God has closed the hearts, ears and eyes of some people, preventing them from understanding spiritual truths. As a result, they will not receive guidance from God and will be deprived. This verse from the Quran describes how God seals the hearts and senses of those who disregard divine signs and messages.

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God has sealed their hearts and ears, and
veiled their eyes. For them
is great deprivation.
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(Quran Surah 2, Ayah 7)