Presentation on clove and neem for oral care

1. Presentation
on
Neem and clove- oral care
Prensented by-
Mohammad Javed Khan(1750991041)
Kunal kumar bansal(1750991035)
B.pharmacy- 8th semester
Chitkara college of pharmacy
Chitkara university,Rajpura(PB)-140401

2. Oral care:- Neem and Clove
INTRODUCTION
 Oral hygiene is the practice of keeping one's mouth clean and free
of disease and other problems
 It is important that oral hygiene be carried out on a regular basis to
enable prevention of dental disease and bad breath.
This is used for formulation of oral care products. Neem and Clove
Oil has strong antibacterial and analgesic properties.
Neem & Clove toothpaste attacks cavity causing bacteria, thus
preventing tooth decay and cavities and a results in preventing all sort
of dental problems.
povide breath fresh for a long time.

3. NEEM
• Azadirachta indica commonly known as Neem.
• Since time immemorial it has been used by Indian people for
treatment of various diseases due to its medicinal properties.
• It possesses anti-bacterial, anti-cariogenic, anti-helminthic, anti-
diabetic, anti-oxidant, astringent, anti-viral, cytotoxic, and anti-
inflammatory activity.
• Nimbidin, Azadirachtin and nimbinin are active compounds
present in Neem which are responsible for antibacterial activity.
• Parts of Neem which is used for oral care are neem leafs,bark,
concoction,twigs.
• Neem bark is used as an active ingredient in a number of
toothpastes and toothpowders. Neem bark has anti-bacterial
properties, it is quite useful in dentistry for curing gingival
problems and maintaining oral health in a natural way.
• Neem twigs are used as oral deodorant, toothache reliever and
for cleaning of teeth.
• Neem used in the form of neem toothpaste,powder, oil,spray etc.

4. • Neem has been extensively used in Ayurveda, Unani and
Homoeopathic medicine and has become a wonder tree of modern
medicine.
• It has been used traditionally for the treatment of inflammation,
infections, fever, skin diseases and dental problems.
• It is effective in several epidermal dysfunctions such as acne,
psoriasis, eczema.
• Neem leaves have been reported to also possess antihyperglycemic,
Immunomodulatory, anti-inflammatory, antimalarial, antioxidant,
antiviral, antimutagenic and anticarcinogenic properties.
• Neem also exhibits antibacterial,antifungal, hepatoprotective, anti-
ulcer, anti-fertility and anti-nociceptive activity.
• Neem twigs are used as oral deodorant, toothache reliever and for
cleaning of teeth.
• Neem bark possesses antibacterial and deodorant activity.

5. • The phytochemical constituents present in neem are nimbidin,
nimbin, nimbolide, Azadirachtin, gallic acid, epicatechin,
catechin, and margolone. All these exhibit potent antibacterial
activity.
• The chief active constituent of neem is azadirachtin, which is an
effective antimicrobial agent.
• Neem has also been traditionally used as a skin moisturizer
• It has been found to be active against many dreadful disorders
like hepatitis, viral infections, malaria and cancer.
How we use neem for oral care
• Just mix one teaspoon neem powder with one teaspoon baking
soda and enough water to make a paste. Brush with this
homemade toothpaste to have shiny yet cleaner teeth.
Neem concoction. All you need is to boil a bunch of neem
leaves in enough water till it reduces to 1/4th of the original
volume. Gargle with this concoction for good breath and
whiter teeth as it kills the bacteria inside your mouth.

6. Neem oil. Neem oil has antibacterial and anti-fungal properties that
can prevent gum inflammation and cavities. Add a drop to your
regular toothpaste and brush with it.
Neem powder . Neem powder is made by grinding dried neem
leaves traditionally. Just mix one teaspoon neem powder with one
teaspoon baking soda and enough water to make a paste. Brush
with this homemade toothpaste to have shiny yet cleaner teeth.
Neem bark. For healthier teeth, you can just chew the neem bark. It
not only fights dental diseases but can prevent cavity as well,
which is one of the common dental problems Indians are facing
today.
Neem twigs. This is one of the oldest methods used in India for
dental health. You can brush your teeth with neem twigs to
prevent gum diseases and for teeth whitening.
Neem toothpaste. There are various kinds of natural toothpaste
available in the market that has neem extracts in them. You
can simply brush your teeth with this toothpaste for whiter
teeth.

7. • It is also effective against periodontal pathogens, and oral
acidogenic bacteria responsible for dental caries and dental
plaque.
• Neem dental care products contains Neem leaf or bark
extract. Neem leaf is rich in antioxidants and helps to boost the
immune response in gum and tissues of the mouth.
• Neem offers a good remedy for curing mouth ulcers, tooth decay
and acts as a pain reliever in toothache problems.
• It reduces the ability of streptococci to colonize tooth
surfaces.
• Neem oil shows significant antibacterial activity and has been
suggested for use in treating dental plaque.
• Mucoadhesive dental gel containing Azadirachta indica is
found to be beneficial in reducing the plaque index and
salivary bacterial count comparatively better than
chlorhexidine gluconate mouthwash.

8. Dental applications of Neem
• Antibacterial activity
• Anti-candidial activity
• Anti-cariogenic activity
• Anti-plaque activity
- EfficacyofNeemextractagainstacidogenicoralbacteriainfixedorthodontic
appliancepatients
the primary acid-tolerant bacteria associated with dental plaque including
Lactobacillus acidophilus, Streptococcus salivarius,and Streptococcus
intermedius that surround orthodontic appliances are a common problem in
many patients undergoing orthodontic treatment. It has also been reported
that presence of fixed orthodontic appliance greatly inhibits oral hygiene
and creates new retentive areas for plaque and debris)
-Efficacy against periodontal pathogens
Brushing with Neem toothpaste after every meal and using a mouthwash
with Neem extract is recommended treatment for preventing gingivitis.
In a study, Neem-based mouth rinse was given to patients for assessing anti-
plaque and anti-gingivitis activity.
Neem stick is found to be effective as a toothbrush in reducing dental plaque
and gingival inflammation.

9. -Neem as root canal irrigant
Sodium hypochlorite has been used as root canal irrigant for decades; it
causes potential weakening of the tooth structure by decreasing the
hardness and structural integrity of the dentin within the root canal.
To overcome this disadvantage herbal drugs are used effectively to
inhibit E. faecalis that causes root canal failure in patients undergoing
endodontic treatment.
-Neem in dental care industry
Various parts of the Neem tree possess astringent and antiseptic
activity. Leaf extracts have been widely used in both traditional and
conventional times to manufacture toothpaste and mouthwash in
the oral care dentistry. Its antibacterial properties due to the
presence of nimbidin, Azadirachtin, and nimbinin help to remove
many oral aerobic and anaerobic pathogens existing in the oral
cavity.
Neem bark and leaf extract is most effectively used in preventing
cavities and gum disease. Mouthwash containing Neem is a remedy
for tooth decay, oral infections, prevents bleeding and sore gums.
Twigs of Neem tree are used as chewing sticks by people all over
India.

10. conclusion/ precaution
• Regular brushing with Neem-containing toothpaste will reduce
the deposition of plaque, prevents caries, and enhances the
immune response for overall oral health.
• Frequent usage of mouthwash containing Neem extract will
lessen gingival problems, and also treats halitosis.
• education can be provided in dental and dental hygiene schools
about the use of Neem-based and also herbal oral care products, it
would help our dentists treat patients more holistically
Neem containing toothpaste are-
 Colgate Swarna Vedshakti Ayurvedic Toothpaste.
 Himalaya Herbals Complete Care Toothpaste.
 Baidyanath Neem Toothpaste
 Himalayan herbals complete care toothpaste
 Dabur herbal’s neem germ protection toothpaste
 Jeva Ayurfresh toothpaste

11. CLOVE
• Clove is a plant grown in parts of Asia and South America. People use the
oils, dried flower buds, leaves, and stems to make medicine.
• Clove is most commonly applied directly to the gums for toothache, pain
control during dental work, and other dental-related issues. But there is
limited scientific research to support these and other uses.
• In foods and beverages, clove is used as a flavoring.
• In manufacturing, clove is used in toothpaste, soaps, cosmetics, perfumes,
and cigarettes. Clove cigarettes, also called kreteks, generally contain 60% to
80% tabacco and 20% to 40% ground clove.
How does it work ?
Clove oil contains a chemical called eugenol that may help to decrease pain and
fight infections.
 Tooth plaque. Early research shows that using a toothpaste or mouth rinse
containing clove and other ingredients helps to reduce plaque on the teeth.
• Toothache. Clove oil and eugenol, one of the chemicals it contains, have
long been applied to the teeth and gums for toothache.The FDA now
believes there is not enough evidence to rate eugenol as effective for
toothache pain.
• A mild form of gum disease (gingivitis).
• Bad breath.
• Cough.
• Dry socket (alveolar osteitis).

12. • Clove oil has long been applied directly to the gums to ease
toothache ,the eugenol in clove oil is effective at fighting several
known oral bacteria. Medicines containing eugenol are widely used
in dentistry.
• found that eugenol is more effective at reducing pain, inflammation,
and infection than another type of analgesic. used the eugenol-based
paste also had better wound healing
• Clove oil contains the active ingredient eugenol, which is a natural
anesthetic. It helps numb and reduce pain to ease a toothache.
• Eugenol also has natural anti-inflammatory properties. It may reduce
swelling and irritation in the affected area. Dry Socket Paste, an over-
the-counter treatment dentists recommend for teeth extraction pain,
has eugenol.
• For centuries, cloves have been used as a pain relief technique.
Historically, treatments called for inserting the clove into an infected
tooth or cavity. They contain an active ingredient that numbs the skin
it touches, which may provide temporary relief from the toothache.
 Clove which may provide temporary relief from the toothache.

13. Precaution/warning while using clove
• Children: In children, clove oil is likely unsafe to take by mouth. It
can cause severe side effects such as seizures, liver damage, and
fluid imbalances.
• Pregnancy and breast-feeding: Clove is likely safe when taken by
mouth in amounts commonly found in food. There isn't enough
reliable information to know if clove is safe to use in larger
medicinal amounts when pregnant or breast-feeding. Stay on the
safe side and stick to food amounts.
• Bleeding disorders: Clove oil contains a chemical called eugenol
that seems to slow blood clotting. There is a concern that taking
clove oil might cause bleeding in people with bleeding disorders.
• Diabetes: Clove contains chemicals that might affect blood sugar
levels in people with diabetes. Watch for signs of low blood sugar
(hypoglycemia) and monitor your blood sugar closely if you have
diabetes and take clove.

14. Side effects
While clove oil is usually safe when applied to the skin, repeated use inside the
mouth and on the gums can have side effects.
Side effects may include damage to the:
• gums
• tooth pulp — the central part of the tooth which is made of connective
tissue and cells
• the skin on the inside of the mouth
• mucous membranes inside of the mouth
• Using dried cloves inside of the mouth can cause sensitivity and irritation,
as well as damage the dental tissues.
• Consuming clove oil can be dangerous for children and may lead to
seizures, liver damage, and fluid imbalances.
• Pregnant women are advised against using this remedy, as it is not known
whether clove oil is safe for the growing baby.

15. • To use it for a toothache, dip a clean tissue, cotton swab, or cotton ball
into the oil and wipe it over the gums at the point of the pain.
• People can also use whole cloves. Simply place them on the affected
area for several minutes at a time.
 clove oil does have antibacterial, antifungal, and pain-relief properties.
However, it’s not a cure, and the usage of clove oil
Interactions
Medications that slow blood clotting (Anticoagulant / Antiplatelet
drugs) interacts with CLOVE
• Clove might slow blood clotting. Taking clove oil along with
medications that also slow clotting might increase the chances of
bruising and bleeding.
• Clove contains eugenol. Eugenol is the part of clove that might slow
blood clotting. Eugenol is very fragrant and gives allspice and clove
their distinctive smell.
• Some medications that slow blood clotting include aspirin,
clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others),
ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn,
others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin,
warfarin (Coumadin), and others.

16. Steps( or process while using)
• Collect the supplies and ingredients you need.
• Squeeze a few drops of clove oil with 1 teaspoon of olive oil into
your dish.
• Soak your swab or cotton ball with the clove oil.
• Gently swipe the swab or ball around the area that is bothering
you. Or place the cotton ball over the area.
• Allow the oil sit for 5 to 10 minutes before it starts working.
• Reapply every 2 to 3 hours for relief.
 Oil pulling: clove oil mixed with coconut oil in your mouth.
Focus on swishing the oil in the affected area to avoid
numbing your whole mouth.
 Clove paste: You can also make a paste or gel by grinding
fresh whole cloves and mixing them with oil. This is less
effective than using concentrated oil.

17. list of market products containing clove in oral care are-
• Oral B
• Vicco
• Colgate
• Dabur
• Pepsodent
• Close up
• Himalaya toothpaste
• Lever ayush- anti-cavity clove oil tooth paste
• Amar Clove Gel Toothpaste
• Vicco Vajradanti toothpaste

18. Reference
• https://www.webmd.com/vitamins/ai/ingredientmono-
251/clove
• https://www.webmd.com/vitamins/ai/ingredientmono-
577/neem
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441161/
• https://timesofindia.indiatimes.com/most-searched-
products/health-and-fitness/health-care/neem-toothpaste-
popular-options-for-overall-oral-
hygiene/articleshow/81109021.cms
• https://europepmc.org/article/med/26009692