1. Dsh
Sclerostin
Wnt
TCF
β-catenin
PAPC
Axin
GSK3
FrizzledLrp5/6 Bone remodeling plays a role in cartilage
homeostasis (Funck-Brentano et al, 2011)
Role of Sclerostin in cartilage
maintenance and in OA ?
Nucleus
Sclerostin is a main regulator of bone formation
Wnt in Bone and Cartilage
Provided by: Wafa BouazizProvided by: Wafa Bouaziz
2. Mature
chondrocyte
Hypertrophic
chondrocyte
Wnt3a
Wnt3a
Col X
Col II, SOX9 and Aggrecan
ADAMTS-4 & 5, MMP3 and MMP13
Sclerostin
Sclerostin
Summary
Sclerostin preserves chondrocyte maintenance by the inhibition of
chondrocyte catabolism and hypertrophy.
Wnt and its antagonists might be promising targets in studying
cartilage homeostasis in osteoarthritis.
Provided by: Wafa Bouaziz
Editor's Notes
Wnt is regulated by endogenous antagonists among them Sclerostin which is a protein mainly produced by osteocytes. Many studies show an effect of bone remodeling on cartilage homeostasis. Therefore, in the present work, we assess the role of Sclerostin in cartilage maintenance and in OA.
Inhibition of the Wnt/B-catenin pathway by Sclerostin abolished the metalloproteinases increase induced by wnt and had a slight effect on the differentiation gene regulation. And finally Sclerostin was able to inhibit the hypertrophic phenotype induced by Wnt.
