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OTCQXBIOAF!
TSX.VBTIJuly2014
OTCQXBIOAF
TSX.VBTI
ForwardLookingStatements
Certainstatementsinthispressreleasecontainforward-lookingstatementswithinthemeaningofthePrivateSecurities
LitigationReformActof1995orforward-lookinginformationunderapplicableCanadiansecuritieslegislationthatmaynot
bebasedonhistoricalfact,includingwithoutlimitationstatementscontainingthewords“believe”,“may”,“plan”,“will”,
“estimate”,“continue”,“anticipate”,“intend”,“expect”andsimilarexpressions.Suchforward-lookingstatementsor
informationinvolveknownandunknownrisks,uncertaintiesandotherfactorsthatmaycauseouractualresults,eventsor
developments,orindustryresults,tobemateriallydifferentfromanyfutureresults,eventsordevelopmentsexpressor
impliedbysuchforward-lookingstatementsorinformation.
Suchfactorsinclude,amongothers,ourstageofdevelopment,lackofanyproductrevenues,additionalcapital
requirements,riskassociatedwiththecompletionofclinicaltrialsandobtainingregulatoryapprovaltomarketour
products,theabilitytoprotectourintellectualproperty,dependenceoncollaborativepartnersandtheprospectsfor
negotiatingadditionalcorporatecollaborationsorlicensingarrangementsandtheirtiming.Specifically,certainrisksand
uncertaintiesthatcouldcausesuchactualeventsorresultsexpressedorimpliedbysuchforward-lookingstatementsand
informationtodiffermateriallyfromanyfutureeventsorresultsexpressedorimpliedbysuchstatementsandinformation
include,butarenotlimitedto,therisksanduncertaintiesthat:productsthatwedevelopmaynotsucceedinpreclinicalor
clinicaltrials,orfutureproductsinourtargetedcorporateobjectives;ourfutureoperatingresultsareuncertainandlikelyto
fluctuate;wemaynotbeabletoraiseadditionalcapital;wemaynotbesuccessfulinestablishingadditionalcorporate
collaborationsorlicensingarrangements;wemaynotbeabletoestablishmarketingandthecostsoflaunchingour
productsmaybegreaterthananticipated;wehavenoexperienceincommercialmanufacturing;wemayfaceunknown
risksrelatedtointellectualpropertymatters;wefaceincreasedcompetitionfrompharmaceuticalandbiotechnology
companies;andotherfactorsasdescribedindetailinourfilingswiththeCanadiansecuritiesregulatoryauthoritiesat
www.sedar.com.
Giventheserisksanduncertainties,youarecautionednottoplaceunduerelianceonsuchforward-lookingstatements
andinformation,whicharequalifiedintheirentiretybythiscautionarystatement.Allforward-lookingstatementsand
informationmadehereinarebasedonourcurrentexpectationsandweundertakenoobligationtoreviseorupdatesuch
forward-lookingstatementsandinformationtoreflectsubsequenteventsorcircumstances,exceptasrequiredbylaw.
2"
OTCQXBIOAF
TSX.VBTI
MarketProfile

OTCQX:BIOAF;TSX.V:BTI
3"
Datasource:S&PCapitalIQ
TrailingtwelvemonthsasofFeb28,2014
Shares–June23,2014
52WeekLow-High!$0.67-$1.35!
(Jun.23,2014)
SharesIssued&Outstanding!41,963,130"!
FullyDiluted!48,485,405!
Options!
"!
6,272,275!
($0.52-$1.42)

Directors,officers&employees
Warrants!250,000"!
($0.575)Exp.5/08/2016
MarketCap"!~$52.9m!
@$1.26SharePrice(Jun.23,2014)
CashPosition

$1,860,135!
(Feb.28,2014)
Ownership!Insiders&Affiliates~35%!
Institutional~10%!
OTCQXBIOAF
TSX.VBTI
Whoweare…
BoardofDirectors

RobHutchison,Chair&CEO!
Former:CEO&ChiefScientistateChargeCorporation
(World’sFirstInternetPaymentSystem)

ChrisFibiger,PhD!
Former:HeadofNeuroscience,Amgen;VPNeuroscience,EliLily&
CSO,BiovailLaboratories
!
GregGubitz,LLB!
Former:VP,BiovailCorporation(mergedValeantPharmaceuticals)
COO,MDSCapital(LifeScienceVCfirm$1bnundermanagement)

TerryPearson,PhD!
Professor:Biochemistry&Microbiology,UVIC
Bench-mates:NobelLaureate,Dr.GeorgeKohler(monoclonalantibody)
Discovered&commercializedhighly-successfulSISCAPAAssay
Technology!!
RonErickson!
Over30yearsexperience:attorney&seniorlevelexecutive
Current:Chair&CEO,VisulantTechnologies(nano-photonicscompany)

MichaelHutchison,QC,LLB!
Partner,SmithHutchisonLawCorporation




Team!
!
JudiDalling,LLB,CFO!
Over35yearsaccountancyexperience
SeasonedpubliccompanyCFOandcorporatelawyer
!
WilfredJefferies,PhD,FoundingScientist!
OxfordUniversity,MolecularImmunology
Discoveredp97’sabilitytocrosstheBBB&Ox26(foundational
antibodyforBBBresearch)
Professor:Microbiology&Immunology,UBC
!
ReinhardGabathuler,PhD,ChiefScientist!
UniversityofLausanne,Switzerland,PlantBiochemistry
Over25yearsexperience,academicresearch&early-stagebiotech
companies
Former:VPBrainResearch,Biomarin&CSO,AngiochemInc.
!
MeiMeiTian,PhD,Scientist!
UBC,MicrobiologyandImmunology
ExpertiseinBBBtransport,cellbiology,molecularbiology
!
LauraHo,MSc,Scientist!
UBC,MicrobiologyandImmunology
!
TiffanyTolmie,CorporateCommunications!
Honours,WilfridLaurierUniversity
OTCQXBIOAF
TSX.VBTI
Whatwedo…
BrainDeliveryPlatform
Patented“TranscendFamily”oftechnologies
allowsdrugtherapiestopenetratetheBlood-
BrainBarrier(“BBB”)totreatdiseasesofthe
CentralNervousSystem(“CNS”)
Potentialtreatmentsfor:


MarketLeadingTechnology
Transcend&Transcendpep!

5"
Oncology
Metabolic
Diseases
Neurodegenerative
Diseases
OTCQXBIOAF
TSX.VBTI


TheBlood-BrainBarrierChallenge


BloodBrainBarrier
ProtectivebarrieroftheCNSpreventingtoxic
compoundsfromenteringthebrainfromthe
circulatorysystem
Problem
BBBpreventstherapeuticsfromenteringthebrain
• ~98%ofsmallmoleculedrugs
• ~100%oflargemoleculedrugs1
Solution
Discoveringa‘carrier’todelivertherapeutictreatments
acrosstheBBB
i. Opportunitytoextendpatentlifeofexistingdrugtherapies
ii. ContributetothegrowthinCNSdrugmarketandrevitalize
dormantcandidates
iii. Assistdevelopmentofnewtherapiesforcurrentlyuntreatable
diseases

6"
1) RoyalSocietyofChemistry
Tightly"woven"capillary"network"of"
endothelial"cells"lining"the"blood"vessels"
in"the"brain,"which"is"responsible"for"
maintaining"homeostasis"
OTCQXBIOAF
TSX.VBTI
BreakthroughSolution
FirstGeneration:Transcend
• KnownasMelanotransferrin(MTforp97)
• Nativehumanproteinfoundatlow
concentrationsintheblood
• TechnologypatentedatUniversityofBritish
Columbia;laterpurchasedbybiOasis
7"
TheTranscendFamily
…isanaturallyoccurringphysiologicaltransportmechanism
…actsasa‘Trojan-Horse’totransporttherapeuticsacrosstheBBBandintothebraintissue
SecondGeneration:Transcendpep
• Anewlydiscoveredpeptidefoundwithin
Transcend,whichoffersimprovedbrain
penetrationoverTranscend
OTCQXBIOAF
TSX.VBTI
AdvantageofTranscendpep
 GreaterefficiencyofBBBdelivery
 Lowercostofproduction
 Improvedqualitycontrol
 Simplertolinktotherapeutics
 Transportsavarietyofcompounds
withnoapparentsizelimitation
 ExtendsbiOasispatentportfolio
 Pharmaceuticalcollaborators
currentlylicensingTranscendpep
8"
BBB"
Transcendpep
Therapeutic
TranscendpepinAction
OTCQXBIOAF
TSX.VBTI
MarketOpportunities
MajorUnmetMedicalNeeds
DrugmarketlimitedbytheBBB
9"
Acarrierto
crossthe
BBBwould
establisha
foothold
withinthese
major
markets
Central
Nervous
System

~$81.2bn
Neuro-
degenerative
Diseases
~$20bn
!
Stroke&
Traumatic
BrainInjury

~$7.5bn

Pain&
Migraine
~$33.7bn
2014Estimatesin$USD
Clinicalneedmet
butimprovedBBB
penetrationcould
increaseefficacy
Psychiatry

~$32.3bn

Infection
(Bacterial,Viral,Fungal)

~$138bn

Lysosomal
Storage
Disease!
>$1.9bn
OTCQXBIOAF
TSX.VBTI
BrainCancerMarket
SalesforCurrentCancerTherapeutics
Treatmentsforcancers,whichfrequentlymetastasizeinthebrain,
DoNotcrosstheBBBinefficaciouslevels


10"
1) GlobalData“BrainTumor–PipelineAssessmentandMarketForecaststo2017”releasedJan.17,2011.
2) CompanyReportedData
3) BT2111ProgramResultsslides19&20
$0.9B
$2.1B
2009
2010
2011
2012
2013F
2014F
2015F
2016F
2017F
($Billions)
GlobalBrainTumorTherapiesMarket1
Herceptin®
(trastuzumab)
HER2+BreastCancer
Rituxan®
(Rituximab)
lymphomas,
leukemias
Taxol®
(Paclitaxel)
lung,ovarian,
etc.
Erbitux®
(Cetuximab)
Metastatic
coloncancer,
etc.
$92millionin
sales20132
$7.5billionin
sales20132
$1.9billionin
sales20132
$6.6billion
insales
20132
Results
Trancend+Trastuzumab
(Herceptin®)conjugate
notonlycrossedtheBBB
butincreasedcancer
killingactivities
throughoutthebody3

Opportunity

Potentialtoincrease
effectivenessofcancer
therapeuticsandtreat
tumoursthatmetastasize
inthebrain
$1.4billionMarketin2013
OTCQXBIOAF
TSX.VBTI
MultipleDevelopmentOpportunities
ConjugatedwithTranscend:

• Antibodies
• Enzymes
• Biologicsagents
• Smallmoleculesdrugs
Targeting:
11"
PatentCliff
Estimated~$250billioninlost
revenuefrompatentexpiration
between2012-20151

Transcendfamilylinkedwith
existingdrugsoffersthepotential
forpatenttermextensionsthrough
NewChemicalEntity(“NCE”)
"
Specificbraincells
(e.g.,neurons,astrocytesand
glia)

Intracellularcompartments
(e.g.,lysosomes,endosomes,
mitochondria)
Deliveryintothebrainof
existingtherapeuticdrugs
currentlynotapprovedfor
CNSindications
Deliveryintothebrainof
promisingnewagentsin
development

""
"
1)"DeRuiter,"J.,"&"Holston,"P."L."(2012,"June"20)."Drug"Patent"ExpiraOons"and"the"“Patent"Cliff”."U.S."Pharm."2012;37(6)(Generic"suppl):12Y20.""
OTCQXBIOAF
TSX.VBTI
Transcend:RapidUptakeinBrain
12"
Compound
BrainKin
(mL-1/s-1/g-1)
Reference
Glucose
9.5x10-3
Smith(2003)
Transcend
6.4x10-4
Demeuleetal.(2002)
Morphine
2.0x10-4
Cisterninoetal.(2001)
Aprotinin!1.6x10-4
Demeuleetal.(2008)
InsulinRecAntibody!1.0x10-4
Pardridge(1997)
Leu-Enkephalin
6.0x10-5
Zlokovic(1987)
Morphine-6-Glucuronide
2.4x10-5
Temsamanietal.(2005)
RAP!1.0x10-5
Pan(2004)
BetaAmyloid
6.5x10-6
Banks(1991)
DADLE
6.5x10-6
Chen(2002)
TNF-α
4.3x10-6
Pan(2002)
Transport
Efficiency
More
Less
Insitubrainuptake–measurementofrateoftransport
Competitors""
OTCQXBIOAF
TSX.VBTI
Independent
3rdparty
validation
Expandand
protect
Intellectual
Property
portfolio
Advance
internal
development
programs
Collaborate
withreputable
pharmaceutical
companies
CorporateStrategy
13"
• Low-costprojects
• Potentialtoachieve
majormilestones:
Short-Mid-Large
MarketPotential
• Many“shotson
goal”leadingto
commercial
transactionswith
numerousstrong
partnersor
licensees
• Over30patents
grantedrelatingto
Transcend&
Trancendpepfor
BBBdeliveryand
neurodegenerative
diseases
• NationalResearch
Council
• BCCancer
ResearchCentre
• TexasTech
UniversityHealth
SciencesCenter
OTCQXBIOAF
TSX.VBTI
DevelopmentPrograms
Completed4strategiccollaborationson
FirstGenerationTranscend:
• ShireHGT
• AbbVie
• MedImmune
• UCBPharmaceuticals
SecondGenerationTranscendpep:
• MedImmuneexecutedLicenseAgreement
• On-goingdiscussionwithAbbVie&UCB
Pharmaceuticalsforlicensing
• Furtherdiscussionswithlarge
pharmaceuticalcompaniesonlicensingand
researchopportunities
14"
OTCQXBIOAF
TSX.VBTI
DevelopmentPrograms:

Transcend+Anti-AmyloidBeta(“Aβ”)Antibody
Results
!
Transcend+anti-Aβantibodyconjugate
increasestransportintobraintissueby~5-fold
0.000#
0.001#
0.002#
0.003#
0.004#
0.005#
0.006#
0.007#
Transcend3an43AB#mAb#an43Ab#mab#
Volume'Frac,on'''
Parenchyma#
QuantitativeImageAnalysisbyLaser
ScanningConfocalMicroscopy
15"
Alzheimer’sDisease

Anti-Aβantibodieshave
undergoneclinicaltrialsfor
treatmentofAlzheimer’s
disease

Opportunity

Usingantibodiesdirectedat
Aβarepotential
therapeuticsforreducing
amyloidplaquesinthebrain

NationalResearchCouncilofCanada(NRC)
Anti-Aβ
Transcend+Anti-Aβ
OTCQXBIOAF
TSX.VBTI
DevelopmentProgram:

Transcend+α-L-iduronidase(“IDU”)
LysosomalStorageDiseases
Rareinheritedmetabolicdiseasescausedbyan
enzymedeficiencyprimarilyaffectingchildren
HurlerSyndrome(MPSI)
Problem
• MPSIiscausedbyanIDUdeficiency
• CurrentlyCNSeffectsuntreatable
Results
• Transcend+IDU(lysosomalenzyme)
conjugateincreasedIDUbrainenzyme
activity~4-fold
Opportunity
• Offerspromiseofanenzymereplacement
therapy
16"
0"
0.2"
0.4"
0.6"
0.8"
1"
1.2"
IDU
Transcend-IDU
Total"IDU"acOvity"
Capillaries
Parenchyma
OTCQXBIOAF
TSX.VBTI
DevelopmentProgram:

Transcend+iduronate-2-sulfatase(“IDS”)
LysosomalStorageDiseases
Rareinheritedmetabolicdiseasescausedbyan
enzymedeficiencyprimarilyaffectingchildren
HuntersSyndrome(MPSII)
Problem
• MPSIIiscausedbyanIDSdeficiency
• CurrentlyCNSeffectsuntreatable
Results
• Transcend+IDS(lysosomalenzyme)
conjugateincreasedIDSbrainenzyme
activity~20-fold
Opportunity
• Offerspromiseofanenzymereplacement
therapy
17"
NativeEnzyme
Transcend+IDSEnzyme
OTCQXBIOAF
TSX.VBTI
DevelopmentProgram:

Transcend+Doxorubicin
• Doxorubiciniscurrentlyusedasa
cancertreatment(e.g.non-Hodgkin's
lymphoma,multiplemyeloma,acuteleukemias,
etc.)
Problem
• CurrentlydoesnotpenetratetheBBB
Results
• SignificantINCREASEinbrainuptakewith
theTranscend+Doxorubicinconjugate
VSDoxorubicinalone
Opportunity
• Wouldbehighlyeffectiveintreating
braintumorsifitcouldbedeliveredinto
thebrain
18"
0.00"
1.00"
2.00"
3.00"
Transcend-Doxo
Doxo
%INJECTEDDOSE
(GTISSUE/GBODYMASS)*100%
TranscendSignificantlyEnhances
DoxorubicinTransportintotheBrain
Conjugate
retainsfull
activityonce
releasedin
thebrain
OTCQXBIOAF
TSX.VBTI
TranscendSignificantlyReduces
DoxorubicinUptakeintotheHeart
Problem
• Doxorubicin’smostserious
adverseeffectislife-threatening
heartdamage
Results
• Transcend+DoxorubicinVS
Doxorubicinonitsownshowed
asignificantDECREASEinuptake
intheheart
Solution
• Couldbeusedtotreatbrain
cancersanddecreaseheart-
uptakesideeffect,offering
increasedusage
19"
0.0"
5.0"
10.0"
15.0"
20.0"
Transcend-Doxo
Doxo
% INJECTED DOSE
(gram brain tissue/gram body mass)*100
OTCQXBIOAF
TSX.VBTI
DevelopmentProgram:

Transcend+Trastuzumab(Herceptin®)
• Trastuzumab(Herceptin®)1isa
humanizedmonoclonalantibody
usedtotreatHER2+breastcancer
• Annualglobalsales~$6.6bn2
• Increasessurvivalratebut~40%
patientseventuallydevelopbreast
cancermetastasisinthebrain3
• Trastuzumab(Herceptin®)does
notcrosstheBBB
20"
1) Herceptin®isaregisteredtrademarkofRoche/Genentech
2) CompanyReportedData–2013
3) BrittaWeigelt,JohannesL.Peterse&LauraJ.van'tVeer.(2005,August).Breast
cancermetastasis:markersandmodels.NatureReviewsCancer5,591-602.
BrainCapillaries
CellNuclei
BT2111:Transcend–
Trastuzumab(Herceptin®)
ConfocalImagePerformedbyiCaptureatSt.Paul’sHospital
VancouverCanada
BT2111Program:Transcend+
Trastuzumab(Herceptin®)conjugate
ConfocalImagesTwoHoursPostIVAdministration
OTCQXBIOAF
TSX.VBTI
ReducedthenumberofHER2+breast
cancertumorsinthebrainby68%


Thetumorsthatremainedafter
treatmentwere57%smaller
BT2111:Transcend+Trastuzumab(Herceptin®)

InVivoEfficacyinBreastCancerModel
21"
…comparedtothosetreatedwithTrastuzumab(Herceptin®)alone.
0"
10"
20"
30"
40"
50"
60"
70"
80"
90"
NumberofTumors
0.0"
0.5"
1.0"
1.5"
2.0"
2.5"
MeanTumorVolume
Transcend""(MTF"or"p97)"
mm3!
OTCQXBIOAF
TSX.VBTI
DevelopmentProgram:

Transcendpep+siRNA
SmallInterferingRNA(siRNA)
• Silencestargetgenes
• Nox4isageneassociatedwithhumandiseases
(i.e.cancers,neurodegenerativediseases,metabolicdiseases,etc.)
Problem
• siRNAdoesnotcrosstheBBB
• Genetargetingwithinthebrainiscurrentlyunachievable
Results
• Transcendpep+siRNAconjugatedeliveredintothebraintissue
• Demonstrated~2folddecreaseinNox4signalVSsiRNA
alone
Opportunity
• Apotentialcornerstonetechnologyforthedevelopmentof
newtherapeuticssuppressingdisease-linkedgenesinthe
brain

22"
NationalResearchCouncil
NOsiRNAdetectedinBrain
Transcendpep+siRNA
detectedinBrain
OTCQXBIOAF
TSX.VBTI
Highlights

23"
TranscendFamily

“…wouldbethefirstcarrierto
efficaciouslyshuttle
compoundsacrosstheBBB”

DiscoveryofTranscendpep
• Enhancedtechnology
• Greatercommercialization
potential
CompanyProfile

• Goodcashposition
• Cleansharestructure
• Highinternalownership
• StrongIRProgram
• Exitstrategyinplace

Management

Majorsuccessin:
• Drugcommercialization
• Academia(BBB&
monoclonalantibodies)
• Biotechnology&venture
capitalstartups
IP&Collaborations

• Fullpatentprotection
• Largepharmaceutical
collaborations
• Positiveresults;
demonstratedefficacy
LargeMarketOpportunities

• Abilitytoextendpatentlife
• Commercializenew
therapeuticsand/orrevitalize
dormantcandidates
• Contributetothegrowthin
CNSdrugmarket
TreatmentPotential

• Oncology
• Metabolicdiseases
• Neurodegenerativediseases
…amongothers
OTCQXBIOAF
TSX.VBTI
Timeline2014-2015
MilestonesAchieved

! Proofofprinciple
demonstrated
! Discoveryof
Transcendpep-
extendedpatent
protection
! Strong
pharmaceutical
collaborations
! Completionof
necessaryfinancings

Q1
Q2
Q3
Q4
Q1
Q2
Q3
Q4
Leaderin
providing
shareholder
value
Awarded
TSX.V
Top50®
"
Financing:TBD
Licensing:Transcendpep
Collaborations:Newresearchand/orlicensingagreements
ExternalR&D:DevelopmentofNewR&DPrograms
InternalR&D
BT2211&LSDPrograms
Animalefficacystudies
InternalR&D
PreINDToxicityStudies
ProposedINDFiling
Evaluation:Exitstrategies:


Licensing/M&A
2014!2015!


OTCQXBIOAF!
TSX.VBTIJuly2014

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