The Glomerular Filtration Membrane consists of three layers of membranes that work simultaneously to perform blood filtration at the glomerulus level, which helps in the flow of solvents in blood along with small solutes. At the same time, it is responsible for inhibiting the flow of large plasma proteins through it. Glomerular Filtration Membrane consists of an endothelial layer, fenestrations between their cells, a highly complex extracellular Basement Membrane Glomerulus, and the visceral epithelial cells along with the foot processes. The filtrate then moves to the distal convoluted tubule, where the process of tubular reabsorption is completed. In this article, I will chiefly discuss the basement membrane of the Glomerulus, its composition, and how it contributes to the Glomerulus’s filtration cascade. The basement membrane Glomerulus (BMG) is assumed as formed through the endothelial cells layer and visceral epithelial cells layer (podocytes). It is infused in between both the upper and lower layers of cells. to explore completely please visit: https://wellnessbionavigator.com/2023/08/basement-membrane-glomerulus/

1. Components
Laminin.
Collagen type IV
Nidogen (Entactin)
Argin
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Composition
BASEMENT
Associated disorder
Goodpasture syndrome
Alport’s syndrome
Diabetic neuropathy
Thin basement membrane
nephropathy
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GLOMERULUS
MEMBRANE
Charge
The basement membrane
of the glomerulus has
many polyanionic
proteoglycans like
laminin, argin responsible
for the electronegativity
of the membrane.
Function
Filtration barrier
Restriction of water
flow.
Support and stability
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Overview
The GBM consists of
three layers of
membranes that work
simultaneously to
perform blood
filtration at the
glomerulus level.
Lamina Rara Interna.
Lamina Densa
Lamina Rara Externa
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OF