The document describes SnoreSounds, a smartphone app and algorithm that can accurately diagnose obstructive sleep apnea (OSA) using acoustic analysis of snoring sounds. It has the potential to disrupt the sleep diagnostics market by providing an inexpensive, convenient home test. Clinical studies show the algorithm achieves over 90% accuracy compared to in-lab polysomnography tests. The business model involves direct-to-consumer sales of the app as well as licensing the algorithm to partners. Regulatory clearance is underway to allow diagnosis and treatment based on the app results.
Cardiac Holter Monitor Market PPT: Demand, Trends and Business Opportunities ...IMARC Group
According to the latest report by IMARC Group, the global cardiac Holter monitor market reached a value of US$ 386 Million in 2020.
A cardiac Holter monitor is a battery-operated portable electrocardiography (ECG) device that records the heart rhythm continuously for around 24 to 48 hours.
It consists of a monitor, software and electrodes, which aid in interpreting the recorded data, determining if the heart is getting adequate oxygen and diagnosing conditions concerning irregular cardiac rhythms, such as tachycardia, arrhythmia and atrial fibrillation.
Electrophysiology Devices Market PPT: Trends and Dynamics, Drivers, Competiti...IMARC Group
According to the latest report by IMARC Group,finds that the global electrophysiology devices market size reached US$ 6.1 Billion in 2020.
Electrophysiology (EP) devices refer to different medical instruments that evaluate electrical impulses of the heart and calculate normal heartbeat.
Refurbished medical equipment Market PPT 2021: Size, Growth, Demand and Forec...IMARC Group
According to the latest report by IMARC Group, the global refurbished medical equipment market reached a strong growth in 2020.
Refurbished medical equipment are devices that are restored to their original safety and effectiveness.
Nebulizers Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group, the global nebulizers market reached a value of US$ 1.67 Billion in 2020.
Nebulizers are medical devices used for the direct delivery of medication into the human respiratory system. These electric or battery-powered machines convert the liquid drug into an aerosol form of mist or fine spray by utilizing compressed air.
Water Soluble Film Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group, the global water soluble film market reached a value of US$ 389 Million in 2020.
A water soluble film (WSF) refers to a plastic layer that has the unique characteristic of completely dissolving and disappearing in the water at room temperature.
Nowadays, the demand for water soluble films has escalated around the world as it is a smart and sustainable solution for packaging, which offers gas barrier protection, and resistance to oil and organic solvents.
Personal Care Electrical Appliances Market PPT: Demand, Trends and Business O...IMARC Group
According to the latest report by IMARC Group, the global personal care electrical appliances market size reached US$ 26.1 Billion in 2020.
Personal care electrical appliances comprise plaque removers, electric toothbrushes, shavers, epilators, hair straighteners, trimmers, and dryers. These appliances assist in maintaining oral and hair care and personal hygiene of the users.
Neurosurgery devices Market PPT 2021-26 | Enhancing Huge Growth and Latest T...IMARC Group
According to the latest report by IMARC Group,the global neurosurgery devices market exhibited moderate growth during 2015-2020.
Neurosurgery devices are used for performing and treating pathologies in the central and peripheral nervous systems.
Camping Tent Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group,the global camping tent market experienced stable growth during 2015-2020.
A tent is a shelter comprising of sheets of fabric and other durable materials that are draped over a frame or poles attached to supporting ropes.
Cardiac Holter Monitor Market PPT: Demand, Trends and Business Opportunities ...IMARC Group
According to the latest report by IMARC Group, the global cardiac Holter monitor market reached a value of US$ 386 Million in 2020.
A cardiac Holter monitor is a battery-operated portable electrocardiography (ECG) device that records the heart rhythm continuously for around 24 to 48 hours.
It consists of a monitor, software and electrodes, which aid in interpreting the recorded data, determining if the heart is getting adequate oxygen and diagnosing conditions concerning irregular cardiac rhythms, such as tachycardia, arrhythmia and atrial fibrillation.
Electrophysiology Devices Market PPT: Trends and Dynamics, Drivers, Competiti...IMARC Group
According to the latest report by IMARC Group,finds that the global electrophysiology devices market size reached US$ 6.1 Billion in 2020.
Electrophysiology (EP) devices refer to different medical instruments that evaluate electrical impulses of the heart and calculate normal heartbeat.
Refurbished medical equipment Market PPT 2021: Size, Growth, Demand and Forec...IMARC Group
According to the latest report by IMARC Group, the global refurbished medical equipment market reached a strong growth in 2020.
Refurbished medical equipment are devices that are restored to their original safety and effectiveness.
Nebulizers Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group, the global nebulizers market reached a value of US$ 1.67 Billion in 2020.
Nebulizers are medical devices used for the direct delivery of medication into the human respiratory system. These electric or battery-powered machines convert the liquid drug into an aerosol form of mist or fine spray by utilizing compressed air.
Water Soluble Film Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group, the global water soluble film market reached a value of US$ 389 Million in 2020.
A water soluble film (WSF) refers to a plastic layer that has the unique characteristic of completely dissolving and disappearing in the water at room temperature.
Nowadays, the demand for water soluble films has escalated around the world as it is a smart and sustainable solution for packaging, which offers gas barrier protection, and resistance to oil and organic solvents.
Personal Care Electrical Appliances Market PPT: Demand, Trends and Business O...IMARC Group
According to the latest report by IMARC Group, the global personal care electrical appliances market size reached US$ 26.1 Billion in 2020.
Personal care electrical appliances comprise plaque removers, electric toothbrushes, shavers, epilators, hair straighteners, trimmers, and dryers. These appliances assist in maintaining oral and hair care and personal hygiene of the users.
Neurosurgery devices Market PPT 2021-26 | Enhancing Huge Growth and Latest T...IMARC Group
According to the latest report by IMARC Group,the global neurosurgery devices market exhibited moderate growth during 2015-2020.
Neurosurgery devices are used for performing and treating pathologies in the central and peripheral nervous systems.
Camping Tent Market PPT: Demand, Trends and Business Opportunities 2021-26IMARC Group
According to the latest report by IMARC Group,the global camping tent market experienced stable growth during 2015-2020.
A tent is a shelter comprising of sheets of fabric and other durable materials that are draped over a frame or poles attached to supporting ropes.
In-Vitro Diagnostics Packaging Market PPT 2021: Size, Growth, Demand and For...IMARC Group
According to the latest report by IMARC Group,the global in-vitro diagnostics packaging market size reached US$ 6.7 Billion in 2020.In-vitro diagnostics (IVDs) refer to the various kinds of medical devices and accessories that are widely used for performing tests on samples. These equipment assist in analyzing several bodily fluids, such as urine, stool and blood, to detect diseases and infections. These tests are utilized to assist in monitoring drug therapies while facilitating the early diagnosis of chronic diseases at the initial stage.
Electrophysiology Devices Market PPT 2021: Size, Growth, Demand and Forecast...IMARC Group
According to the latest report by IMARC Group,the global home audio equipment market exhibited moderate growth during 2015-2020.Home audio equipment refers to an electronic audio system that is installed across households to imitate the sound performance of a theatre. Some home audio tools include a home theatre system, soundbars, smart speakers, shelf stereos, radio receivers, AV receivers, microphones, and tape recorders.
Artificial Heart Lung Machine Market PPT(2021- 2026) : Global Trends, Scope, ...IMARC Group
According to the latest report by IMARC Group, the global artificial heart-lung machine market reached a value of US$ 319.3 Million in 2020.
An artificial heart-lung machine (HLM), also known as a cardiopulmonary bypass pump, refers to an apparatus that performs the function of both the heart and lungs during open-heart surgery or a transplant. It ensures that the blood receives oxygen and removes carbon dioxide before the blood is pumped back into the body.
Process analyzer Market PPT 2021-26 | Enhancing Huge Growth and Latest Trends...IMARC Group
According to the latest report by IMARC Group,the global process analyzer market reached a value of US$ 6.40 Billion in 2020.
Process analyzers are electronic instruments utilized for examining the physical and chemical composition of substances present in industrial processes.
According to the latest report by IMARC Group,The global artificial heart-lung machine market reached a value of US$ 319.3 Million in 2020.An artificial heart-lung machine (HLM), also known as a cardiopulmonary bypass pump, refers to an apparatus that performs the function of both the heart and lungs during open-heart surgery or a transplant. It ensures that the blood receives oxygen and removes carbon dioxide before the blood is pumped back into the body.
Mercer Capital's Value Focus: Medical Device Manufacturers | Q4 2015 | Five T...Mercer Capital
Mercer Capital provides medical device manufacturers, related start-up enterprises, and private equity funds with valuation services, including purchase price allocation, 409a compliance, goodwill impairment testing, and other transaction and valuation advisory services.
Anti Drone Market PPT: Growth, Outlook, Demand, Keyplayer Analysis and Opport...IMARC Group
-According to the latest report by IMARC Group,the global anti drone market exhibited strong growth during 2015-2020.Anti drone systems comprise advanced technologies, such as staring radar, micro-Doppler, and electronically scanned array (ESA). They assist in detecting, identifying, tracking, and intercepting unmanned aerial vehicles (UAVs).
PPT- Educational Robot Market Growth, Demand and Challenges of the Key Indus...IMARC Group
According to the latest report by IMARC Group,the global electric power transmission and distribution equipment market size reached US$ 152.5 Billion in 2020.Electric power transmission and distribution (T&D) equipment assists in transporting and delivering electrical energy from the utility generating station to different outlets. It facilitates the flow of electrical energy and the distributed power is then consumed domestically and industrially for the generation of light and heat and the operation of other electrical devices.
Magnetic Stirrer Market PPT: Trends and Dynamics, Drivers, Competitive lands...IMARC Group
According to the latest report by IMARC Group,The global magnetic stirrer market reached a value of US$ 1.97 Billion in 2020.A magnetic stirrer refers to a device consisting of a stationary electromagnet that creates a rotating magnetic field. It is used for spinning a stir bar immersed in a solution for mixing or stirring. Magnetic stirrers are used with glass or non-metal beakers to avoid interference with the magnetic field.
Vaccine Storage and Packaging Market PPT 2021-26 | Enhancing Huge Growth and ...IMARC Group
According to the latest report by IMARC Group,The global vaccine storage and packaging market reached around US$ 21.8 Billion in 2020.Vaccine storage and packaging are laboratory devices that are utilized to preserve and store vaccines in optimum temperatures and ensure proper handling of vaccine vials and ampoules during transportation and storage. These storage solutions, including refrigerators and freezers, are widely available in a vast range of capacities that vary depending upon the user requirements.
PPT- Dermatology Diagnostic Devices Market Growth, Demand and Challenges of t...IMARC Group
According to the latest report by IMARC Group,the global dermatology diagnostic devices market size reached a value of US$ 13.1 Billion in 2021.Dermatology diagnostic devices involve the use of numerous tools and machines that facilitate the early detection and identification of several skin disorders. Microscopes, cameras, dermatoscopes and imaging devices are increasingly employed for identifying numerous skin conditions, including acne, pigmentation, psoriasis, skin cancer and melanoma.
Rolling Stock Market PPT 2021: Size, Growth, Demand and Forecast till 2026IMARC Group
According to the latest report by IMARC Group,The global rolling stock market reached a value of US$ 37.2 Billion in 2020.Rolling stock refers to powered and unpowered vehicles that run on railway tracks and are widely used as a cost-effective mode of transportation. It can also be utilized to transport heavy goods, agricultural products, construction materials and bulky machinery over long distances
This is a comprehensive report on medical devices interoperability in India
This report covers global developments in interoperability of medical devices
Neurostimulation Devices Market PPT 2021-26 | Enhancing Huge Growth and Lates...IMARC Group
As per the latest report by IMARC Group, the global neurostimulation devices market size reached US$ 5.5 Billion in 2019.
Neurostimulation devices are medical instruments that generate electrical impulses to stimulate, modify, inhibit, regulate and alter the activity of the central, autonomous, and peripheral nervous systems in the patient’s body.
Calcium Stearate Market PPT: Opportunities by Types, Demand, Top Manufacture...IMARC Group
According to the latest report by IMARC Group,The global calcium stearate market exhibited moderate growth during 2015-2020.Calcium stearate (C36H70O4.Ca), also known as octadecanoic acid calcium salt, is a type of metallic stearate that has a high melting point of around 356-degree Fahrenheit. It is a non-toxic and non-irritating carboxylate of calcium, which is produced through the reaction of stearic acid and calcium salt.
Forehead Thermometer Market PPT: Growth, Outlook, Demand, Keyplayer Analysis...IMARC Group
According to the latest report by IMARC Group,The global forehead thermometer market exhibited moderate growth during 2015-2020.Forehead thermometers utilize an infrared scanner to measure the temperature of the temporal artery in the forehead. They are non-intrusive devices that are made up of infrared sensors, capacitors, LCD screen, LCD driver, and PCB microcontroller diodes.
Global Air Quality Monitoring Market PPT: Demand, Trends and Business Opport...IMARC Group
According to the latest report by IMARC Group,the global air quality monitoring market size reached US$4.3 Billion in 2021.Air quality monitoring involves the use of sensor-based instruments to detect and measure the wind speed and the concentration of air pollutants in indoor and outdoor environments. Some of these pollutants include sulfur dioxide, carbon monoxide, nitrous oxide, volatile organic compounds, total hydrocarbons and particulate matter.
Mercer Capital's Value Focus: Medical Device Industry | Q3 2016 Mercer Capital
Mercer Capital provides medical device manufacturers, related start-up enterprises, and private equity funds with valuation services, including purchase price allocation, 409a compliance, goodwill impairment testing, and other transaction and valuation advisory services.
Each issue includes a segment focus, market overview, mergers and acquisitions review, and more.
This is a 20-minute lecture covering points to consider when building value proposition unique to medical technology. It begins with a brief review of issues related to market adoption for medical technology and the hurdles that a medical technology innovator may encounter when taking a product to market. You will learn about the 7 key factors that would boost market fit.
http://semoegy.com
In-Vitro Diagnostics Packaging Market PPT 2021: Size, Growth, Demand and For...IMARC Group
According to the latest report by IMARC Group,the global in-vitro diagnostics packaging market size reached US$ 6.7 Billion in 2020.In-vitro diagnostics (IVDs) refer to the various kinds of medical devices and accessories that are widely used for performing tests on samples. These equipment assist in analyzing several bodily fluids, such as urine, stool and blood, to detect diseases and infections. These tests are utilized to assist in monitoring drug therapies while facilitating the early diagnosis of chronic diseases at the initial stage.
Electrophysiology Devices Market PPT 2021: Size, Growth, Demand and Forecast...IMARC Group
According to the latest report by IMARC Group,the global home audio equipment market exhibited moderate growth during 2015-2020.Home audio equipment refers to an electronic audio system that is installed across households to imitate the sound performance of a theatre. Some home audio tools include a home theatre system, soundbars, smart speakers, shelf stereos, radio receivers, AV receivers, microphones, and tape recorders.
Artificial Heart Lung Machine Market PPT(2021- 2026) : Global Trends, Scope, ...IMARC Group
According to the latest report by IMARC Group, the global artificial heart-lung machine market reached a value of US$ 319.3 Million in 2020.
An artificial heart-lung machine (HLM), also known as a cardiopulmonary bypass pump, refers to an apparatus that performs the function of both the heart and lungs during open-heart surgery or a transplant. It ensures that the blood receives oxygen and removes carbon dioxide before the blood is pumped back into the body.
Process analyzer Market PPT 2021-26 | Enhancing Huge Growth and Latest Trends...IMARC Group
According to the latest report by IMARC Group,the global process analyzer market reached a value of US$ 6.40 Billion in 2020.
Process analyzers are electronic instruments utilized for examining the physical and chemical composition of substances present in industrial processes.
According to the latest report by IMARC Group,The global artificial heart-lung machine market reached a value of US$ 319.3 Million in 2020.An artificial heart-lung machine (HLM), also known as a cardiopulmonary bypass pump, refers to an apparatus that performs the function of both the heart and lungs during open-heart surgery or a transplant. It ensures that the blood receives oxygen and removes carbon dioxide before the blood is pumped back into the body.
Mercer Capital's Value Focus: Medical Device Manufacturers | Q4 2015 | Five T...Mercer Capital
Mercer Capital provides medical device manufacturers, related start-up enterprises, and private equity funds with valuation services, including purchase price allocation, 409a compliance, goodwill impairment testing, and other transaction and valuation advisory services.
Anti Drone Market PPT: Growth, Outlook, Demand, Keyplayer Analysis and Opport...IMARC Group
-According to the latest report by IMARC Group,the global anti drone market exhibited strong growth during 2015-2020.Anti drone systems comprise advanced technologies, such as staring radar, micro-Doppler, and electronically scanned array (ESA). They assist in detecting, identifying, tracking, and intercepting unmanned aerial vehicles (UAVs).
PPT- Educational Robot Market Growth, Demand and Challenges of the Key Indus...IMARC Group
According to the latest report by IMARC Group,the global electric power transmission and distribution equipment market size reached US$ 152.5 Billion in 2020.Electric power transmission and distribution (T&D) equipment assists in transporting and delivering electrical energy from the utility generating station to different outlets. It facilitates the flow of electrical energy and the distributed power is then consumed domestically and industrially for the generation of light and heat and the operation of other electrical devices.
Magnetic Stirrer Market PPT: Trends and Dynamics, Drivers, Competitive lands...IMARC Group
According to the latest report by IMARC Group,The global magnetic stirrer market reached a value of US$ 1.97 Billion in 2020.A magnetic stirrer refers to a device consisting of a stationary electromagnet that creates a rotating magnetic field. It is used for spinning a stir bar immersed in a solution for mixing or stirring. Magnetic stirrers are used with glass or non-metal beakers to avoid interference with the magnetic field.
Vaccine Storage and Packaging Market PPT 2021-26 | Enhancing Huge Growth and ...IMARC Group
According to the latest report by IMARC Group,The global vaccine storage and packaging market reached around US$ 21.8 Billion in 2020.Vaccine storage and packaging are laboratory devices that are utilized to preserve and store vaccines in optimum temperatures and ensure proper handling of vaccine vials and ampoules during transportation and storage. These storage solutions, including refrigerators and freezers, are widely available in a vast range of capacities that vary depending upon the user requirements.
PPT- Dermatology Diagnostic Devices Market Growth, Demand and Challenges of t...IMARC Group
According to the latest report by IMARC Group,the global dermatology diagnostic devices market size reached a value of US$ 13.1 Billion in 2021.Dermatology diagnostic devices involve the use of numerous tools and machines that facilitate the early detection and identification of several skin disorders. Microscopes, cameras, dermatoscopes and imaging devices are increasingly employed for identifying numerous skin conditions, including acne, pigmentation, psoriasis, skin cancer and melanoma.
Rolling Stock Market PPT 2021: Size, Growth, Demand and Forecast till 2026IMARC Group
According to the latest report by IMARC Group,The global rolling stock market reached a value of US$ 37.2 Billion in 2020.Rolling stock refers to powered and unpowered vehicles that run on railway tracks and are widely used as a cost-effective mode of transportation. It can also be utilized to transport heavy goods, agricultural products, construction materials and bulky machinery over long distances
This is a comprehensive report on medical devices interoperability in India
This report covers global developments in interoperability of medical devices
Neurostimulation Devices Market PPT 2021-26 | Enhancing Huge Growth and Lates...IMARC Group
As per the latest report by IMARC Group, the global neurostimulation devices market size reached US$ 5.5 Billion in 2019.
Neurostimulation devices are medical instruments that generate electrical impulses to stimulate, modify, inhibit, regulate and alter the activity of the central, autonomous, and peripheral nervous systems in the patient’s body.
Calcium Stearate Market PPT: Opportunities by Types, Demand, Top Manufacture...IMARC Group
According to the latest report by IMARC Group,The global calcium stearate market exhibited moderate growth during 2015-2020.Calcium stearate (C36H70O4.Ca), also known as octadecanoic acid calcium salt, is a type of metallic stearate that has a high melting point of around 356-degree Fahrenheit. It is a non-toxic and non-irritating carboxylate of calcium, which is produced through the reaction of stearic acid and calcium salt.
Forehead Thermometer Market PPT: Growth, Outlook, Demand, Keyplayer Analysis...IMARC Group
According to the latest report by IMARC Group,The global forehead thermometer market exhibited moderate growth during 2015-2020.Forehead thermometers utilize an infrared scanner to measure the temperature of the temporal artery in the forehead. They are non-intrusive devices that are made up of infrared sensors, capacitors, LCD screen, LCD driver, and PCB microcontroller diodes.
Global Air Quality Monitoring Market PPT: Demand, Trends and Business Opport...IMARC Group
According to the latest report by IMARC Group,the global air quality monitoring market size reached US$4.3 Billion in 2021.Air quality monitoring involves the use of sensor-based instruments to detect and measure the wind speed and the concentration of air pollutants in indoor and outdoor environments. Some of these pollutants include sulfur dioxide, carbon monoxide, nitrous oxide, volatile organic compounds, total hydrocarbons and particulate matter.
Mercer Capital's Value Focus: Medical Device Industry | Q3 2016 Mercer Capital
Mercer Capital provides medical device manufacturers, related start-up enterprises, and private equity funds with valuation services, including purchase price allocation, 409a compliance, goodwill impairment testing, and other transaction and valuation advisory services.
Each issue includes a segment focus, market overview, mergers and acquisitions review, and more.
This is a 20-minute lecture covering points to consider when building value proposition unique to medical technology. It begins with a brief review of issues related to market adoption for medical technology and the hurdles that a medical technology innovator may encounter when taking a product to market. You will learn about the 7 key factors that would boost market fit.
http://semoegy.com
A presentation about a series of exercises to practice how to analyze and improve paragraphs. First, a text about how to stop soring needs to be divided into paragraphs. Later, a paragraph about pesticide suicide needs to be organized/sequenced in a logical way. Next, some sentences in a paragraph about elderly people living on a reduced income need to be omitted or eliminated. Finally, in two paragraphs, people need to work out the topic and the topic sentence. Additionally, one sentence needs to be omitted or eliminated.
Snoring has a much greater clinical impact on Women and Children. The condition we know as snoring is in fact much more serious. Snoring is the sound that partial airway obstruction makes.
ApolloDx is developing a Mobile Diagnostic Platform comprised of a smart device attached to an analyzer. This system provides and transmits laboratory-quality, GPS-tagged results in 10 minutes or less. It is capable of multiplexing a broad range of analytes from ions to cells and discerning viable versus non-viable pathogens. The bidirectional data transmission with real-time analytics enables medical professionals to practice evidence-based medicine.
Healthcare is undergoing a technological transformation, and it is imperative for the industry to leverage new technologies to generate, collect, and track novel data. Panel chaired by Ralf Reilmann of the George Huntington Institut, Muenster.
Real world clinical medical data. Corporate presentation of Ad Scientiam which is a startup specialized in real life data acquisition during clinical trials.
Learn more at : www.adscientiam.com
Recent Advances in Respiratory Physiotherapy 2.pptxSaumyaKine
Recent advances in Respiratory physiotherapy covers a comprehensive aspect of newer technologies helpful in the field of pulmonary physiotherapy. Useful for MPT students. Has articles added up for reference.
Accelerating the translation of medical research - 27 JuneInnovation Agency
Slides from the event focusing on translational research in Liverpool and North of England and why companies are establishing and growing operations in the region.
These slides use concepts from my (Jeff Funk) course entitled Biz Models for Hi-Tech Products to analyze the business model for Infra V’s Smart Watch. This watch can continuously monitor glucose using a non-invasive spectrometric process, which enables better management of diabetes through more timely insulin injections. The watch replaces the widely used finger-pricking method that is painful for users and thus discourages effective monitoring of a patient’s glucose levels. The watch is also smaller and cheaper than other methods of continuous monitoring. These slides describe the specific value proposition for patients and doctors other aspects of the business model such as the method of value capture, scope of activities, and method of strategic control.
Real-Time Data. Real-World Impact. Info sheet Covance
Data can help, but simply accessing more data only muddies your decision making. With Covance, you get the right analysis on the right data to empower your studies.
2. •Software/algorithm validated to accurately diagnose (93%) sleep apnea via overnight recordings of snoring vs. PSG.
•FDA 510k OTC clearance for software as definitive rule in/rule out diagnostic test
•CMS designation of software as a home sleep study (HST) device so that therapy will be reimbursed for Appian diagnosed OSA patients .
•Multiple exits generating 4x to 80x returns for investors
•Raised over $125M in VC and public company funding
•3rd OSA diagnostic technology venture
•$4.5B sleep study market (USA 2014) growing to $8.5B (Worldwide 2018).
Summary of Appian Medical Opportunity
Proprietary & Confidential
2
Disruptive Technology
Disruptive Business Model
Successful, Seasoned Team
Billion Dollar Exit
3. The Disruptive Evolution of mHealth
Stage 1
Consumer Adoption
Stage 2 MD Adoption
Stage 3 Payer Adoption
Activity tracking for health & wellness
Self diagnosis & disease monitoring
Neural networks & data mining
Outcomes
Quantification of Self
Pro-Active Disease Management
Disease Risk Prediction
Consumer Directed Diagnostics
Proprietary & Confidential
3
4. Vision: Big Data Empowered By Consumer Directed Diagnostics
Potential to aggregate data from multiple diseases OSA diagnostic app offers universal API links to other hardware & software
Hypertension
Depression
Stroke
Diabetes
Obesity
CHF
Erectile Dysfunction
OSA
Consumer directed diagnostics empower patients to detect disease risks earlier and seek physician counsel & treatment.
CDD Data Pool Could Touch ≥100 Million People in USA
33%
90%
50%
50%
60%
50%
90%
(Co-morbid % with OSA)
OSA is the 1st focal point:
•Touches many other diseases
•Significant unmet need
•OSA diagnostic algorithm in development
Proprietary & Confidential
4
Afib
80%
OSA has significant links to >25 diseases
5. Dilemma: Obstructive Sleep Apnea (OSA) Epidemic
•100 million globally suffer from OSA (25 million in USA)
•Global trend: The older and fatter the population gets, the greater the prevalence of OSA
•85% remain undiagnosed
•Untreated OSA causes or worsens other chronic, costly disorders: high blood pressure, diabetes
•OSA results from repeated airway collapse during sleep – can occur hundreds of time a night, reducing oxygen circulation in the blood
5
Proprietary & Confidential
Collapsed Airway
Open Airway
6. ×Need referral
×Uncomfortable testing environment
×Lengthy wait lists at some labs
×$1,500-$3,000 per night
×25% test completion failure rates
×Up to 40% false negative results documented in studies
×Not suitable for mass screening
×Require physician prescription
×Most are uncomfortable
×Often need additional training
×Up to $750 per night
×Optimum detection requires multiple night testing
×Completion rates unreliable
Need: Low Cost + In Home + Comfortable + Accurate
Competition: Inefficient Detection of Therapy Candidates
Proprietary & Confidential
6
PSG In-lab Tests
In Home Tests
7. •A unique algorithm that diagnoses OSA from sound analysis
•Uses proprietary High Order Statistical (HOS) algorithms for acoustic analysis of snore characteristics caused by airway collapse.
•Software platform can be delivered by various means: smartphone apps, wearable sensors, medical or consumer devices
What is SnoreSounds?
Proprietary & Confidential
7
A prototype app has been developed & tested
8. SnoreSounds Customer Value Proposition & Benefits
•SnoreSounds has no wires, no cuffs, no straps or head attachments.
•SnoreSounds preserves the natural sleep environment – no discomfort or disturbance
•Simple operation needs no special instruction - place the phone at bedside and activate the app.
Proprietary & Confidential
8
Typical Home Sleep Test Equipment
SnoreSounds Mobile App
9. SnoreSounds: Advancing the Diagnosis of OSA
Proprietary & Confidential
9
1970
Advent of Polysomnography (PSG)
•1st sleep Lab at Stanford University
•Only approved method of diagnosing OSA
•$1500 avg. cost
2008 - 2009
Validation of Home Sleep Tests (HST)
•Medicare (CMS) Nat’l Coverage Decisions
•Equivalent to PSG @ 50% of cost
•$750 avg. cost
2016
Introduction of App Sleep Test (AST)
•SnoreSounds validation as diagnostic device
•Equivalent to PSG @ 2% of cost
•$50 avg. cost
The comfort, convenience & cost advantages of SnoreSounds align with payer-driven momentum to increase consumer access to OSA testing.
2014
Payers are actively steering patients away from PSG to HST
10. OSA Diagnostic + Treatment Pathway – Cost Comparison
Proprietary & Confidential
10
The cost advantages of SnoreSounds will be a significant inducement for payers to continue to steer patients toward consumer directed diagnosis.
Diagnostic + Treatment Pathway Step
PSG
HST
SnoreSounds
PCP visit – suspects OSA
$ 85
$ 85
--
Sleep Medicine Specialist referral
$ 125
--
--
Sleep Test
$1500
$ 750
$ 50
Titration Test
$1500
--
--
Post Diagnosis Physician Visit
$ 125
(Sleep Med)
$ 85
(PCP)
$ 85
(PCP)
Purchase Therapy (1 year)
$ 425
(CPAP)
$ 650
(APAP)
$ 650
(APAP)
Follow – up titration
$1500
--
--
TOTAL Diagnosis + Treatment Cost
$5260
$1570
$ 785
11. SnoreSounds Regulatory & Medicare/Payer Pathway
Proprietary & Confidential
11
SnoreSounds
Diagnostic Medical Policy Approval
Validated Algorithm Accuracy in Lab
Transfer Lab Technology to Smartphone/ cloud
Smartphone Testing in Patient’s Home
Rx to OTC Diagnostic Clearance
CMS/Payer Adoption
Step
Indication/Outcome
Study
510(k) #1
Rx for diagnosis of OSA using technology in Lab
Validation of algorithm accuracy vs. lab PSG
510(k) #2
Rx for diagnosis of OSA using smartphone technology in lab (30 day expedited review)
Equivalence of algorithm on smartphone to lab recording method
510(k) #3 a
Rx for diagnosis of OSA using smartphone in home setting
Accuracy of algorithm vs. standard home sleep tests
510(k) #3 b
Rx to OTC conversion for consumer diagnosis in home
Consumer ease-of-use & outcomes study
CMS Review
Medical policy approval of smartphone algorithm diagnosis as equivalent to approved home sleep tests
•Enables reimbursement of therapy based on diagnosis with SnoreSounds technology
A step-wise approach will be required to achieve the ultimate goal of a FDA OTC approval for SnoreSounds as a consumer diagnostic app.
12. Two developmental studies conducted by University of Queensland in Brisbane have demonstrated the feasibility of a low-cost, unattended OSA detection test using acoustic monitoring & proprietary algorithms for analysis of snoring sounds.
•Both studies compared acoustic snore detection algorithm to PSG in sleep labs
Feature
STUDY 1
STUDY 2
Subjects
n=41
n = 86
Sensitivity
89%
93%
Specificity
92%
93%
AHI Threshold
10
15
Publication
Karunajeewa et al, Physiol. Meas. 2011; 32: 83-97
Abeyratne et al,
Physiol. Meas. 2013;
34: 99-121
•The SnoreSounds detection method & analytical algorithm (US Patent pending) has robust potential for OSA diagnosis in an unattended environment.
•Additional clinical studies are required to replicate & validate these results.
SnoreSounds Clinical Evidence
Proprietary & Confidential
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13. Goal: Replace Traditional Tests with Disease Management Tool
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Patient Needs
Provider Needs
Payer Needs
•Easy to use
•No discomfort
•Accurate results
•Affordable
•Easy to order
•Accurate
•Immediate results
•Reimbursement
•Cost efficient
•Reduce PMPY cost
•Proven outcomes
•Therapy adherence
Consumer strategy
•Social media
•Online advertising
•PR & mass media
Provider strategy
•Strategic partner sales force
•KOL Advocacy
Payer strategy
•Clinical evidence
•Cost savings
•Nat’l Acct force
A low cost app uniquely addresses patient, provider, and payer needs, efficiently & economically increasing detection of patients-at-risk. The app also delivers therapy adherence techniques to improve disease management & outcomes.
Proprietary & Confidential
14. SnoreSounds Consumer Business Model
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A simultaneous, three-prong business model will enable the company to grow substantial revenue from: 1. Consumer in-app purchases
•Distribute app directly to snoring consumers
•Record & analyze snoring to predict OSA
•Charge in-app fee for MD report for positive OSA patients
•In-app purchases of additional services
•Validated diagnostic app allows MD to treat without further testing
SnoreSounds Smartphone App
Developed for iPhone & Android platforms
Proprietary & Confidential
15. SnoreSounds B2B Business Model
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2. License the SnoreSounds algorithm to other health, fitness & wellness partners.
•Therapy companies
•Wearable fitness monitors
•mHealth sensor leaders in diabetes, cardio, respiratory
•Disease management firms
•Payers concerned about OSA
Universal Platform Integration
Universal application program interface (API)
Proprietary & Confidential
Company/Product
Description
User/Patient Base*
Fitbit, Jawbone, Nike
Wearable activity tracker devices
12.6 mil
Azumio, Sanofi, etc.
All combined diabetes apps
3.7 mi
United HC, WellPoint
Top 2 US health insurers
68.8 mil
Healthways, Alere, etc.
Major disease management firms
50.0 mil
Examples
* 2013 estimate
Integrating SnoreSounds with popular activity trackers, related mHealth apps & healthcare companies would result in millions of downloads and a massive patient database.
16. SnoreSounds Recurring Revenue Model
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3. Recurring revenue will be generated by repeat tests, data fees & member fees from participating health plans.
•Repeat tests advised for patients with mild-moderate symptoms or negative tests with risk factors
•Monthly data access fees to licensees
•Annual per-member fees from participating health plans
Recurring Revenue Stream
Monthly Data Access for Trend Analysis
Proprietary & Confidential
* 2013 estimate
17. Consumer Directed Diagnostics (CDD) Pipeline
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Appian pipeline benefits patients & physicians:
•A second medical app for use by physicians and parents to identify children at risk for OSA – a growing problem in the USA, linked to ADHD, diabetes, and growing obesity.
oSnorKid screens for moderate-to-severe OSA
oHighly predictive & clinically validated
•Appian is actively seeking & evaluating complementary technologies to cement leadership in the delivery of accessible, accurate & affordable OSA diagnosis and management
Global OSA Diagnostic Market (100 M)
Adult Diagnosis Needs
Therapy Effectiveness Measurement Needs
Pediatric
Diagnosis
Needs
CDD Needs
•Accessible
•Accurate
•Affordable
SnoreSounds
SnorKid
Proprietary & Confidential
18. In the News: Digital Health Partnerships
Recent mHealth deals with major pharma, medical device & consumer brand companies demonstrate the growing interest in digital technology:
•Corventis – acquired by Medtronic for ~$150 million
oFluid sensing & cardiac telemetry patch system
oViewed as enhancement to MDT acquisition of Cardiocom
oStrategic focus on congestive heart failure
•Proteus Digital Health - $120 million investment from Novartis and Otsuka Pharmaceutical
oHelius system “smart pill” – ingestible sensor & patch
oMonitors medication adherence
oTracking data for physicians & family caregivers
•Zephyr Technology - acquired by Covidien (undisclosed sum)
oSensors measure heart rate, breathing, ECG, posture
oStrategic focus on remote patient monitoring to reduce hospital re-admissions
•MapMyFitness - acquired by Under Armour (athletic apparel) for $150 million
oActivity & fitness tracking apps & social networks with integration capabilities
Proprietary & Confidential
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19. Prime Targets
Key Benefits
Consumer Technology & Software
Payers & Disease Management
Therapy & Medical Devices
•Competitive differentiation
•Enhance customer experience
•Aggregate relevant user data
•Qualified leads
•Qualified leads
•In-home convenience
•Mass market screening
•Test therapy effectiveness
Potential SnoreSounds Partnerships
Proprietary & Confidential
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•Large scale risk assessment
•Efficient cost per member
•High completion rates with no false negatives
•Access to big data
Wearable Sensors & Health Apps
•Apple
•Samsung
•Google
•Intel
•Fitbit
•Jawbone
•Nike
•Basis
•ResMed
•Philips/Respironics
•Medtronic
•Abbott
•J&J
•Azumio
•Dexcom
•Telcare
•WellDoc
•United HC
•WellPoint
•Healthways
•Alere
•Cardiocom
•Add sleep assessment data
•Gather co-morbidity data
•Increase customer value
•Enhance connectivity
20. SnoreSounds Key Milestones Timeline
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Seed Round $0.5 - $1 MM
Series A $2 - $4MM
Q4 2014
Q3 2015
Q2 2015
Q1 2015
Q4 2015
Q1 2016
Q2 2016
Q3 2016
Develop commercial app + API
Submit 510k #1
Build core management team
Confirmatory validation study
B2B partnership pitches
OTC validation study
Medicare Outcomes study
FDA OTC pre-sub mtg
Market pre-launch
US launch
OTC clearance
Proprietary & Confidential
CMS Policy Approval
21. Funding Needs
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•Seed round funding of up to $1M to complete in Q4 2014
$500K already raised/closed
File initial 510(k) application for OSA algorithm with FDA
Initiate app validation study program
Fill key management team gaps
Initiate market research & preparation
Operating capital
•Series A financing of $2MM-$4MM sought in Q4 2014/Q1 2015
Conduct outcomes study to support OTC filing
Commercial app design & development
Submit 510(k) applications to support OTC clearance
Business Development initiatives & partnership presentations
Market pre-launch
Proprietary & Confidential
22. Appian Valuation at Milestones
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Round
Amount
Pre-Value
Milestone
Post Value
Seed Round
$1MM
$5MM
Rx clearance for algorithm use in lab
$20MM
Series A
$2MM-$4MM
TBD
FDA cleared as consumer OTC diagnostic
$200MM
Series B
$7MM - $10MM
TBD
CMS Therapy coverage via app diagnosis
$2BB
Proprietary & Confidential
1)Initial FDA 510(k) application & support studies
•Yields clearance for OSA algorithm as equivalent to existing standards
•Access to diagnostic device market generating $200MM annually in USA
•Sell or license to sleep physicians & labs
•Valuation based on potential market share
2)Consumer OTC diagnostic 510(k) & support studies
•Yields clearance for consumer diagnostic tool & physician path to treatment
•Access to OSA testing market generating >$6BB annually in USA
•Clearance with clinical evidence will set the standard for mobile OSA detection
•Prime licensing candidate for related health & fitness apps & monitoring devices
3)CMS coverage decision for home diagnosis
•Cements role as disruptive method for wide scale OSA detection
•Opens payers to partnership for disease management of co-morbid members
•Prime candidate for respiratory device acquisition
•Elimination of sleep labs for OSA dx
23. Management Team
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Michael J. Thomas
Chairman, CEO, Founder
•Former CEO of iSonea Ltd (ASX:ISN), created $250MM shareholder value in a respiratory mobile health & medical device company
•CEO of Appian Partners LLC, a device & healthcare consulting firm
•Former President & CEO of Sleep Solutions, a VC-backed medical device company & pioneer in home sleep testing
•Raised >$100 million in VC / public funding over 4 start ups
•Former EVP Sales & Marketing for National Sleep Technologies, leading the acquisition of 80 sleep labs (NST acquired by GE Medical)
•Former VP Sales at Patient InfoSystems (NASDAQ:PATI) and instrumental in taking company public
•Pharmaceutical experience at Merck and GlaxoWellcome
•Microbiology degree from Cornell University
Michael Cheney
Chief Marketing Officer
•Former VP Marketing for iSonea Ltd, a respiratory mobile health & device company
•Former VP Marketing & International Business Unit , Cyberonics Inc.
•Former Marketing Officer, NovaSom Inc, a pioneer in OSA home sleep tests
•25 years in strategic marketing leadership roles in phama, biotech, device
•Launched market leading/shaping brands for Wyeth, BASF/Knoll, Cyberonics
Jonathan Freudman, MD
Medical Director
•Founder, Freudman Healthcare Consulting LLC with 25 years of healthcare experience
•Medical Director, iSonea Ltd ; former Medical Director, Sleep Solutions Inc.
•Pivotal role in Medicare National Coverage Decision for home sleep testing for OSA
•Previously managed Medical Policy Dept. , Blue Shield of California & chaired P&T Committee; served on national BCBSA Medical Policy Committee
•16 years in practice of internal medicine at Kaiser Permanente; dept. Chief of IM
•Board Certified IM; FACP; grad. George Washington University School of Medicine
Proprietary & Confidential
TBD
Chief Technology Officer
•TBD
TBD
VP Sales & Business Development
•TBD
25. •Software/algorithm validated to accurately diagnose (93%) sleep apnea via overnight recordings of snoring vs. PSG.
•FDA 510k OTC clearance for software as definitive rule in/rule out diagnostic test
•CMS designation of software as a home sleep study (HST) device so that therapy will be reimbursed for Appian diagnosed OSA patients .
•Multiple exits generating 4x to 80x returns for investors
•Raised over $125M in VC and public company funding
•3rd OSA diagnostic technology venture
•$4.5B sleep study market (USA 2014) growing to $8.5B (Worldwide 2018).
Summary of Appian Medical Opportunity
Proprietary & Confidential
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Disruptive Technology
Disruptive Business Model
Successful, Seasoned Team
Billion Dollar Exit