Curcumin is a anticancer agent, it can shows anti-angiogenesis activity.

1. Curcumin Anti-cancer agent
Mr. Sagar Kishor Savale
M. Pharm (Pharmaceutics)
Mr. Sagar Kishor Savale

2. Curcumin

3. Mr. Sagar Kishor Savale

4. Mr. Sagar Kishor Savale

5. Biological Source: The isolation of a “yellow coloring-matter”
from the rhizomes of Curcuma longa (turmeric) and named as
Curcumin, which is a member of the ginger family
(Zingiberaceae).
Mr. Sagar Kishor Savale

6. Mr. Sagar Kishor Savale

7. Curcumin
Mr. Sagar Kishor Savale

8. Biosynthesis of Curcumin
Mr. Sagar Kishor Savale

9. Chemical ConstituentsMr. Sagar Kishor Savale

10. Chemical Name (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6 heptadiene-3,5-dione
Synonyms Polyphenols
Molecular Formula C21 H20 O6
Molecular Weight 368.39 g/mol
Density 1.28 g/cm3
Log P/ hydrophobicity 1.82
pKa 8.3±0.04
Refractive Index n20
D 1.42
Solubility Slightly Soluble in Water, Soluble in Ethanol and Methanol (10 mg/ml), DMSO (25 mg/ml), acetic acid,
0.1M NaOH, acetone, water (< 0.1 mg/ml).
BCS Class Class II
λmax Methanol: 430 nm
Appearance Bright yellow-orange powder
Physical State Solid Powder
Melting point 175°C
Identification Melting point, infrared absorption spectrophotometry (IR), Differential scanning Calorimetry (DSC)
Mr. Sagar Kishor Savale

11. Dose and dosing frequency: Up to 12 gm per day.
Bioavailability: The mean oral bioavailability of curcumin is 2% due mainly to hepatic first
pass metabolism.
Plasma Protein binding: 90 %
Plasma half-life: 11 hrs.
Mr. Sagar Kishor Savale

12. Mr. Sagar Kishor Savale

13. Mechanisam action of Curcumin
(Anti-cancer activity)
Mr. Sagar Kishor Savale

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16. Mr. Sagar Kishor Savale

17. Mr. Sagar Kishor Savale

18. Mr. Sagar Kishor Savale

19. Mr. Sagar Kishor Savale

20. Mr. Sagar Kishor Savale

21. Mr. Sagar Kishor Savale

22. Mr. Sagar Kishor Savale

23. Mr. Sagar Kishor Savale

24. Mr. Sagar Kishor Savale

25. Mr. Sagar Kishor Savale

26. Contact:
savalesgar484@gmail.com
+91 9960885333