2. a O2 O2.- b O2 O2.-
Nox1 p22phox Nox2 p22phox
H+ + NADP+ H+ + NADP+
NADPH NOXO1 NADPH P47
NOXA1 P67 phox
phox
Rac Rac
GTP GTP
c O2 H2O2 d O2 O2.-
O2.-
Nox4 p22phox Nox5
Ca2+
H+ + NADP+ H+ + NADP+
NADPH NADPH
-
-

3. -
tat

4. - -
-
-
a b
NOX1 NOX2 NOX4
O2.- H2O2
-
NO
ONOO-
Improved
Vascular Endothelial endothelial
remodeling dysfunction function
top
Ach
Tg SBP
DBP
P

5. .
--
--
.
--
.
.
--
-
--
tat

6. b
.
a a
j

7. a
WT/Sham KO/Sham WT/Band KO/Band
A
B
C
b Stress (hypertension)
Myocardial hypoxia
Preservation of
capillaries
Hydroxylated HIF-1α
Nox4
stable HIF-1α
HIF-1 complex VEGF
α β
VEGF-HRE
WT
Panel A scale bar
panel B
panel C
scale bars l
.

8. WT
.
.

9. --

11. --

12. -