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Chemokine signaling pathway
- 2. Actin/Focal Adhesion Assembly/Disassembly Cell Migration Chemokine Signaling Pathways G Protein GDP GTP G α ARRB GRK Gβ Gγ Gβ Gγ G α GTP P P DAG PKC IP3 BCAR1 PXN Crk FAK P BCAR1 PXN Crk PYK2 P IKK P NFKB NFKBIB P PREX1 ADCY ATP cAMP RAC p38 P JNK P PAK LIMK P Jak STATP STAT Dimer ITK P Vav PDK1 P Akt PKB P Src Shc P GRB2 SOS RasGDP GTPRas Raf P MEK1/2 P ERK1/2 P p90 RSK P FAK P BCAR1 PXN Crk Rho PYK2 P BCAR1 PXN Crk Chemokine Chemokine Chemokine Receptor Chemokine Receptor PLCβ PIP2 CDC42 WASP Arp2/3 P TSC1/2 RhoA ROCK P MLC PI3K p101 p110 PI3K p110p85 P ITK Vav RhoA RAC CDC42 WASPP LIMK P MLC Arp2/3 P PAK P JNK P p38 P IKK P NFKBIB NFKB GTP Rheb mTORC1 P p70 S6k P RPS6 P 4EFP1 eIF4E eIF4E P 4EBP1 P GSK3B P Bad P CASP9 P ELMO1 DOCK2 P FOXO P NFATC CALM PPP3CA Ca2+ NFATC STAT Dimer FOXO NFKB CREB cFos cJUN ELK1 IP3R Receptor Desensitization Internalization Degradation Recruitment Proteasomal Degradation Regulation of Actin Cytoskeleton Cell Migration Cell Survival Cell Motility Cell Survival Proliferation Adhesion Cell Survival Proliferation Migration Cell Proliferation Chemotactic Response Protein Synthesis
- 4. βγ β