Name of organization: ABC Technologies, LLC Project participant No. 1120077 dated 3/20/2012 Innovation project name: Development and Productization of Orthopedic Trauma 3D Implants Skolkovo Foundation Resident No. 414 Skolkovo Industrial Park Resident No. 14 Sarov Industrial Park Resident

1. 3D OSTEO LIFE
«Development and commercialization of orthopedic
traumatology 3D implants»

2. 1. Company
Skolkovo Foundation Resident No. 414
Skolkovo Industrial Park Resident No. 14
Sarov Industrial Park Resident
Ph: +7 (495) 28-0000-1 p5070
Ph: +7 (495) 7-43-43-45
e-mail: abc@3d-medicina.ru
Company information on the Internet:
www.3d-medicina.ru
Development and commercialization of orthopedic traumatology 3D implants

3. PROBLEMS OF PATIENTS WITH COMPLEX FRACTURES
Unstable
fixation in 60%
Duration of disability
patients with complex
fractures of the 3-9
months
The bones
deformation in
30%
With traditional
implants, the risk of
becoming disabled is
up to 60%
Development and commercialization of orthopedic traumatology 3D implants

4. 2. Innovative Project Summary (hereinafter - Project)
Product:
 All-purpose, anatomic, three-plane 3D implants
made of titanium alloy for surgical treatment of
human bone fractures, which have no analogues in
the world;
Project Objectives:
 Improving health, quality and the duration of
human life;
 Active introduction of the innovative development
of Russian scientists and health professionals –
high-tech 3D implants – on the market of medical
trauma and orthopedic implants;
 Creating a range of competitive fixators;
 Expansion into international markets.
Development and commercialization of orthopedic traumatology 3D implants

5. 3D PLATES (IMPLANTS). ABSOLUTE ANATOMICAL
THE MAIN ADVANTAGES: -developed on the natural
human bones;
HIGH BIOCOMPATIBILITY -symmetrical to the right and
The use of special medical titanium Ti6Al7Nb provides high left parts of the skeleton;
biocompatibility implant tissues of the human body without -differ by gender patients
the risk of the onset of tissue oxidation (metallosis) and the (male and female);
development of chronic intoxication with heavy metals. -vary in height of the patient
Reducing the time and complexity of surgery plates
previously modeled, reducing the time of surgery for 30 -
60 minutes depending on the type of fracture.
Possibility of early function, reduced disability time by 2-3
times, reducing the risk of invalidity
No need to apply plaster after surgery
Frame shape of the plates and anatomical geometry
retaining elements provide stability to reconcile fracture
consolidation period to the period of rehabilitation
patients, which is an effective measure to prevent the
disabling contractures and ankylosis.
Development and commercialization of orthopedic traumatology 3D implants

6. 2. Innovative Project Summary (hereinafter - Project)
Current Project Status:
• So far, one of the products planned for
production and sale "3D Crab" plate has been
introduced.
• "3D Crab" plate has been developed based on
the model of comminuted intraarticular
fractures of the distal humeral metaepiphysis.
• Fixator was centrally purchased: in
Arkhangelsk Region, by the N.V. Sklifosovsky
Research Institute of Emergency Medicine
(Moscow), and N.I. Pirogov City Clinical
Hospital No. 1. (Moscow). It is also being used
at the clinic of the Traumatology, Orthopedics
and Field Surgery Department at the Moscow
State University of Medicine and Dentistry
(City Clinical Hospital No. 59, Moscow), and at
the Russian Railways, LLC Hospital at the
Lyublino Station (Moscow).
Development and commercialization of orthopedic traumatology 3D implants

7. 3. Target Market and Competition
Competitive Advantages:
 Product uniqueness lies in the possibility of reducing the
disability times for patients with fractures (3-5 times
shorter) and the risk of disability by 30-70%.
 Comparison with competitive products (SYNTHES;
KONIGSEE; STRYKER; ChM; OSTEOSYNTHESIS):
competitive retail price; strength (kN) is 2 times higher;
the number of screws needed for fixation is 2 times
smaller; surgeries are 30-90 minutes shorter; minimum
need for modeling; recovery period is 3-5 times shorter;
patient disability period is 3-5 times shorter; the risk of
disability in patients is 30-70% lower.
Development and commercialization of orthopedic traumatology 3D implants

8. 3. Target Market and Competition
Comparison with competitors' products on the key
parameters:
Manufacturer Model
Surgery Recovery
Product RF market Strength No. of ing
Price ($) time period
name share (kN) screws +++
(min) (weeks)
country ++
Osteosynthesis
62% of the +++
1,6 35 16 120 - 180 10-14
market ++
Russia
Plates SYNTHES
with 21% of the RF
angular 1,9 29 16 120 - 180 8-14 +++
market
stability Switzerland
KONIGSEE
7% of the RF
1,7 25 12 120 - 180 10-14 ++
market
Germany
ABC
3D
Technologies 2-5 65 8 60 - 90 2-4 -
implants
Russia
Development and commercialization of orthopedic traumatology 3D implants

9. 3. Target Market and Competition
Similar product development:
 Currently, there are no analogues in the world;
 Existing products on the market are not 3D implants;
 Virtually 100% of the market is occupied by regular
linear and pre-modeled plates.
Potential consumers of 3D implants are:
 Patients and their relatives;
 Orthopedic trauma hospitals;
 Private clinics and surgical centers;
 Departmental agencies;
 Army.
Development and commercialization of orthopedic traumatology 3D implants

10. 3. Target Market and Competition
Commercialization scheme:
• Maintaining a competitive market value of the product;
• Creating Sales Offices with a complete set of the
necessary equipment to ensure individual design and
development of implants in all major cities
• Creating an Internet Sales Center to possibly provide
free on-line consultations with the leading
traumatologists using scanned images or 3D CT scans;
• Company's product range allows us to satisfy more
than 60% of the consumer needs.
• Sale of technology (license)
Development and commercialization of orthopedic traumatology 3D implants

11. 4. Project Geography
China EU
1,349,718,000 € 502,000,000 €
India Russia
1,222,172,000 € 143,000,000 €
USA Japan
313,328,000 € 127,000,000 €
Indonesia Mexico
245,612,000 € 112,000,000 €
Brazil Annual market volume Vietnam
195,962,000 € 7,000,000,000 € 90,500,000 €
The project has a broad geographical application as trauma care is provided in
all major cities of the World. According to statistics, every year one out of
1,000 people receives bone implant.
Average implant price = 1,000 €
Development and commercialization of orthopedic traumatology 3D implants

12. 5. SWOT Analysis – Strengths – Russia
Preferences in NO TAXES GR and PR resource
national sales Benefits for Skolkovo Foundation
under the brand Skolkovo YIC Sarov
name “Made in participants Russian Association
Skolkovo” of Industrial Parks
Authority of the
developers and HIGH SOCIAL
positive image of IMPORTANCE
the product
Development Reducing surgery
strategy duration and
Implants: 75% R&D traumatic effect
ups and downs by half
Development and commercialization of orthopedic traumatology 3D implants

13. 5. SWOT Analysis – Possibilities
MEDICAL Competitive price
EDUCATION Dealers network
(bulk sale)
Internet Sales LICENSE TO
Center in all MANUFACTURE
major languages MEDICAL
of the World PRODUCTS
PRODUCT RANGE
3D, 2D and 1D MATERIAL
implants and Bioinert
screws titanium
Development and commercialization of orthopedic traumatology 3D implants

14. 5. SWOT Analysis – Weaknesses and Threats
Lack of material and Presence of foreign
technical base competitors in the
market
Competitors with
unfair marketing
policy (kickbacks)
Development and commercialization of orthopedic traumatology 3D implants

15. 6. Technology and Intellectual Property
Innovation Description:
 3D implants are anatomic and solid in structure and can
provide even distribution of appendicular bone joints weight
bearing thanks to multiplane fixation (screws are inserted in
all 3 planes - x, y and z - of the three-dimensional coordinate
system);
 Angular stability in 3 planes ensures absolute stability of
fracture fixation. Plates are symmetrical for left and right
skeleton regions, have six standard sizes, are differentiated
by gender and race depending on the width of
metaepiphyseal regions, and combine all the positive
features of the traditionally used fixators (diaphyseal,
metaphyseal, reconstruction plates, etc.).
Development and commercialization of orthopedic traumatology 3D implants

16. 6. Technology and Intellectual Property
Patents obtained
• RF Patent PM No. 66183 "Fixator for osteosynthesis of
distal humeral fractures,"
• RF Patent PM No. 104445 "Fixator for tibia
osteosynthesis."
• RF Patent PM 116335 "Fixator for treatment of
fractures of the distal radial metaepiphysis."
• RF Patent PM 116340 "Fixator for osteosynthesis of
proximal tibia fractures"
Patent applications
•  pplication for RF patent PM No. 2011145082 dated
A
11/8/2011 "Fixator for osteosynthesis of distal
humeral lateral fractures (outer epicondyle and
trochlea of humerus)";
• Application for RF patent PM No. 2011145083 dated
11/8/2011 "Fixator for osteosynthesis of proximal
femoral fractures (basilar, pertrochanteric and
subtrochanteric fractures)";
• Application for RF patent PM No. 2011146436 dated
11/17/2011 "Fixator for osteosynthesis of fractures of
the proximal humeral metaepiphysis";
Development and commercialization of orthopedic traumatology 3D implants

17. PLATE «CRAB 3D»
We have developed and successfully introduced into clinical practice innovative implant
"Crab plate 3D". This clip has reduced the period of rehabilitation of patients with fractures of the distal
humerus in 5 times (14-20 days instead of 70-100 days). Successfully carried out more than 50 surgery.
Development and commercialization of orthopedic traumatology 3D implants

18. Development and commercialization of orthopedic traumatology 3D implants

19. Clinical example: patient S-ova O.S., 40 years old (case number 4988/10, Moscow City
Clinical Hospital № 59). Diagnosis: internal multisplintered metaepifizarny fracture of
the distal part of the left humerus with displacement of bone fragments - Type 13 C 3
(AO / ASIF).
Development and commercialization of orthopedic traumatology 3D implants

20. Pictures in the surgery and
after surgery radiograph
the same patient
Development and commercialization of orthopedic traumatology 3D implants

21. Functional outcome in 10 days after surgery
Control examination in 6 weeks after surgery
Development and commercialization of orthopedic traumatology 3D implants

22. Analysis of the traditional techniques of
surgical treatment
plate bone failure of union
fracture fracture in fracture
bone
deformation
unstable
osteosynthesis
Development and commercialization of orthopedic traumatology 3D implants

23. 7. Project Team
A
 leksej Babovnikov of the contest of young scientists
Director General – PhD (MK-2006) for the Grant
M.D.,Professor - Traumatology, from the President of the Russian
Orthopedics and Field Surgery Federation
Department at the Moscow State Dmitri Rubekin
University of Medicine and irector of Development
D
Dentistry Business angel
uthor of 99 studies, 10 RF
A Serial entrepreneur
patents and 1 monograph; winner
Development and commercialization of orthopedic traumatology 3D implants