This document summarizes a presentation on efficiently assessing whether most favored nation (MFN) clauses are likely to lessen competition. It outlines a four step process: 1) applying safe harbors based on market power, coverage, and type of MFN. 2) determining if there is a coherent theory of harm consistent with facts and economic theory. 3) assessing if there are likely substantial benefits also consistent with facts and theory. 4) conducting an empirical assessment using techniques like natural experiments and hypothesis testing. Examples are provided on MFNs in the hotel booking and gas pipeline industries.