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INVESTOR FACT SHEET
  Period ended June 30, 2012




Corporate profile                                                                                                  Symbol
AxoGen, Inc. is a leading regenerative medicine company focused on the commercialization                           AXGN
of its portfolio of proprietary products and technologies for peripheral nerve reconstruction
                                                                                                                   Exchange
and regeneration.
                                                                                                                   OTCBB
Headquarters: Alachua, FL                                                                                          Price at 08.15.12
Number of employees: 46                                                                                            $3.25
Products and Services: Peripheral Nerve Reconstruction
                                                                                                                   52-Week High

Peripheral nerves provide the pathways for both motor and sensory signals throughout the body and                  $4.00
their damage can result in the loss of function and feeling. In order to improve surgical reconstruction           52-Week Low
and regeneration of peripheral nerves, AxoGen has developed and licensed patented and patent-                      $1.10
pending technologies, which are used in its portfolio of products. This portfolio includes Avance®
Nerve Graft, the only commercially available allograft nerve for bridging peripheral nerve discontinuities         Market Capitalization
(a gap created when the nerve is severed) of up to 70mm in length.                                                 $36 Million
AxoGen’s portfolio also includes AxoGuard® Nerve Connector, a coaptation aid allowing for close                    2Q12 Revenues
approximation of severed nerves, and AxoGuard® Nerve Protector, a bioscaffold used to reinforce a                  $2.0 Million
coaptation site, wrap a partially severed nerve or isolate and protect nerve tissue. AxoGen is bringing
the science of nerve repair to life with thousands of surgical implants of AxoGen products performed               Cash
in hospitals and surgery centers across the United States, including military hospitals serving U.S.               $4.6 Million
service men and women.
                                                                                                                   Total
                                                                                                                   Debt Outstanding
                                                                                                                   $5.0 Million

Strong performance
dollars in millions, except where noted


                   Revenues                                                    Gross Profit                       Second quarter
                                                                                                                  2012 highlights
                              $4.8
                                       $3.7                                                                       Record second quarter
                                                                                               $3.3               revenues
                                                                                                                  Record revenues of $2.01 million, a
                     $3.0                                                                                         64% increase from second quarter
                                                                                                           $2.7
                                                                                                                  2011

            $2.0                                                                                                  Achieved record profit margins
                                                                                                                  Gross profit for second quarter
                                                                          $1.5       $1.6
                                                                                                                  2012 increased 89% to a record
   $1.2                                                                                                           $1.5 million

                                                                $0.8                                              Gross profit margins improved to
                                                                                                                  75% compared to 65% for the
                                                                                                                  same period in 2011
   2Q11     2Q12     2010      2011 YTD 2012                    2Q11      2Q12       2010      2011* YTD 2012
                                                                *Excludes one-time write-off of inventory




                                                                                                                                       Continued >
Financial summary
dollars in thousands

                                                               2Q 2012                            1Q 2012      2Q 2011                   2011(1)
  Income Statement:
   Net Revenues                                                  $2,012                             $1,653     $1,225                    $4,849
   Gross Profit                                                   $1,510                             $1,214      $801                     $2,422
    Gross Margin                                                  75%                                 73%       65%                       50%
   Net Income (Loss) (2)                                        ($1,766)                           ($2,109)    ($1,678)                  ($9,220)
  Balance Sheet:
   Cash & Cash Equivalents                                       $4,638                             $5,642     $2,230                    $8,191
  1. Gross Profit excludes one-time write-off of inventory
  2. Excludes non-recurring income tax benefit of $736,000 for 2Q 2012.

Business summary                                                                                               Investment highlights
                                                                                                               • The US market opportunity
AxoGen is a regenerative medicine company with a proprietary product portfolio for                               exceeds $1 billion
peripheral nerve reconstruction and regeneration in a wide range of nerve gap sizes.
                                                                                                               • First mover in peripheral nerve
   mm
   gap                                                                                                           reconstruction
                                                                               •  Processed nerve
   70
                                                                                  allograft for bridging       • Only complete peripheral nerve
   65                                                                             severed peripheral             product portfolio
   60                                                                             nerves
                                                                                                               • Highly scalable infrastructure
   55

   50                                                                                                          • Poised for rapid growth
   45

   40

   35                                                                          •  Wraps and protects injured
                                                                                  nerves
   30                                                                                                          2012 objectives
   25                                                                          •  Reinforces coaptation
   20
                                                                                                               • Increase investment in sales and
   15
                                                                                                                 marketing
   10
                                                                              •  Bridges gaps up to 5mm        • Execute on commercialization
    5                                                                                                            strategy
                                                                              •  Coaptation aid
    0
                                                                                                               • Expand to new markets, while
                                                                                                                 penetrating existing markets

    The January, 2012 edition of Microsurgery contains an article summarizing the RANGER study results         • Educate the market about
    to date, reporting over 87% meaningful recovery in sensory, motor and mixed nerve injuries treated           products’ value proposition
    with the Avance® Nerve Graft (Published Microsurgery DOI: 10.1002/micr.20975.)



   “  It is commonly accepted among surgeons who do peripheral nerve repair that success of surgery      21

    depends on the type of injury, length of nerve discontinuity, the patient’s age and the type of nerve.
    Our study findings show that with processed nerve allograft, patients can have meaningful recovery
    regardless of these factors.

    Based on our findings, the information I use to counsel my patients prior to surgery will change — this


                          ”
    is a paradigm shift.

    Darrell Brooks, M.D., plastic surgeon,
    The Buncke Clinic


   Company leadership:                                                     Company contact:                     Investor contact:
   Karen Zaderej – Chief Executive Officer                                   Greg Freitag
   Greg Freitag – Chief Financial Officer                                    Chief Financial Officer
   Jill Schiaparelli – SVP Business Strategy & Marketing                   AxoGen, Inc.                          1230 Peachtree Street
                                                                           13859 Progress Blvd., Suite 100       19th Floor
   John Engels – Vice President
                                                                           Alachua, FL 32615                     Atlanta, GA 30309
   Mark Friedman, Ph.D. – VP of Regulatory Affairs
                                                                           P 972.308.6830                        P 404.942.3369
   Brad Hedger – VP of Sales
                                                                           axogeninc.com                         cockrellgroup.com

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2Q12 AxoGen Inc. Fact Sheet

  • 1. INVESTOR FACT SHEET Period ended June 30, 2012 Corporate profile Symbol AxoGen, Inc. is a leading regenerative medicine company focused on the commercialization AXGN of its portfolio of proprietary products and technologies for peripheral nerve reconstruction Exchange and regeneration. OTCBB Headquarters: Alachua, FL Price at 08.15.12 Number of employees: 46 $3.25 Products and Services: Peripheral Nerve Reconstruction 52-Week High Peripheral nerves provide the pathways for both motor and sensory signals throughout the body and $4.00 their damage can result in the loss of function and feeling. In order to improve surgical reconstruction 52-Week Low and regeneration of peripheral nerves, AxoGen has developed and licensed patented and patent- $1.10 pending technologies, which are used in its portfolio of products. This portfolio includes Avance® Nerve Graft, the only commercially available allograft nerve for bridging peripheral nerve discontinuities Market Capitalization (a gap created when the nerve is severed) of up to 70mm in length. $36 Million AxoGen’s portfolio also includes AxoGuard® Nerve Connector, a coaptation aid allowing for close 2Q12 Revenues approximation of severed nerves, and AxoGuard® Nerve Protector, a bioscaffold used to reinforce a $2.0 Million coaptation site, wrap a partially severed nerve or isolate and protect nerve tissue. AxoGen is bringing the science of nerve repair to life with thousands of surgical implants of AxoGen products performed Cash in hospitals and surgery centers across the United States, including military hospitals serving U.S. $4.6 Million service men and women. Total Debt Outstanding $5.0 Million Strong performance dollars in millions, except where noted Revenues Gross Profit Second quarter 2012 highlights $4.8 $3.7 Record second quarter $3.3 revenues Record revenues of $2.01 million, a $3.0 64% increase from second quarter $2.7 2011 $2.0 Achieved record profit margins Gross profit for second quarter $1.5 $1.6 2012 increased 89% to a record $1.2 $1.5 million $0.8 Gross profit margins improved to 75% compared to 65% for the same period in 2011 2Q11 2Q12 2010 2011 YTD 2012 2Q11 2Q12 2010 2011* YTD 2012 *Excludes one-time write-off of inventory Continued >
  • 2. Financial summary dollars in thousands 2Q 2012 1Q 2012 2Q 2011 2011(1) Income Statement: Net Revenues $2,012 $1,653 $1,225 $4,849 Gross Profit $1,510 $1,214 $801 $2,422 Gross Margin 75% 73% 65% 50% Net Income (Loss) (2) ($1,766) ($2,109) ($1,678) ($9,220) Balance Sheet: Cash & Cash Equivalents $4,638 $5,642 $2,230 $8,191 1. Gross Profit excludes one-time write-off of inventory 2. Excludes non-recurring income tax benefit of $736,000 for 2Q 2012. Business summary Investment highlights • The US market opportunity AxoGen is a regenerative medicine company with a proprietary product portfolio for exceeds $1 billion peripheral nerve reconstruction and regeneration in a wide range of nerve gap sizes. • First mover in peripheral nerve mm gap reconstruction •  Processed nerve 70 allograft for bridging • Only complete peripheral nerve 65 severed peripheral product portfolio 60 nerves • Highly scalable infrastructure 55 50 • Poised for rapid growth 45 40 35 •  Wraps and protects injured nerves 30 2012 objectives 25 •  Reinforces coaptation 20 • Increase investment in sales and 15 marketing 10 •  Bridges gaps up to 5mm • Execute on commercialization 5 strategy •  Coaptation aid 0 • Expand to new markets, while penetrating existing markets The January, 2012 edition of Microsurgery contains an article summarizing the RANGER study results • Educate the market about to date, reporting over 87% meaningful recovery in sensory, motor and mixed nerve injuries treated products’ value proposition with the Avance® Nerve Graft (Published Microsurgery DOI: 10.1002/micr.20975.) “ It is commonly accepted among surgeons who do peripheral nerve repair that success of surgery 21 depends on the type of injury, length of nerve discontinuity, the patient’s age and the type of nerve. Our study findings show that with processed nerve allograft, patients can have meaningful recovery regardless of these factors. Based on our findings, the information I use to counsel my patients prior to surgery will change — this ” is a paradigm shift. Darrell Brooks, M.D., plastic surgeon, The Buncke Clinic Company leadership: Company contact: Investor contact: Karen Zaderej – Chief Executive Officer Greg Freitag Greg Freitag – Chief Financial Officer Chief Financial Officer Jill Schiaparelli – SVP Business Strategy & Marketing AxoGen, Inc. 1230 Peachtree Street 13859 Progress Blvd., Suite 100 19th Floor John Engels – Vice President Alachua, FL 32615 Atlanta, GA 30309 Mark Friedman, Ph.D. – VP of Regulatory Affairs P 972.308.6830 P 404.942.3369 Brad Hedger – VP of Sales axogeninc.com cockrellgroup.com