This document provides an introduction to the book "Biointeractions of Nanomaterials" which covers various aspects of nanomaterial interactions within biological systems. The 20 chapters address challenges in characterizing nanomaterial toxicity, effects on specific organs and tissues, analytical tools for hazard assessment, and regulatory implications. The book aims to help understand potential risks to safely apply nanotechnology.
Leonidas Irene's on "Final draft pdfThe contribution of advertisement on incr...Denis Mpagaze
The study is about contribution of advertisement on increasing sales performance of
Nyanza Bottling Company. The main objective was to find out the contribution of
advertisement in increasing sales of Nyanza Bottling products. Push theory was used as a
guideline for problem development and data collection. The theory argues that in order
for any organization to grow and get market for their products they need to advertise and
promote more their products.
The researcher used interviews and question to collect data from 50 respondents in
Ilemela district in Mwanza region Qualitative and quantitative methods were used to
analyze the data. The major Discovery was that advertisement plays great role promoting
products of NBCL to increase sales and create awareness of their products.
Liembe Ibrahim on, "The Influence of Soap Operas on Youth Moral Behavior in M...Denis Mpagaze
Largely, the development of science and technology has brought a wide improvement in
communication context through various media formats. Because of this exponential
growth in media technology, the public consume a lot of soap operas across the country.
This being the case, this study sought to assess the influence of soap opera on youth
moral behavior in Mwanza city because youth have high attempts to adopt various
practices from the media beyond their culture.
Under this study, chapter one explains the background of the study, statement of the
problem, research objectives, significance of the study, scope of the study, definition of
the keys terms, limitation of the study, assumption and conclusion.
More over in chapter two under literature review, researcher discusses much on the
related literature that is portrayed by different schools of thought pertaining to influence
of media content on youth moral behavior..
More or less in chapter three, the study indicates the type of research implemented. In
this study, a quantitative research has been used to gather information through
observation and a random selection technique has been employed whereby questionnaire
was directed to fifty respondents for valid and reliable information.
This document summarizes a capstone project that assessed RN case managers' knowledge of current evidence-based nutritional guidelines for heart failure patients. The researcher administered a 17-question assessment to 33 RN case managers at their organization. Evaluation of the results revealed a significant knowledge deficit, as no single clinical guideline question had a majority of correct answers. This suggests an urgent need for additional education on updated clinical guidelines for heart failure nutrition. The capstone aims to determine if providing further education to RN case managers could help improve patient outcomes and reduce the growing costs associated with heart failure.
1. The document discusses India's involvement in World War II and the failure of the Cripps Mission in 1942 to gain Indian cooperation.
2. It then covers Gandhi's Quit India speech on August 8th, 1942 where he called for non-violent civil disobedience and an orderly British withdrawal from India.
3. The Quit India Movement began after Gandhi and other Congress leaders were arrested on August 9th, leading to mass demonstrations across India that were met with swift British repression.
Subhash Chandra Bose was a charismatic leader in pre-Independence India who fought for independence. He was born in 1897 and was a brilliant student. Though he passed the Civil Service exam in 1920, he resigned to join the Indian independence movement. He worked under leaders like Deshbandhu Chittaranjan Das and Gandhi but disagreed with Gandhi's policy of non-violence. He was imprisoned multiple times by the British and later sought help from Nazi Germany and Imperial Japan to form an army to liberate India. While the date and place of his death remains a mystery, Bose is remembered as a revolutionary leader who fought courageously for India's freedom.
This document is the table of contents for the third edition of the book "Cosmeceuticals and Active Cosmetics" edited by Raja K. Sivamani and others. The book contains 32 chapters summarizing the use of various active ingredients and compounds in cosmetic applications. Each chapter provides an overview on the biochemical basis and skin benefits of ingredients such as bakuchiol, caffeine, curcumin, epicatechin-3-gallate, ellagic acid, and more. The chapters also discuss cosmetic treatments for various skin conditions like rosacea, alopecia, eczema, melasma, and vitiligo.
2015 geriatric pharma frontmatter fundamentals of geriatric pharmacotherapyROBERTO CARLOS NIZAMA
Fundamentals of Geriatric Pharmacotherapy, Second Edition - 2015
Author: Lisa C. Hutchison, Rebecca B. Sleeper
Publisher: American Society of Health-System Pharmacists - ASHP
Publication date: 2015
Format: Paperback, 1 volume
Pages: 500 pp.
Leonidas Irene's on "Final draft pdfThe contribution of advertisement on incr...Denis Mpagaze
The study is about contribution of advertisement on increasing sales performance of
Nyanza Bottling Company. The main objective was to find out the contribution of
advertisement in increasing sales of Nyanza Bottling products. Push theory was used as a
guideline for problem development and data collection. The theory argues that in order
for any organization to grow and get market for their products they need to advertise and
promote more their products.
The researcher used interviews and question to collect data from 50 respondents in
Ilemela district in Mwanza region Qualitative and quantitative methods were used to
analyze the data. The major Discovery was that advertisement plays great role promoting
products of NBCL to increase sales and create awareness of their products.
Liembe Ibrahim on, "The Influence of Soap Operas on Youth Moral Behavior in M...Denis Mpagaze
Largely, the development of science and technology has brought a wide improvement in
communication context through various media formats. Because of this exponential
growth in media technology, the public consume a lot of soap operas across the country.
This being the case, this study sought to assess the influence of soap opera on youth
moral behavior in Mwanza city because youth have high attempts to adopt various
practices from the media beyond their culture.
Under this study, chapter one explains the background of the study, statement of the
problem, research objectives, significance of the study, scope of the study, definition of
the keys terms, limitation of the study, assumption and conclusion.
More over in chapter two under literature review, researcher discusses much on the
related literature that is portrayed by different schools of thought pertaining to influence
of media content on youth moral behavior..
More or less in chapter three, the study indicates the type of research implemented. In
this study, a quantitative research has been used to gather information through
observation and a random selection technique has been employed whereby questionnaire
was directed to fifty respondents for valid and reliable information.
This document summarizes a capstone project that assessed RN case managers' knowledge of current evidence-based nutritional guidelines for heart failure patients. The researcher administered a 17-question assessment to 33 RN case managers at their organization. Evaluation of the results revealed a significant knowledge deficit, as no single clinical guideline question had a majority of correct answers. This suggests an urgent need for additional education on updated clinical guidelines for heart failure nutrition. The capstone aims to determine if providing further education to RN case managers could help improve patient outcomes and reduce the growing costs associated with heart failure.
1. The document discusses India's involvement in World War II and the failure of the Cripps Mission in 1942 to gain Indian cooperation.
2. It then covers Gandhi's Quit India speech on August 8th, 1942 where he called for non-violent civil disobedience and an orderly British withdrawal from India.
3. The Quit India Movement began after Gandhi and other Congress leaders were arrested on August 9th, leading to mass demonstrations across India that were met with swift British repression.
Subhash Chandra Bose was a charismatic leader in pre-Independence India who fought for independence. He was born in 1897 and was a brilliant student. Though he passed the Civil Service exam in 1920, he resigned to join the Indian independence movement. He worked under leaders like Deshbandhu Chittaranjan Das and Gandhi but disagreed with Gandhi's policy of non-violence. He was imprisoned multiple times by the British and later sought help from Nazi Germany and Imperial Japan to form an army to liberate India. While the date and place of his death remains a mystery, Bose is remembered as a revolutionary leader who fought courageously for India's freedom.
This document is the table of contents for the third edition of the book "Cosmeceuticals and Active Cosmetics" edited by Raja K. Sivamani and others. The book contains 32 chapters summarizing the use of various active ingredients and compounds in cosmetic applications. Each chapter provides an overview on the biochemical basis and skin benefits of ingredients such as bakuchiol, caffeine, curcumin, epicatechin-3-gallate, ellagic acid, and more. The chapters also discuss cosmetic treatments for various skin conditions like rosacea, alopecia, eczema, melasma, and vitiligo.
2015 geriatric pharma frontmatter fundamentals of geriatric pharmacotherapyROBERTO CARLOS NIZAMA
Fundamentals of Geriatric Pharmacotherapy, Second Edition - 2015
Author: Lisa C. Hutchison, Rebecca B. Sleeper
Publisher: American Society of Health-System Pharmacists - ASHP
Publication date: 2015
Format: Paperback, 1 volume
Pages: 500 pp.
Cytogenetics and Molecular Cytogenetics (CRC Press, 2022).pdfQusayAlMaghayerh
Leon Liehr
Friedrich Schiller University Jena
Jena, Germany
Peining Li
Yale School of Medicine
New Haven, CT, USA
Thomas Liehr
Friedrich Schiller University Jena
Jena, Germany
Susan Liedtke
Technische Universität Dresden
Dresden, Germany
Ivan Y. Iourov
Mental Health Research Center
Moscow, Russia
Marcelo Land
Instituto Nacional de Câncer José de
Alencar Gomes da Silva (INCA-RJ)
Rio de Janeiro, Brazil
Eunice Matoso
Faculty of Medicine of the University
Ethical Ideas in Indian Philosophical Tradition 4.1–4.28 Hinduism 4.1 Four Principal Moral Ends 4.1 Varnashrama Dharma 4.2 Contents xi Bhagavat Gita 4.3 Main Message 4.3 Paths to Salvation 4.3 Virtues 4.4 Action without Craving 4.4 Positive and negative emotions 4.5 Comparison with Western Moral Ideals 4.5 Other Aspects of Gita’s Moral Message 4.6 Moral Criteria and Concepts 4.6 Law of Karma 4.7 Manu’s Ideas 4.7 Mahabharata 4.8 Samyama 4.8 Jainism 4.9 Ahimsa 4.9 Path to Salvation 4.10 Five Moral Principles 4.10 Pride 4.10 Buddhism 4.11 Life of Buddha 4.11 Conceptual framework of Buddhist thought 4.11 Truth of Dukkha 4.12 Origin of Dukkha 4.12 Cessation of Dukkha 4.13 Path Leading to the Cessation of Dukkha 4.13 Prescriptions for Family and Society 4.14 Non-Violence and Peace 4.14 Middle Course 4.15 Altruism 4.15 Gandhian Ethics 4.15 Faith in God 4.16 Ethical Conduct 4.16 Truth 4.17 Service to Society 4.17 Purity of Heart 4.18 Ends and Means 4.18 Human Nature 4.18 xii Contents Ahimsa 1.19 Non-violent Non-cooperation 4.20 Qualities of a Satyagrahi 4.20 Gandhi’s Economic Ideas 4.21 Summary 4.22 Practice Questions 4.27 References 4.28 5. Lessons From The Lives Of Great Indian Leaders, Reformers And Administrators 5.1–5.39 Introduction and Approach 5.1 Human Values 5.2 Vivekananda 5.4 Discovery of Real India 5.4 Awakening his Countrymen 5.5 His Spiritual Thoughts 5.5 His Contributions to India 5.6 His Contributions to Hinduism 5.7 Some Famous Sayings of Vivekananda 5.7 Ramakrishna Paramahamsa 5.8 Intense Spiritual Practices 5.8 Contributions of Sri Ramakrishna to World Culture 5.9 Other Contributions 5.10 Sri Aurobindo 5.10 The Patriot 5.11 A Divine Life 5.11 A Great Litterateur 5.11 Five Dreams 5.12 Raja Ram Mohan Roy 5.13 Religious Reforms 5.14 Social Reforms 5.14 Education 5.15 Journalism 5.15 Religious Catholicity 5.15 Dayananda Saraswati 5.15 Transformative Event 5.16 Spiritual Search 5.16 Basic Doctrine 5.16 Contents xiii Practical Reformer 5.17 Opposition to Obscurantism 5.17 Assessment 5.18 Narayana Guru 5.18 Education 5.18 Marriage 5.19 Spiritual Wanderings 5.19 Religious Mission 5.19 Opposition to Old Customs 5.19 Commandments 5.20 Tolerance and Catholicity 5.20 Sir Rabindranath Tagore 5.21 Nobel Prize 5.21 Poetic Vision of India
Considerations For The Provision Of E-TherapySTEPHEN MARTIN
This document provides guidance on the provision of e-therapy (electronic therapy) for substance abuse treatment. It defines e-therapy as using electronic media like email, texting, videoconferencing to provide behavioral health services from a distance. The document discusses appropriate uses of e-therapy including for screening, assessment, treatment, and aftercare. It also addresses evaluating e-therapy outcomes, ensuring cultural competence, navigating legal/regulatory issues, and administrative considerations like security, billing and support. The goal is to help expand access to substance abuse treatment through new technology.
Information Technology to Support Transformation to Proactive Primary CareMatthew Quinn
This document describes a project to identify information management functionalities that can support practice-based population health (PBPH). PBPH aims to use data on patients within a practice to improve preventive care and chronic disease management. The project developed a list of functionalities through expert input and provider interviews. It found practices need better tools and data to perform all the functionalities. Widespread adoption faces challenges but policies like health reform and HIT funding could help address them by changing payment models and training the workforce to support PBPH.
Acing the Orthopedic Board Exam - Brett Levine , 1E.pdfdeepjha1
This document provides information about a book titled "Acing the Orthopedic Board Exam: The Ultimate Crunch-Time Resource" written by Brett R. Levine, MD, MS. It includes a dedication to Dr. Levine's family for their support in writing the book, as well as contents, acknowledgments, information about the author, contributing authors, and copyright information. The book aims to help readers prepare for and pass the orthopedic board exam through challenging case-based questions and critical facts and figures.
This document provides an overview of the book "On Call Radiology" which presents case discussions on common clinical emergencies and their corresponding imaging findings encountered on-call. The book combines a case-based discussion format with practical advice on imaging decision making in the acute setting and guidance on radiology report writing. It discusses various conditions organized by body system including thoracic, gastrointestinal, genitourinary, neurological and trauma imaging. Each case includes a clinical history, imaging examples, diagnosis and basic management discussion.
A research report on the establishment of private independent blood banks in ...Rijo Stephen Cletus
This document is a research report on establishing private independent blood banks in India for civilian use. It provides an abstract that outlines issues with India's decentralized blood banking system and the need for qualified professionals and adequate infrastructure. The report then covers the legal framework and guidelines for licensing blood banks and manufacturing blood products in India. It examines requirements for operating blood banks, collecting and processing blood components, and manufacturing blood products to ensure quality, safety and compliance with standards. The document also provides clinical information on blood grouping, cross-matching, transfusion medicine concepts and risks of transfusion-transmitted infections to help blood banks serve patients effectively.
This document is the preface to the Toxicologist's Pocket Handbook. It provides background on the author, Michael J. Derelanko, and the purpose and contents of the handbook. The handbook aims to provide a concise yet comprehensive toxicology reference source in a portable format. It contains selected tables and figures from the larger CRC Handbook of Toxicology on topics such as laboratory animals, acute/chronic toxicology, and dermal toxicology. Acknowledgments are provided for contributors to the original CRC handbook.
The document discusses drug delivery. It provides an overview of factors considered in drug development like commercial goals, chemical limitations, efficacy studies, pharmacokinetics, and final formulation characteristics. It also discusses barriers to drug delivery like physiological barriers, biochemical barriers, and chemical barriers. Finally, it discusses strategies to overcome these barriers like prodrug modification, formulations, and other approaches.
27.Fermentation Microbiology and Biotechnology -2011.pdfBurgasmoRomania
This document provides an overview of the third edition of the book "Fermentation Microbiology and Biotechnology". The book explores the diverse metabolic pathways used by microorganisms to produce primary and secondary metabolites as well as biopharmaceuticals. The third edition contains four new chapters on topics such as functional genomics, solid-state fermentations, applications of metabolomics to microbial cell factories, and culturing complex plant tissues. The book aims to reflect the multidisciplinary nature of fermentation microbiology and biotechnology. It contains contributions from global experts and is intended to pave the way for new innovations in exploiting microorganisms.
US National Drug Abuse Statistics Sept 4 2014Anna Sosa
This document provides a summary of results from the 2013 National Survey on Drug Use and Health (NSDUH). Some key findings include:
- Rates of illicit drug use among persons aged 12 or older have generally declined or stabilized since 2002 for most drugs, including marijuana, cocaine, hallucinogens, and nonmedical use of psychotherapeutics. Heroin use has increased in recent years.
- Alcohol and tobacco use rates have generally declined or stabilized since 2002 among persons aged 12 or older, youths, and young adults. However, binge drinking remains high among certain groups such as young adults aged 18 to 25.
- Initiation of substance use typically occurs during adolescence or young
This document is a handbook on pharmaceutical manufacturing formulations for compressed solid products. It contains three parts: regulatory and manufacturing considerations for compressed solids, guidance on formulating compressed solids, and specific formulations for various compressed solid dosage forms. The handbook provides an overview of key factors involved in developing stable and reproducible solid oral dosage forms that meet regulatory specifications.
This document discusses how exposure to toxic chemicals may be harming human development from prenatal development through adulthood. It notes that scientists can find over 100 industrial chemicals in people's bodies and that exposure comes through food, consumer products, homes and personal care products. The timing of exposure is important, as chemicals can interfere with development during critical windows and have effects that appear later in life. Mixtures of chemicals may cause greater harm than individual chemicals. The document reviews evidence linking chemical exposures to conditions like preterm birth, learning disabilities, obesity, declining fertility and some cancers. It concludes that reducing exposures through policy changes can improve public health outcomes.
Practical Manual on Plant Cytogenetics (CRC Press, 2018).pdfQusayAlMaghayerh
This document provides instructions for performing fluorescence in situ hybridization (FISH) techniques on plant chromosomes. It describes how to isolate DNA, label probes with fluorescent tags, prepare buffers and enzyme solutions, and process slides to allow for visualization of hybridized probes on target chromosomes from various plant species including soybean and wheat. The goal is to use FISH to map DNA sequences to specific chromosome locations to better understand plant genomes.
Immunity poses a major barrier in the translational development of biotherapeutic drugs. Recent advances in immunology have highlighted the protective role of Factor H, an immune regulatory protein involved in the alternate complement system. Modulating Factor H has potential for developing novel biotherapeutics to prevent, treat, and control global diseases in a more cost-effective manner. India offers a favorable legal and scientific framework for multinational companies to develop such biotherapeutics through clinical trials while leveraging lower costs compared to Western nations.
This document contains instructions for accessing the electronic version of a medical textbook. It states that access is limited to the first individual who redeems the pin code located inside the book's cover. It also provides contact information for technical support.
This document is a thesis submitted by Francis Justin Kinoti to Jomo Kenyatta University of Agriculture and Technology in partial fulfillment of the requirements for a Master of Science degree in Nursing (Oncology and Palliative Care) in 2021. The thesis examines psychosocial distress among patients with cancer at Machakos Palliative Care Unit. It includes chapters on the background of the study, literature review on psychosocial distress and factors associated with it among cancer patients, methodology used for data collection and analysis, results of the study, and conclusions. The study aimed to determine the level and problems of psychosocial distress experienced by cancer patients, and sociodemographic, cancer-related, and institutional factors associated with it.
This study aimed to determine the prevalence and factors associated with psychosocial distress among patients diagnosed with cancer at Machakos palliative care unit in Kenya. A total of 97 patients participated in the study through questionnaires and interviews. The study found that the majority (72.2%) of respondents reported experiencing psychosocial distress, with 43.2% reporting severe levels. The leading psychosocial problems reported were pain (83.3%), problems with treatment decision making (64.9%), and fatigue (59.8%). Male patients were found to be 85% less likely to experience distress compared to females. The qualitative findings highlighted financial problems, pain, chemotherapy side effects, lack of medical insurance and supplies, and workload issues as contributing to psychos
This document provides guidelines for researching and evaluating herbal medicines used in traditional medicine. It defines key terms related to herbal medicines and outlines approaches for assessing quality, safety, and efficacy. Specifically, it recommends verifying the botanical identity of herbal materials and standardizing herbal preparations to contain defined amounts of active ingredients when possible. It also provides guidance on acute and long-term toxicity testing to evaluate safety. The guidelines aim to improve research while respecting the history of established herbal medicine practices.
Cytogenetics and Molecular Cytogenetics (CRC Press, 2022).pdfQusayAlMaghayerh
Leon Liehr
Friedrich Schiller University Jena
Jena, Germany
Peining Li
Yale School of Medicine
New Haven, CT, USA
Thomas Liehr
Friedrich Schiller University Jena
Jena, Germany
Susan Liedtke
Technische Universität Dresden
Dresden, Germany
Ivan Y. Iourov
Mental Health Research Center
Moscow, Russia
Marcelo Land
Instituto Nacional de Câncer José de
Alencar Gomes da Silva (INCA-RJ)
Rio de Janeiro, Brazil
Eunice Matoso
Faculty of Medicine of the University
Ethical Ideas in Indian Philosophical Tradition 4.1–4.28 Hinduism 4.1 Four Principal Moral Ends 4.1 Varnashrama Dharma 4.2 Contents xi Bhagavat Gita 4.3 Main Message 4.3 Paths to Salvation 4.3 Virtues 4.4 Action without Craving 4.4 Positive and negative emotions 4.5 Comparison with Western Moral Ideals 4.5 Other Aspects of Gita’s Moral Message 4.6 Moral Criteria and Concepts 4.6 Law of Karma 4.7 Manu’s Ideas 4.7 Mahabharata 4.8 Samyama 4.8 Jainism 4.9 Ahimsa 4.9 Path to Salvation 4.10 Five Moral Principles 4.10 Pride 4.10 Buddhism 4.11 Life of Buddha 4.11 Conceptual framework of Buddhist thought 4.11 Truth of Dukkha 4.12 Origin of Dukkha 4.12 Cessation of Dukkha 4.13 Path Leading to the Cessation of Dukkha 4.13 Prescriptions for Family and Society 4.14 Non-Violence and Peace 4.14 Middle Course 4.15 Altruism 4.15 Gandhian Ethics 4.15 Faith in God 4.16 Ethical Conduct 4.16 Truth 4.17 Service to Society 4.17 Purity of Heart 4.18 Ends and Means 4.18 Human Nature 4.18 xii Contents Ahimsa 1.19 Non-violent Non-cooperation 4.20 Qualities of a Satyagrahi 4.20 Gandhi’s Economic Ideas 4.21 Summary 4.22 Practice Questions 4.27 References 4.28 5. Lessons From The Lives Of Great Indian Leaders, Reformers And Administrators 5.1–5.39 Introduction and Approach 5.1 Human Values 5.2 Vivekananda 5.4 Discovery of Real India 5.4 Awakening his Countrymen 5.5 His Spiritual Thoughts 5.5 His Contributions to India 5.6 His Contributions to Hinduism 5.7 Some Famous Sayings of Vivekananda 5.7 Ramakrishna Paramahamsa 5.8 Intense Spiritual Practices 5.8 Contributions of Sri Ramakrishna to World Culture 5.9 Other Contributions 5.10 Sri Aurobindo 5.10 The Patriot 5.11 A Divine Life 5.11 A Great Litterateur 5.11 Five Dreams 5.12 Raja Ram Mohan Roy 5.13 Religious Reforms 5.14 Social Reforms 5.14 Education 5.15 Journalism 5.15 Religious Catholicity 5.15 Dayananda Saraswati 5.15 Transformative Event 5.16 Spiritual Search 5.16 Basic Doctrine 5.16 Contents xiii Practical Reformer 5.17 Opposition to Obscurantism 5.17 Assessment 5.18 Narayana Guru 5.18 Education 5.18 Marriage 5.19 Spiritual Wanderings 5.19 Religious Mission 5.19 Opposition to Old Customs 5.19 Commandments 5.20 Tolerance and Catholicity 5.20 Sir Rabindranath Tagore 5.21 Nobel Prize 5.21 Poetic Vision of India
Considerations For The Provision Of E-TherapySTEPHEN MARTIN
This document provides guidance on the provision of e-therapy (electronic therapy) for substance abuse treatment. It defines e-therapy as using electronic media like email, texting, videoconferencing to provide behavioral health services from a distance. The document discusses appropriate uses of e-therapy including for screening, assessment, treatment, and aftercare. It also addresses evaluating e-therapy outcomes, ensuring cultural competence, navigating legal/regulatory issues, and administrative considerations like security, billing and support. The goal is to help expand access to substance abuse treatment through new technology.
Information Technology to Support Transformation to Proactive Primary CareMatthew Quinn
This document describes a project to identify information management functionalities that can support practice-based population health (PBPH). PBPH aims to use data on patients within a practice to improve preventive care and chronic disease management. The project developed a list of functionalities through expert input and provider interviews. It found practices need better tools and data to perform all the functionalities. Widespread adoption faces challenges but policies like health reform and HIT funding could help address them by changing payment models and training the workforce to support PBPH.
Acing the Orthopedic Board Exam - Brett Levine , 1E.pdfdeepjha1
This document provides information about a book titled "Acing the Orthopedic Board Exam: The Ultimate Crunch-Time Resource" written by Brett R. Levine, MD, MS. It includes a dedication to Dr. Levine's family for their support in writing the book, as well as contents, acknowledgments, information about the author, contributing authors, and copyright information. The book aims to help readers prepare for and pass the orthopedic board exam through challenging case-based questions and critical facts and figures.
This document provides an overview of the book "On Call Radiology" which presents case discussions on common clinical emergencies and their corresponding imaging findings encountered on-call. The book combines a case-based discussion format with practical advice on imaging decision making in the acute setting and guidance on radiology report writing. It discusses various conditions organized by body system including thoracic, gastrointestinal, genitourinary, neurological and trauma imaging. Each case includes a clinical history, imaging examples, diagnosis and basic management discussion.
A research report on the establishment of private independent blood banks in ...Rijo Stephen Cletus
This document is a research report on establishing private independent blood banks in India for civilian use. It provides an abstract that outlines issues with India's decentralized blood banking system and the need for qualified professionals and adequate infrastructure. The report then covers the legal framework and guidelines for licensing blood banks and manufacturing blood products in India. It examines requirements for operating blood banks, collecting and processing blood components, and manufacturing blood products to ensure quality, safety and compliance with standards. The document also provides clinical information on blood grouping, cross-matching, transfusion medicine concepts and risks of transfusion-transmitted infections to help blood banks serve patients effectively.
This document is the preface to the Toxicologist's Pocket Handbook. It provides background on the author, Michael J. Derelanko, and the purpose and contents of the handbook. The handbook aims to provide a concise yet comprehensive toxicology reference source in a portable format. It contains selected tables and figures from the larger CRC Handbook of Toxicology on topics such as laboratory animals, acute/chronic toxicology, and dermal toxicology. Acknowledgments are provided for contributors to the original CRC handbook.
The document discusses drug delivery. It provides an overview of factors considered in drug development like commercial goals, chemical limitations, efficacy studies, pharmacokinetics, and final formulation characteristics. It also discusses barriers to drug delivery like physiological barriers, biochemical barriers, and chemical barriers. Finally, it discusses strategies to overcome these barriers like prodrug modification, formulations, and other approaches.
27.Fermentation Microbiology and Biotechnology -2011.pdfBurgasmoRomania
This document provides an overview of the third edition of the book "Fermentation Microbiology and Biotechnology". The book explores the diverse metabolic pathways used by microorganisms to produce primary and secondary metabolites as well as biopharmaceuticals. The third edition contains four new chapters on topics such as functional genomics, solid-state fermentations, applications of metabolomics to microbial cell factories, and culturing complex plant tissues. The book aims to reflect the multidisciplinary nature of fermentation microbiology and biotechnology. It contains contributions from global experts and is intended to pave the way for new innovations in exploiting microorganisms.
US National Drug Abuse Statistics Sept 4 2014Anna Sosa
This document provides a summary of results from the 2013 National Survey on Drug Use and Health (NSDUH). Some key findings include:
- Rates of illicit drug use among persons aged 12 or older have generally declined or stabilized since 2002 for most drugs, including marijuana, cocaine, hallucinogens, and nonmedical use of psychotherapeutics. Heroin use has increased in recent years.
- Alcohol and tobacco use rates have generally declined or stabilized since 2002 among persons aged 12 or older, youths, and young adults. However, binge drinking remains high among certain groups such as young adults aged 18 to 25.
- Initiation of substance use typically occurs during adolescence or young
This document is a handbook on pharmaceutical manufacturing formulations for compressed solid products. It contains three parts: regulatory and manufacturing considerations for compressed solids, guidance on formulating compressed solids, and specific formulations for various compressed solid dosage forms. The handbook provides an overview of key factors involved in developing stable and reproducible solid oral dosage forms that meet regulatory specifications.
This document discusses how exposure to toxic chemicals may be harming human development from prenatal development through adulthood. It notes that scientists can find over 100 industrial chemicals in people's bodies and that exposure comes through food, consumer products, homes and personal care products. The timing of exposure is important, as chemicals can interfere with development during critical windows and have effects that appear later in life. Mixtures of chemicals may cause greater harm than individual chemicals. The document reviews evidence linking chemical exposures to conditions like preterm birth, learning disabilities, obesity, declining fertility and some cancers. It concludes that reducing exposures through policy changes can improve public health outcomes.
Practical Manual on Plant Cytogenetics (CRC Press, 2018).pdfQusayAlMaghayerh
This document provides instructions for performing fluorescence in situ hybridization (FISH) techniques on plant chromosomes. It describes how to isolate DNA, label probes with fluorescent tags, prepare buffers and enzyme solutions, and process slides to allow for visualization of hybridized probes on target chromosomes from various plant species including soybean and wheat. The goal is to use FISH to map DNA sequences to specific chromosome locations to better understand plant genomes.
Immunity poses a major barrier in the translational development of biotherapeutic drugs. Recent advances in immunology have highlighted the protective role of Factor H, an immune regulatory protein involved in the alternate complement system. Modulating Factor H has potential for developing novel biotherapeutics to prevent, treat, and control global diseases in a more cost-effective manner. India offers a favorable legal and scientific framework for multinational companies to develop such biotherapeutics through clinical trials while leveraging lower costs compared to Western nations.
This document contains instructions for accessing the electronic version of a medical textbook. It states that access is limited to the first individual who redeems the pin code located inside the book's cover. It also provides contact information for technical support.
This document is a thesis submitted by Francis Justin Kinoti to Jomo Kenyatta University of Agriculture and Technology in partial fulfillment of the requirements for a Master of Science degree in Nursing (Oncology and Palliative Care) in 2021. The thesis examines psychosocial distress among patients with cancer at Machakos Palliative Care Unit. It includes chapters on the background of the study, literature review on psychosocial distress and factors associated with it among cancer patients, methodology used for data collection and analysis, results of the study, and conclusions. The study aimed to determine the level and problems of psychosocial distress experienced by cancer patients, and sociodemographic, cancer-related, and institutional factors associated with it.
This study aimed to determine the prevalence and factors associated with psychosocial distress among patients diagnosed with cancer at Machakos palliative care unit in Kenya. A total of 97 patients participated in the study through questionnaires and interviews. The study found that the majority (72.2%) of respondents reported experiencing psychosocial distress, with 43.2% reporting severe levels. The leading psychosocial problems reported were pain (83.3%), problems with treatment decision making (64.9%), and fatigue (59.8%). Male patients were found to be 85% less likely to experience distress compared to females. The qualitative findings highlighted financial problems, pain, chemotherapy side effects, lack of medical insurance and supplies, and workload issues as contributing to psychos
This document provides guidelines for researching and evaluating herbal medicines used in traditional medicine. It defines key terms related to herbal medicines and outlines approaches for assessing quality, safety, and efficacy. Specifically, it recommends verifying the botanical identity of herbal materials and standardizing herbal preparations to contain defined amounts of active ingredients when possible. It also provides guidance on acute and long-term toxicity testing to evaluate safety. The guidelines aim to improve research while respecting the history of established herbal medicine practices.
3. Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
Edited by
Vijaykumar B. Sutariya
University of South Florida
College of Pharmacy
Tampa, Florida, USA
Yashwant Pathak
University of South Florida
College of Pharmacy
Tampa, Florida, USA
Biointeractions of
Nanomaterials
Downloadedby[202.142.72.34]at21:2803September2014
5. Dedicated to the loving memory of my father, Bhadabhai
Chakubhai Sutariya, who passed away on April 22, 2013. He was my
role model and mentor throughout my life and whatever I have
achieved in life is because of his blessings. I would also like to
dedicate this book to the memory of Swami Vivekananda; the
world celebrated the 150th birthday of Swamijee in 2013.
Vijaykumar B. Sutariya
To the loving memories of my parents and Dr. Keshav Baliram Hedgewar,
who showed the right direction; my wife Seema, who gave my life positive
meaning; and my son Sarvadaman who gave a golden lining to my life.
Yashwant Pathak
Downloadedby[202.142.72.34]at21:2803September2014
8. viii Contents
Chapter 10 Toxicogenomic Approaches to Understanding the Toxicity of Nanoparticles..........209
Qiwen Shi, Mahavir B. Chougule, Vijaykumar B. Sutariya, and Deepak Bhatia
Chapter 11 Nanomaterial-Based Gene and Drug Delivery: Pulmonary Toxicity
Considerations...........................................................................................................225
Mahavir B. Chougule, Rakesh K. Tekade, Peter R. Hoffmann, Deepak Bhatia,
Vijaykumar B. Sutariya, and Yashwant Pathak
Chapter 12 Cardiovascular Toxicity of Nanomaterials................................................................249
Saijie Zhu and Minghuang Hong
Chapter 13 Toxicity of Nanomaterials on the Gastrointestinal Tract..........................................259
Jayvadan Patel and Vibha Champavat
Chapter 14 Toxicity of Nanomaterials on the Liver, Kidney, and Spleen...................................285
Jayvadan Patel and Anita Patel
Chapter 15 Regulatory Implications of Nanotechnology............................................................ 315
Lynn L. Bergeson and Michael F. Cole
Chapter 16 Ocular Toxicity of Nanoparticles..............................................................................347
Aditya Grover, Anjali Hirani, Yong Woo Lee, Vijaykumar B. Sutariya,
and Yashwant Pathak
Chapter 17 Genotoxicity of Nanoparticles.................................................................................. 353
Amaya Azqueta, Leire Arbillaga, and Adela López de Cerain
Chapter 18 Interactions of Polysaccharide-Coated Nanoparticles with Proteins........................365
Christine Vauthier
Chapter 19 Models for Risk Assessments of Nanoparticles........................................................383
Sanjay Dey, Bhaskar Mazumder, and Yaswant Pathak
Chapter 20 Immunotoxicity of Carbon Nanoparticles.................................................................425
Paulami Pal, Bhaskar Mazumder, and Yaswant Pathak
Index...............................................................................................................................................443
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9. ix
Foreword
Nanomaterials are those in the nanometer range (10−9 m). These
incredibly small particles can be organic or inorganic, with examples
ranging from poly(lactic-co-glycolic acid) or gold nanoparticles to
carbon nanotubes and quantum dots. These particles may be used to
encapsulate drugs, recognize biological markers, or visualize body
tissues among many other possibilities, all enabling their widespread
application in biology, medicine, and pharmaceutics. Indeed, these
nanomaterials may have beneficial effects that have not even been
imagined.
The small size of these particles provides an enormous surface
area, which is ideal for interactions with cells on a molecular level,
but also raises the question of their biosafety. The chemical composi-
tion of the diverse nanomaterials available for biological interactions
may have unforeseen consequences in living systems. Whether the good that these interactions
accomplish outweighs the risk of harm will have to be addressed before nanomaterials are used on
a wide scale, especially in biological systems.
This book is a collaborative effort of the editors Drs. Vijaykumar B. Sutariya and Yashwant
Pathak and the numerous contributors who are leading scientists in this field. The subject mat-
ter is of prime importance in the area of nanotechnology and its applications. These contributors,
knowledgeable and experienced in their field, attempt to elucidate the potential biointeractions of
nanomaterials with their respective applications in efforts to answer the questions posed above. This
book presents the possible biointeractions of various nanomaterials with a number of different body
tissues in a multitude of applications. I would like to congratulate Drs. Vijaykumar B. Sutariya and
Yashwant Pathak at the University of South Florida for editing this important and timely book.
It is my great pleasure to write a foreword and present to you Biointeractions of Nanomaterials.
I sincerely hope you will gain as much insight as I did from these chapters.
Shyam S. Mohapatra, PhD, MBA, FAAAAI, FNAI
Distinguished USF Health Professor and Director
Division of Translational Medicine-USF Nanomedicine Research Center
Vice Chair of Research
Department of Internal Medicine
President, USF Chapter of the National Academy of Inventors
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11. xi
Preface
The purpose of this book is to focus on the biointeractions of nanomaterials, an area that has not
been previously addressed in detail. It also covers various techniques and tests that have been devel-
oped to evaluate the toxicity of materials at the nanolevel. The interactions of nanomaterials and
nanosystems within biosystems are a concern for the scientific community.
This book is targeted toward academic researchers as well as industry members who are involved
in the development of nanosystems. Many graduate schools have initiated courses in nanotechnol-
ogy and applications, and this book will be a great resource for students as well as professors.
Additionally, this will be a useful tool for industrial scientists investigating technology to update
their nanotoxicology and nanosafety understanding.
The objective of the book is to address issues related to the toxicity and safety of nanomaterials
and nanosystems. It also covers the interactions of these in biological systems, and various tools and
methods used to evaluate toxicity and safety issues.
The volume comprises 20 chapters written by leading scientists in the field of nanotechnol-
ogy. Chapter 1 covers the challenges and solutions of biointeractions of nanomaterials. This is fol-
lowed by three chapters that address the assessment and characterization of nanosystems in the
bioenvironment.
The next group of chapters covers toxicity and includes biosensing devices for toxicity assess-
ment, carbon nanotubes, and pulmonary toxicity, as well as nanotoxicity of solid lipid nanoparticles.
The final group of chapters from 8 to 20 covers nanosafety concerns and solutions. Each of these
chapters delves into the effects of nanoparticles on different organs and sheds light on regulatory
implications of nanomaterials.
We sincerely hope this book gets an overwhelming response from the scientific community in
the field of nanotechnology.
We thank and acknowledge our families, the publishers, and our contributing authors. We would
also like to acknowledge Aditya Grover, Anastasia Groshev, and Anjali Hirani for their assistance
in editing and obtaining copyright clearance as well as the staff of Taylor & Francis who assisted in
shaping this wonderful book in the field of nanotechnology.
Vijaykumar B. Sutariya
Yashwant Pathak
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13. xiii
Editors
Dr. Vijaykumar B. Sutariya earned his bachelor of pharmacy and master of pharmacy from
L. M. College of Pharmacy, Gujarat University, Ahmedabad, India and his PhD in pharmacy from
The M.S. University of Baroda, Vadodara, India. He did his postdoctoral training in the field of
pharmaceutics and drug delivery at Butler University, Indianapolis, Indiana.
Dr. Sutariya is an assistant professor in the Department of Pharmaceutical Sciences at the
University of South Florida (USF) College of Pharmacy. He has a joint appointment with the
Department of Internal Medicine, Division of Translational Medicine at USF.
Dr. Sutariya has published more than 30 research papers in peer-reviewed journals and has pre-
sented at various national and international meetings. He is a reviewer of many international journals
and an editorial board member of more than six journals related to drug delivery and pharmaceutical
sciences. Dr. Sutariya’s research is focused on the development of novel drug delivery systems such
as nanoparticles, liposome, and thermoreversible gel. His main research focus is on brain-targeted
drug delivery and ocular drug delivery. Dr. Sutariya is currently serving as a coinvestigator on two
NIH grants (R01 and R15). In addition to research, Dr. Sutariya teaches various courses related to
pharmaceutics in the Doctor of Pharmacy curriculum.
Dr. Yashwant Pathak completed his MS and PhD in pharmaceutical technology at Nagpur
University, India and his EMBA and MS in conflict management from Sullivan University,
Kentucky. He is an associate dean for faculty affairs at the College of Pharmacy, University of
South Florida, Tampa, Florida. With extensive experience in academia as well as industry, he has to
his credit more than 100 publications, 5 books on nanotechnology, 4 books on nutraceuticals, and
several books on cultural studies, including 2 on aging studies from an Indian perspective. His areas
of research include drug delivery systems and their characterization in animal models.
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15. xv
Contributors
Leire Arbillaga
Department of Pharmacology and Toxicology
University of Navarra
Pamplona, Spain
Amaya Azqueta
Department of Pharmacology and Toxicology
University of Navarra
Pamplona, Spain
Lynn L. Bergeson
Bergeson & Campbell, P.C.
Washington, D.C.
Deepak Bhatia
Department of Pharmaceutical Sciences
Northeast Ohio Medical University
Rootstown, Ohio
Vibha Champavat
Nootan Pharmacy College
North Gujarat, India
Harsh Chauhan
Department of Pharmacy Sciences
Creighton University
Omaha, Nebraska
Ching-Hwa Chen
Department of Environmental and
Occupational Health, Medical College
National Cheng Kung University
Tainan, Taiwan
Chun-Wan Chen
Institute of Occupational Safety and Health
Ministry of Labor
Taipei, Taiwan
Hongzheng Chen
Department of Polymer Science and
Engineering
Zhejiang University
Zhejiang, China
Mahavir B. Chougule
Department of Pharmaceutical Sciences
University of Hawaii
Hilo, Hawaii
Michael F. Cole
Bergeson & Campbell, P.C.
Washington, D.C.
Malay K. Das
College of Pharmacy
University of South Florida
Tampa, Florida
Vivek Dave
Wegmans School of Pharmacy
St. John Fisher College
Rochester, New York
Adela López de Cerain
Department of Pharmacology and Toxicology
University of Navarra
Pamplona, Spain
Sanjay Dey
Department of Pharmaceutical Sciences
Dibrugarh University
Dibrugarh, India
Daisuke Fujita
Advanced Key Technologies Division
National Institute for Materials Science
Ibaraki, Japan
Ana Groshev
College of Pharmacy
University of South Florida
Tampa, Florida
Aditya Grover
College of Pharmacy
University of South Florida
Tampa, Florida
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16. xvi Contributors
Nobutaka Hanagata
Interdisciplinary Laboratory for Nanoscale
Science and Technology
National Institute for Materials Science
Ibaraki, Japan
Anjali Hirani
School of Biomedical Engineering and
Sciences
Virginia Tech
Blacksburg, Virginia
and
College of Pharmacy
University of South Florida
Tampa, Florida
Peter R. Hoffmann
Department of Cell and Molecular Biology
John A. Burns School of Medicine
Honolulu, Hawaii
Evangelia Hondroulis
College of Engineering and Computing
Florida International University
Miami, Florida
Minghuang Hong
Pharmaceutical Crystal Engineering Research
Group
Shanghai Institute of Pharmaceutical Industry
Shanghai, China
Yong Woo Lee
School of Biomedical Engineering and Sciences
Virginia Tech
Blacksburg, Virginia
Chen-Zhong Li
College of Engineering and Computing
Florida International University
Miami, Florida
Bhaskar Mazumder
Department of Pharmaceutical Sciences
Dibrugarh University
Dibrugarh, India
Sachin Naik
Formulation Department
SunPharma Advanced Research Co. Ltd.
Gujarat, India
Moses O. Oyewumi
Department of Pharmaceutical Sciences
Northeast Ohio Medical University
Rootstown, Ohio
Paulami Pal
Department of Pharmaceutical
Sciences
Dibrugarh University
Dibrugarh, India
Anita Patel
Nootan Pharmacy College
North Gujarat, India
Deepa Patel
Parul Institute of Pharmacy and Research
Gujarat, India
Jayvadan Patel
Nootan Pharmacy College
North Gujarat, India
Vrinda Pathak
College of Pharmacy
University of South Florida
Tampa, Florida
Yashwant Pathak
College of Pharmacy
University of South Florida
Tampa, Florida
Dev Prasad
School of Pharmacy
Massachusetts College of Pharmacy and
Health Sciences
Boston, Massachusetts
Charles Preuss
Department of Molecular Pharmacology and
Physiology
Morsani College of Medicine
University of South Florida
Tampa, Florida
Prabodh Sadana
Department of Pharmaceutical Sciences
Northeast Ohio Medical University
Rootstown, Ohio
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17. xviiContributors
Hardeep Saluja
College of Pharmacy
Southwestern Oklahoma State University
Weatherford, Oklahoma
Ankur P. Shah
Pharmaceutical Technology Center
Zydus Cadila Healthcare Ltd.
Gujarat, India
Hiral J. Shah
Department of Pharmaceutics
Arihant School of Pharmacy and BRI
Gujarat, India
Jigar N. Shah
Department of Pharmaceutics
Nirma University
Ahmedabad, India
Pratik Shah
College of Engineering and Computing
Florida International University
Miami, Florida
Qiwen Shi
Department of Pharmaceutical Sciences
College of Pharmacy
Northeast Ohio Medical University
Rootstown, Ohio
Huanxing Su
State Key Laboratory of Quality Research in
Chinese Medicine
and
Institute of Chinese Medical Sciences
University of Macau
Macau SAR, China
and
Interdisciplinary Laboratory for Nanoscale
Science and Technology
National Institute for Materials Science
Ibaraki, Japan
Vijaykumar B. Sutariya
College of Pharmacy
University of South Florida
Tampa, Florida
Rakesh K. Tekade
Department of Pharmaceutical Sciences
University of Hawaii at Hilo
Hilo, Hawaii
Perng-Jy Tsai
Department of Environmental and
Occupational Health
National Cheng Kung University
Tainan, Taiwan
Christine Vauthier
Institut Galien Paris-Sud
Université de Paris Sud Faculté de Pharmacie
Chatenay-Malabry, France
Ying-Fang Wang
Department of Environmental and
Occupational Health
Medical College
National Cheng Kung University
Tainan, Taiwan
Daniel Wehrung
Department of Pharmaceutical Sciences
Northeast Ohio Medical University
Rootstown, Ohio
Mingsheng Xu
Department of Polymer Science and
Engineering
Zhejiang University
Zhejiang, China
Li-Hao Young
Department of Occupational Safety
and Health
School Public Health
China Medical University
Taichung, Taiwan
Saijie Zhu
College of Pharmacy
The University of Texas at Austin
Austin, Texas
Xuena Zhu
College of Engineering and
Computing
Florida International University
Miami, Florida
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