This document outlines 12 common mistakes or "sins" that can doom startups. It lists assuming you know what customers want without validating, focusing on launch dates over product-market fit, prematurely scaling the company before proving success, writing rigid business plans that do not allow for testing and learning, hiring co-founders based only on resumes rather than fit, prioritizing traditional job titles over startup needs, managing by constant crisis rather than planning, basing the company around an exit strategy rather than sustainable growth, not accepting that success takes years, and emphasizing execution over testing ideas and iterating as the top mistakes according to the source and the author's own experience.