This document summarizes regenerative medicine services from Cellentis including autologous cell therapies derived from a patient's own cells. It describes Cellentis' vision to develop safe and effective novel cell therapies and technologies to improve patient outcomes. Several Cellentis products and therapies are summarized, including CellGrow-C which uses a platelet lysate containing growth factors, Biokine which contains anti-inflammatory cytokines, Chondrostem which contains stem cells, and combo therapies combining stem cells and biomolecules for a more powerful approach. The benefits of these therapies are noted as reducing pain, improving function, delaying disease progression and avoiding surgery. Training is described to become an expert in applying these personalized regenerative medicine treatments.

1. LET YOUR CELLS
BE THE MEDICINE

2. About us
Customised
regenerative
medicine
services to the
doctor
Personalised
cell therapies
to the patient

3. Our job
Autologous
treatments
derived from the
patients’ own cells

4. Through
Activate the
mechanisms
that will put the
patient's cells to
work
Directly at the
site of the injury
Harness the
natural ability of
the human body
tο heal itself

5. Therefore
Patient
Effective
Personalized
treatments
Well
tolerated
Absolutely
safe

6. Continuous breakthroughs
Application
of stem sells
Biomolecules in
regenerative
treatments

7. Our Vision
We constantly follow the scientific trends and we strive to
improve patients' lives by developing and employing safe and
effective novel cell therapies, therapeutic tools and
technologies that hold the promise for better treatments.

8. ORTHOPEDICS
Products | Services

9. CELLGROW-C

10. CellGrow-C
What is it?
Indications
Application
• It is not PRP – it is 20 times more effective than PRP
• Innovative and unique product
• Platelet lysate that contains only the useful proteins (growth factors)
• Consists of a pure mix of growth factors (an Enhanced Growth Factor Mix -
EGFM) taken from patient's own blood
• Minor cartilage defects caused by sports activities
• Early-stage (mild) osteoarthritis
• Tendon & ligament injuries (such as tears)
• Tendonitis and tendinosis
• Produced from the patient’s blood and processed for 1,5 hour
• Almost 100% of the growth factors contained within the platelets are isolated.
All other cellular components are discarded
• EGFM is applied locally at the site of the injury
• Two injections locally, at the site of the injury

11. CellGrow-C benefits
Patient
returns faster
to his/her
daily
activities
Activates effectively the
intrinsic mechanism of
regeneration and repair
of at the site of the
injury
Early-stage
osteoarthritis, the
treatment gives the
patient the opportunity
to return to his/her daily
activities soon
Speeds up the healing
process for minor
cartilage, tendon and
ligament injuries that
occur frequently in
athletes

12. BIOKINE

13. Biokine
What is it?
Indications
Application
•Rich in anti-inflammatory cytokines
•Fundamental component is a molecule called Interleukin-1 Receptor
Antagonist (IL-1Ra)
•This molecule blocks the action of interleukin-1
•Contains additional anti-inflammatory cytokines, as well as growth
factors
•Joint pain due to stage 2-3 osteoarthritis, or sports activities
•Back pain
•Muscle injuries that occur during sports activities
•Produced from the patient’s blood and processed for about 24 hours
•The therapy is applied through several injections locally, at the site of the
injury
•The number and the frequency of injections required for the treatment
depend on the type of the injury treated
•Several injections locally, at the site of the injury

14. Biokine benefits
Patients with
more advanced
defects improve
their quality of
life
Reduces inflammation
and relieves pain in a
number of orthopaedic
injuries that are the
effect of aging or are
caused by sports
activities
In osteoarthritis, the
treatment helps the
patient return to his/her
daily activities soon
In sports injuries, it
speeds up the return of
the athletes to their
sports activities sooner
compared to other
therapies.

15. CHONDROSTEM

16. Chondrostem
What is it?
Indications
Application
•Autologous injectable product
•Contains stem cells isolated from the patient’s bone marrow or,
alternatively from adipose tissue (fat)
•They act through a triple mechanism of action that treats the causes of
osteoarthritis
•Delaying or even stopping the progression of the disease
•Cartilage defects that are the effect of late-stage osteoarthritis, mainly
due to aging
•Major cartilage defects due to sports activities
•Collection of a small amount of bone marrow from the patient, through
the use of local anaesthesia or sedation
•A large number of high quality and potency stem cells is obtained through
the use of specialized techniques
•Stem cells are then activated through an autologous proprietary
methodology and given to the doctor for injection into the joint

17. Chondrostem benefits
Patients could
delay or even
avoid surgery
Could postpone the
need for a joint
replacement surgery
They delay the
disease from further
progressing
Has a significant
effect in pain relief
and in the functional
improvement of the
joint
Improves significantly
the quality of life of
the osteoarthritic
patients

18. COMBO THERAPIES

19. Combo therapies
What is it?
Indications
Application
•Combination of autologous stem cells and active biomolecules
(such as growth factors and anti-inflammatory cytokines)
•Perhaps, the most powerful tool in our effort to provide more
effective treatments
•Novel approach which is now used in the majority of patients
we treat
• Stage 3-4 osteoarthritis
• Stepwise approach for treating orthopaedic injuries
• A more effective & innovative approach for major cartilage
defects
• A unique therapeutic protocol that comprises three stages:
• 1st stage – preparation/activation of the joint
• 2nd stage – application of the cell therapy
• 3rd stage - stimulation of the injected cells for optimal
therapeutic effect

20. Combo therapies benefits
Improve
quality of life
with the most
advanced
approach
Activation of the joint, so
that we create an optimal
environment for the stem
cells
Application of the cell
therapy through the use of
autologous bone marrow
stem cells and the reduction
of mechanical forces that
further destroy the cartilage
within the joint
Stimulation of the injected
cells so that they produce
the optimal therapeutic
effect

21. OUR CERTIFICATE AWAITS YOU…
Are you THE Expert?

22. How to become and expert…
● Cellentis’ services are
customised for the doctor
● Application of personalised
regenerative medicine
treatments require knowledge,
precision and experience
● After successfully applying a
total of ten regenerative
medicine treatments, you will be
awarded the Cellentis’
Certificate of Training

23. LET YOUR CELLS
BE THE MEDICINE
www.cellentis.uk