The premier of the second season of 'Metanomics,' hosted by Robert Bloomfield, features discussions on business and policy in virtual worlds, with highlights including an interview with Linden Lab founder Philip Rosedale. Bloomfield introduces new sponsors and a shift to a virtual replica of his office for filming, reflecting on the evolving landscape of virtual worlds and their implications. Notable segments include insights into participatory research conducted by guest Sisse Jensen, who explores interactions in virtual environments and the development of intelligent bots for social interaction in gaming contexts.