The document discusses collaborative assistants being developed at AIISC focused on health and education. Examples include a COVID-19 symptom checker, assistants for pediatric asthma, nutrition, mental health, autism, and more. Complex assistants for health domains require context using deep domain knowledge, personalization with personalized health graphs, sensing data from multiple modalities like text, voice and images. The virtual health assistant for asthma aims to do self-monitoring, self-appraisal, management, and disease tracking using sensors, social media, clinical data and knowledge graphs to have informed intelligent conversations. Developing such assistants is quite challenging due to big data issues, need for domain context, personalization, explainability, and ease of use.