The document discusses various signaling pathways involved in cell migration, including the roles of actin, focal adhesion assembly, and chemokine signaling. It details the interactions of G-proteins, kinases, and various other molecules that regulate cell motility, survival, and proliferation. Overall, it highlights the complexity of the cellular responses mediated by these pathways.

2. Actin/Focal Adhesion
Assembly/Disassembly
Cell Migration
Chemokine Signaling Pathways
G Protein
GDP
GTP
G α
ARRB
GRK
Gβ
Gγ
Gβ Gγ
G α
GTP
P
P
DAG
PKC
IP3
BCAR1
PXN Crk
FAK P
BCAR1
PXN Crk
PYK2
P
IKK
P
NFKB
NFKBIB
P
PREX1
ADCY
ATP
cAMP
RAC
p38
P
JNK
P
PAK
LIMK
P
Jak
STATP
STAT Dimer
ITK
P
Vav
PDK1
P
Akt
PKB
P
Src Shc
P
GRB2
SOS
RasGDP GTPRas
Raf
P
MEK1/2
P
ERK1/2
P
p90 RSK
P
FAK
P
BCAR1
PXN Crk
Rho
PYK2
P
BCAR1
PXN Crk
Chemokine
Chemokine Chemokine
Receptor
Chemokine
Receptor
PLCβ
PIP2
CDC42
WASP
Arp2/3
P
TSC1/2
RhoA
ROCK
P
MLC
PI3K
p101 p110
PI3K
p110p85
P
ITK
Vav
RhoA
RAC
CDC42
WASPP
LIMK
P
MLC
Arp2/3
P
PAK
P
JNK
P
p38
P
IKK
P
NFKBIB
NFKB
GTP
Rheb
mTORC1
P
p70 S6k
P
RPS6
P
4EFP1
eIF4E
eIF4E
P
4EBP1
P
GSK3B
P
Bad
P
CASP9
P
ELMO1
DOCK2
P
FOXO
P
NFATC
CALM PPP3CA
Ca2+
NFATC
STAT Dimer
FOXO
NFKB
CREB
cFos cJUN
ELK1
IP3R
Receptor
Desensitization
Internalization
Degradation
Recruitment
Proteasomal
Degradation
Regulation of Actin
Cytoskeleton
Cell Migration
Cell Survival
Cell Motility
Cell Survival
Proliferation
Adhesion
Cell Survival
Proliferation
Migration
Cell Proliferation
Chemotactic Response
Protein
Synthesis

4. βγ
β