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Structural variations and reactive lesions of the oral cavity
1.
2. Structural variations of the jaw bones and
overlying oral soft tissues are sometimes
mistakenly identified as tumours
Examples of such structural variants are
tori,localised nodualr thickening of the
attached gingiva,papilla associated with the
opening of stensen’s duct,circumvallate
papillae of the dorsum of tongue and
sublingual varicosties in older individuals
3. Localised nodular enlargements (exostosis) of
the cortical bone of the midline of the palate
(torus palatinus),the lingual aspect of
mandible(torus mandibularis) are also
considered normal
4. Reactive hyperplasia of fibrous connective
tissue in response to local irritation or trauma
Also called Traumatic fibroma/Irritation
fibroma
CLINICAL FEATURES
Common in 4th to 6th decades of life
Small lesions ,lesions >1cm are rare
Most common in buccal mucosa
Also occur in labial mucosa,tongue,gingiva
Appears as a smooth surfaced pink nodule
5. Lesions are generally less than 1.5cm
Fibromas occur either pedunculated or sessile
growth on any surface of the oral mucosa
membrane
Firm on palpation
Associated with:-
Multiple fibromas indicate cowden syndrome
(autosominal dominant trait characteerised by
multiple papillomatosis,pebbly or fissured
tongue,-cobblestone effect on mucous
membrane)or tuberous sclerosis(seizures & mental
retardation)
6. Differential Diagnosis
Lipofibroma and myxofibroma- but these are
soft on palpation
Giant cell fibroma-younger age,on histological
examination stellate shaped and
multinucleated cells in connective tissue
TREATMENT
Conservative surgical
excision
7. Epulis is any tumour of the gingiva or alveolar
mucosa
Examples of epulides are:-
Giant cell epulis (peripheral giant cell
granuloma)
Ossifying fibroid epulis(peripheral ossifying
fibroma)
Congenital epulis
8. It is a tumour like hyperplasia of fibrous
connective tissue that develops in association with
ill fitting complete or partial denture
Also called inflammatory fibrous
dysplasia/denture irritation hyperplasia
CLINICAL FEATURES
Common in middle aged and older adults
Occur mostly in maxilla
Mostly seen under the buccal and labial flanges
Anterior portion of the jaws are most affected than
posterior region
Female predilection
9. The exophytic often elongated epulis usually
has atleast one cleft into which the denture
flange fits with a proliferation of tissue on each
side
Size vary from localised hyperplasia measuring
less than 1cm size to massive lesions involve
most length of the vestibule
Appears as single or multiple fold or folds of
hyperplastic tissues in the alveolar vestibule
10. DIFFERENTIAL DIAGNOSIS
On rare occasions squamous cell
carcinomas,verrucous carcinomas and
malignant salivary gland tumours have arisen
around denture flanges thus microscopic
examination of excised tissue is imperative
TREATMENT
Surgical removal
11. It is a reactive tissue growth that develops beneath
the denture
Condition mostly associated with ill fitting denture
Also called pallatal papillomatosis
CLINICAL FEATURES
Usually occurs on the hard plate beneath the
denture base
Usually associated with denture stomatitis due to
candidal infection ,poor oral hygiene,AIDS are also
its etiologic factors
12. Asymptomatic
The lesion may be red to scarlet with swollen and
tightly packed projections resembling overripe
berry
Lesions are friable and often bleed with minimal
trauma,may be covered with a thin whitish
exudate
DIFFERENTAL DIAGNOSIS
1.Nicotine stomatitis:-
> exclusive in pipe smokers
> More nodular and broader
lesions
> Nodules in NS has a red dot
(inflammed minor salivary duct openings) in their
approximate centre
13. TREATMENT
Removal of the denture may allow the
erythema and edema to subside
Topical or systemic antifungal therapy
Surgical methods include:-
Curettage
Electrosurgery
Cryosurgery
Laser surgery
14. It is rare spindle cell neoplasm that consists of
myofibroblasts
Mostly solitary lesions but some patients
develops multicentric tumour process known
as myofibromatosis
CLINICAL FEATURES
predilection for head and neck region
first 4 decade of life,mean age:22 years
Painless mass that sometimes rapidly exhibits
rapid enlargement
15. Mostly,solitary lesions,multicentric tumour
also develop known as myofibromatosis
Multicentric myofibromatosis primarily affects
neonates and infants who may have tumours of
skin,subcutaneous tissues,muscle,bone,viscera
Number of tumours can vary from several to
more than 100
16. RADIOGRAPHIC FEATURES
Intrabony tumours create
radioluscent defects that usually
tend to be poorly defined
Some may be well defined or
multilocular
TREATMENT
Surgical excision
17. It is a common tumour like growth of the oral
cavity
Exuberant tissue response to local irritation or
trauma
CLINICAL FEATURES
Common in maxilla
Mostly occurs in young adults
Female predilection because of the vascular
effects of female hormones
18. Gingival irritation and inflammation due to
poor oral hygiene may be a precipitating factor
Oral PG show striking predilection for gingiva
Lips,tongue ,buccal mucosa ,vestibule,and
alveolar mucosa in edentulous regions are
other common sites
Mass is painless and bleeds often
Exhibit rapid growth
No pus in the lesion
19. Smooth or lobulated mass that is usually
pedunculated or sessile
Surface is characteristically ulcerated and ranges
from pink to red
Young PG are vascular in appearance which are
soft and bleeds easily but older lesions are more
collaginized and pink
They may vary from small growth only a few
millimeter in size to larger lesions that cause
several cm in size
Strong tendency to recur after simple excision
20.
21. Frequently occurs in pregnant women so also
termed pregnancy tumour or granuloma
gravidarium
These lesions develop in first trimester and
their incidence increases upto 7th month of
pregnanacy
AFTER PREGNANCY AND THE RETURN
OF NORMAL HORMONE LEVELS ,SOME
OF THESE GRANULOMAS RESOLVE
WITHOUT TREATMNET
23. Radiographic features
Does not show seperation of adjacent teeth
TREATMENT
Conservative surgical excision
For gingival lesions,the excision should extend
down to periosteum and the adjacent teeth
should be thoroughly scaled to remove any
source of irritation
24. It is a reactive lesion caused by local irritation
or trauma
It originate from PDL,mucoperiosteum
CLINICAL FEATURES
Female predilection,in the age group above 20
yrs
Presents as red or red blue nodular mass
Occurs as an exophytic lesion in gingiva and
edentulous alveolar mucosa
Develop either in the anterior and posterior
regions of the gingiva or alveolar mucosa
25. Smaller than 2cm diamter
Sessile or pedunculated
Mandible is affceted more than maxilla
Cuffing resorption of underlying bone is seen
It may feels soft to hard depending upon the relative
proportions of collagen and inflammatory component
The lesion may be vascular or haemorragic with ulcerations
and tenderness
On microscopic examination ,multinucleated giant cells are
scattered through out the granulation tissue
26. RADIOGRAPHIC FEATURES
In dentulous cases there may be superficial
destruction of the alveolar margins of crest of
interdental bone
In the edentulous areas,exhibits superficial
erosion of bone with periapical cuffing of bone
27. DIFFERENTIAL DIAGNOSIS
haemangioma-present at birth
Pyogenic granuloma:-no seperation of tooth
Lymphangioma-rarely occurs in gingiva,much
paler colour
Metastatic carcinoma-history of primary
tumour,evidence of bone destruction under
exophytic lesions
Oral nevi-darker in colour,firmer to palpation
TREATMENT
Local surgical excision down to the underlying
bone
28. Common benign gingival overgrowth which is
considered to be inflammatory hyperplastic lesion
It involves the PDL superficially and it often contains
odontogenic epithelial nests,deposits of cementum,bone
and dystrophic calcification scatterd throughout a
background of fibrous tissue
Some POF initially start as pyogenic granulomas that
undergo fibrous maturation and subsequent calcification
CLINICAL FEATURES
Predominantly seen in the ages of 10 and 19
Female predilection
More in maxilla
29.
30. Occurs exclusively on gingiva
Lesions less than 2cm in size
Color ranges from red to pink
It appears as nodular mass which is either
pedunculated or sessile
Surface is frequently ulcerated
Growth begins as an ulcerated lesion ,older
ones are more likely to demonstrate healing of
ulcer and an intact surface
31. DIFFERENTIAL DIAGNOSIS
> Chondrosarcoma and osteogenic sarcoma
-less frequent gingival lesions than PF
-widening of PDL space of involved teeth
> Gingival inflammatory hyperplastic lesions-
Pyogenic granuloma,hormonal tumour( does
not show seperation of adjacent teeth and
calcified foci are present in gingival
inflammatory hyperplastic lesions)
32. RADIOGRAPHIC FEATURES
Superficial erosion may be seen
Presence of radiopaque foci within the tumour
mass,due to calcifications within the tumour
Causes seperation of adjacent teeth
Minimal bone resorption beneath the lesion
TREATMENT
Local surgical excision
33. Lipoma is a benign tumour of mature fat cells
When occuring in the superficial soft
tissue,lipoma appears as a yellowish mass with
a thin surface epithelium and presents delicate
pattern of blood vessels on the surface
CLINICAL FEATURES
Majority of lipomas are found in buccal
mucosa and tongue
Occur in individuals over 40 years of age
without sex predilection
34.
35. Less than 3cm in size
Lesion may varies from well contoured,well
defined round swelling to large ill defined
,lobulated mass
Solitary lesion may be sessile ,pedunculated or
submerged
Multiple lesions are also present
On palpation,the lesion is
nontender,soft,cheesy in consistency
It may be fluctuant
37. Proliferation of nerve tissue caused by injury to a
peripheral nerve
CLINICAL FEATURES
Traumatic nueromas can occur in anywhere in the
oral cavity
Mental foramen, area ,tongue ,lower lip are the
common location
Most often in middle age
Slow growing,seldom grows beyond 1cm in dm
Pain on palpation to severe constant radiating pain
The patient may have reflex nueralgia with pain
referred to eyes,face,head
38.
39. RADIOGRAPHIC FEATURES
Seen as radioluscent lesion with well defined
corticated borders
Shape may vary depending upon the amount
of resistance to expansion
Expansion of inferior dental canal
DIFFERENTIAL DIAGNOSIS
Odontogenic cyst-no history of trauma
Other benign nueral tumours
Diagnosis:-biopsy,microscopic examination
Treatment:-
surgical excision
40. It is a benign tumour of peripheral nerve
Contains schwann cells,perinueral cells and
axons
Also called solitary circumscribed nueroma
CLINICAL FEATURES
Predilection for face,nose and cheek are the
most common sites
5th and 7th decade of life
Lesion appears in hard palate and maxillary
labial mucosa
41. Smooth surfaced painless dome shaped papule
or nodule usually less than 1cm in diameter
No sex predilection
Well circumscribed,partially encapsulated
nodule composed of spindle shaped cells
TREATMANT
conservative local surgical lesion
42. Benign nueral neoplasm of schwann cell origin
CLINICAL FEATURES
No sex predilection
slow growing encapsulated mass
Asymptomatic
Tenderness or pain in some case
Mandible and saccrum are the common sites
43. Tongue and buccal mucosa are the most
common intraoral sites
RADIOGRAPHIC FEATURES
Tumour is radioluscent with well defined
corticated margins
Sometimes lesion may have a scalloping
outline gives a false multilocular appearance
44. It usually located in inferior alveolar nerve
canal
DIFFERENTIAL DIAGNOSIS
Cysts:-no expansion of inferior alveolar canal
Ameloblastoma:-occurs above inferior alveolar
canal
TREATMENT
LOCAL SURGICAL EXCISION
45. Most common type of peripheral nerve neoplasm
Arises from schwann cells and perinueral
fibroblasts
CLNICAL FEATURES
Common in young adults
It may expand and perforate the cortex causing a
swelling that is hard to firm on palpation
Present as slow growing ,painless lesions that vary
in size from small nodules to large masses
Those associated with mandibular nerve may
produce pain and parasthesia
Occur as solitary components or be a component of
nuerofibromatosis
46. RADIOGRAPHIC FEATURES
Unilocular radioluscency with
sharpely defined corticated border
Sometimes appear multilocular
NF of inferior dental canal shows Fusiform
enlargement of inferior dental canal
DIFFERENTIAL DIAGNOSIS
Vascular lesions-enlarges
whole canal and alter its path
Other nueral lesions
TREATMENT
Surgical excision
47. This is a syndrome consisting of café au lait
spots on the skin ,multiple peripheral nerve
tumours and other abnormalities of
skin,nervous system ,skin
NF1:-this is a generalised form
NF2:-central form
Oral lesion may occur as part of NF1
48. CLINICAL FEATURES
Genetic disease manifest
gradually during childhood and adult life
Most common in skin
Clinical appearance
vary from small papules to
larger soft nodules to
massive pendulous mass
49. Accelerated growth seen at pregnancy
Another highly characteristic feature is the
presence of “café au lait “ pigmentation on the
skin
“café au lait” spots become larger with age
usually 6 spots larger than 1.5cm
Lisch nodules ,transluscent brown pigmented
spots on the iris are also found in affected
individuals
Central form is rare
50. RADIOGRAPHIC FEATURES
Alterations in shape of mandible
Enlargement of mandibular canal
Erosive changes to the outer contour of
mandible
Interference with the normal eruption of
molars
51. TREATMENT
No specific therapy NF
Treatmnet done to reduce complications
facial nuerofibromas are removed for cosmetic
purposes with co2 laser and dermabrasion
52. This is a group of rare conditions characterised
by tumours or hyperplasia of the
nueroendocrine tissues
MEN TYPE1:-benign tumours of pancreatic
islets,adrenal cortex,parathyroid glands
MEN TYPE 2:- (sipple syndrome) includes
devolopment of adrenal
pheochromocytomas,Medullary Carcinoma
Thyroid
53. CLINICAL FEATURES
Marfanoid body characterised by thin
,elongated limps with muscle wasting ,narrow
face,thick lips
Oral mucosal nueromas are usually first sign of
the condition
Nueromas appear as soft,painless papules or
nodules that prinicipally affcet the lips and
anterior tongue,buccal mucosa,gingiva
54. Bilateral nueromas of the commissural mucosa
are highly characteristic feature.
pheochromocytomas develop in 50% of all
patients
The tumour cells secrete catecholamines which
result in symptoms such as profuse
sweating,intractable diarrhoea,headaches ,heart
palpitations,hypertension
55. The most significant aspect is the development
of MCT of thyroid gland
LABORTARY VALUES
If MCT present serum or urinary levels of
calcitonin are elevated
Pheochromocytomas may result in increase
levels of urinary vanillylmandelic acid and
increased epinephrine to norepinephrine ratios
56. TREATMENT:
Prophylactic removal of thyroid gland because
MCT is most certain to occur
Patient observed for development of
pheochromocytomas
57. GRANULAR CELL TUMOUR CONGENITAL EPULIS
Benign tumour composed
of large cells with a
granular cytoplasm
Arises from schwaann cells
or their primitive
mesenchymal precursors
Common in tongue(dorsal
surface),also seen in buccal
and labial mucosa
Painless,non ulcerated
nodule
The mass is typically pink
but occasionaly yellow also
Benign neoplasm
composed of cells
resembles granular cell
tumour
Arises from primitive
mesenchymal cells
Common in anterior
maxilla,alveolar ridge
Smooth surfaced,polypod
mass which is sessile or
pedunculated mass on
gingiva
Appears pink to red
58. 2cm or less in size
Occurs in adults
Female predilection
Treatment:surgical
excision
2cm or less in size
Present at birth
Female predilection
Surgical excision
59. Additional points for congenital epulis:-
Can be also seen in tongue(rare) thus called
congenital granular cell lesion
More common in maxillary ridge than in
mandibular ridge
Most frequently occurs lateral to the midline in
the area of developing lateral incisor and
canine teeth
Predilection for female due to hormonal effects
61. Vascular malformations may be clinically apparent
at birth,grow slowly proportional to the growth of
child and never involute
Vascular malformations are classified basis on the
type of vessel involved:-
Arterial and arteriovenous-high flow
Capillary or cavernous- low flow Arterial and
arteriovenous malformation may devolop
following hormonal changes ,infections or
trauma,clinically they are firm,pulsatile,warm
Venous malformations appear in early adulthood
,clinically they are soft and easily compressible
62. DIAGNOSIS
Diascopy-is the technique of applying pressure
to a suspected vascular lesion to visualize the
evacuation of coloration and may facilitate the
differensiation from a pigmented lesion
Angiography
CT,MRI are useful imaging techniques
64. Osler weber rendu syndrome –
Also called heriditary haemorragic telangiectasia
Autosomal dominant trait
Characterised by numerous vascular
hamartomas affectng skin ,mucosa,
Arteriovenous fistula seen,
greater dgree of pulmonary and hepatic
involvement
Telangiectasia
Blue rubber bleb nevus syndrome –
Rare condition
Characterised by numerous malformations of
venous system involving the skin and viscera
65. Sturge weber syndrome –
Non heriditary developmental condition
Characterised by hamartomatous vascular
proliferation involving the face and brain
Maffuci’s syndrome –
Skeletal chondromatosis
soft tissue angiomas
66. It is a benign tumour of patent blood vessels
that may be congenital or traumatic in origin
Frequently noticed in skin and subcutaneous
tissues
Hemangiomas of and and neck appear a few
weeks after birth and grow rapidly
It may be superficial or deep
Commonly appear as solitary lesions but also
appear as multiple lesions
67. There are different types:-
Central:-occurs in bone
Capillary:-is a mass of
intercommunicating capillary vessels
-strawberry angioma
- port wine stain
- salmon’s patch
Cavernous:-consists of dilated blood containing
spaces lined with endothelium
Arterial or plexiform haemangiomas-arises from
arteries
68. CLINICAL FEATURES
Central haemangioma
More common in females in the 1st to 3rd
decade
More common in mandible {ramus and body}
The lesion may originate form the periosteum
and resorb the underlying bone
Non tender,hard swelling
Throbbing type of pain
Lesion may cause loosening and migration of
involved teeth
Aspiration produces blood
69. Strawberry angioma
Red patch which is noticed at birth
Usually regresses in size and involution
completed by 7-8 years
Involves skin and subcutaneous tissues
Dark red or strawberry coloured
Compressible
Small areas of ulceration with stabs may be
present
70. Port wine stain
Reddish deep purple coloured
Not more than 5mm
Occurs at birth and darkens as the child grows
Found on face,shoulders.necks,buttock
Blanches on pressure
71. Salmon’s patch
Present at birth over the forehead and occiput
or anywhere in the midline of the body
Disappears before the 1st birthday
72. Cavernous haemangioma
More common in females in the 1st to 3rd decade of
life
Commonly seen on the lip,tongue,buccal mucosa
and palate
Swelling is Compressible
Superficial lesion are lobulated and Blanch on
pressure
Swelling may increase in size and burry the
involved teeth causing disfigurement
In case of haemangioma of tongue there is loss of
mobility of tongue
73. Arterial or plexiform hemangioma
This is congenital arteriovenous fistula with
pulsatile swelling of the arteries
Veins become tortuous and thick walled
Lesion is pulsatile
74. RADIOGRAPHIC FEATURES
Central
The periphery may be well defined
radioluscency within which trabecular spaces
get enlarged and corticated or it may be ill
defined
Larger lesion may be cause cortical expansion
with radiating spicules at the expanding
periphery producing sun ray or sun burst
appearance
75. Some lesions are totally radioluscent
Roots of the involved area are resorbed or
displaced
Involved bone may enlarge and have coarse
internal trabaculae ,developing teeth may be
larger and erupt earlier
76. Associated with:-
Sturge weber angiomatosis
DIFFERENTIAL DIAGNOSIS
Central giant cell granuloma:-crosses midline
Ameloblastic fibroma:-no local gingival
bleeding
Mucoceole,ranula,superficial cyst-which are
fluctuant and nonemptiable
77. Cherubism:-seen in children,typical facial
apperance and is bilateral
Giant cell lesions of hyperparathyroidism:-
biochemical investigations
Metastatic tumour:-history of primary tumour
DIAGNOSIS
Diascopy
TREATMENT
Surgery
Sclerosing techniques
78. Rare non heriditary developmental condition
characterised by vascular proliferation
involving tissues of brain and fcae
Caused by the persistence of vascular plexus
around the cephalic portion of the nueral tube
CLINICAL FEATURES
Patients with SWA born with dermal capillary
vascular malformationof the face known as
port wine stain or nevus flammeus because of
its deep purple colour
79. Port wine stain has unilateral distribution
along one or more segments of trigeminal
nerve
Bilateral involvement is also seen
Affected individuals have leptomeningeal
angiomas which usually associated with
convulsive disorder and often results in mental
retardation or contralateral hemiplegia
80. Intra oral involvement in SWA is common
Gingiva exhibit slight vascular hyperplasia or
massive haemangiomatous proliferation that
resemble PG
81. TREATMENT
Facial port wine nevi can be improved by using
newer flashlamp pulsed dye lasers
Cortical excision of angiomatous meningeal
lesion may be necessary
Patient with intractable epilepsy and
progressive mental retardation require
extensive nuerosurgical treatmnet
82. It is a lymphatic malformation characterised by
abnormal proliferation of lymphatic vessels
CLINICAL FEATURES
Common extraoral site:-neck
intraoral site:-tongue(dorsal and
lateral surface)
Intraosseous lymphangiomas are also reported
Commonly arise with in first 2 years of life and
cause macroglossia
Lymphangiomas are slow growing ,painless soft
tissue mass
83. Colour ranges from normal mucosal pink to bluish
Aspiration yields lymph fluid that is high in lipid
content
Dilated lymph channels of a lymphangioma
characterstically reach high into the lamina propria
and often contact epithelial basement membrane
,this imparts a pebbly appearance to the surface of
the lesion
Large lymphangiomas may become life
threatening if they comprise the airway or vital
blood vessels and those spreading the neck are
macrocystic are reffered to as cystic hygroma
85. Benign neoplasms of skeletal muscles are called
rhabdomyoma
Extracardiac rhabdomyomas are show striking
predilection for the head and neck
Rhabdoomyomas of head and neck are
classified into:-
Adult rhabdomyoma
Fetal rhabdomyoma
86. ADULT RHABDOMYOMA
CLINICAL FEATURES
Occur in middle aged and older patients
Men predilection
Most frequent sites are pharynx,oral
cavity,larynx
Intra oral lesions are:-floor of mouth,soft
plate,base of tongue
Tumour appear as a nodule or mass that can
grow into several centimeters
87. FETAL RHABDOMYOMAS
CLINICAL FEATURES
occur in children
male predilection
common location:-face and periauricular region
TREATMENT
local surgical excision
88. Choristoma is a tumour like growth of
microscopically normal tissue in an abnormal
location
CLINICAL FEATURES
Osseous and cartlaginous choristomas show
predilection to tongue
The most common location is the posterior
tongue near the foramen caecum
89. The lesion is usually firm,smooth surfaced
,sessile or pedunculated nodule between 0.5
and 2.0 cm diameter
TREATMENT
local surgical excision