Creative ideas to improve oral palatability of drugs in pediatrics
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How to improve compliance in pediatric patients
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Creative ideas to improve oral palatability of drugs in pediatrics
- 1. Creative & Critical Thinking Dr Ranjan 21-09-19
- 2. Creative ways to improve 2 the palatability of drugs for paediatric use
- 3. “A survey of 500 parents conducted by Ascent Pediatrics, Inc. (Wilmington, Massachusetts) indicated that ~50% of children refuse to take their medication at some time and that, for the 75% of those who were noncompliant, the reason reported was related to a drug's taste.” C.‐P. Milne et al, Clin Ther 2008 30 (11) 2133‐2145 3
- 4. 4
- 5. 5 ༝ Since 1900’s we have been trying to improvise the palatability of paediatric medicine
- 6. 6 Good medicine tastes bitter.. Chinese Proverb
- 7. Here are some tips! 7
- 8. 1. Gummy Bears • Attractive colours, Shapes & Sized drugs
- 10. 3. Aldie-hack Iso-valeraldehyde: nutty, fruity, cocoa- like.
- 11. 4. Dauntless dropper Easily we can deliver the drug bypassing posterior part of tongue
- 12. 5. Borate Bob Tasteless slimy bob can deliver the drug
- 13. 6. Melting Med Freeze drying: fast‐dissolving oral technology
- 14. 7. Micro-encap Hydroxyethyl cellulose and Hydroxypropyl methylcellulose * Kostag M, Jedvert K, Achtel C, Heinze T, El SeoudO. Recent advances in solventsfor the dissolution,shaping and derivatization of cellulose: quaternary ammonium electrolytesand their solutions in water and molecular solvents.Molecules.2018;23(3):511.
- 15. 8. Sanctimonious Spray Lecithin and Lecithin‐like Substances * Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: recent developmentsand approaches. Drug development
- 16. 9. Numb nutting • Neohesperidin dihydrochalcone (NHDC) • 6-n-propylthiouracil (PROP) * DuffyVB, Davidson AC, Kidd JR, Kidd KK, SpeedWC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM. Bitter receptor gene (TAS2R38),6‐n‐propylthiouracil (PROP) bitterness and alcohol intake. Alcoholism:Clinical and Experimental
- 18. Air blowing A puff of air blown on babies face! Startle response- Swallow!!
- 19. Raagi ball • Easily palatable, tasteless & nutritive
- 20. Drug guns • Powerful drug injectors into pharynx
- 21. Mobie-PAL • Deviating babies concentration using smart gadgets while giving drug
- 22. Trick-toe • Wrapping solid drugs in Candy covers!!
- 23. “Good medicine tastes better.. ༝ Future Proverb 23 Thank You !
Editor's Notes
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.
- This method is used to develop fast‐dissolving oral technologies such as Zydis and Lyoc technology. Zydis is a tablet‐shaped dosage form that spontaneously disintegrates in the mouth in seconds. This is due to the high porosity produced by the freeze drying process. The Zydis process requires the active ingredient to be dissolved or suspended in an aqueous solution of water‐soluble structure formers. The resultant mixture is then poured into the preformed blister pockets of a laminate film and freeze dried. The two most commonly used structural excipients are gelatin and mannitol, although other suitable excipients can be used (e.g., starches, gums, etc.). This process is ideally suited to low‐solubility drugs as these are more readily freeze dried. Taste is very important for this type of dosage form and it is possible to produce palatable formulations by using artificial sweeteners (e.g., aspartame) and conventional flavors. Lyoc differs from Zydis in that the product is frozen on freeze‐dryer shelves.105
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.
- Borax is marketed as a green product because it doesn’t contain phosphates or chlorine. Instead, its main ingredient is sodium tetraborate, a naturally occurring mineral. People sometimes confuse sodium tetraborate — the main ingredient in borax — and boric acid, which has similar properties. Boric acid, however, is usually used exclusively as a pesticide and is much more toxic than sodium tetraborate, so it should be handled with extra special care. While borax may be natural, that doesn’t mean it’s completely safe. Borax often comes in a box with a caution label warning users that the product is an eye irritant and that it may be harmful if swallowed. While people are mostly exposed to borax in their homes, they may also encounter it at work, such as in factories or at borax mining and refining plants.