clinical trial, we hope that this webinar helps to answer many of your questions.
In the presentation you'll learn the difference between different types of clinical trial and the design and purpose of clinical trials, and you'll get an inside look at the approval process.
The webinar was hosted by Dawn Richards, Director of Patient and Public Engagement at Clinical Trials Ontario and featured a panel of patients, James Davidson, Eric Pitters and Kathie LaForge.
1820201Chapter 2Conducting Health ResearchHe.docxaulasnilda
1/8/2020
1
Chapter 2
Conducting Health Research
Health Psychology (PSYC 172)
Professor: Andrea Cook, PhD
January 9, 2020
1
Placebos
• Placebo - inactive substance or condition that
has the appearance of an active treatment
• A belief in the effectiveness of a treatment
boosts the treatment’s effectiveness
• Placebo effect may account for around 35%
of treatment effects
• Placebos have been shown to lead to positive
health outcomes for many health disorders and
symptoms
– Migraine headaches, pain, depression,
anxiety, insomnia, asthma, hypertension
Research and the Placebo
• Treatments are effective when the treatment is more
effective than the placebo
• To determine if treatments are effective
– Need to directly compare treatment versus the
placebo
– Use two groups of people: one group receives
treatment and one group receives placebo
What you think about the treatment will impact its
effectiveness.
Who should you believe to decide if a treatment is likely to
be effective?
1/8/2020
2
Correlation Studies
Correlation is not causation
4
Correlation Studies
5
Correlation Studiies
6
http://www.tylervigen.com/spurious-correlations
1/8/2020
3
Correlation Studies
7
http://www.tylervigen.com/spurious-correlations
Correlation Studies
• Example – cholesterol
– Consumed cholesterol raises blood cholesterol
– Dietary guidelines recommend low cholesterol diet
for last 50+ years without validation
– Today causal relationship completely invalidated
• The French Paradox (1991)
– Serge Renaud, French researcher
– Disconnect French high saturated fat consumption
and low rates of cardiovascular disease
– Attributed to large red wine consumption
8
Longitudinal Studies
9
1/8/2020
4
Longitudinal Studies
• Longitudinal studies draw conclusions about how
individuals change over time
– Follow the same set of participants over time
– Example - if a researcher wanted to know how
dietary choices affect health across the lifespan
• Annual diet survey over 20 years and analyze
major medical diagnoses
• Challenges – self report accuracy, other lifestyle
factors
Determining Causality
• Correlational, cross-sectional, and
longitudinal designs only examine
relationships between variables
– They do not determine causality - if one
variable directly causes another variable
Experimental Design
• Experimental designs — compare at least two
groups to be able to draw cause and effect
conclusions
– The experimental group receives treatment
– The control group does not receive treatment
• Randomized Controlled Trial (RCT) — similar
to experimental studies
– Participants are randomly assigned to either a study
group or a control group
– RCTs are considered the “gold standard” of research
design
1/8/2020
5
The Hidden Side of Clinical Trials
13The hidden side of clinical trials | Sile Lane | TEDxMadrid (YouTube)
Research for Marketing Purposes
14
Research for M ...
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Philippa Robinson's presentation on dog health and welfare at BSAVA 2015Dog-ED
Many, if not most, canine health and welfare problems are linked to people, their behaviour and attitudes. And the issues surrounding such problems are far more complex than have been argued in recent years.
So said Philippa Robinson at the British Small Animals Veterinary Association’s recent congress, adding that ‘finger pointing’ was no longer helpful and blame counter-productive.
Colorectal Cancer Awareness Month may be behind us, but that doesn't mean our efforts to increase screening rates will slow down! Join Mary Doroshenk, MA, to learn about initiatives to increase colorectal cancer screening nationwide! In this webinar, designed for all those touched by colorectal cancer, Mary will discuss what 80% by 2018 is and how the effort is working. She will explain the role of survivors and caregivers and inspire you to participate in the effort.
This is a slideshow for a ten minute talk on system leadership challenges in health and social care, aimed at elected members as part of a "system challenges" workshop
"How Scientific Wellness will Drive The Future of Health" - Nathan Price (Pro...Hyper Wellbeing
"How Scientific Wellness will Drive The Future of Health" - Nathan Price (Professor, Institute of Systems Biology)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
This webinar will tell you what you need to know about clinical trials, their history, and help you prepare for a trial. If you’re currently considering participating in a clinical trial, we hope that this webinar helps to answer many of your questions.
In the presentation you'll learn the difference between different types of clinical trial and the design and purpose of clinical trials, and you'll get an inside look at the approval process.
The webinar was hosted by Dawn Richards, Director of Patient and Public Engagement at Clinical Trials Ontario and featured a panel of patients, James Davidson, Eric Pitters and Kathie LaForge.
1820201Chapter 2Conducting Health ResearchHe.docxaulasnilda
1/8/2020
1
Chapter 2
Conducting Health Research
Health Psychology (PSYC 172)
Professor: Andrea Cook, PhD
January 9, 2020
1
Placebos
• Placebo - inactive substance or condition that
has the appearance of an active treatment
• A belief in the effectiveness of a treatment
boosts the treatment’s effectiveness
• Placebo effect may account for around 35%
of treatment effects
• Placebos have been shown to lead to positive
health outcomes for many health disorders and
symptoms
– Migraine headaches, pain, depression,
anxiety, insomnia, asthma, hypertension
Research and the Placebo
• Treatments are effective when the treatment is more
effective than the placebo
• To determine if treatments are effective
– Need to directly compare treatment versus the
placebo
– Use two groups of people: one group receives
treatment and one group receives placebo
What you think about the treatment will impact its
effectiveness.
Who should you believe to decide if a treatment is likely to
be effective?
1/8/2020
2
Correlation Studies
Correlation is not causation
4
Correlation Studies
5
Correlation Studiies
6
http://www.tylervigen.com/spurious-correlations
1/8/2020
3
Correlation Studies
7
http://www.tylervigen.com/spurious-correlations
Correlation Studies
• Example – cholesterol
– Consumed cholesterol raises blood cholesterol
– Dietary guidelines recommend low cholesterol diet
for last 50+ years without validation
– Today causal relationship completely invalidated
• The French Paradox (1991)
– Serge Renaud, French researcher
– Disconnect French high saturated fat consumption
and low rates of cardiovascular disease
– Attributed to large red wine consumption
8
Longitudinal Studies
9
1/8/2020
4
Longitudinal Studies
• Longitudinal studies draw conclusions about how
individuals change over time
– Follow the same set of participants over time
– Example - if a researcher wanted to know how
dietary choices affect health across the lifespan
• Annual diet survey over 20 years and analyze
major medical diagnoses
• Challenges – self report accuracy, other lifestyle
factors
Determining Causality
• Correlational, cross-sectional, and
longitudinal designs only examine
relationships between variables
– They do not determine causality - if one
variable directly causes another variable
Experimental Design
• Experimental designs — compare at least two
groups to be able to draw cause and effect
conclusions
– The experimental group receives treatment
– The control group does not receive treatment
• Randomized Controlled Trial (RCT) — similar
to experimental studies
– Participants are randomly assigned to either a study
group or a control group
– RCTs are considered the “gold standard” of research
design
1/8/2020
5
The Hidden Side of Clinical Trials
13The hidden side of clinical trials | Sile Lane | TEDxMadrid (YouTube)
Research for Marketing Purposes
14
Research for M ...
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
1. Breed Health
Improvement
Strategies:
Why, what and how?
Ian J Seath
Chairman: Dachshund Breed
Council UK
& Founder: Dog-ED
16th December 2021
Slides online at:
https://www.slideshare.net/Dog-ED
2. Who am I – in the dog
world?
Chairman of the UK Dachshund Breed
Council
Director, UK Kennel Club
Founder, Dog-ED
Trustee, Dachshund Health UK
Lived with Dachshunds since 1980
Judge Dachshunds at championship level
Speaker and Facilitator at 3rd & 4th
International Dog Health Workshops (IPFD)
3. Published papers:
as a co-author
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc
disease in Dachshunds
Neuter status as a risk factor for canine intervertebral disc herniation (IVDH) in dachshunds: a
retrospective cohort study
Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired
Dachshunds in the United Kingdom
Moving from information and collaboration to action: report from the 3rd International Dog
Health Workshop, Paris in April 2017
Moving from information and collaboration to action: report from the 4th international dog
health workshop, Windsor in May 2019
4. Who am I –
in the real
world?
BSc (Hons.) Chemistry
Post-graduate Diploma in Human Resources
Management
Career in Manufacturing (R&D, HR, Marketing,
Commercial) & Management Consultancy
Run my own
Management
Consultancy business
Performance
improvement
Change management
5. Agenda
Part 1
What is a Breed Health Strategy?
Why every breed needs one
A process for developing one
The role of human behaviour change in
breed health improvement
Q&A
Part 2
2 UK case studies
Dachshund Breed Council Health Strategy
and achievements
Lafora Disease in Miniature Wirehaired
Dachshunds
Q&A
6. What is a
Breed Health
Strategy?
“A Strategy is an Action Plan with a rationale.”
7. “Plans are
nothing,
planning is
everything.”
Dwight D. Eisenhower
A Breed Health Improvement
Strategy document is the
tangible output of the work
done by a breed to define its
position, identify improvements
and set out its plans
8. We now have plenty of good examples of Breed
Health Strategy documents
JTO RAS RAS BHCP
9. In the UK
we have
BHCPs
113 breeds have Breed Health and Conservation Plans,
covering 79% of KC registrations
10. Definitions
A breed health improvement strategy may include any, or
all, of the following:
disease, genetic diversity, conformation, temperament, working
ability
A breed health improvement strategy is broader than a
plan for addressing a particular health issue
These may be called “breeding strategies”
A breed health improvement strategy includes plans for
implementation, including:
Changing owners’ and breeders’ behaviours
Data collection, analysis and monitoring
11. What’s
included in a
strategy?
Breed History
Function
Conformation &
appearance
Registration trends
Current state of the
breed
Diseases
Temperament
Exaggerations
Genetic diversity
Plans
Objectives
Priorities
Research projects
Guidance
Recommendations
Advice for breeders,
judges, owners
12. Why does
every Breed
need a Health
Strategy?
“If you don’t know where you are going, any
road will get you there.”
Lewis Carroll
13. The challenge today is not:
“Are you improving?”, but…
“How fast
are you
improving?”
“Can you
prove it?”
14. 2 drivers for Breed Strategies
Breed-
specific
Health
Strategy
Pressure for change
Vision for change
16. Who is driving the need for Breed Strategies?
Breed-
specific
Health
Strategy
Pressure for change
Vision for change
• Governments/Legislators
• Kennel Clubs
• Breed Clubs
• Veterinary Surgeons
• Scientists & Researchers
• Breeders
• Owners & Buyers
• Campaigners
• Media
17. “For many years, lecturing about
breed-specific issues in dogs, even
before the existence of IPFD, in
discussions with the breeding
community, veterinarians and others, it
was becoming self-evident that if
concerns were not addressed by the
dog community, society would likely
impose 'solutions' on them. This is
coming to fruition in many areas, and
society and the media wants to move
at a much faster pace than many in the
pedigreed dog world.”
Brenda Bonnett,
CEO, IPFD
18. A process for
developing a
Breed Health
Strategy
“A goal without a plan is just a wish.”
Antoine de Saint-Exupery
23. My 2 Golden Rules for Breed Health
Improvement are:
There should be no action without
evidence
There can be no evidence without
data
This Photo by Unknown Author is licensed under CC BY-NC-ND
24. Breed health
improvement is not a
conformation problem,
or a genetics problem,
or a veterinary
problem…
It’s a Change
Management and
Continuous
Improvement problem.
IDHW3 – Paris 2017
31. COM-B Model for behaviour change
Behaviour
Capability
Motivation
Opportunity
Michie et al 2011
32. Michie et al 2011
Capability & Opportunity
= “Can people change?”
Motivation
= “Will people change?”
Sources of behaviour
Intervention functions
Policy categories
The Behaviour
Change Wheel
34. Agenda
Part 1
What is a Breed Health Strategy?
Why every breed needs one
A process for developing one
The role of human behaviour change in
breed health improvement
Q&A
Part 2
2 UK case studies
Dachshund Breed Council Health Strategy
and achievements
Lafora Disease in Miniature Wirehaired
Dachshunds
Q&A
58. “The ‘tell, sell, yell’ strategy for
Change Management never
works.”
“Culture change happens in
units of 1.”
“And that is how change
happens. One gesture. One
person. One moment at a time.”
Some final thoughts…