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The document discusses blood pressure regulation by the renin-angiotensin system including ACE, angiotensin II receptors, and renin. It covers the topics of ACE inhibitors, angiotensin receptor antagonists, and angiotensin receptor blockers. The learning outcomes include understanding how these drug classes work and predicting their metabolites based on their functional groups. Diagrams of example drugs from each class are provided to illustrate their structures.
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An English 🇬🇧 translation of a presentation to the speech I gave about the main changes brought by CCS TSI 2023 at the biggest Czech conference on Communications and signalling systems on Railways, which was held in Clarion Hotel Olomouc from 7th to 9th November 2023 (konferenceszt.cz). Attended by around 500 participants and 200 on-line followers.
The original Czech 🇨🇿 version of the presentation can be found here: https://www.slideshare.net/slideshow/hlavni-novinky-souvisejici-s-ccs-tsi-2023-2023-1695/269688092 .
The videorecording (in Czech) from the presentation is available here: https://youtu.be/WzjJWm4IyPk?si=SImb06tuXGb30BEH .
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Aces [compatibility mode]
- 1. 11/9/2010 ACE INHIBITORS, ANTAGONISTS & BLOCKERS Malina Jasamai Faculty of Pharmacy, UKM malina@pharmacy.ukm.my Blood pressure regulation by renin- angiotensin system - ACE - angiotensin II receptors - renin Regulation of aldosterone secretion BACKGROUND KNOWLEDGE Predicts metabolites produced by ACE inhibitors and angiotensin anatagonists Relates modification of functional groups with potency of ACE inhibitors and angiotensin anatagonists LEARNING OUTCOMES 1
- 2. 11/9/2010 Wilson & Gisvold’s textbook of organic Medicinal & pharmaceutical chemistry, 12th ed. Beale Jr., J.M. & Block, J.H., Lippincott Williams & Wilkins REFERENCES anthropology.net/2007/07/30/find...yme-ace/ ACE INHIBITORS Active site presumed to be the arginine residue - provide cationic site which attract carboxylate & zinc ions Side effects of rash & loss sense of taste with thiol containing compound ACE INHIBITORS 2
- 3. 11/9/2010 O O HO HO O O OH O N N H O Benzylsuccinic acid Ramipril O O HS O O N N N OH H O OH O Captopril Enalapril ACE INHIBITORS Losartan - nonpeptide drug - parent drug & metabolite both has high affinity fot T1. - acidic tetrazole involves in binding - biphenyl separates tetrazole from aliphatic N ANGIOTENSIN ANTAGONISTS Ibersartan - doesn’t possess acidic side chain Valsartan - COOH chain in valine moiety ANGIOTENSIN ANTAGONISTS 3
- 4. 11/9/2010 OH Cl O N N N N NH N NH N N N N N Losartan Ibersartan OH N O N NH N N O Valsartan ANGIOTENSIN ANTAGONISTS 4