This document discusses squamous cell carcinoma of the oral mucosa. It notes that squamous cell carcinoma comprises 90% of all oral malignant tumors. Strong risk factors include tobacco smoking, chewing, and drinking alcohol. Histologically, it can range from well-differentiated to undifferentiated. Prognosis is generally poor due to late detection and early lymph node metastasis, especially for tongue and soft palate cancers. The document also briefly mentions other less common oral cancers.
Chronic atrophic gastritis results in thinning of the stomach mucosa with reduced glands, increased connective tissue, and lymphocyte and plasmocyte infiltration. Microscopically there is marked gastric atrophy with disappearance of glands and presence of intestinal metaplasia and goblet cells. Type A gastritis mainly involves the corpus and is associated with autoimmune factors, while Type B mainly involves the antrum and is related to H. pylori infection.
Most esophageal tumors are malignant carcinomas. The two main types are adenocarcinoma, which usually occurs in the lower third, and squamous cell carcinoma, which is more common worldwide. Adenocarcinoma arises from Barrett's esophagus and is associated with gastroesophageal reflux disease. It has a poor prognosis as symptoms usually appear after it has spread. Squamous cell carcinoma is linked to tobacco, alcohol and nutritional deficiencies and has varying incidence worldwide. Both cause dysphagia and have dismal survival rates.
Chronic gastritis is defined as chronic inflammatory changes in the gastric mucosa leading to mucosal atrophy and epithelial metaplasia. The most important cause is chronic Helicobacter pylori infection, which causes type B gastritis affecting mainly the antrum. Autoimmune mechanisms can cause type A gastritis affecting the body and fundus. Chronic gastritis is usually asymptomatic but long term risks include gastric atrophy, intestinal metaplasia, and increased risk of gastric adenocarcinoma.
Gastric cancer is the second most common fatal cancer worldwide. It most commonly presents in the 5th and 6th decades of life and affects males twice as often as females. The vast majority are adenocarcinomas that arise from chronic gastritis and intestinal metaplasia. Gastric cancers are broadly classified into polyps and carcinomas, with adenocarcinoma making up about 90% of carcinomas. Early gastric cancer is confined to the mucosa and submucosa, while advanced gastric cancer has invaded deeper into the stomach wall.
Renal pathology lecture 4 Tumors of kidney and urinary tract. Sufia Husain 2020Sufia Husain
This document provides an overview of tumors of the kidney and urinary tract. It begins by outlining the objectives and key topics to be covered, which include benign kidney tumors, renal cell carcinoma, Wilms tumor, and transitional cell and squamous carcinomas of the bladder. The document then covers these topics in detail over several sections, describing the histology, risk factors, clinical features, and characteristics of each tumor type. The major tumor types discussed are renal oncocytoma, angiomyolipoma, renal cell carcinoma (clear cell and papillary subtypes), Wilms tumor, and transitional cell neoplasms of the bladder.
This ppt is intended for teaching cervical pathology to medical graduates. It covers anatomy, basic inflammatory conditions, dysplasia and malignancy and its pathogenesis and diagnosis
This document discusses malignant tumors of the salivary glands. It covers risk factors like smoking, alcohol consumption and radiation exposure. It also discusses various types of salivary cancers like acinic cell carcinoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. For each cancer, it describes characteristics like prevalence, presentation, histology, treatment options and prognosis. It highlights the importance of surgery and radiation therapy in treating these cancers. Molecular techniques are providing new insights but clinical applications are still limited.
1. The document discusses various types of ovarian tumours, including benign, borderline, and malignant surface epithelial tumours as well as germ cell tumours and sex cord-stromal tumours.
2. Etiological factors for ovarian tumours include nulliparity, heredity such as BRCA gene mutations, and genetic syndromes like Lynch syndrome.
3. Common epithelial tumours include serous and mucinous tumours. Germ cell tumours include mature teratomas, dysgerminomas, and choriocarcinomas. Sex cord-stromal tumours include granulosa cell tumours and thecomas.
Chronic atrophic gastritis results in thinning of the stomach mucosa with reduced glands, increased connective tissue, and lymphocyte and plasmocyte infiltration. Microscopically there is marked gastric atrophy with disappearance of glands and presence of intestinal metaplasia and goblet cells. Type A gastritis mainly involves the corpus and is associated with autoimmune factors, while Type B mainly involves the antrum and is related to H. pylori infection.
Most esophageal tumors are malignant carcinomas. The two main types are adenocarcinoma, which usually occurs in the lower third, and squamous cell carcinoma, which is more common worldwide. Adenocarcinoma arises from Barrett's esophagus and is associated with gastroesophageal reflux disease. It has a poor prognosis as symptoms usually appear after it has spread. Squamous cell carcinoma is linked to tobacco, alcohol and nutritional deficiencies and has varying incidence worldwide. Both cause dysphagia and have dismal survival rates.
Chronic gastritis is defined as chronic inflammatory changes in the gastric mucosa leading to mucosal atrophy and epithelial metaplasia. The most important cause is chronic Helicobacter pylori infection, which causes type B gastritis affecting mainly the antrum. Autoimmune mechanisms can cause type A gastritis affecting the body and fundus. Chronic gastritis is usually asymptomatic but long term risks include gastric atrophy, intestinal metaplasia, and increased risk of gastric adenocarcinoma.
Gastric cancer is the second most common fatal cancer worldwide. It most commonly presents in the 5th and 6th decades of life and affects males twice as often as females. The vast majority are adenocarcinomas that arise from chronic gastritis and intestinal metaplasia. Gastric cancers are broadly classified into polyps and carcinomas, with adenocarcinoma making up about 90% of carcinomas. Early gastric cancer is confined to the mucosa and submucosa, while advanced gastric cancer has invaded deeper into the stomach wall.
Renal pathology lecture 4 Tumors of kidney and urinary tract. Sufia Husain 2020Sufia Husain
This document provides an overview of tumors of the kidney and urinary tract. It begins by outlining the objectives and key topics to be covered, which include benign kidney tumors, renal cell carcinoma, Wilms tumor, and transitional cell and squamous carcinomas of the bladder. The document then covers these topics in detail over several sections, describing the histology, risk factors, clinical features, and characteristics of each tumor type. The major tumor types discussed are renal oncocytoma, angiomyolipoma, renal cell carcinoma (clear cell and papillary subtypes), Wilms tumor, and transitional cell neoplasms of the bladder.
This ppt is intended for teaching cervical pathology to medical graduates. It covers anatomy, basic inflammatory conditions, dysplasia and malignancy and its pathogenesis and diagnosis
This document discusses malignant tumors of the salivary glands. It covers risk factors like smoking, alcohol consumption and radiation exposure. It also discusses various types of salivary cancers like acinic cell carcinoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. For each cancer, it describes characteristics like prevalence, presentation, histology, treatment options and prognosis. It highlights the importance of surgery and radiation therapy in treating these cancers. Molecular techniques are providing new insights but clinical applications are still limited.
1. The document discusses various types of ovarian tumours, including benign, borderline, and malignant surface epithelial tumours as well as germ cell tumours and sex cord-stromal tumours.
2. Etiological factors for ovarian tumours include nulliparity, heredity such as BRCA gene mutations, and genetic syndromes like Lynch syndrome.
3. Common epithelial tumours include serous and mucinous tumours. Germ cell tumours include mature teratomas, dysgerminomas, and choriocarcinomas. Sex cord-stromal tumours include granulosa cell tumours and thecomas.
Ca ovary staging(AJCC 8th Edition& FIGO 2014) and classificationDr.Bhavin Vadodariya
Pathological classification of ovary in details.
Principles of Staging in Ca Ovary.
Staging according to AJCC 8th edition & Figo 2014.
Summary of changes in 8th Edition AJCC
A malignant neoplasm that contains elements of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat) so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue.
- Ovarian tumours can be benign or malignant and arise from the surface epithelium, germ cells, or sex cord-stromal tissues.
- Risk factors for ovarian cancer include nulliparity, hereditary factors like BRCA gene mutations, and genetic syndromes.
- The most common ovarian tumours are serous and mucinous cystadenomas, which usually present as abdominal masses.
- Malignant ovarian tumours often spread before diagnosis. Metastatic tumours to the ovaries are also possible.
More than 90% of malignant tumors in the oral region are squamous cell carcinomas arising from the mucosal epithelium.
However, it is now apparent that these mucosal carcinomas comprise a number of different diseases that must be considered separately, due to differences in site, etiology, prognosis and management.
More than 90% of malignant tumors in the oral region are squamous cell carcinomas arising from the mucosal epithelium.
However, it is now apparent that these mucosal carcinomas comprise a number of different diseases that must be considered separately, due to differences in site, etiology, prognosis and management.
Lec 24 24 female reproductive system pathologyimrana tanvir
This document provides information on pathology of the female reproductive system. It discusses various non-neoplastic and neoplastic lesions that can occur in the vulva, vagina, cervix and ovaries. Some of the key points mentioned include vulvar leukoplakia and lichen sclerosus, cervical intraepithelial neoplasia and invasive squamous cell carcinoma, ovarian serous and mucinous tumors, endometrial hyperplasia and endometrioid carcinoma of the uterus. Risk factors, histological features and clinical implications of these conditions are summarized.
The document discusses tumors of the small and large intestines. It classifies intestinal tumors and provides details on various benign and malignant tumor types. The most common tumors are epithelial tumors, with colorectal cancer representing 70% of all gastrointestinal malignancies. Adenomas are precursors to most colorectal cancers. Risk factors include inflammatory bowel disease, familial polyposis, and diet. Prognosis and treatment depend on tumor stage and characteristics.
The document discusses pathology of oral cancer, including histological features and classifications. It notes that over 90% of oral cancers are squamous cell carcinoma, which can be well, moderately, or poorly differentiated. Other variants include verrucous, basaloid, and sarcomatoid squamous cell carcinoma. Prognostic factors discussed include tumor size and extent, lymph node involvement, histologic grade, and the presence of perineural or vascular invasion. Accurate classification of histologic type and grade is important for determining prognosis and treatment for oral cancers.
This document provides information on benign and malignant breast tumors. It begins by discussing the normal anatomy of the breast and then describes several common benign tumors - fibroadenoma, phyllodes tumor, and intraductal papilloma. Fibroadenoma is the most common benign breast tumor and typically appears as a solitary nodule. Phyllodes tumor is rarer and can be large with leaf-like projections. Intraductal papilloma presents with nipple discharge. The document then discusses carcinoma, or malignant breast tumors. Risk factors and pathogenesis of breast cancer are outlined. Carcinomas are classified as non-invasive (in situ) or invasive. Examples of specific tumor types are described along with their
Tumors of the stomach can be benign or malignant. Benign tumors include adenomas and stromal tumors, while malignant tumors include gastric carcinoma, leiomyosarcoma, leiomyoblastoma, carcinoid tumors, and lymphomas of the gut. Gastric carcinoma is the most common malignant tumor and has risk factors including H. pylori infection, certain dietary factors, geographical location, genetics, and premalignant conditions. Gastric carcinoma can be early or advanced, and advanced gastric carcinoma has subtypes including ulcerative carcinoma, fungating carcinoma, scirrhous carcinoma, and colloid carcinoma.
Colonic adenomas are benign epithelial tumors that can develop into colorectal cancer over time. They range in size and can be pedunculated or sessile. Microscopically, they are characterized by epithelial dysplasia and nuclear abnormalities. Certain familial polyposis syndromes, like familial adenomatous polyposis and Lynch syndrome, are associated with an increased risk of developing numerous colonic adenomas and colorectal cancer at a young age due to genetic mutations. Surveillance colonoscopy is recommended to screen for and remove adenomas to prevent cancer.
This document discusses uterine cancer, vulva and vagina cancer. It provides detailed information on:
1. Types of uterine cancers including endometrial carcinoma, leiomyosarcoma, and malignant mixed mullerian tumor. Risk factors, pathogenesis, classification and clinical presentations are described.
2. Gross and microscopic images of various uterine cancers like endometrial adenocarcinoma and leiomyosarcoma are shown along with summaries.
3. Vulvar cancer is defined and risk factors like HPV infection, aging, and conditions like VIN are explained. Clinical images show appearances of VIN lesions on the vulva.
This document discusses uterine cancer, vulva and vagina cancer. It provides detailed information on the following topics:
1. Endometrial carcinoma - its incidence, risk factors, pathogenesis, classification, clinical course, and histopathology. Images of endometrial carcinoma grades and subtypes are shown.
2. Uterine sarcomas - definitions, classifications, and images of specific types including leiomyosarcoma, endometrial stromal sarcoma, and malignant mixed mullerian tumor.
3. Vulvar cancer - definitions, risk factors, clinical appearance, and images of vulvar intraepithelial neoplasia.
Here are the answers to your questions:
1. Common types of salivary gland benign tumors with origin of each:
- Pleomorphic adenoma - originates from the intercalated duct cells and myoepithelial cells.
- Oncocytic tumors - originate from the striated duct cells.
- Acinous cell tumors - originate from the acinar cells.
- Mucoepidermoid tumors and squamous cell carcinomas develop in the excretory duct cells.
2. The histological features of mucoepidermoid carcinoma include:
- Containing mucin-producing cells and epithelial cells of the epidermoid variety.
- Divided into
The document discusses neoplasia (abnormal cell growth), including:
1. Malignant tumors cause over 1 million cancer deaths worldwide each year from cancers like gastric, lung, and breast. The highest frequency of cancers is seen in countries like Italy, France, and the US.
2. Tumors are classified based on structure, location, benign vs malignant characteristics, and organ of origin. There are over 200 tumor types grouped into 7 categories.
3. Tumors can be benign (noncancerous), malignant (cancerous), or have local destructive growth. Malignant tumors spread via metastasis and affect the body, while benign tumors do not spread or affect the body.
4.
This document provides information on endometrial carcinoma and ovarian tumours. It discusses that endometrial carcinoma is the most common pelvic malignancy in females, presenting with abnormal bleeding in postmenopausal women. Risk factors include chronic unopposed estrogen excess and obesity. Most are endometrioid adenocarcinomas. Ovarian tumours include serous and mucinous tumours, with serous tumours making up about 50% of surface epithelial ovarian tumours. Mucinous tumours are characterized by containing mucin and forming large multiloculated cysts. Both benign and malignant forms of ovarian tumours are described.
Pathology of uterine cervix 2018 Sufia HusainSufia Husain
Cervical cancer arises from pre-cancerous lesions called cervical intraepithelial neoplasia (CIN) or squamous intraepithelial lesions (SIL) caused by persistent infection with human papillomavirus (HPV). Regular pap screening allows for early detection of CIN/SIL to prevent the development of invasive cervical cancer. Risk factors for CIN/SIL and cervical cancer include early age of first intercourse, multiple sexual partners, and HPV infection with high-risk strains such as HPV-16 and HPV-18. Most cervical cancers are squamous cell carcinomas that may be asymptomatic or present as an exophytic cervical mass.
Cysts &tumors of salivary glands /certified fixed orthodontic courses by Indi...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
This document discusses invasive cervical cancer and the female genital system. It notes that invasive cervical cancer is most commonly epidermoid carcinoma, with risk factors being the same as for cervical intraepithelial neoplasia. The peak incidence is in the 4th to 6th decades of life. Grossly, cervical carcinoma arises from the squamocolumnar junction and can present as fungating, ulcerating or infiltrating. Distant metastases can occur in various organs. Histologically, epidermoid carcinoma is most common, and other patterns include adenocarcinoma and others. Clinical staging is done using the FIGO system. The document then discusses other topics related to the female genital system like dysfunctional uterine bleeding,
The document discusses breast pathology and benign breast diseases. It begins by describing the anatomy of the breast including lobes, lobules, acini, and ducts. It then discusses clinical presentations of benign breast diseases such as pain, palpable masses, and nipple discharge. Various benign breast lesions are outlined including inflammatory conditions, benign epithelial lesions (nonproliferative changes, proliferative disease without atypia, and proliferative disease with atypia), and breast tumors. Risk of subsequent breast cancer is higher for proliferative disease with atypia compared to other benign breast conditions.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
More Related Content
Similar to Carcinoma GI tract- Buccal, Esophagial, Gastric & intestinal.pptx
Ca ovary staging(AJCC 8th Edition& FIGO 2014) and classificationDr.Bhavin Vadodariya
Pathological classification of ovary in details.
Principles of Staging in Ca Ovary.
Staging according to AJCC 8th edition & Figo 2014.
Summary of changes in 8th Edition AJCC
A malignant neoplasm that contains elements of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat) so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue.
- Ovarian tumours can be benign or malignant and arise from the surface epithelium, germ cells, or sex cord-stromal tissues.
- Risk factors for ovarian cancer include nulliparity, hereditary factors like BRCA gene mutations, and genetic syndromes.
- The most common ovarian tumours are serous and mucinous cystadenomas, which usually present as abdominal masses.
- Malignant ovarian tumours often spread before diagnosis. Metastatic tumours to the ovaries are also possible.
More than 90% of malignant tumors in the oral region are squamous cell carcinomas arising from the mucosal epithelium.
However, it is now apparent that these mucosal carcinomas comprise a number of different diseases that must be considered separately, due to differences in site, etiology, prognosis and management.
More than 90% of malignant tumors in the oral region are squamous cell carcinomas arising from the mucosal epithelium.
However, it is now apparent that these mucosal carcinomas comprise a number of different diseases that must be considered separately, due to differences in site, etiology, prognosis and management.
Lec 24 24 female reproductive system pathologyimrana tanvir
This document provides information on pathology of the female reproductive system. It discusses various non-neoplastic and neoplastic lesions that can occur in the vulva, vagina, cervix and ovaries. Some of the key points mentioned include vulvar leukoplakia and lichen sclerosus, cervical intraepithelial neoplasia and invasive squamous cell carcinoma, ovarian serous and mucinous tumors, endometrial hyperplasia and endometrioid carcinoma of the uterus. Risk factors, histological features and clinical implications of these conditions are summarized.
The document discusses tumors of the small and large intestines. It classifies intestinal tumors and provides details on various benign and malignant tumor types. The most common tumors are epithelial tumors, with colorectal cancer representing 70% of all gastrointestinal malignancies. Adenomas are precursors to most colorectal cancers. Risk factors include inflammatory bowel disease, familial polyposis, and diet. Prognosis and treatment depend on tumor stage and characteristics.
The document discusses pathology of oral cancer, including histological features and classifications. It notes that over 90% of oral cancers are squamous cell carcinoma, which can be well, moderately, or poorly differentiated. Other variants include verrucous, basaloid, and sarcomatoid squamous cell carcinoma. Prognostic factors discussed include tumor size and extent, lymph node involvement, histologic grade, and the presence of perineural or vascular invasion. Accurate classification of histologic type and grade is important for determining prognosis and treatment for oral cancers.
This document provides information on benign and malignant breast tumors. It begins by discussing the normal anatomy of the breast and then describes several common benign tumors - fibroadenoma, phyllodes tumor, and intraductal papilloma. Fibroadenoma is the most common benign breast tumor and typically appears as a solitary nodule. Phyllodes tumor is rarer and can be large with leaf-like projections. Intraductal papilloma presents with nipple discharge. The document then discusses carcinoma, or malignant breast tumors. Risk factors and pathogenesis of breast cancer are outlined. Carcinomas are classified as non-invasive (in situ) or invasive. Examples of specific tumor types are described along with their
Tumors of the stomach can be benign or malignant. Benign tumors include adenomas and stromal tumors, while malignant tumors include gastric carcinoma, leiomyosarcoma, leiomyoblastoma, carcinoid tumors, and lymphomas of the gut. Gastric carcinoma is the most common malignant tumor and has risk factors including H. pylori infection, certain dietary factors, geographical location, genetics, and premalignant conditions. Gastric carcinoma can be early or advanced, and advanced gastric carcinoma has subtypes including ulcerative carcinoma, fungating carcinoma, scirrhous carcinoma, and colloid carcinoma.
Colonic adenomas are benign epithelial tumors that can develop into colorectal cancer over time. They range in size and can be pedunculated or sessile. Microscopically, they are characterized by epithelial dysplasia and nuclear abnormalities. Certain familial polyposis syndromes, like familial adenomatous polyposis and Lynch syndrome, are associated with an increased risk of developing numerous colonic adenomas and colorectal cancer at a young age due to genetic mutations. Surveillance colonoscopy is recommended to screen for and remove adenomas to prevent cancer.
This document discusses uterine cancer, vulva and vagina cancer. It provides detailed information on:
1. Types of uterine cancers including endometrial carcinoma, leiomyosarcoma, and malignant mixed mullerian tumor. Risk factors, pathogenesis, classification and clinical presentations are described.
2. Gross and microscopic images of various uterine cancers like endometrial adenocarcinoma and leiomyosarcoma are shown along with summaries.
3. Vulvar cancer is defined and risk factors like HPV infection, aging, and conditions like VIN are explained. Clinical images show appearances of VIN lesions on the vulva.
This document discusses uterine cancer, vulva and vagina cancer. It provides detailed information on the following topics:
1. Endometrial carcinoma - its incidence, risk factors, pathogenesis, classification, clinical course, and histopathology. Images of endometrial carcinoma grades and subtypes are shown.
2. Uterine sarcomas - definitions, classifications, and images of specific types including leiomyosarcoma, endometrial stromal sarcoma, and malignant mixed mullerian tumor.
3. Vulvar cancer - definitions, risk factors, clinical appearance, and images of vulvar intraepithelial neoplasia.
Here are the answers to your questions:
1. Common types of salivary gland benign tumors with origin of each:
- Pleomorphic adenoma - originates from the intercalated duct cells and myoepithelial cells.
- Oncocytic tumors - originate from the striated duct cells.
- Acinous cell tumors - originate from the acinar cells.
- Mucoepidermoid tumors and squamous cell carcinomas develop in the excretory duct cells.
2. The histological features of mucoepidermoid carcinoma include:
- Containing mucin-producing cells and epithelial cells of the epidermoid variety.
- Divided into
The document discusses neoplasia (abnormal cell growth), including:
1. Malignant tumors cause over 1 million cancer deaths worldwide each year from cancers like gastric, lung, and breast. The highest frequency of cancers is seen in countries like Italy, France, and the US.
2. Tumors are classified based on structure, location, benign vs malignant characteristics, and organ of origin. There are over 200 tumor types grouped into 7 categories.
3. Tumors can be benign (noncancerous), malignant (cancerous), or have local destructive growth. Malignant tumors spread via metastasis and affect the body, while benign tumors do not spread or affect the body.
4.
This document provides information on endometrial carcinoma and ovarian tumours. It discusses that endometrial carcinoma is the most common pelvic malignancy in females, presenting with abnormal bleeding in postmenopausal women. Risk factors include chronic unopposed estrogen excess and obesity. Most are endometrioid adenocarcinomas. Ovarian tumours include serous and mucinous tumours, with serous tumours making up about 50% of surface epithelial ovarian tumours. Mucinous tumours are characterized by containing mucin and forming large multiloculated cysts. Both benign and malignant forms of ovarian tumours are described.
Pathology of uterine cervix 2018 Sufia HusainSufia Husain
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Cysts &tumors of salivary glands /certified fixed orthodontic courses by Indi...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
This document discusses invasive cervical cancer and the female genital system. It notes that invasive cervical cancer is most commonly epidermoid carcinoma, with risk factors being the same as for cervical intraepithelial neoplasia. The peak incidence is in the 4th to 6th decades of life. Grossly, cervical carcinoma arises from the squamocolumnar junction and can present as fungating, ulcerating or infiltrating. Distant metastases can occur in various organs. Histologically, epidermoid carcinoma is most common, and other patterns include adenocarcinoma and others. Clinical staging is done using the FIGO system. The document then discusses other topics related to the female genital system like dysfunctional uterine bleeding,
The document discusses breast pathology and benign breast diseases. It begins by describing the anatomy of the breast including lobes, lobules, acini, and ducts. It then discusses clinical presentations of benign breast diseases such as pain, palpable masses, and nipple discharge. Various benign breast lesions are outlined including inflammatory conditions, benign epithelial lesions (nonproliferative changes, proliferative disease without atypia, and proliferative disease with atypia), and breast tumors. Risk of subsequent breast cancer is higher for proliferative disease with atypia compared to other benign breast conditions.
Similar to Carcinoma GI tract- Buccal, Esophagial, Gastric & intestinal.pptx (20)
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
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5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
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Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
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Carcinoma GI tract- Buccal, Esophagial, Gastric & intestinal.pptx
1.
2. • malignant neoplasms of epithelial cells from
all three germ cell layers are called
carcinomas.
3. Squamous Cell (Epidermoid)
Carcinoma of bucal or oral mucosa
INCIDENCE. Squamous cell (epidermoid) carcinoma
comprises 90% of all oral malignant tumours and
5% of all human malignancies. The peak incidence
in the UK and the USA is from 55 to 75 years of age,
whereas in India it is from 40 to 45 years of age.
Oral cancer is a very frequent malignancy in India,
Sri Lanka and some Eastern countries, probably
related to habits of betel-nut chewing and reversed
Smoking.
4. ETIOLOGY.
Strong association:
i) Tobacco smoking and tobacco chewing causing leukoplakia is the
most important factor as discussed above.
ii) Chronic alcohol consumption.
iii) Human papilloma virus infection, particularly HPV 16, 18 and 33
types.
Weak association:
i) Chronic irritation from ill-fitting denture or jagged teeth.
ii) Submucosal fibrosis as seen in Indians consuming excess of chillies.
iii) Poor orodental hygiene.
iv) Nutritional deficiencies.
v) Exposure to sunlight (in relation to lip cancer).
vi) Exposure to radiation.
vii) Plummer-Vinson syndrome, characterised by atrophy of the upper
alimentary tract.
5. MORPHOLOGIC FEATURES
i) Ulcerative type—is the most frequent type and is characterised by
indurated ulcer and firm everted or rolled edges.
ii) Papillary or verrucous type—is soft and wart-like growth.
iii) Nodular type—appears as a firm, slow growing submucosal nodule.
iv) Scirrhous type—is characterised by infiltration into deeper
structures.
All these types may appear on a background of leukoplakia or
erythroplasia of the oral mucosa. Enlarged cervical lymph nodes may
sometimes be present.
Histologically, squamous cell carcinoma ranges from well-
differentiated keratinising carcinoma to highly undifferentiated
neoplasm. Changes of epithelial dysplasia are often present in the
surrounding areas of the lesion. Carcinoma of the lip and intraoral
squamous carcinoma are usually always well differentiated.
6.
7. Oral mucosa showing epithelial dysplasia progressing to invasive
squamous cell carcinoma. There is keratosis, irregular stratification
cellular pleomorphism, increased and abnormal mitotic figures and
individual cell keratinisation, while a few areas show superficial
invasive islands of malignant cells in the subepithelial soft tissues
8. Carcinoma of the lip has a more favourable prognosis due to
visible and easily accessible location and less frequent
metastasis to the regional lymph nodes. However, intraoral
squamous carcinomas have poor prognosis because they are
detected late and metastasis to regional lymph nodes occur
early, especially in the case of carcinoma of tongue and soft
palate. Verrucous carcinoma, on the other hand, is composed
of very well-differentiated squamous epithelium with minimal
atypia and hence has very good prognosis.
OTHER MALIGNANT TUMOURS
Other less common malignant neoplasms which may be
encountered in the oral cavity are: malignant melanoma,
lymphoepithelial carcinoma,
9. Carcinoma of Oesophagus
ETIOLOGY. :
1. Diet and personal habits:
i) Heavy smoking
ii) Alcohol consumption
iii) Intake of foods contaminated with fungus
iv) Nutritional deficiency of vitamins and trace elements.
2. Oesophageal disorders:
i) Oesophagitis (especially Barrett’s oesophagus in adenocarcinoma)
ii) Achalasia
iii) Hiatus hernia
iv) Diverticula
v) Plummer-Vinson syndrome.
3. Other factors:
i) Race—more common in the Chinese and Japanese than
in Western races; more frequent in blacks than whites.
ii) Family history—association with tylosis (keratosis palmaris et plantaris).
iii) Genetic factors—predisposition with coeliac disease, epidermolysis bullosa, tylosis.
iv) HPV infection—is the recent addition in etiologic factors.
10.
11. Squamous cell carcinoma oesophagus. A, Gross appearance.
The tubular structure has thick muscle in its wall and has
longitudinal mucosal folds. There is a concentric circumferential
thickening in the middle (arrow) causing narrowing of the
lumen (arrow). The mucosal surface is ulcerated.
B, Photomicrograph shows whorls of anaplastic squamous cells
invading the underlying soft tissues.
12. Grossly, 3 types of patterns are recognised:
i) Polypoid fungating type—is the most common form. It
appears as a cauliflower-like friable mass protruding into the
lumen.
ii) Ulcerating type—is the next common form. It looks grossly
like a necrotic ulcer with everted edges iii) Diffuse infiltrating
type—appears as an annular, stenosing narrowing of the lumen
due to infiltration into the wall of oesophagus.
Microscopically, majority of the squamous cell carcinomas
of the oesophagus are well-differentiated or moderately
differentiated
Prickle cells, keratin formation and epithelial pearls are
commonly seen. However, non-keratinising and anaplastic
growth patterns can also occur. An exophytic, slow-growing,
extremely welldifferentiated variant, verrucous squamous cell
carcinoma, has also been reported in the oesophagus.
13. ADENOCARCINOMA. Adenocarcinoma of the
oesophagus constitutes less than 10% of primary
oesophageal cancer. It occurs predominantly in men in
their 4th to 5th decades. The common locations are
lower and middle third of the oesophagus. These
tumours have a strong and definite association with
Barrett’s oesophagus in which there are foci of gastric
or intestinal type of epithelium.
Grossly, oesophageal adenocarcinoma appears as
nodular, elevated mass in the lower oesophagus.
14. Grossly, oesophageal adenocarcinoma appears as nodular,
elevated mass in the lower oesophagus.
Microscopically, adenocarcinoma of the oesophagus can have 3
patterns:
i) Intestinal type—is the adenocarcinoma with a pattern similar to
that seen in adenocarcinoma of intestine or stomach.
ii) Adenosquamous type—is the pattern in which there is an
irregular admixture of adenocarcinoma and squamous cell
carcinoma.
iii) Adenoid cystic type—is an uncommon variety and is akin to
similar growth in salivary gland i.e. a cribriform appearance in an
epithelial tumour.
Adenocarcinoma of the oesophagus must be distinguished from
denocarcinoma of the gastric cardia. This is done by identifying
normal oesophageal mucosa on distal as well as proximal margin
of the tumour.
15. OTHER CARCINOMAS. Besides the two main histological types of
oesophageal cancer, a few other varieties are occasionally
encountered. These are as follow:
i) Mucoepidermoid carcinoma is a tumour having characteristics of
squamous cell as well as mucus-secreting
carcinomas.
ii) Malignant melanoma is derived from melanoblasts in the
epithelium of the oesophagus.
iii) Oat cell carcinoma arises from argyrophil cells in the basal layer
of the epithelium.
iv) Undifferentiated carcinoma is an anaplastic carcinoma which
cannot be classified into any recognisable type of carcinoma.
v) Carcinosarcoma consists of malignant epithelial as well as
sarcomatous components.
vi) Secondary tumours rarely occur in the oesophagus from
carcinomas of the breast, kidney and adrenals.
18. ETIOLOGY
1. H. pylori infection.
2. Dietary factors.
i) Occurrence of gastric cancer in the region of gastric canal
(i.e. along the lesser curvature and the pyloric antrum) where
irritating foods exert their maximum effect.
ii) Populations consuming certain foodstuffs have high risk
of developing gastric cancer e.g. ingestion of smoked foods,
high intake of salt, pickled raw vegetables, high intake of
carcinogens as nitrates in foods and drinking water, nitrites
as preservatives for certain meats.
iii) Tobacco smoke, tobacco juice and consumption of alcohol
19. 3. Geographical factors. There are geographic variations in
the incidence of gastric cancer. Japan, Chile and Italy have the
highest recorded death rate from gastric cancer.
4. Racial factors. incidence is higher in Blacks, American
Indians, Chinese in Indonesia, North Wales than other parts of
Wales.
5. Genetic factors. common in individuals with blood group O.
6. Pre-malignant changes in the gastric mucosa.
i) Hypo- or achlorhydria in atrophic gastritis of gastric mucosa
with intestinal metaplasia.
ii) Adenomatous (neoplastic) polyps of the stomach.
iii) Chronic gastric ulcer (ulcer-cancer), and its association with
achlorhydria.
iv) Stump carcinoma in patients who have undergone partial
gastrectomy.
20. MORPHOLOGIC FEATURES
I. Early gastric carcinoma (EGC).
Histologically, EGC is a typical glandular adenocarcinoma,
usually well-differentiated type.
II. Advanced gastric carcinoma, which has 5 further major
gross subtypes:
i) Ulcerative carcinoma
ii) Fungating (Polypoid) carcinoma
iii) Scirrhous carcinoma (Linitis plastica)
iv) Colloid (Mucoid) carcinoma
v) Ulcer-cancer
21. A, Ulcerative carcinoma stomach. The luminal surface of the stomach in the region of pyloric
canal shows an elevated irregular growth with ulcerated surface and raised margins. B,
Malignant cells forming irregular glands with stratification are seen invading the layers of the
stomach wall. C, Linitis plastica. The wall of the stomach in the region of pyloric canal is
markedly thickened and fibrotic while the mucosal folds are lost. D, Microscopy shows
characteristic signet ring tumour cells having abundant mucinous cytoplasm positive for
mucicarmine (inbox). The stroma is desmoplastic.
22.
23. Colorectal carcinoma
CLINICAL FEATURES. Clinical symptoms in colorectal
cancer appear after considerable time. These are as
follows:
i) Occult bleeding (melaena)
ii) Change in bowel habits, more often in left-sided
growth
iii) Loss of weight (cachexia)
iv) Loss of appetite (anorexia)
v) Anaemia, weakness, malaise.
24. Gross appearance of colorectal carcinoma. A, Right-sided growth—fungating polypoid
carcinoma showing cauliflower-like growth projecting into the lumen. B, Left-sided growth—
napkin-ring configuration with spread of growth into the bowel wall.