1. Quantitative Proteomics of Different Zones
in Articular Cartilage Reveals Unique
Patterns of Protein Distribution
Molecular Skeletal Biology
Lund University, Sweden
Patrik Önnerfjord
Provided by: Patrik Önnerfjord

2. Protein distribution between tissues
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1
1
2
2
3
Aggrecan
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2
4
6
8
Lubricin
Önnerfjord et al, J. Biol. Chem. in press 2012
RatiovsREF
RatiovsREF
0
1
1
2
2
3
Chondroadherin
0
1
2
3
4
5
Asporin
RatiovsREF
RatiovsREF
Provided by: Patrik Önnerfjord

3. Conclusions
• Quantitative proteomics can identify
difference in protein patterns between
cartilage subtypes
• Quantitative proteomics can identify
difference in protein patterns within one
cartilage (e.g. layers from articular cartilage)
• Targeted proteomics can be applied for
highest sensitivity
Provided by: Patrik Önnerfjord