This research work was contributed by all authors mentioned in this presentation. However the research paper published by journal of Homeopathy (publisher: thieme) might not have been informed about the correct sequence of authorship. (https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-1776039) Author had already presented this work in LMHI 2021 conference when affiliated with Dr. D.Y.Patil HMC, Pune. Dr. Aditya D Patil is not affiliated with Dr. D Y Patil HMC from 11/02/2022. The work carried out was from 02/03/2021 to 11/02/2022). Hereby expressing the thoughts of dishonesty for the all authors by ignoring the informed consent for publishing this work. Background: The ongoing COVID-19 pandemic caused by the outbreak of SARS-CoV-2 is a global emergency wherein implementation of social measures along with boosting prophylactic immunity is considered to be effective. In India, Arsenicum Album 30C (AA30) is one of the key homeopathic medicine intervened in order to enhance the prophylactic immunity against SARS-CoV-2 during the pandemic. Although, AA30 has been found effective in improving the CD4/CD8 cell ratio which aids in defence against SARS-CoV-2 infections, its detailed mechanism of action remains elusive. Material and methods: Immunomodulatory potential of AA30 was investigated in the stem cell model isolated from dental pulp (DPMSCs). Cytotoxicity of the AA30 was determined by the MTT and BrdU incorporation assay at the 1, 3, 5, 10, 20, 30 and 50%. The effect of AA30 on the cytokine release (CCL2, TNF –alpha, IL -1beta, CXCL 10, IL-2, IL-4, TGF- beta, CXCL-8, IL-12, IFN-gamma, IL-10, IL-6 and IL-17) of DPMSCs were assessed by the fluorescence activated cell sorter (FACS). Results: AA30 exhibited significant increase in the proliferation of DPMSCs at the concentration range 10-50% (p<0.05 whereas none of the diluted dose were cytotoxic to the cells as evidenced by the MTT and BrdU incorporation assay. Interestingly, treatment if AA30 resulted into increased levels of anti inflammatory cytokines (IL4 and IL10, p<0.05) whereas levels of pro-inflammatory cytokines were down regulated (IL 1 beta, TNF alfa, p<0.05). Conclusion: Our data unequivocally demonstrates for the first time that AA30 is non cytotoxic in nature and exhibits immunomodulatory potential. Our results support current intervention policy to use AA30 as a prophylactic candidate to boost immunity against SARS-CoV-2. Further studies are required to elucidate its role in the management of SARS-CoV-2 infection. Keywords: Arsenicum Album 30C (AA30), Immunomodulator, Inflammatory cytokines, Prophylactic, SARS-CoV-2 infection