View course materials: openmi.ch/med-M1PatientsPopulations

1. Author(s): Gerald Abrams, M.D., 2009
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3. M1 Patients and Populations:
NEOPLASIA II
Gerald D. Abrams MD
Fall 2008

4. MICROSCOPIC FEATURES OF
NEOPLASMS
• CONCEPT OF STROMA /
ANGIOGENESIS
• CONCEPT OF DIFFERENTIATION
• GRADING / STAGING

5. CANCER CELLS AND STROMA
G.D. Abrams, University of Michigan Medical School

6. CANCER CELLS AND STROMA
SCIRRHOUS
G.D. Abrams, University of Michigan Medical School

7. NORMAL COLONIC MUCOSA
G.D. Abrams, University of Michigan Medical School

8. COLON CANCER, MODERATELY
DIFFERENTIATED
G.D. Abrams, University of Michigan Medical School

9. NORMAL BRONCHIAL MUCOSA
G.D. Abrams, University of Michigan Medical School

10. CANCER OF THE BRONCHUS
ANAPLASTIC
G.D. Abrams, University of Michigan Medical School

11. GRADING OF NEOPLASMS
• ASSESSMENT OF THE DEGREE OF
DIFFERENTIATION OF A NEOPLASM
• BASED ON THE RESEMBLANCE OF
THE NEOPLASM TO THE NORMAL
TISSUE OF ORIGIN

12. WELL DIFFERENTIATED
SQUAMOUS CELL CARCINOMA
G.D. Abrams, University of Michigan Medical School

13. MODERATELY DIFFERENTIATED
SQUAMOUS CELL CARCINOMA
G.D. Abrams, University of Michigan Medical School

14. POORLY DIFFERENTIATED
SQUAMOUS CELL CARCINOMA
G.D. Abrams, University of Michigan Medical School

15. STAGING OF NEOPLASMS
• ASSESSMENT OF THE EXTENT OF
PROGRESSION OF A NEOPLASM IN THE
BODY
• BASED ON THE SIZE AND EXTENT OF THE
PRIMARY, AND ON THE PRESENCE OR
ABSENCE OF REGIONAL AND DISTANT
METASTASES

16. HISTOPATHOLOGIC DIAGNOSIS
OF NEOPLASMS
• DIAGNOSIS AS A PREDICTION
• EVALUATION OF:
-ARCHITECTURAL ARRANGEMENT
-RELATION OF NEOPLASTIC CELLS
TO NORMAL SURROUNDINGS
-CYTOLOGIC FEATURES OF
NEOPLASTIC CELLS

17. INVASION
G.D. Abrams, University of Michigan Medical School

18. NORMAL COLONIC EPITHELIAL
CELLS
G.D. Abrams, University of Michigan Medical School

19. NEOPLASTIC COLONIC
EPITHELIAL CELLS
G.D. Abrams, University of Michigan Medical School

20. NORMAL SQUAMOUS
EPITHELIUM
G.D. Abrams, University of Michigan Medical School

21. DYSPLASTIC SQUAMOUS
EPITHELIUM
G.D. Abrams, University of Michigan Medical School

22. CARCINOMA IN SITU
G.D. Abrams, University of Michigan Medical School

23. CELLULAR FEATURES
OF ANAPLASIA
G.D. Abrams, University of Michigan Medical School

24. PAP SMEAR
NORMAL CELLS
G.D. Abrams, University of Michigan Medical School

25. PAP SMEAR
MALIGNANT CELLS
G.D. Abrams, University of Michigan Medical School

26. NEOPLASIA III
Gerald D. Abrams

27. CLINICAL CONSEQUENCES
OF NEOPLASMS
BENIGN
LOCAL MECHANICAL EFFECTS
LOCAL COMPLICATIONS
SYSTEMIC ENDOCRINE EFFECTS
MALIGNANT
ALL OF THE ABOVE
CANCER CACHEXIA
PARANEOPLASTIC SYNDROMES

28. NOMENCLATURE OF
NEOPLASMS
• BASED ON
TISSUE OF ORIGIN
BENIGN OR MALIGNANT

29. EPITHELIAL NEOPLASMS
• ADENOMA!!!ADENOCARCINOMA
• PAPILLOMA...PAPILLARY CARCINOMA
• CYSTADENOMA.....
CYSTADENOCARCINOMA

30. ADRENAL CORTICAL ADENOMA
Source Undetermined

31. PANCREAS, ISLET CELL
ADENOMA
Department of Pathology, University of Michigan

32. COLON, ADENOMA
Department of Pathology, University of Michigan

33. COLON, ADENOMA
Department of Pathology, University of Michigan

34. Image of sketch
of papilloma
removed

35. OROPHARYNX, PAPILLOMA
G.D. Abrams, University of Michigan Medical School

36. OVARY
CYSTADENOMA
Source Undetermined

37. OVARY
CYSTADENOMA
Source Undetermined

38. PENIS, SQUAMOUS CELL
CARCINOMA
Source Undetermined

39. VULVA, SQUAMOUS CELL
CARCINOMA
Source Undetermined

40. CERVIX, SQUAMOUS CELL
CARCINOMA
Source Undetermined

41. TONGUE, SQUAMOUS CELL
CARCINOMA
Department of Pathology, University of Michigan

42. LARYNX, SQUAMOUS CELL
CARCINOMA
Source Undetermined

43. ESOPHAGUS, SQUAMOUS CELL
CARCINOMA
Department of Pathology, University of Michigan

44. STOMACH, ADENOCARCINOMA
Source Undetermined

45. COLON, ADENOCARCINOMA
Department of Pathology, University of Michigan

46. COLON, ADENOCARCINOMA
Source Undetermined

47. LUNG, SQUAMOUS CELL
CARCINOMA
Source Undetermined

48. LUNG, SQUAMOUS CELL
CARCINOMA
Department of Pathology, University of Michigan

49. BRONCHUS, SQUAMOUS CELL
CARCINOMA
Department of Pathology, University of Michigan

50. BRONCHUS, SQUAMOUS CELL
CARCINOMA
Department of Pathology, University of Michigan

51. OVARY
CYSTADENOCARCINOMA
Source Undetermined

52. OVARY
CYSTADENOCARCINOMA
Source Undetermined

53. SUPPORTING TISSUE
NEOPLASMS
• LIPOMA!!!!LIPOSARCOMA
• CHONDROMA!CHONDROSARCOMA
• FIBROMA!!! FIBROSARCOMA
• OSTEOMA!! OSTEOSARCOMA
ETC

54. COLON, LIPOMA
Department of Pathology, University of Michigan

55. UTERUS, LEIOMYOMAS
Department of Pathology, University of Michigan

56. BONE, OSTEOSARCOMA
Department of Pathology, University of Michigan

57. MUSCLE,
RHABDOMYOSARCOMA
Department of Pathology, University of Michigan

58. LYMPHOID / HEMATOPOIETIC
NEOPLASMS
• LYMPHOMA(S)
• LEUKEMIA(S)

59. LYMPHOMA
Source Undetermined

60. RETROPERITONEUM,
LYMPHOMA
Department of Pathology, University of Michigan

61. SPLEEN, LYMPHOMA
Department of Pathology, University of Michigan

62. KIDNEY, LYMPHOMA
Department of Pathology, University of Michigan

63. CNS NEOPLASMS
• MENINGIOMA
• GLIOMA

64. BRAIN, GLIOMA
Department of Pathology, University of Michigan

65. NEOPLASMS WITH MIXED
DIFFERENTIATION
• CARCINOSARCOMA
• TERATOMA
BENIGN
MALIGNANT

66. OVARY, TERATOMA
Department of Pathology, University of Michigan

67. OVARY, TERATOMA
Department of Pathology, University of Michigan

68. OVARY, TERATOMA
Department of Pathology, University of Michigan

69. Additional Source Information
for more information see: http://open.umich.edu/wiki/CitationPolicy
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Slide 30: Source Undetermined
Slide 31: Department of Pathology, University of Michigan
Slide 32: Department of Pathology, University of Michigan
Slide 33: Department of Pathology, University of Michigan
Slide 35: G.D. Abrams, University of Michigan Medical School
Slide 36: Source Undetermined
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70. Slide 49: Department of Pathology, University of Michigan
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