Top Global Patient Recruitment using Facebook

1. Phase III Clinical Trial
Mild to Moderate Asthma
The Implementation of a Non-Traditional Recruitment Strategy led us to
be the Top Performer in the Global Study / 115 pts Randomized
2015-2016
CENTRO DE INVESTIGACION CLINICA RICARDO PALMA
LIMA PERU

2. Patient Recruitment Strategy
• Lima is the 30th largest city in the world , close to 10 Million Population
• Internet penetration has empowered patients to search and find medical
information directly
• Facebook penetration in the City of Lima was over 80% of the adult Population
that had internet and predominantly via smartphone
• Research Center Facebook Page over 5 years. Close to 35,000 likes
• Our previous Social Media Outreach campaigns led to a significant number of
patients registered for other indications , with minor and moderate increase in
pts enrollment
• Asthma is close to 10% prevalent in the population in Lima
• The study called for patients with mild and moderate Asthma which is close to
90% of the asthmatic patients
• A Recruitment Site Team at was set up in advance to enrollment initiation
• The sponsor supported our strategy

3. Research Site Facebook Campaign
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QUESTIONAIRE

4. 8 MONTHS
FACEBOOK CAMPAIGN
Facebook outreach
# of Pts Registered
• The add was placed for a 48 or
72 hours
• Stop rules were in place if
number of registered were
over the targeted # of pts
expected to be registered
• Outreach communication
manager available to respond
any online question within the
first 30 minutes of being
posted
• Prescreening personnel
contacted registered pts on a
continuous basis to avoid time
gaps

5. › Comparative # Pts available with
Asthma
We wanted to compared the total
number of unique pts available in the
Clinica during the same recruitment
period
The total number of pts register was
higher via Facebook for the same
period
In two occasions Facebook yield was
lower related to the lack of campaigns
during those months
Notoriously high during the summer
time, when a the Clinica is typically
lower
UNIQUE ASTHMA PTS OF THE
CLINICA RICARDO PALMA
VS
PTS REGISTERED VIA FACEBOOK

6. Simulated Recruitment efforts
If Pts were recruited from Asthma Pts
Pneumology Service at the CRP
# Pts
Registered /
Available
% signed Signed % Rand Rand
FACEBOOK 2216 13.4% 296 39.9% 115
1286 13.4% 172 41.4% 71
1286 13.9% 178 42.9% 76
1286 14.4% 185 44.4% 82
1286 14.9% 191 45.9% 88
1286 15.4% 197 47.4% 94
1286 15.9% 204 48.9% 100
1286 16.4% 210 50.4% 106
1286 16.9% 217 51.9% 113
1286 17.4% 223 53.4% 119
1652 13.4% 221 41.4% 91
1652 13.9% 229 42.9% 98
1652 14.4% 237 44.4% 105
1652 14.9% 245 45.9% 113
1652 15.4% 254 47.4% 120
6 MDs
15 MDs
Stress test for individuals
Physicians
Only 2 Physician would have
been able to have theoretical
enough pts but Unrealistic
endeavor
PHYSICIAN TOTA Unique pts % En
MD 1 467 63.4%
MD 2 322 91.9%
MD 3 218 135.8%
MD 4 100 296.0%
MD 5 93 318.3%
MD 6 86 344.2%
MD 7 80 370.0%
MD 8 71 416.9%
MD 9 66 448.5%
MD 10 46 643.5%
MD 11 45 657.8%
MD 12 29 1020.7%
MD 13 18 1644.4%
MD 14 6 4933.3%
MD 15 5 5920.0%
It could theoretically if a higher % of pts were to
be enrolled and if the % of Randomization is
increased but unrealistic coordination efforts
Stress test for collective
Physicians

7. Final Comments
• For this asthma study with pts with mild to moderate Asthma Facebook
recruitment strategy proved to be effective in yielding high number of
randomized pts
• Singular position of being the TOP Global enroller, the next best site
globally randomized xx pts
• If the study would have been implemented by any or several of the
Pneumologist(s) at the Clinica Ricardo Palma, would not have yielded a
comparative number of Randomized pts.
• This a solid evidence that a non traditional recruitment strategy could
yield a high number of randomized pts(outlier) in certain indications
› The Sponsor for this Study dared to support our approach and together
we were able to convert this effort to a truly successful story
› We believe that this experience is a protagonist event in how patient
recruitment could change.