What does relative binding mean? Solution The relative binding affinity means the capability of ligands to form coordination bonds with a receptor or its a measure of strength of attraction between a receptor and its ligand.The binding affinity of a ligand with a receptor depends upon the interaction force of attraction between the ligands and their receptor binding sites.Strong intermolecular force of attraction results to show high bonding affinity ligand binding while ligand bonding of low affinity involves lower and weak intermolecular force between the ligands ant their receptors. Receptor:is a protein moleclue that receives a signal by binding to a chemical (its ligand). Ligand:is an atom,molecule or ion which has one or more pairs of electrons.For every ligand there is a specific receptor..