This document discusses rational antibiotic use and resistance. It describes the mechanisms of different antibiotic classes and how bacteria develop resistance. Resistance occurs through genetic mutations or extrachromosomal elements like plasmids, which allow resistance genes to spread between bacteria. The document emphasizes using antibiotics appropriately based on diagnosis, obtaining cultures, and giving the minimum effective treatment to reduce resistance.
Management of antibiotic resistance uploadAnimesh Gupta
This document discusses antibiotic resistance and its management. It defines antibiotic resistance as when microorganisms become resistant to drugs that previously treated infections from them. It outlines various mechanisms of antibiotic resistance in microorganisms and lists priority resistant bacteria. It also discusses superbugs and different strategies to manage antibiotic resistance like prudent antibiotic use, infection control, developing new drugs, and reducing agricultural overuse of antibiotics.
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
The document discusses various classes of antimicrobial agents including their classification, mechanisms of action, spectra of activity, and examples. It covers antibiotics such as penicillin, cephalosporins, aminoglycosides, and macrolides. It also addresses antimicrobial resistance, rational antibiotic usage, and combination therapy.
Antibiotic prescription and bacterial resistanceMamdouh Sabry
- Overuse of antibiotics, especially in patients with fever of unknown origin, can lead to increased bacterial resistance. When antibiotics are used prudently and appropriately, it can minimize excess use and enhance selecting the right antibiotic for the susceptible bacteria in a given patient.
- As antibiotic prescriptions rise, so does bacterial resistance. Bacteria can develop resistance through mutations, acquiring genetic material from other bacteria, or through selective pressure from antibiotic use that favors resistant strains.
- To combat rising resistance, guidelines should be followed for proper antibiotic indication, culture collection, infecting organism identification, appropriate antibiotic selection, dose, duration and modification after culture results. Prudent antibiotic use can help preserve the effectiveness of our existing antibiotics
This document discusses antimicrobial resistance, which is one of the most important clinical problems today. It provides definitions of key terms like antibiotics, antimicrobials, and mechanisms of antibiotic resistance. The document also summarizes how resistance has developed and spread for certain microbes like MRSA and describes various mechanisms that bacteria use to develop resistance, such as modifying drug targets, inactivating antibiotics, or limiting drug uptake.
This document provides definitions and information about chemotherapy and antimicrobial agents. It discusses the history of chemotherapy beginning with Paul Ehrlich and the discovery of penicillin. It then classifies antibiotics according to spectrum of activity, type of action, organisms targeted, mechanism of action, chemical structure, and source. The document discusses drug resistance, combination therapy, chemoprophylaxis, superinfection, and principles of rational antibiotic use. It emphasizes the importance of proper antibiotic selection, dosage, duration and monitoring treatment to improve outcomes and reduce drug resistance.
Role of pharmacists in combating drug resistatnceLarry Mweetwa
This document discusses the role of pharmacists in combating drug resistance through evidence-based practice. It begins by defining antimicrobial resistance and explaining why it is a concern for pharmacists. It then covers how antibiotics work, the mechanisms of resistance, and strategies to contain resistance such as developing new antibiotics, prudent use of existing drugs, vaccination, education, and antibiotic stewardship programs led by pharmacists. The document emphasizes that pharmacists must understand resistance at the molecular level and play a key role as experts in medicines and custodians of drug resistance.
Antimicrobial drugs include antibacterial, antiviral, antifungal, antiprotozoan, and antihelminthic medications. They work by interfering with microbial growth within the host. Many modern antibiotics are produced by microorganisms found in soil. Antimicrobials vary in their spectrum of activity and mechanisms of action. Resistance develops through spontaneous mutations and horizontal gene transfer, highlighting the need for appropriate antimicrobial usage.
Management of antibiotic resistance uploadAnimesh Gupta
This document discusses antibiotic resistance and its management. It defines antibiotic resistance as when microorganisms become resistant to drugs that previously treated infections from them. It outlines various mechanisms of antibiotic resistance in microorganisms and lists priority resistant bacteria. It also discusses superbugs and different strategies to manage antibiotic resistance like prudent antibiotic use, infection control, developing new drugs, and reducing agricultural overuse of antibiotics.
Antibiotic resistance occurs when bacteria change in response to antibiotic use, making infections harder to treat. Bacteria, not humans or animals, become resistant. This leads to higher medical costs, prolonged hospital stays, and increased deaths. Antibiotic resistance threatens global health and can affect anyone, of any age, in any country. It occurs naturally but also because of misuse of antibiotics in humans and farm animals. This is making many infections like pneumonia, tuberculosis, and gonorrhea more difficult to treat.
The document discusses various classes of antimicrobial agents including their classification, mechanisms of action, spectra of activity, and examples. It covers antibiotics such as penicillin, cephalosporins, aminoglycosides, and macrolides. It also addresses antimicrobial resistance, rational antibiotic usage, and combination therapy.
Antibiotic prescription and bacterial resistanceMamdouh Sabry
- Overuse of antibiotics, especially in patients with fever of unknown origin, can lead to increased bacterial resistance. When antibiotics are used prudently and appropriately, it can minimize excess use and enhance selecting the right antibiotic for the susceptible bacteria in a given patient.
- As antibiotic prescriptions rise, so does bacterial resistance. Bacteria can develop resistance through mutations, acquiring genetic material from other bacteria, or through selective pressure from antibiotic use that favors resistant strains.
- To combat rising resistance, guidelines should be followed for proper antibiotic indication, culture collection, infecting organism identification, appropriate antibiotic selection, dose, duration and modification after culture results. Prudent antibiotic use can help preserve the effectiveness of our existing antibiotics
This document discusses antimicrobial resistance, which is one of the most important clinical problems today. It provides definitions of key terms like antibiotics, antimicrobials, and mechanisms of antibiotic resistance. The document also summarizes how resistance has developed and spread for certain microbes like MRSA and describes various mechanisms that bacteria use to develop resistance, such as modifying drug targets, inactivating antibiotics, or limiting drug uptake.
This document provides definitions and information about chemotherapy and antimicrobial agents. It discusses the history of chemotherapy beginning with Paul Ehrlich and the discovery of penicillin. It then classifies antibiotics according to spectrum of activity, type of action, organisms targeted, mechanism of action, chemical structure, and source. The document discusses drug resistance, combination therapy, chemoprophylaxis, superinfection, and principles of rational antibiotic use. It emphasizes the importance of proper antibiotic selection, dosage, duration and monitoring treatment to improve outcomes and reduce drug resistance.
Role of pharmacists in combating drug resistatnceLarry Mweetwa
This document discusses the role of pharmacists in combating drug resistance through evidence-based practice. It begins by defining antimicrobial resistance and explaining why it is a concern for pharmacists. It then covers how antibiotics work, the mechanisms of resistance, and strategies to contain resistance such as developing new antibiotics, prudent use of existing drugs, vaccination, education, and antibiotic stewardship programs led by pharmacists. The document emphasizes that pharmacists must understand resistance at the molecular level and play a key role as experts in medicines and custodians of drug resistance.
Antimicrobial drugs include antibacterial, antiviral, antifungal, antiprotozoan, and antihelminthic medications. They work by interfering with microbial growth within the host. Many modern antibiotics are produced by microorganisms found in soil. Antimicrobials vary in their spectrum of activity and mechanisms of action. Resistance develops through spontaneous mutations and horizontal gene transfer, highlighting the need for appropriate antimicrobial usage.
The document discusses antimicrobial agents and mechanisms of resistance. It covers several topics:
1. Definitions and classifications of antibiotics based on chemical structure, source, mechanism of action, and spectrum.
2. Mechanisms of antibiotic resistance in bacteria including production of enzymes to destroy drugs and genetic/non-genetic resistance.
3. Approaches to address rising antibiotic resistance such as appropriate use and preventing overprescription.
This document presents information on antimicrobial resistance (AMR). It defines AMR as microorganisms becoming resistant to antimicrobial drugs like antibiotics, antivirals, and antimalarials. The document discusses factors that contribute to AMR, including overuse of antibiotics. It describes mechanisms of resistance such as mutations, plasmids, and enzymes that inactivate drugs. It recommends strategies to control AMR like prudent antibiotic use, developing new drugs, and reducing unnecessary use in animals. The conclusion emphasizes that AMR is a global threat that requires strategies to prevent further resistance development.
1. chemotherapy principles and problems JagirPatel3
The objective of chemotherapy is to study and to apply the drugs that have highly selective toxicity to the pathogenic microorganisms in the host body and have no or less toxicity to the host, so as to prevent and cure infective diseases caused by pathogens
This document discusses principles of chemotherapy and antimicrobial drugs. It defines chemotherapy and different types of antimicrobials such as antibiotics, antimicrobials, antivirals etc. It describes sources of antimicrobial drugs and factors to consider for drug selection and administration like diagnosis, drug properties, and patient factors. It also covers classification of antimicrobials, mechanisms of drug resistance, problems of antimicrobial use, and advantages/disadvantages of combined drug use.
This document provides an introduction to principles of anti-microbial therapy. It discusses key topics including:
- Sir Alexander Fleming's discovery of penicillin in 1928.
- The definition of chemotherapy and agents used to treat infections and cancer.
- Factors considered in selecting appropriate anti-microbial agents, including the infecting organism, site of infection, and patient factors.
- Mechanisms of anti-microbial resistance that can develop, including genetic alterations in microbes and changes in target sites or drug accumulation.
- Complications of anti-microbial therapy like hypersensitivity, direct toxicity, and superinfections.
This document provides an overview of antimicrobial agents and antibiotics. It discusses the germ theory of disease, the timeline of antibiotic discovery, and classifications of antimicrobial agents. It describes different types of antimicrobial therapy including prophylaxis, empirical, and definitive therapy. Key concepts covered include bacteriostatic vs bactericidal agents, minimum inhibitory concentration, and principles of antibiotic dosing. The document also addresses factors influencing antimicrobial choice, problems with antimicrobial use including resistance, and Schedule HX regulations in India.
The document discusses various topics related to chemotherapy in infectious diseases including:
1. It defines chemotherapy as using chemicals to treat diseases caused by microorganisms. Antimicrobials kill or inhibit microorganism growth.
2. Antibiotics are a type of antimicrobial but not all antimicrobials are antibiotics. The first antibiotic, penicillin, was discovered by Alexander Fleming.
3. Antimicrobials can be classified based on their source, chemical structure, mechanism of action, and spectrum of activity.
4. Combination antimicrobial therapy and issues of antimicrobial resistance are also discussed.
Pk pd analysis and mic interpretation in microbiological reportsCentral Govt, India
1) PK/PD analysis and determining MIC values are important for optimizing antimicrobial therapy in critically ill patients. MIC breakpoints help guide therapy based on susceptibility.
2) Inappropriate antimicrobial therapy is common, especially for hospital-acquired infections, and is associated with increased mortality. Optimizing therapy based on PK/PD principles like maximizing time above MIC can improve outcomes.
3) Determining the MIC of pathogens is important to predict treatment success and interpret susceptibility results based on clinical breakpoints. Automated systems are commonly used to efficiently obtain MICs in clinical microbiology laboratories.
This document provides an overview of antibiotics, including their history, classification, mechanisms of action, and principles of administration. It discusses how antibiotics are classified based on their targets in bacteria and spectra of activity. Common antibiotics are also reviewed, along with how bacteria can develop resistance through modifications to antibiotic targets, altered uptake or efflux, and antibiotic inactivation through enzymes. Proper dosing, timing, route, and monitoring of patients are important to achieve the desired therapeutic effects of antibiotics.
The document discusses antibiotics, including their definition, types, mechanisms of action, and clinical uses. It defines antibiotics as substances obtained from microorganisms that can inhibit or kill other microorganisms. It describes two main types - broad spectrum antibiotics that affect a wide range of bacteria, and narrow spectrum antibiotics that affect a limited range. Antibiotics can be bacteriostatic, inhibiting bacterial growth, or bactericidal, killing bacteria. Key factors in antibiotic selection include the suspected bacteria, resistance patterns, safety, dosage, and cost. Common classes discussed are penicillins, cephalosoxins, and macrolides.
This document provides information about antibiotics. It begins by defining antibiotics and their uses in treating bacterial infections. It then discusses bacterial cell structure, important medically relevant bacteria including gram-positive and gram-negative organisms. The document also covers antibiotic classification based on mechanism of action, new classes of antibiotics, dosing considerations, and common antibiotics including penicillins, their uses, mechanisms of action, and side effects. It concludes with a brief discussion of antibiotic resistance.
This document discusses several key factors related to choosing and optimizing antimicrobial therapy. It addresses:
1) Host factors like medical history, age, pregnancy status that influence drug choice.
2) Pharmacologic considerations like a drug's absorption, distribution, toxicity profile.
3) Increasing emphasis on cost when multiple equally effective agents exist.
4) Interpreting culture results, the importance of susceptibility testing, and evaluating treatment failure.
The document discusses general principles of antimicrobial therapy and chemotherapy of infectious diseases. It covers topics such as the ideal properties of antimicrobial drugs, mechanisms of bacterial resistance, principles of antimicrobial selection and combination therapy. It also discusses appropriate and misuse of antimicrobial agents, highlighting the importance of judicious antibiotic use to prevent resistance.
This document discusses principles of antibiotic use in critical care. It notes that up to 50% of antibiotics prescribed are inappropriate and outlines consequences like increased resistance. The key principles for appropriate use are described as using the right antibiotic, at the right time, duration and dose based on the patient's condition and likely pathogens. Factors affecting pharmacokinetics and pharmacodynamics in critical illness are also reviewed to optimize dosing for better outcomes.
To understand the mechanisms of antimicrobial action and the classification of antimicrobial drugs.
To explain the process of microbial resistance.
To understand the spread of resistant microbes.
Outlines the prevention of microbial resistance.
Antimicrobial chemotherapy & bacterial resistance dr. ihsan alsaimarydr.Ihsan alsaimary
This document discusses antimicrobial chemotherapy and antibiotic principles. It covers the major classes of antibiotics including cell wall active agents, protein synthesis inhibitors, nucleic acid synthesis inhibitors, and metabolic pathway inhibitors. It describes their mechanisms of action, spectra of activity, and common resistance mechanisms. Key points covered include the importance of appropriate antibiotic usage to prevent resistance, factors influencing antibiotic choice, and definitions of antibiotic properties.
Antimicrobial chemotherapy & bacterial resistance dr. ihsan alsaimarydr.Ihsan alsaimary
This document discusses antimicrobial chemotherapy and antibiotic resistance. It provides definitions and principles related to antimicrobial agents, including their spectrum of activity, mechanisms of action against bacteria, and factors that influence antibiotic choice. The document addresses various classes of antibiotics like beta-lactams, glycopeptides, macrolides and their mechanisms. It also discusses concepts like minimum inhibitory concentration, combination therapy, and factors that can accelerate the development of antibiotic resistance.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
The document discusses antimicrobial agents and mechanisms of resistance. It covers several topics:
1. Definitions and classifications of antibiotics based on chemical structure, source, mechanism of action, and spectrum.
2. Mechanisms of antibiotic resistance in bacteria including production of enzymes to destroy drugs and genetic/non-genetic resistance.
3. Approaches to address rising antibiotic resistance such as appropriate use and preventing overprescription.
This document presents information on antimicrobial resistance (AMR). It defines AMR as microorganisms becoming resistant to antimicrobial drugs like antibiotics, antivirals, and antimalarials. The document discusses factors that contribute to AMR, including overuse of antibiotics. It describes mechanisms of resistance such as mutations, plasmids, and enzymes that inactivate drugs. It recommends strategies to control AMR like prudent antibiotic use, developing new drugs, and reducing unnecessary use in animals. The conclusion emphasizes that AMR is a global threat that requires strategies to prevent further resistance development.
1. chemotherapy principles and problems JagirPatel3
The objective of chemotherapy is to study and to apply the drugs that have highly selective toxicity to the pathogenic microorganisms in the host body and have no or less toxicity to the host, so as to prevent and cure infective diseases caused by pathogens
This document discusses principles of chemotherapy and antimicrobial drugs. It defines chemotherapy and different types of antimicrobials such as antibiotics, antimicrobials, antivirals etc. It describes sources of antimicrobial drugs and factors to consider for drug selection and administration like diagnosis, drug properties, and patient factors. It also covers classification of antimicrobials, mechanisms of drug resistance, problems of antimicrobial use, and advantages/disadvantages of combined drug use.
This document provides an introduction to principles of anti-microbial therapy. It discusses key topics including:
- Sir Alexander Fleming's discovery of penicillin in 1928.
- The definition of chemotherapy and agents used to treat infections and cancer.
- Factors considered in selecting appropriate anti-microbial agents, including the infecting organism, site of infection, and patient factors.
- Mechanisms of anti-microbial resistance that can develop, including genetic alterations in microbes and changes in target sites or drug accumulation.
- Complications of anti-microbial therapy like hypersensitivity, direct toxicity, and superinfections.
This document provides an overview of antimicrobial agents and antibiotics. It discusses the germ theory of disease, the timeline of antibiotic discovery, and classifications of antimicrobial agents. It describes different types of antimicrobial therapy including prophylaxis, empirical, and definitive therapy. Key concepts covered include bacteriostatic vs bactericidal agents, minimum inhibitory concentration, and principles of antibiotic dosing. The document also addresses factors influencing antimicrobial choice, problems with antimicrobial use including resistance, and Schedule HX regulations in India.
The document discusses various topics related to chemotherapy in infectious diseases including:
1. It defines chemotherapy as using chemicals to treat diseases caused by microorganisms. Antimicrobials kill or inhibit microorganism growth.
2. Antibiotics are a type of antimicrobial but not all antimicrobials are antibiotics. The first antibiotic, penicillin, was discovered by Alexander Fleming.
3. Antimicrobials can be classified based on their source, chemical structure, mechanism of action, and spectrum of activity.
4. Combination antimicrobial therapy and issues of antimicrobial resistance are also discussed.
Pk pd analysis and mic interpretation in microbiological reportsCentral Govt, India
1) PK/PD analysis and determining MIC values are important for optimizing antimicrobial therapy in critically ill patients. MIC breakpoints help guide therapy based on susceptibility.
2) Inappropriate antimicrobial therapy is common, especially for hospital-acquired infections, and is associated with increased mortality. Optimizing therapy based on PK/PD principles like maximizing time above MIC can improve outcomes.
3) Determining the MIC of pathogens is important to predict treatment success and interpret susceptibility results based on clinical breakpoints. Automated systems are commonly used to efficiently obtain MICs in clinical microbiology laboratories.
This document provides an overview of antibiotics, including their history, classification, mechanisms of action, and principles of administration. It discusses how antibiotics are classified based on their targets in bacteria and spectra of activity. Common antibiotics are also reviewed, along with how bacteria can develop resistance through modifications to antibiotic targets, altered uptake or efflux, and antibiotic inactivation through enzymes. Proper dosing, timing, route, and monitoring of patients are important to achieve the desired therapeutic effects of antibiotics.
The document discusses antibiotics, including their definition, types, mechanisms of action, and clinical uses. It defines antibiotics as substances obtained from microorganisms that can inhibit or kill other microorganisms. It describes two main types - broad spectrum antibiotics that affect a wide range of bacteria, and narrow spectrum antibiotics that affect a limited range. Antibiotics can be bacteriostatic, inhibiting bacterial growth, or bactericidal, killing bacteria. Key factors in antibiotic selection include the suspected bacteria, resistance patterns, safety, dosage, and cost. Common classes discussed are penicillins, cephalosoxins, and macrolides.
This document provides information about antibiotics. It begins by defining antibiotics and their uses in treating bacterial infections. It then discusses bacterial cell structure, important medically relevant bacteria including gram-positive and gram-negative organisms. The document also covers antibiotic classification based on mechanism of action, new classes of antibiotics, dosing considerations, and common antibiotics including penicillins, their uses, mechanisms of action, and side effects. It concludes with a brief discussion of antibiotic resistance.
This document discusses several key factors related to choosing and optimizing antimicrobial therapy. It addresses:
1) Host factors like medical history, age, pregnancy status that influence drug choice.
2) Pharmacologic considerations like a drug's absorption, distribution, toxicity profile.
3) Increasing emphasis on cost when multiple equally effective agents exist.
4) Interpreting culture results, the importance of susceptibility testing, and evaluating treatment failure.
The document discusses general principles of antimicrobial therapy and chemotherapy of infectious diseases. It covers topics such as the ideal properties of antimicrobial drugs, mechanisms of bacterial resistance, principles of antimicrobial selection and combination therapy. It also discusses appropriate and misuse of antimicrobial agents, highlighting the importance of judicious antibiotic use to prevent resistance.
This document discusses principles of antibiotic use in critical care. It notes that up to 50% of antibiotics prescribed are inappropriate and outlines consequences like increased resistance. The key principles for appropriate use are described as using the right antibiotic, at the right time, duration and dose based on the patient's condition and likely pathogens. Factors affecting pharmacokinetics and pharmacodynamics in critical illness are also reviewed to optimize dosing for better outcomes.
To understand the mechanisms of antimicrobial action and the classification of antimicrobial drugs.
To explain the process of microbial resistance.
To understand the spread of resistant microbes.
Outlines the prevention of microbial resistance.
Antimicrobial chemotherapy & bacterial resistance dr. ihsan alsaimarydr.Ihsan alsaimary
This document discusses antimicrobial chemotherapy and antibiotic principles. It covers the major classes of antibiotics including cell wall active agents, protein synthesis inhibitors, nucleic acid synthesis inhibitors, and metabolic pathway inhibitors. It describes their mechanisms of action, spectra of activity, and common resistance mechanisms. Key points covered include the importance of appropriate antibiotic usage to prevent resistance, factors influencing antibiotic choice, and definitions of antibiotic properties.
Antimicrobial chemotherapy & bacterial resistance dr. ihsan alsaimarydr.Ihsan alsaimary
This document discusses antimicrobial chemotherapy and antibiotic resistance. It provides definitions and principles related to antimicrobial agents, including their spectrum of activity, mechanisms of action against bacteria, and factors that influence antibiotic choice. The document addresses various classes of antibiotics like beta-lactams, glycopeptides, macrolides and their mechanisms. It also discusses concepts like minimum inhibitory concentration, combination therapy, and factors that can accelerate the development of antibiotic resistance.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central19various
Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa CentralClinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
2. OUTLINE
Introduction
Overview of antibiotics mechanism of action
Rationale use and choice of antibiotics.
Combination therapy.
Resistance to antibiotics
Summary
3. Introduction
Antibiotics are substances produced by various microorganisms ( or synthetic
agents ) that suppress growth of other microorganisms.
Among the most prescribed drugs.
Proper use can be life saving
Indiscriminate use: more cost of h/care, side effects, drug interactions and foster
emergence of drug resistance.
6. Rationale use of antibiotics
Is an antimicrobial agent indicated on the basis of clinical finding?
Have appropriate clinical specimens been obtained?
What are the likely etiologic agents for the patients illness?
What measures should be taken to protect individuals exposed to the index case to
prevent secondary cases?
Is there clinical evidence that antimicrobial therapy will confer clinical benefit for
the patient?
7. Choice of an antibiotic
To choose the appropriate antibiotic to use, one needs to consider:
1. Infectious agent.
2. Antimicrobial agent to use.
3. Host factors.
8. Factors affecting choice of an antibiotic
Host factors
Concomitant disease states (e.g immune status)
Prior adverse drug effects
Impaired elimination of the drugs
Age of the patient
Pregnancy status
9. Factors affecting choice of an antibiotics
Pharmacologic factors
Pharmacodynamics of the drug (concentration dependent vs. time dependent
killing)
Site of infection (BBB, vegetations in IE)
Toxicity of the agent
Interactions with other drugs
Bactericidal or bacteriostatic
Resistance patterns
10. Antibiotic therapy
Empirical therapy.
-Based on best guess guided by knowledge of likely pathogen in that site or clinical
setting.
-appropriate in life threatening infections, justified for by the hope that early
intervention will improve the outcome
Rx comm. Acquired infections e.g. CAP, UTI
-Once MCS results out change to specific agent
-Adv: immediate. Rx, short hosp. stay
-Disadv: use of many drugs, unnecessary S/E, good clinical acumen needed.
11. Empirical therapy: Approach
Formulate a clinical diagnosis of microbial infection
Obtain specimen for laboratory examination
Formulate a microbiologic diagnosis
Determine the necessity for empirical therapy
Institute treatment
12. Examples of empiric antibiotic therapy based on
microbiological aetiology
Suspected org. 1st choice Alternative drug
N. Gonorrhea Ceftriaxone Spectinomycin
N.Meningitidis Pen G Ceftriaxone
E.coli, klebsiella Septirin, Ceph, Quinolone, AG
Pseudomonas Antips+AG Antips+QN,CPH
S. Pneu Pen Cphl,macrldes,qnlns
V.Strep Pen Cphl, vanco
Enterococcus Pen+AG Vanc+AG
Clostrdm Metrndzle Vanc, bacitracin
13. Definitive therapy
-depend on susceptibility & sensitivity tests.
-requires isolation of the pathogen.
-requires knowledge of the MIC and MBC.
-Advantage: accuracy, cheaper
-Disadvantage: delay treatment, specimen may be difficult to get, varying
sensitivity patterns in different hospitals.
14. Methods of susceptibility tests
Broth microdilution
Microdilution
Agar dilution method
Disk diffusion test (Bauer Kurby procedure)
Susceptible
Intermediate
Resistant
15. Duration of therapy
Depends on:
the pathogen;
site of infection and
host factors.
16. Duration of Therapy for Bacterial Infections
Duration of
therapy
Infections
Single dose GU, Strep pharyngitis, prim and secondary syphilis
3 days Cystitis in young women, community/travel acquired dirrhea
3-10 days CAP(3-5days);CAM(pnemo or meningo);Antbtc assctd
diarrhea(10 days);cellulitis ;epididymitis
2 weeks H.Pylori assctd PUD; neurosyphilis; disseminated gon infctns;
acute pyelonephritis; Pen-suscptble VSE
3 weeks Lyme disease; septic arthritis (NG)
4 weeks Acut and chronic prostitis; IE (Pen resistant)
>4 weeks A and C ostemyltis; S.aureaus endocarditis; FB infections
17. Combination of antibiotics
USED
Provide broad-spectrum empiric therapy in seriously ill patients.
Treat polymicrobial infection such as intraabdominal abscess.
To decrease emergence of resistance strains.
To enhance antibacterial activity (synergy)
To use lower doses of a toxic drug
18. Antibiotic prophylaxis
Risk of infection must be greater than S/E of drugs
Shortest time possible
Primary or secondary prophylaxis
Surgical or nonsurgical prophylaxis
19. Antibiotic prophylaxis
Surgical
Contaminated and clean contaminated procedures
Operations in which postop infections may be catastrophic eg open heart
surgery
Placement of prosthetic materials
Procedures in imunocompromised pts.
Nonsurgical
Individuals at high risk for temporary exposure to selected virulant org.
Patients at increased risk for developing infection because of underlying
disease e.g immunocompromised pts
20. MISUSE OF ANTIBIOTICS
Treating FUO
Improper dosing
Inappropriate reliance on chemotherapy alone
Lack of adequate bacteriological information
22. RESISTANCE TO ANTIBIOTICS
Genetic determinants of resistance
Biochemical mechanisms of resistance
Current status of antibiotic resistance
Limiting resistance to antibiotics
23. Genetic determinant of Resistance
Chromosomal determinant
Spontaneous mutation rate in bacteria popn. For any particular gene very low
(1: 1000000)
In most org., resistance from chromosomal mutation not of great significance
coz mutants have decreased pathogenecity
Impo. in MRSA and mycobacterium infections - TB
24. Genetic determinant of Resistance
Extrachromosomal determinants
Plasmids: extra chromosomal genetic elements called plasmids that exist
free in the cytoplasm. These genetic elements can replicate on their own.
They are closed loops of DNA that consist of single gene or many genes.
Plasmids that carry genes for resistance for antibiotics (r genes) are called
R plasmids. Much drug resistance in clinical medicine is plasmid
mediated.
Transfer of r genes between bacteria take place in one of these form:
1. Transposons: stretches of DNA that can be transferred (transposed) from
one plasmid to another or plasmid to chromosome.
2. Conjugation: conjugate plasmids which cause bacteria to make a
connecting tube btn bacteria through which the plasmid or other plasmids
can pass.
3. Transduction: transmission of r gene-carrying plasmid by bacteriophage
(bacteria virus)
25.
26. BIOCHEMICAL MECHANISM OF RESISTANCE
TO ANTIBOITICS
1. Production of enzymes that inactivate the drug:B lactamase –penicillins,
cephalosporins, acetyltransferase –CAF
2. Alteration of drug sensitive site or binding site
-plasmid mediated alt 50s binding site-erythromycin
- alt of 30s subunit- amino glycoside (xsomal mutation)
3. Decreased drug accumulation in the bacteria
-active efflux of the drug: resistance to B lactams, amino glycosides, quinolones.
-plasmid mediated resistance to TCs through efflux of the TCs
4. Alteration of enzyme pathways
-plasmid mediated synthesis of DHFR with low affinity for trimethoprim.
27. Examples of antibiotic resistance
Enteroccocci:
B-lactam: b-lactamse enzyme
AG: enzymes that modify the drugs
Clindamycin:gene that effluxes the drug
Vancomycin: modified targets of vanco (low level and high level resistance)
28. Examples..ctd
MRSA
Many strains of staph now resistant to all currently available antibiotics.
Produce B-latamase –resist to B-lactams
-B-lactam binding protein –resist to methicillin
-staph also show resistance to other antibiotics:
streptomycic(alt of target site)
-CAF & macrolides, (change enzymes
-trim/sulfo,(DHFR, incr PABA)
-amino glycosides (alt target site)
-quinolones( decr uptake.
29. Summary
1. Make a diagnosis
as precisely as possible
state org. responsible and site of infection
2. Decide if chemotherapy is necessary: if no symptomatic rx. If yes:
3. Select best drug
4. Administer drug: best route, optimum dose , freq & duration.
5. Continue therapy until cured/improvement.
6. Test for cure/improvement. (clinical & lab.)
7. ? Prophylaxis & how long
EXAMPLE: IE