TB 500 is a synthetic replica of Thymosin Beta 4, a protein peptide that occurs naturally in the bodies of both animals and humans. In horse racing, TB 500 is shown to have a significant effect on the reduction of inflammation and the inhibition of adhesions from injury.

1. TB 500

2. TB 500 – Product Details
TB 500 is a synthetic replica of Thymosin Beta 4, a protein peptide that occurs naturally in
the bodies of both animals and humans. In horse racing, TB 500 is shown to have a
significant effect on the reduction of inflammation and the inhibition of adhesions from injury.
In a rat full-thickness wound model, TB 500 exhibited potent wound-healing effects. Wounds
treated topically with TB 500 showed an 18% decrease in gap compared with saline-treated
control wounds as early as 4 days after injury. They also contracted at least 7% more than
controls by day 7. [R]

3. What is TB 500?
As stated earlier, TB 500 is a man-made replica of TB-4, a peptide found naturally in human
and animal cells. Thymosin Beta 4 plays a pivotal role in increasing angiogenesis (formation
of new blood vessels) in dermal tissues. [R]
TB 500, like Thymosin Beta 4, consists of 43 amino acids. This synthetic peptide was
originally developed for veterinary purposes and is claimed to offer various therapeutic
benefits to a racehorse. Such claims led to the development of a testing procedure to detect
the use of this drug in equines. [R]

4. How does TB 500 Work?
TB 500 up-regulates the action of actin and blocks actin polymerization in eukaryotic cells.
Actin is a cell-building protein that promotes cell migration and proliferation. It plays a pivotal
role in muscle contraction as well as in cell differentiation and helps with tissue repair and
regeneration. [R]
TB 500 has also been shown to promote angiogenesis or blood vessel formation, likely
through the Notch signaling pathway. In a rat study, the TB-4 treated group showed
increased expression of genes associated with angiogenesis than the control group. [R]

5. TB 500 Vs. BPC 157
TB 500, as stated above, is a synthetic form of TB-4, a regenerative compound found in the
majority of tissues and circulating cells in the body. In vivo and in vitro testing has shown that
TB-4 could alleviate premature cell death or apoptosis of tubular endothelial cells. [R]
BPC 157, meanwhile, is a partial sequence of the body protection compound found in human
gastric juices. It has been shown to be safe in clinical trials for treating inflammatory bowel
disease (IBD).

6. TB 500 Research
1. TB 500 and Heart Health
In a clinical phase 2 trial, TB-4 was found to reduce the volume of scars after a heart attack. The trial was
conducted on patients with acute myocardial infarction (MI), the leading cause of cardiac death worldwide. It
was confirmed that TB-4 could protect and repair the heart. [R]
2. TB 500 and Duchenne Muscular Dystrophy
In a mouse model of Duchenne muscular dystrophy (DMD), the effects of chronic TB-4 administration on
skeletal and cardiac muscle were studied. DMD is characterized by weakness and wasting of the pelvic area
muscles. As the disease spreads, the trunk and forearms are affected.

7. Summary
Multiple animal studies have demonstrated that TB-4 offers potential therapeutic
benefits for multiple conditions. However, with human trials lacking on this synthetic
peptide, the FDA hasn’t approved it for human consumption.