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Left Main and Multivessel PCI
Arasi Maran MD, FSCAI, FACC
Associate Professor of Medicine
Director of Coronary CTO Program
Medical University of South Carolina
Ralph H Johnson VA Medical Center
Charleston SC
Within the past 12 months, I or my spouse/partner have had a
financial interest/arrangement or affiliation with the organization(s)
listed below.
Affiliation/Financial Relationship Company
Consulting Fees/Honoraria Boston Scientific, Teleflex,
Medtronic, Shockwave
Disclosure Statement of Financial Interest
Faculty disclosure information can be found on the app
Case 1
• 77yr old with ESRD, Chest Pain during HD
• NSTEMI with normal EF, mild AS
• LHC – Severe ostial Left main
• CT Surgery – 25% mortality with ESRD
• Came back to the cath lab
DIAGNOSTIC CATH
IVUS
PCI - Plan
Femoral access
– issues with
left main
engagement
Wolverine
Cutting balloon
NC Balloon
IVUS Stent IVUS
3.5 Wolverine
4.0 NC Balloon
Post Wolverine and NCB
Stent Placement
4.0 Megatron
Conclusions for Case 1
• Intravascular imaging is key to plan for a complex case
• Not technically complex, but hemodynamics can get tricky
• Wolverine is a great tool for managing superficial calcium,
ostial disease
• Trust intravascular imaging and Hemodynamics
Case II
49 yr old WM with
H/O Recurrent
Necrotizing
Pancreatitis
Disconnected
Pancreas with
Pancreatic stent
in place
H/O Alcohol
abuse
Chronic Kidney
disease
NSTEMI
presentation
3 V disease
CT Surgery
Turndown
Labs
4/2022
Echo: 4/11/2022 <20%
Bun/Cr -30/1.5, eGFR >60
BNP 2278
HbA1 C 7.0
• Evaluated in 6/2022
• Started on DAPT
• On GDMT
Discussion
Distal Left Main
Long LAD lesion
Long Cx Lesion
Calcium
Low EF
High risk of bleeding
Short DAPT
• MCS
• Atherectomy choice
• Access
• Stent strategy
My Plan
RHC
MCS based on
numbers
IVUS
SWL if balloon
delivers
If not
atherectomy
Double Stent
Strategy for Left
Main Bifurcation
Swan Numbers:
CO/CI:
TD- 4.27/2.11
Fick- 3.57/1.77
Pa sat- 45%
• Access – 6/7 Fr
Terumo sheath
• Guide: 7 Fr
EBU 3.75
• LAD wire –
Runthrough
• IVUS – could
not cross
1.75 Burr
2.75x20 & 3x30 DES
Circumflex
3x12 SWL
• 3x20 NC
Balloon
3x12 SWL
3x230NC
Mid LAD 3x38
Left Main to mid LAD 4x38
Kiss POT
Final Angiogram
FU Echo in 3 mos – EF – 42%
Conclusions
Follow Hemodynamics
Jumping to Highest
MCS is not ‘latest’
anymore
Combining strategies –
Atherectomy, Cutting
balloon & Lithotripsy
Case III
• 91yr old with 87yr old wife to clinic to discuss PCI options
• Worsening dyspnea on exertion and LE edema
• PMH: Atrial fibrillation, Asthma, Tobacco abuse
• Echo and Coronary Calcium score -1655---LHC
• Meds: Aspirin , Atorvastatin, Lopressor 25 mg BID, Warfarin,
Inhalers
Vital Signs
135/102/23
-----------------
4.4/ 25 /1.2
BP = 150/94
O2 Sat – 100%
Ht -6 Fr Wt – 72 Kg
Echo
EF of 72%
Severe biatrial
enlargement
AVA -1.1sq cm
Mean gradient
of 14. mm of
Hg
Max pg - 27
Peak velocity
of 2.61m/s
Moderate TR,
RVSP – 36 mm
of Hg
Factors To Consider
• Poor visualization of the bifurcation
• Need for atherectomy in the setting of HR of 45 BPM
• Moderate AS
• Normal EF
• Frailty
Single access
Impella CP
6/7 Terumo sheath
7 Fr EBU 3.5
Extremely
tortuous iliacs
Dilated aorta
Very tight/guide-
kinks
Take Home Points
• Iliac tortuosity can be a major issue with single access via
Impella sheath
• Intravascular imaging
• Shockwave Lithotripsy can be used to modify plaque at
bifurcation points
• Occlusion balloon technique is extremely useful to wire vessel
take off at difficult angles
• Sometimes – walk away with the simplest strategy
Cautionary Tale
• 59yr old
• Indian male
• Works in our hospital
• Typical Angina
• Stress Test – Anterior ischemia
• Normal EF
• Known Elevated Ca Score
Cautionary Tale
Cautionary Tale
Final Take Home Points – Left Main/Multivessel
PCI
• Failing to Planning = Planning to fail
• Review – Alone, With another partner, Find another partner
• Make Plan A
• Then make plan B and then Plan C
• Figure out your back up person
• Do not forget your documentation – risk benefit ratio, alternate
treatment options
It is Okay
• Despite your best efforts,
outcome was devastating if
• You did it for the right
reason
• You have done due
diligence
• You learn from what you
missed.
Thank You
• maran@musc.edu
• @arasimaran
• 843-303-1897

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6d13ad17-73dc-4a10-9b7b-f5e806dcdf2f.pdf

  • 1. Left Main and Multivessel PCI Arasi Maran MD, FSCAI, FACC Associate Professor of Medicine Director of Coronary CTO Program Medical University of South Carolina Ralph H Johnson VA Medical Center Charleston SC
  • 2. Within the past 12 months, I or my spouse/partner have had a financial interest/arrangement or affiliation with the organization(s) listed below. Affiliation/Financial Relationship Company Consulting Fees/Honoraria Boston Scientific, Teleflex, Medtronic, Shockwave Disclosure Statement of Financial Interest Faculty disclosure information can be found on the app
  • 3. Case 1 • 77yr old with ESRD, Chest Pain during HD • NSTEMI with normal EF, mild AS • LHC – Severe ostial Left main • CT Surgery – 25% mortality with ESRD • Came back to the cath lab
  • 6. PCI - Plan Femoral access – issues with left main engagement Wolverine Cutting balloon NC Balloon IVUS Stent IVUS
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  • 14. Conclusions for Case 1 • Intravascular imaging is key to plan for a complex case • Not technically complex, but hemodynamics can get tricky • Wolverine is a great tool for managing superficial calcium, ostial disease • Trust intravascular imaging and Hemodynamics
  • 15. Case II 49 yr old WM with H/O Recurrent Necrotizing Pancreatitis Disconnected Pancreas with Pancreatic stent in place H/O Alcohol abuse Chronic Kidney disease NSTEMI presentation 3 V disease CT Surgery Turndown
  • 16. Labs 4/2022 Echo: 4/11/2022 <20% Bun/Cr -30/1.5, eGFR >60 BNP 2278 HbA1 C 7.0 • Evaluated in 6/2022 • Started on DAPT • On GDMT
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  • 21. Discussion Distal Left Main Long LAD lesion Long Cx Lesion Calcium Low EF High risk of bleeding Short DAPT • MCS • Atherectomy choice • Access • Stent strategy
  • 22. My Plan RHC MCS based on numbers IVUS SWL if balloon delivers If not atherectomy Double Stent Strategy for Left Main Bifurcation
  • 24. • Access – 6/7 Fr Terumo sheath • Guide: 7 Fr EBU 3.75 • LAD wire – Runthrough • IVUS – could not cross
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  • 27. 2.75x20 & 3x30 DES Circumflex 3x12 SWL
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  • 31. Mid LAD 3x38 Left Main to mid LAD 4x38
  • 34. FU Echo in 3 mos – EF – 42%
  • 35. Conclusions Follow Hemodynamics Jumping to Highest MCS is not ‘latest’ anymore Combining strategies – Atherectomy, Cutting balloon & Lithotripsy
  • 36. Case III • 91yr old with 87yr old wife to clinic to discuss PCI options • Worsening dyspnea on exertion and LE edema • PMH: Atrial fibrillation, Asthma, Tobacco abuse • Echo and Coronary Calcium score -1655---LHC • Meds: Aspirin , Atorvastatin, Lopressor 25 mg BID, Warfarin, Inhalers
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  • 38. Vital Signs 135/102/23 ----------------- 4.4/ 25 /1.2 BP = 150/94 O2 Sat – 100% Ht -6 Fr Wt – 72 Kg
  • 39. Echo EF of 72% Severe biatrial enlargement AVA -1.1sq cm Mean gradient of 14. mm of Hg Max pg - 27 Peak velocity of 2.61m/s Moderate TR, RVSP – 36 mm of Hg
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  • 43. Factors To Consider • Poor visualization of the bifurcation • Need for atherectomy in the setting of HR of 45 BPM • Moderate AS • Normal EF • Frailty
  • 44. Single access Impella CP 6/7 Terumo sheath 7 Fr EBU 3.5
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  • 61. Take Home Points • Iliac tortuosity can be a major issue with single access via Impella sheath • Intravascular imaging • Shockwave Lithotripsy can be used to modify plaque at bifurcation points • Occlusion balloon technique is extremely useful to wire vessel take off at difficult angles • Sometimes – walk away with the simplest strategy
  • 62. Cautionary Tale • 59yr old • Indian male • Works in our hospital • Typical Angina • Stress Test – Anterior ischemia • Normal EF • Known Elevated Ca Score
  • 65. Final Take Home Points – Left Main/Multivessel PCI • Failing to Planning = Planning to fail • Review – Alone, With another partner, Find another partner • Make Plan A • Then make plan B and then Plan C • Figure out your back up person • Do not forget your documentation – risk benefit ratio, alternate treatment options
  • 66. It is Okay • Despite your best efforts, outcome was devastating if • You did it for the right reason • You have done due diligence • You learn from what you missed.
  • 67. Thank You • maran@musc.edu • @arasimaran • 843-303-1897