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High intensity UV-CXL:  advantages and limitations Michael Mrochen, PhD IROC AG   Institut für Refraktive und Ophthalmo-Chirurgie Stockerstrasse 37 8002 Zürich WWW.IROC.CH
What have we learned?  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Purpose of experimental work ,[object Object],[object Object],[object Object],[object Object],[object Object]
Two experimental setups: 1. Increase of  Riboflavin concentration (0.05 – 0.5 %)  2. Decrease of  treatment time (30 min - 9 min) Increase of UV  intensity (3 and 10 mW / cm 2 , Constant energy dose)    Primary outcome measure: Change in corneal stiffness / Young‘s modulus
Methods ,[object Object],[object Object],[object Object],[object Object]
Results of concentration increase ,[object Object],[object Object],[object Object]
Results for intensity increase ,[object Object],[object Object],[object Object]
Results for endothelium safety (human donor eyes) ,[object Object],[object Object],[object Object],[object Object],No statistical difference in endothelium cell count or apoptosis 10 mW / cm 2 ; 9 min 3000 3000 3150 3150 M15457 2400 2400 2600 2600 M15309 2900 2900 2800 2800 M1529B 24 hours after 24 hours before 24 hours after 24 hours before Treated Untreated Pair
Beam optimization for the prolate cornea •  More corneal tissue is cross-linked •  Improved corneal strength
Summary ,[object Object],[object Object],[object Object],[object Object]
Model of photopolymerization ,[object Object],[object Object],[object Object],Rate for creating new cross-links:
Future perspective Gone in 60 seconds! Ultra-short fast CXL for  corneal laser surgery. www.cxl-congress.org December 9 th  and 10 th , 2011 in Zurich

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Corneal cross linking with new beam profile

  • 1. High intensity UV-CXL: advantages and limitations Michael Mrochen, PhD IROC AG Institut für Refraktive und Ophthalmo-Chirurgie Stockerstrasse 37 8002 Zürich WWW.IROC.CH
  • 2.
  • 3.
  • 4. Two experimental setups: 1. Increase of Riboflavin concentration (0.05 – 0.5 %) 2. Decrease of treatment time (30 min - 9 min) Increase of UV intensity (3 and 10 mW / cm 2 , Constant energy dose)  Primary outcome measure: Change in corneal stiffness / Young‘s modulus
  • 5.
  • 6.
  • 7.
  • 8.
  • 9. Beam optimization for the prolate cornea • More corneal tissue is cross-linked • Improved corneal strength
  • 10.
  • 11.
  • 12. Future perspective Gone in 60 seconds! Ultra-short fast CXL for corneal laser surgery. www.cxl-congress.org December 9 th and 10 th , 2011 in Zurich

Editor's Notes

  1. Assuming that the polymers before the treatment are evenly distributed throughout the cornea allows the assumption that the number of polymers before the treatment M0 is proportional to its thickness z0 (M0~z0)