This document proposes new approaches for data reduction in generalized multi-valued decision information systems (GMDIS). It introduces the concept of GMDIS, which generalizes rough set theory to allow attributes to take set values. Two relations are defined on condition and decision attributes to form new equivalence classes for reduction. The degree of dependency between attributes is also studied. As a case study, rheumatic fever patient data is converted to a GMDIS and new reduct algorithms are applied. The results show the new approach provides a more refined reduction of the data compared to traditional rough set methods.