Jesse and Matty were brothers living in a small town in 1989. One night, Matty was attacked and taken by a pale creature while they were in the woods. Jesse found Matty again but he had red eyes and was making strange noises. In the present day, Sam and Dean investigate disappearances in the same town. They learn that similar events occurred 27 years ago, and 27 years before that. They meet Jesse, now 39, who witnessed his brother's abduction as a boy and has returned to town seeking revenge. Jesse and his partner Cesar explain that the creatures are Bisaan, which take over humans to mate. Sam, Dean, Jesse and Cesar track the Bisa