This document discusses principles of disease control in agricultural microbiology. It outlines four main principles: 1) Avoidance/Exclusion to prevent import and spread of pathogens, 2) Eradiation to reduce pathogen amounts, 3) Protection to directly protect plants from infection, and 4) Resistant varieties that hinder pathogen development. Specific control methods are described under each principle, including quarantine, sanitation, crop rotation, biological and chemical controls, and genetic engineering to develop resistant varieties.