This document discusses using CFFI to call C APIs from Python. It provides an overview of why Python extensions are useful, specifically for accessing low-level APIs like OpenGL/Vulkan, linking to existing C libraries, and improving performance. It then compares CFFI to other options like Cython and ctypes, explaining how CFFI allows both inline and out-of-line bindings. Various code examples are provided for common tasks like defining constants, objects, and building CFFI extensions.