Leukemia is a type of cancer that results from an uncontrolled increase in white blood cells in the bone marrow. It was first discovered in 1845 in Edinburgh by John Hughes Bennett. Leukemia is the most common cancer in children under 15, with around 256,000 new cases of leukemia diagnosed in children and adults worldwide in 2000. There are different types of leukemia depending on the affected cell population and severity. While the cause is unknown, risk factors include radiation, chemotherapy, genetic syndromes, family history, and radiation exposure. Common symptoms include decay, fever, joint pain, and pallor. Treatment involves chemotherapy through oral, intravenous or intralateral routes as well as radiotherapy and bone marrow transplantation.