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Roth	
  Conference	
  
March	
  16,	
  2016	
  
NEMUS	
  Bioscience	
  
OTCQB:	
  NMUS	
  
2	
  
Forward	
  Looking	
  Statement	
  
This	
  presenta-on	
  contains	
  “forward-­‐looking	
  statements”	
  within	
  the	
  meaning	
  of	
  the	
  “safe	
  harbor”	
  provisions	
  of	
  
the	
  Private	
  Securi-es	
  Li-ga-on	
  Reform	
  Act	
  of	
  1995.	
  All	
  of	
  the	
  statements	
  in	
  this	
  presenta-on,	
  whether	
  wriGen	
  or	
  
oral,	
   that	
   refer	
   to	
   expected	
   or	
   an-cipated	
   future	
   ac-ons	
   and	
   results	
   of	
   NEMUS	
   Bioscience,	
   Inc.	
   (NEMUS)	
   are	
  
forward-­‐looking	
   statements.	
   These	
   forward-­‐looking	
   statements	
   reflect	
   the	
   beliefs	
   and	
   expecta-ons	
   of	
   the	
  
management	
  of	
  NEMUS	
  as	
  of	
  the	
  date	
  of	
  this	
  presenta-on.	
  NEMUS	
  cannot	
  give	
  any	
  assurance	
  that	
  such	
  forward-­‐
looking	
  statements	
  will	
  prove	
  to	
  be	
  correct.	
  The	
  reader	
  is	
  cau-oned	
  not	
  to	
  place	
  undue	
  reliance	
  on	
  these	
  forward-­‐
looking	
  statements.	
  	
  
	
  	
  
The	
  informa-on	
  provided	
  in	
  this	
  presenta-on	
  does	
  not	
  iden-fy	
  or	
  include	
  any	
  risk	
  or	
  exposures,	
  of	
  NEMUS	
  that	
  
would	
   materially	
   adversely	
   affect	
   the	
   performance	
   or	
   risk	
   of	
   the	
   company.	
   For	
   a	
   descrip-on	
   of	
   the	
   risks	
   and	
  
uncertain-es	
  related	
  to	
  the	
  business	
  of	
  NEMUS,	
  see	
  our	
  Annual	
  Report	
  on	
  Form	
  10-­‐K	
  	
  filed	
  with	
  the	
  Securi-es	
  and	
  
Exchange	
  Commission	
  	
  and	
  our	
  subsequent	
  periodic	
  reports	
  filed	
  with	
  the	
  Securi-es	
  and	
  Exchange	
  Commission.	
  	
  
	
  	
  
All	
  informa-on	
  contained	
  in	
  this	
  presenta-on	
  is	
  provided	
  as	
  of	
  the	
  date	
  of	
  the	
  presenta-on	
  and	
  is	
  subject	
  to	
  
change	
   without	
   no-ce.	
   Neither	
   NEMUS,	
   nor	
   any	
   other	
   person	
   undertakes	
   any	
   obliga-on	
   to	
   update	
   or	
   revise	
  
publicly	
  any	
  of	
  the	
  forward-­‐looking	
  statements	
  set	
  out	
  herein,	
  whether	
  as	
  a	
  result	
  of	
  new	
  informa-on,	
  future	
  
events	
  or	
  otherwise,	
  except	
  as	
  required	
  by	
  law.	
  This	
  presenta-on	
  does	
  not	
  convey	
  an	
  offer	
  of	
  any	
  type	
  and	
  is	
  not	
  
intended	
   to	
   be,	
   and	
   should	
   not	
   be	
   construed	
   as,	
   an	
   offer	
   to	
   sell,	
   or	
   the	
   solicita-on	
   of	
   an	
   offer	
   to	
   buy,	
   any	
  
securi-es	
  of	
  NEMUS.	
  
3	
  
OTCQB	
   NMUS	
  
Price	
  (3/15/16)	
   $0.785	
  
Market	
  Cap	
  (3/15/16)	
   $15.6	
  M	
  
Shares	
  Outstanding	
  
19.9	
  M	
  common	
  &	
  4500	
  PS,	
  
25.5	
  M	
  if	
  100%	
  converted	
  
%	
  Ownership	
  by	
  Directors	
  &	
  
Employees	
  
31.4%	
  shares	
  
1.2	
  M	
  op-ons	
  	
  
Warrants	
  Outstanding	
   10.9	
  M	
  (Avg.	
  Strike	
  @	
  $1.15)	
  
Founded	
   2012	
  
Base	
  of	
  Opera-ons	
  
Costa	
  Mesa,	
  California	
  	
  
&	
  Oxford,	
  Mississippi	
  
Company	
  Overview	
  
NEMUS	
  Bioscience	
  is	
  a	
  publicly	
  traded,	
  life-­‐science	
  biotech	
  company,	
  focused	
  
on	
  developing	
  regulatory-­‐approved,	
  cannabinoid-­‐based	
  therapies,	
  for	
  a	
  
spectrum	
  of	
  diseases,	
  especially	
  those	
  of	
  unmet	
  medical	
  need	
  
4	
  
NEMUS	
  Value	
  ProposiNon	
  
•  NEMUS	
  is	
  focused	
  on	
  developing	
  cannabinoid	
  molecules	
  for	
  the	
  treatment	
  and	
  
management	
  of	
  acute	
  and	
  chronic	
  diseases,	
  especially	
  those	
  of	
  unmet	
  medical	
  need	
  
•  NEMUS	
  is	
  the	
  sole	
  development	
  and	
  commercializaNon	
  partner	
  of	
  the	
  University	
  of	
  
Mississippi,	
  drawing	
  on	
  47	
  years	
  of	
  intellectual	
  capital	
  in	
  cannabinoid	
  chemistry	
  and	
  
physiology	
  from	
  the	
  only	
  enNty	
  with	
  a	
  Federal	
  license	
  to	
  directly	
  study	
  cannabinoids	
  
•  NEMUS	
  is	
  advancing	
  therapeuNcs	
  for	
  medical	
  applicaNons	
  in	
  global	
  mulN-­‐billion	
  dollar	
  
markets	
  including:	
  
ü  	
  A	
  cannabinoid	
  franchise	
  in	
  ophthalmology	
  in	
  glaucoma	
  and	
  re6nal	
  diseases	
  	
  
ü  Pallia6ve	
  care	
  in	
  oncology	
  (CINV	
  and	
  CIPN)	
  	
  
ü  An6-­‐infec6ves,	
  especially	
  in	
  strains	
  developing	
  resistance	
  to	
  an6bio6cs	
  (MRSA)	
  
•  Proprietary	
  product	
  pipeline	
  led	
  by	
  a	
  pro-­‐drug	
  of	
  tetrahydrocannibinol	
  (THC)	
  and	
  novel	
  
deriva-ves	
  of	
  cannabidiol	
  (CBD)	
  
•  NEMUS	
  management	
  team	
  has	
  proven	
  track-­‐record	
  in	
  drug	
  research,	
  pharmaceu-cal	
  &	
  
biotech	
  development,	
  and	
  public	
  company	
  experience	
  on	
  a	
  global	
  scale	
  
5	
  
Recent	
  Milestones	
  
•  August,	
  2015:	
  Comple-on	
  of	
  Series	
  B	
  $5	
  million	
  financing	
  round	
  
•  September,	
  2015:	
  globally-­‐recognized	
  glaucoma	
  expert	
  Dr.	
  Robert	
  N.	
  Weinreb	
  joins	
  NEMUS	
  
Scien-fic	
  Advisory	
  Board	
  
•  October,	
  2015:	
  Patent	
  issued	
  in	
  Japan	
  for	
  NB1111	
  (THC	
  prodrug)	
  
•  December,	
  2015:	
  NEMUS	
  in-­‐licenses	
  CBD	
  deriva-ves	
  from	
  UM	
  and	
  ini-ates	
  research	
  into	
  
chemotherapy	
  induced	
  periphernal	
  neuropathy	
  (CIPN)	
  
•  January,	
  2016:	
  interna-onally	
  recognized	
  cancer	
  expert	
  Dr.	
  Donald	
  I.	
  Abrams	
  joins	
  NEMUS	
  Scien-fic	
  
Advisory	
  Board	
  
	
  
•  January,	
  2016:	
  NEMUS	
  announces	
  valida-on	
  of	
  NB1111	
  data	
  in	
  glaucoma	
  with	
  45%	
  decline	
  in	
  IOP	
  
•  January,	
  2016:	
  NEMUS	
  announces	
  ini-a-on	
  of	
  development	
  program	
  for	
  chemotherapy-­‐induced	
  
nausea	
  and	
  vomi-ng	
  (CINV)	
  and	
  expects	
  to	
  request	
  a	
  pre-­‐IND	
  mee-ng	
  with	
  FDA	
  in	
  H1’16	
  
•  February,	
  2016:	
  NEMUS	
  signs	
  agreement	
  with	
  AMRI	
  to	
  manufacture	
  proprietary	
  API	
  for	
  glaucoma	
  
(NB1111)	
  and	
  CINV	
  (NB1222)	
  programs	
  
6	
  
NEMUS	
  Cannabinoid	
  Prodrug	
  Programs	
  	
  
Hold	
  CompeNNve	
  Advantages	
  
Orally	
  administered	
  cannabinoids	
  (both	
  pill	
  and	
  spray	
  delivery	
  mechanisms)	
  hold	
  a	
  
variety	
  of	
  disadvantages	
  for	
  paNents:	
  
•  Poor	
  bioavailability	
  vs	
  other	
  routes	
  of	
  administraNon	
  
•  Irregular	
  pharmacokineNcs	
  secondary	
  to	
  GI	
  absorpNon	
  
•  SuscepNble	
  to	
  significant	
  first-­‐pass	
  metabolism	
  by	
  the	
  liver	
  
	
  
–  “Due	
  to	
  extensive	
  first-­‐pass	
  metabolism	
  and	
  high	
  lipid	
  
solubility,	
  a	
  frac-on	
  of	
  the	
  drug	
  reaches	
  the	
  circula-on”1	
  	
  	
  
–  “The	
  pharmacologic	
  effects	
  of	
  Marinol	
  are	
  dose-­‐related	
  
and	
  subject	
  to	
  considerable	
  inter-­‐pa-ent	
  variability”1	
  
–  “Intoxica-on	
  type	
  reac-ons	
  appear	
  dose-­‐related	
  due	
  to	
  
great	
  inter-­‐pa-ent	
  drug	
  level	
  variability”	
  2	
  	
  
–  “The	
  pharmacokine-c	
  data	
  show	
  great	
  inter-­‐subject	
  
variability”3	
  
1) Marinol	
  Summary	
  Basis	
  of	
  Approval	
  
2) Sa6vex	
  Product	
  Labelling	
  -­‐	
  Black	
  Box	
  Warning	
  
3) Sa6vex	
  Product	
  Labelling	
  
NEMUS	
  prodrug	
  technology	
  
designed	
  to	
  capitalize	
  on	
  the	
  
use	
  of	
  proprietary	
  
formulaNons	
  that	
  could	
  
allow	
  for	
  alternaNve	
  delivery	
  
methods	
  miNgaNng	
  risk	
  of	
  
unpredictable	
  plasma	
  levels	
  
that	
  can	
  compromise	
  safety	
  
and	
  efficacy	
  
7	
  
InnovaNve	
  Cannabinoid	
  FormulaNons	
  	
  
Designed	
  for	
  Improved	
  Drug	
  Delivery	
  
-­‐	
  	
  
•  Ocular	
  delivery:	
   	
   	
   	
  Glaucoma	
  &	
  re-nal	
  diseases	
  
	
  	
  
•  Transmucosal	
  delivery:	
   	
   	
  CINV	
  &	
  CIPN	
  (suppository	
  &	
   	
  
	
   	
   	
   	
   	
  buccal	
  patch)	
  
•  Transmembranous	
  delivery:	
   	
  An--­‐infec-ves	
  (An--­‐MRSA)	
  
	
   	
   	
  (nasal/transdermal)	
  
All	
  NEMUS	
  licensed	
  delivery	
  opNons	
  opNmize	
  our	
  prodrug	
  
cannabinoid	
  technology	
  by	
  enhancing	
  bioavailability	
  through	
  
avoiding	
  first-­‐pass	
  liver	
  metabolism	
  and	
  offering	
  more	
  
predictable	
  pharmacokineNcs	
  
8	
  
•  The	
  University	
  of	
  Mississippi	
  (UM)	
  is	
  the	
  only	
  enNty	
  in	
  the	
  US	
  authorized	
  by	
  NIDA	
  and	
  the	
  
DEA	
  to	
  cul-vate	
  cannabis	
  on	
  behalf	
  of	
  the	
  federal	
  government	
  
•  The	
  University	
  of	
  Mississippi	
  has	
  a	
  con-nuous	
  45+	
  year	
  regulatory	
  history	
  in	
  dealing	
  with	
  
FDA,	
  DEA,	
  NIDA,	
  NIH,	
  etc.	
  	
  
•  NEMUS	
  has	
  exclusive,	
  perpetual,	
  worldwide	
  exclusivity	
  for	
  all	
  compounds	
  and	
  targets	
  we	
  
are	
  working	
  on	
  with	
  UM	
  for	
  key	
  fields	
  of	
  delivery	
  
•  NEMUS	
  has:	
  
•  Recurring	
  op6on	
  agreements	
  for	
  unique	
  THC	
  and	
  CBD	
  deriva6ve	
  molecules	
  including	
  
patent	
  8,809,261	
  issued	
  August,	
  2014	
  covering	
  NCE	
  of	
  cannabinoid	
  prodrug	
  esters	
  
•  Mul6ple	
  method	
  of	
  delivery	
  agreements	
  including	
  ocular,	
  transmembranous,	
  
transmucosal	
  
•  Mul6ple	
  research	
  agreements	
  including	
  CIPN	
  and	
  MRSA	
  
The	
  Only	
  Federally-­‐Approved	
  Source	
  of	
  	
  
Cannabis-­‐Derived	
  Compounds	
  
9	
  
Development	
  Pipeline:	
  OpNmizing	
  THC	
  and	
  CBD	
  
Delivery	
  Through	
  Unique	
  FormulaNons	
  
Drug	
  Name	
   Target	
   Delivery	
   Research	
   Pre-­‐clinical	
   Phase	
  1	
  
Phase	
  
2/3	
  
NB1222	
  
(THC-­‐based)	
  
Chemotherapy-­‐
induced	
  nausea	
  &	
  
vomiNng	
  (CINV)	
  
Suppository	
  &	
  
Buccal	
  Patch	
  
NB1111	
  
(THC-­‐based)	
  
Glaucoma/
Ophthalmology	
  
Targets	
  
Sustained	
  
Ocular	
  
ID	
  pending	
  
(CBD-­‐based)	
  
Chemotherapy-­‐
induced	
  peripheral	
  
neuropathy	
  (CIPN)	
  
Trans-­‐
membranous	
  
ID	
  pending	
  
	
  
Methicillin-­‐Resistant	
  
Staph	
  Aureus	
  (MRSA)	
  	
  
Topical	
  &	
  
Transdermal	
  
Target	
  indicaNons	
  are	
  mulN-­‐billion	
  dollar	
  global	
  markets	
  of	
  urgent	
  medical	
  need	
  
10	
  
	
  
NB1222	
  
Treatment	
  of	
  	
  
Chemotherapy-­‐Induced	
  	
  
Nausea	
  and	
  Vomi-ng	
  (CINV)	
  
	
  
	
  
	
  
11	
  
NB1222:	
  Chemotherapy-­‐Induced	
  	
  
Nausea	
  and	
  VomiNng	
  (CINV)	
  
•  There	
  are	
  an	
  es-mated	
  15	
  million	
  cancer	
  cases	
  globally	
  according	
  to	
  the	
  
Interna-onal	
  Agency	
  for	
  Research	
  on	
  Cancer	
  
•  25%-­‐30%	
  of	
  pa-ents	
  receive	
  chemotherapy;	
  of	
  the	
  chemotherapy	
  recipients,	
  
70%-­‐80%	
  experience	
  CINV	
  
•  The	
  global	
  CINV	
  market	
  exceeds	
  $1.3	
  B	
  
•  Dronabinol	
  is	
  an	
  orally	
  administered	
  synthe-c	
  version	
  of	
  THC	
  approved	
  for	
  
cachexia	
  in	
  HIV	
  and	
  nausea/vomi-ng	
  in	
  CINV	
  with	
  annual	
  sales	
  for	
  CINV	
  in	
  
excess	
  of	
  $110	
  MM	
  (Source:	
  IMS	
  Health)	
  
•  NEMUS	
  plans	
  to	
  develop	
  a	
  suppository	
  version	
  of	
  our	
  proprietary	
  prodrug	
  of	
  
THC,	
  NB	
  1222,	
  for	
  use	
  in	
  CINV	
  by	
  filing	
  an	
  NDA	
  via	
  the	
  expedited	
  regulatory	
  
pathway	
  of	
  505(b)(2)	
  
12	
  
NB1222	
  Advantages	
  Versus	
  Dronabinol	
  in	
  CINV	
  
-­‐1	
  
4	
  
9	
  
PD	
   1	
   3	
   5	
   7	
   9	
   11	
   13	
   15	
   17	
   19	
   21	
   23	
  
Plasma	
  ConcentraNons	
  (ng/
ml)	
  
Timepoint	
  (h)	
  
A	
  Comparison	
  of	
  THC	
  Plasma	
  ConcentraNons	
  From	
  	
  
ProDrug	
  THC	
  Suppository*	
  vs.	
  dronabinol	
  in	
  Humans	
  
Dronabinol	
  10	
  mg	
   THC	
  10	
  mgEg	
  
•  Bioavailability:	
  Dronabinol	
  has	
  been	
  found	
  to	
  have	
  a	
  bioavailability	
  of	
  6%-­‐15%	
  while	
  a	
  
prodrug	
  of	
  THC	
  administered	
  via	
  suppository	
  yielded	
  a	
  bioavailability	
  of	
  roughly	
  70%*	
  
•  AbsorpNon:	
  Orally	
  administered	
  dronabinol	
  can	
  have	
  erra-c	
  absorp-on	
  from	
  the	
  gut	
  
coupled	
  to	
  varying	
  plasma	
  levels	
  due	
  to	
  first-­‐pass	
  metabolism	
  in	
  the	
  liver;	
  a	
  suppository	
  
avoids	
  the	
  upper	
  GI	
  tract	
  and	
  thereby	
  de-­‐risks	
  the	
  nega-ve	
  effect	
  of	
  first-­‐pass	
  
metabolism	
  on	
  the	
  drug	
  pharmacokine-cs	
  
•  Adverse	
  Events:	
  Oral	
  dronabinol	
  has	
  been	
  associated	
  with	
  nausea	
  and	
  vomi-ng	
  adverse	
  
events;	
  a	
  suppository	
  route	
  of	
  administra-on	
  mi-gates	
  that	
  side	
  effect	
  
•  PharmacokineNcs:	
  THC	
  prodrug	
  dosing	
  using	
  a	
  suppository	
  allows	
  greater	
  drug	
  
exposure	
  (graph	
  above)	
  and	
  maintenance	
  within	
  the	
  therapeu-c	
  window	
  versus	
  peak/
trough	
  PK	
  with	
  oral	
  dosing	
  	
  
Source:	
  	
  NEMUS	
  Internal	
  Data	
  	
  
13	
  
NB1111	
  
For	
  the	
  Treatment	
  of	
  	
  
Glaucoma	
  
14	
  
Visual	
  Field	
  Defect	
  in	
  Glaucoma	
  How	
  the	
  World	
  is	
  Seen	
  With	
  Glaucoma	
  
15	
  
The	
  Glaucoma	
  Market	
  
•  $8	
  billion	
  globally	
  and	
  growing	
  with	
  aging	
  popula-ons	
  
•  A	
  leading	
  cause	
  of	
  blindness	
  in	
  the	
  US	
  
•  $2.3	
  billion	
  US	
  market	
  (32	
  MM	
  Rx)	
  
•  Regulatory	
  pathway	
  well-­‐defined	
  
•  Regulatory	
  strategy:	
  Poten-al	
  for	
  “urgent	
  medical	
  need”	
  and	
  
“breakthrough	
  therapy”	
  FDA	
  designa-ons;	
  	
  
•  Glaucoma	
  as	
  a	
  “Non-­‐responder”	
  market	
  presents	
  greater	
  opportuni-es;	
  
>50%	
  of	
  pa*ents	
  on	
  2	
  or	
  more	
  Rx	
  
•  Cannabinoids	
  have	
  shown	
  neuroprotec-ve	
  quali-es	
  in	
  vitro	
  and	
  in	
  vivo	
  
(mul-ple	
  animal	
  species)	
  
•  Licensing	
  and	
  acquisiNons	
  in	
  the	
  glaucoma	
  market	
  occur	
  predominantly	
  
earlier	
  in	
  development	
  (pre-­‐clin,	
  phase	
  1)	
  
16	
  
NB1111	
  (Glaucoma/Ophthalmology)	
  
Sustained	
  release	
  treatment	
  with	
  a	
  proprietary	
  THC	
  prodrug	
  could	
  bring	
  a	
  new	
  
therapeuNc	
  class	
  directly	
  to	
  the	
  target	
  organ,	
  avoiding	
  systemic	
  exposure	
  
OCULAR	
  FEATURES	
  OF	
  NB1111	
  
•  Penetrates	
  all	
  chambers	
  of	
  the	
  eye	
  
•  Produces	
  a	
  45%	
  reduc-on	
  in	
  Intra-­‐Ocular	
  Pressure	
  (IOP)	
  
in	
  glaucoma	
  animal	
  model	
  (THC	
  has	
  been	
  shown	
  to	
  
lower	
  IOP	
  in	
  previous	
  human	
  tes-ng)	
  
•  ReducNon	
  of	
  IOP	
  is	
  the	
  only	
  proven	
  method	
  to	
  treat	
  
glaucoma	
  	
  
•  Sustained	
  release	
  via	
  implantable	
  delivery	
  vehicle	
  
enhance	
  compliance	
  
•  PotenNally	
  first	
  medicaNon	
  to	
  exert	
  direct	
  
neuroprotec-on	
  of	
  the	
  op-c	
  nerve	
  (re-nal	
  ganglion	
  
cells;	
  RGCs)	
  by	
  inhibi-ng	
  apoptosis	
  pathway	
  	
  
•  NeuroprotecNon	
  is	
  the	
  “holy	
  grail”	
  of	
  glaucoma	
  
The	
  proprietary	
  
formulaNon	
  allows	
  
THC	
  to	
  be	
  absorbed	
  
across	
  membranes	
  
that	
  are	
  normally	
  
barriers	
  to	
  absorpNon	
  	
  
17	
  
THC	
  Lowers	
  IOP	
  in	
  Humans;	
  PredicNve	
  Animal	
  Model	
  
Consistent	
  with	
  Human	
  Experience	
  	
  
•  The	
  acNve	
  moiety	
  of	
  NB1111,	
  THC,	
  has	
  	
  been	
  shown	
  to	
  lower	
  IOP	
  in	
  
mul-ple	
  human	
  studies	
  	
  
•  THC	
  delivered	
  by	
  inhala-on	
  (smoking)	
  or	
  edible	
  lowered	
  IOP	
  40%	
  to	
  65%	
  but	
  
compromises	
  blood	
  flow	
  to	
  re-na	
  via	
  systemic	
  vasodila-on	
  and	
  dosing	
  
complicated	
  by	
  short	
  half-­‐life	
  
•  The	
  NEMUS	
  prodrug	
  NB1111	
  achieved	
  a	
  45%-­‐50%	
  reduc-on	
  in	
  IOP	
  
in	
  validated	
  rabbit	
  glaucoma	
  model	
  tes-ng	
  conducted	
  at	
  UM	
  	
  
•  New	
  formulaNon	
  tesNng	
  of	
  NB1111	
  will	
  confront	
  the	
  compliance	
  
issue	
  of	
  topical	
  drops	
  (eyedrops)	
  by	
  development	
  of	
  implantable	
  
sustained	
  release	
  device	
  
•  Next	
  stage	
  tesNng:	
  
•  Canine/primate	
  studies	
  looking	
  at	
  IOP	
  lowering	
  effect	
  as	
  single	
  dose	
  and	
  
mul--­‐dose	
  via	
  implantable	
  device	
  
•  In	
  vitro	
  and	
  in	
  vivo	
  studies	
  assessing	
  neuroprotec-ve	
  biomarkers	
  
18	
  
THC	
  Can	
  Address	
  MulNple	
  MOAs	
  in	
  Lowering	
  IOP	
  and	
  
Preserving	
  ReNnal	
  Ganglion	
  Cells	
  (RGCs)	
  
Therapy	
  Class	
   	
  	
  	
  
	
  
Mechanism	
  of	
  
Ac-on	
  (MOA)	
  
	
  
Increased	
  flow	
  
trabecular	
  mesh	
  
Increased	
  flow	
  
uveoscleral	
  
pathway	
  
	
  
Decreased	
  fluid	
  
produc-on	
  
Direct	
  
neuroprotec-ve	
  
quali-es	
  
Prostaglandins	
  
(50%	
  mkt	
  share)	
  
X	
  
β-­‐	
  adrenergic	
  
blockers	
  (30%)	
  
X	
  
α-­‐	
  adrenergic	
  
agonists	
  (10%)	
  
X	
   X	
  
Carbonic	
  
anhydrase	
  
inhibitors	
  (<5%)	
  
	
  
X	
  
Cholinergic	
  
agonists	
  (<5%)	
  
X	
  
Pro-­‐drug	
  THC	
  
(NB1111)	
  
X	
   X	
   X	
   X	
  
19	
  
CHEMOTHERAPY-­‐INDUCED	
  
PERIPHERAL	
  NEUROPATHY	
  (CIPN)	
  
	
  
CBD	
  DERIVATIVES	
  
20	
  
Chemotherapy-­‐Induced	
  Peripheral	
  	
  
Neuropathy	
  (CIPN):	
  Market	
  Data	
  
•  CIPN	
  is	
  a	
  dose-­‐dependent	
  complica-on	
  associated	
  with	
  many	
  types	
  of	
  	
  
chemotherapeu-c	
  agents	
  
•  In	
  addiNon	
  to	
  severe,	
  someNmes	
  unremimng	
  pain,	
  it	
  can	
  also	
  lead	
  to	
  premature	
  
discon-nua-on	
  of	
  chemotherapy	
  which	
  in	
  turn	
  can	
  compromise	
  responses	
  to	
  cancer	
  
treatment	
  
•  No	
  agents	
  have	
  been	
  shown	
  to	
  prevent	
  CIPN	
  and	
  currently	
  there	
  is	
  a	
  significant	
  unmet	
  
medical	
  need	
  for	
  therapies	
  that	
  can	
  mi-gate	
  the	
  pain	
  without	
  complica-ons	
  associated	
  
with	
  addicNon	
  and	
  gastrointesNnal	
  obstrucNon	
  
•  The	
  CIPN	
  market	
  in	
  the	
  United	
  States	
  exceeds	
  $500	
  MM	
  (LifeSci	
  Advisors,	
  2013)	
  and	
  the	
  
parallel	
  opioid-­‐induced	
  cons-pa-on	
  market	
  is	
  es-mated	
  to	
  be	
  $600	
  MM	
  globally	
  
(GlobalData,	
  2015)	
  
•  NEMUS	
  has	
  signed	
  a	
  research	
  agreement	
  with	
  UM	
  to	
  test	
  CBD-­‐related	
  deriva-ves	
  in	
  
validated	
  animal	
  models	
  of	
  CIPN	
  
•  NEMUS	
  expects	
  to	
  complete	
  proof-­‐of-­‐concept	
  in	
  vivo	
  and	
  in	
  vitro	
  tesNng	
  in	
  2016	
  with	
  
basic	
  science	
  data	
  presented	
  at	
  appropriate	
  scien-fic	
  mee-ngs	
  
21	
  
METHICILLIN-­‐RESISTANT	
  
STAPHYLOCOCCUS	
  AUREUS	
  
	
  
	
  MULTIPLE	
  CANNABINOID	
  
DERIVATIVES	
  
22	
  
MRSA	
  Has	
  Become	
  a	
  Global	
  Urgent	
  Health	
  Concern	
  
23	
  
Methicillan-­‐Resistant	
  Staph	
  Aureus	
  (MRSA)	
  
MRSA	
  FACTS	
  &	
  CURRENT	
  MEDICAL	
  LANDSCAPE	
  
•  First	
  described	
  in	
  1961	
  now	
  a	
  pandemic	
  
•  CDC:	
  prevalence	
  of	
  MRSA	
  in	
  ICU	
  sevng	
  approaching	
  60%	
  
•  1960’s:	
  one	
  gene-c	
  MRSA	
  muta-on/clone;	
  currently	
  six	
  MRSA	
  
gene-c	
  clones;	
  15	
  clones	
  in	
  China	
  
•  2010	
  hospital	
  survey:	
  61.8%	
  of	
  pa-ents	
  admiGed	
  to	
  ICU	
  were	
  
MRSA	
  colonized1	
  
•  50%	
  of	
  screened	
  pa-ents	
  had	
  healthcare-­‐associated	
  
infec-ons1	
  
•  11,000	
  deaths	
  annually;	
  80,000	
  invasive	
  infec-ons/yr.2	
  
•  Annual	
  costs	
  in	
  the	
  US:	
  $3.2	
  -­‐	
  $4	
  billion2	
  
	
  
1)  Jarvis	
  WR	
  et	
  al;	
  Am	
  J	
  Infect	
  Control	
  2012;	
  40(3):	
  194-­‐200	
  
2)  Pew	
  Trust	
  MRSA	
  Survey;	
  April	
  3,	
  2012	
  
24	
  
Methicillan-­‐Resistant	
  Staph	
  Aureus	
  (MRSA)	
  
NEMUS	
  is	
  Assessing	
  a	
  New	
  Class	
  of	
  AnN-­‐InfecNves	
  
to	
  Combat	
  the	
  Threat	
  of	
  AnNbioNc	
  Resistance	
  
CANNABINOID	
  EXPERIENCE	
  IN	
  MRSA1	
  
•  Select	
  cannabinoids	
  have	
  been	
  known	
  to	
  possess	
  some	
  an-bacterial	
  proper-es	
  1	
  	
  
•  AnN-­‐bacterial	
  properNes	
  can	
  be	
  leveraged	
  to	
  address	
  newly	
  developed	
  strains	
  
exhibi-ng	
  an-bio-c	
  resistance	
  to	
  current	
  meds	
  	
  
•  NEMUS	
  intends	
  to	
  seek	
  IP	
  protecNon	
  concerning	
  the	
  use	
  of	
  transmembrane	
  
enhancing	
  formulaNons	
  of	
  cannabinoids	
  to	
  facilitate	
  bacteriocidal	
  ac-vity	
  	
  
•  A	
  spectrum	
  of	
  gram-­‐posi-ve	
  organisms	
  will	
  be	
  screened	
  in	
  addiNon	
  to	
  MRSA	
  
1)  J	
  Nat	
  Prod.	
  2008	
  Aug;71(8):1427-­‐30.	
  doi:	
  10.1021/np8002673.	
  Epub	
  2008	
  Aug	
  6.	
  	
  
-­‐	
  An-bacterial	
  cannabinoids	
  from	
  Cannabis	
  sa-va:	
  a	
  structure-­‐ac-vity	
  study	
  
25	
  
Upcoming	
  InflecNon	
  Point	
  Timelines	
  	
  
2016	
  Developmental	
  Goals	
  
H1-­‐2016	
  
•  Contract	
  API	
  manufacturer	
  
for	
  THC-­‐val-­‐HS	
  
•  Ini-ate	
  2yr	
  stability	
  study	
  API	
  
•  Ini-ate	
  in	
  vivo	
  MRSA	
  studies	
  
•  Ini-ate	
  CIPN	
  in	
  vivo	
  studies	
  
•  Complete	
  ini-al	
  canine/
primate	
  study	
  
•  Hold	
  FDA	
  pre-­‐IND	
  mee-ng:	
  
NB1222	
  (CINV)	
  
H2-­‐2016	
  
•  Hold	
  FDA	
  pre-­‐IND	
  mee-ng:	
  NB1111	
  
(Glaucoma)	
  
•  Ini-ate	
  primate	
  sustained	
  release	
  
glaucoma	
  study:	
  NB1111	
  
•  Ini-ate	
  IND	
  enabling	
  studies:	
  NB1111	
  
•  Complete	
  MRSA	
  in	
  vivo	
  studies	
  
•  Ini-ate	
  MRSA	
  tox	
  studies	
  
•  Ini-ate	
  CINV	
  tox	
  bridging	
  studies:	
  
NB1222	
  
•  Ini-ate	
  human	
  BA-­‐PK	
  study	
  in	
  CINV	
  
•  Ini-ate	
  formula-on	
  work	
  on	
  new	
  CBD	
  
formula-on	
  for	
  CIPN	
  
26	
  
NEMUS	
  Bioscience,	
  Inc.	
  (OTCQB:	
  NMUS)	
  
•  NEMUS	
  is	
  focused	
  on	
  developing	
  cannabinoid	
  molecules	
  for	
  the	
  treatment	
  and	
  
management	
  of	
  acute	
  and	
  chronic	
  diseases,	
  especially	
  those	
  of	
  unmet	
  medical	
  need	
  
•  NEMUS	
  cannabinoid	
  molecules	
  are	
  engineered	
  to	
  enhance	
  trans-­‐membrane	
  transport	
  
resulNng	
  in:	
  
ü  Enhanced	
  bioavailability	
  
ü  Permits	
  routes	
  of	
  administra6on	
  that	
  avoid	
  first-­‐pass	
  metabolism	
  by	
  the	
  liver	
  
ü  Resul6ng	
  in	
  more	
  predictable	
  pharmacokine6cs	
  
ü  Patent	
  issued	
  in	
  August,	
  2014	
  allows	
  long	
  IP	
  runway	
  with	
  broad	
  claims	
  and	
  reach	
  for	
  
the	
  delivery	
  of	
  molecules	
  and	
  condi6ons	
  that	
  can	
  be	
  treated	
  
•  NEMUS	
  is	
  the	
  sole	
  development	
  and	
  commercializaNon	
  partner	
  of	
  the	
  University	
  of	
  
Mississippi,	
  drawing	
  on	
  47	
  years	
  of	
  intellectual	
  capital	
  in	
  cannabinoid	
  chemistry	
  and	
  
physiology	
  
•  NEMUS	
  is	
  advancing	
  therapeuNcs	
  for	
  medical	
  applica-ons	
  in	
  global	
  mul--­‐billion	
  dollar	
  
markets	
  including	
  a	
  cannabinoid	
  franchise	
  in	
  ophthalmology,	
  palliaNve	
  care	
  in	
  oncology,	
  
and	
  anN-­‐infecNve	
  medicines,	
  especially	
  in	
  strains	
  developing	
  resistance	
  to	
  an-bio-cs	
  
27	
  
Management	
  
BRIAN	
  MURPHY,	
  MD,	
  MPH,	
  MBA	
  –	
  Chief	
  ExecuNve	
  Officer;	
  Chief	
  Medical	
  Officer,	
  Director	
  
Dr.	
  Murphy	
  has	
  almost	
  two	
  decades	
  of	
  experience	
  in	
  drug	
  development	
  and	
  evalua-on,	
  both	
  from	
  the	
  academic	
  and	
  industry	
  
perspec-ve.	
   He	
   most	
   recently	
   served	
   as	
   the	
   CMO	
   of	
   Eiger	
   Biosciences.	
   Previously,	
   Dr.	
   Murphy	
   was	
   CMO	
   at	
   Valeant	
  
Pharmaceu-cals	
   Interna-onal	
   (VRX)	
   where	
   his	
   responsibili-es	
   also	
   included	
   oversight	
   of	
   Global	
   Medical	
   Affairs	
   and	
  
Pharmacovigilance.	
  Dr.	
  Murphy	
  also	
  served	
  as	
  Medical	
  Director,	
  then	
  VP	
  of	
  Marke-ng	
  and	
  Commercial	
  Strategy	
  of	
  Hepatology	
  
for	
  InterMune,	
  Inc.	
  (ITMN).	
  Prior	
  to	
  InterMune,	
  Dr.	
  Murphy	
  was	
  Medical	
  Director	
  of	
  North	
  America	
  for	
  An-virals/Interferons	
  at	
  
Hoffmann-­‐LaRoche.	
  Murphy	
  is	
  board-­‐cer-fied	
  in	
  internal	
  medicine	
  and	
  completed	
  his	
  residency	
  at	
  Tuws-­‐New	
  England	
  Medical	
  
Center.	
  He	
  went	
  on	
  to	
  complete	
  parallel	
  fellowship	
  tracts	
  at	
  Harvard	
  Medical	
  School	
  and	
  the	
  MassachuseGs	
  General	
  Hospital.	
  
Dr.	
  Murphy	
  earned	
  his	
  MD,	
  MPH	
  (general	
  public	
  health),	
  and	
  MS	
  (pharmacology)	
  degrees	
  from	
  New	
  York	
  Medical	
  College	
  and	
  
is	
   a	
   graduate	
   of	
   the	
   Harvard	
   School	
   of	
   Public	
   Health	
   (MPH	
   in	
   Health	
   Policy	
   and	
   Management).	
   He	
   earned	
   his	
   MBA	
   at	
   the	
  
Columbia	
  University	
  Graduate	
  School	
  of	
  Business.	
  	
  
	
  
	
  
LIZ	
  BERECZ,	
  MA,	
  CPA	
  -­‐	
  Chief	
  Financial	
  Officer	
  
Elizabeth	
  Berecz	
  is	
  a	
  seasoned	
  financial	
  execu-ve	
  with	
  over	
  20	
  years	
  of	
  experience	
  holding	
  senior	
  level	
  posi-ons	
  in	
  both	
  private	
  
and	
   public	
   companies.	
   She	
   has	
   proven	
   success	
   in	
   leading	
   strategic	
   planning,	
   financial	
   repor-ng,	
   and	
   global	
   system	
  
implementa-ons	
  for	
  companies	
  of	
  various	
  sizes.	
  Liz	
  started	
  her	
  career	
  at	
  Price	
  Waterhouse	
  Silicon	
  Valley	
  where	
  she	
  spent	
  five	
  
years	
  audi-ng	
  several	
  high	
  profile	
  public	
  companies	
  in	
  the	
  technology	
  industry.	
  She	
  then	
  spent	
  10	
  years	
  holding	
  key	
  leadership	
  
posi-ons	
   in	
   various	
   publicly	
   held	
   Companies	
   including	
   Quantum	
   Corpora-on	
   (Corporate	
   Controller),	
   Business	
   Objects	
   (VP	
  
Finance	
  and	
  Administra-on),	
  and	
  Excite	
  (VP	
  Finance),	
  followed	
  by	
  10	
  years	
  of	
  key	
  leadership	
  roles	
  in	
  privately	
  held	
  Companies	
  
including	
   CFO	
   posi-ons	
   with	
   Op-cal	
   Shop	
   Interna-onal,	
   StarTrac	
   Inc.,	
   Power	
   Balance	
   Technologies,	
   Inc.	
   and	
   most	
   recently	
  
Bentley	
   Mills,	
   Inc.	
   She	
   also	
   serves	
   as	
   an	
   Adjunct	
   Professor	
   of	
   Accoun-ng	
   and	
   Finance	
   at	
   the	
   University	
   of	
   San	
   Francisco.	
  
Elizabeth	
   received	
   her	
   BA	
   in	
   Economics	
   from	
   Stanford	
   University	
   and	
   a	
   MA	
   in	
   Sports	
   Management	
   from	
   University	
   of	
   San	
  
Francisco.	
  	
  
28	
  
Management	
  
COSMAS	
  N.	
  LYKOS,	
  ESQ	
  –	
  Co-­‐founder,	
  Officer	
  &	
  Board	
  Member	
  –	
  ExecuNve	
  Chairman	
  	
  	
  
Cosmas	
  Lykos	
  co-­‐founded	
  NEMUS	
  in	
  2012	
  and	
  has	
  served	
  as	
  its	
  Chairman	
  of	
  the	
  Board	
  of	
  Directors	
  since	
  August	
  2014.	
  	
  
Awer	
  gradua-ng	
  with	
  Honors	
  from	
  Duke	
  University	
  School	
  of	
  Law	
  in	
  1993,	
  Mr.	
  Lykos	
  began	
  his	
  career	
  at	
  Gibson	
  Dunn	
  &	
  
Crutcher,	
  LLP,	
  an	
  interna-onal	
  full-­‐service	
  law	
  firm,	
  as	
  a	
  corporate	
  associate	
  un-l	
  1998.	
   	
  From	
  1998	
  to	
  2004,	
  Mr.	
  Lykos	
  
served	
  as	
  Vice	
  President	
  of	
  Business	
  Affairs,	
  General	
  Counsel,	
  Secretary	
  and	
  Chief	
  Compliance	
  Officer	
  of	
  RemedyTemp,	
  
Inc.,	
  a	
  NASDAQ	
  publicly-­‐traded	
  temporary	
  staffing	
  firm	
  with	
  over	
  250	
  directly-­‐owned	
  and	
  franchised	
  offices	
  na-onwide.	
  	
  
From	
  2004	
  un-l	
  2008,	
  Mr.	
  Lykos	
  served	
  as	
  Vice	
  President	
  of	
  Business	
  Development,	
  Chief	
  Legal	
  Officer,	
  Secretary	
  and	
  Chief	
  
Compliance	
  Officer	
  of	
  Oakley,	
  Inc.,	
  a	
  NYSE	
  publicly-­‐traded	
  sports	
  and	
  technical	
  eyewear,	
  apparel,	
  accessories	
  and	
  retail	
  
company.	
   	
   In	
   January	
   of	
   2008,	
   he	
   became	
   Co-­‐owner	
   and	
   President	
   of	
   the	
   Op-cal	
   Shop	
   Interna-onal,	
   a	
   designer	
   and	
  
distributor	
   of	
   licensed	
   eyewear	
   brands,	
   including	
   Chrome	
   Hearts	
   and	
   Blinde,	
   through	
   two	
   wholly-­‐owned	
   foreign	
  
subsidiaries	
  with	
  a	
  direct	
  and	
  distributor	
  sales	
  network	
  in	
  over	
  60	
  countries	
  around	
  the	
  world.	
   	
  Primary	
  responsibili-es	
  
included	
  developing	
  and	
  implemen-ng	
  OSI’s	
  vision	
  and	
  strategies	
  and	
  the	
  management	
  of	
  its	
  foreign	
  subsidiaries,	
  sales,	
  
legal,	
  human	
  resources,	
  finance	
  and	
  administra-ve	
  func-ons.	
  	
  In	
  2011,	
  Mr.	
  Lykos	
  nego-ated	
  and	
  consummated	
  the	
  sale	
  of	
  
OSI	
  to	
  its	
  primary	
  licensor,	
  Chrome	
  Hearts	
  LLC	
  and	
  con-nues	
  to	
  provide	
  consul-ng	
  services.	
  	
  Mr.	
  Lykos	
  has	
  extensive	
  public	
  
and	
  private	
  company	
  board	
  of	
  directors	
  experience.	
  	
  As	
  Chief	
  Compliance	
  and	
  Legal	
  Officer	
  and	
  Secretary	
  of	
  both	
  Oakley,	
  
Inc.	
  and	
  RemedyTemp,	
  Inc.,	
  Mr.	
  Lykos	
  aGended	
  all	
  board	
  of	
  director	
  mee-ngs	
  and	
  board	
  commiGee	
  mee-ngs.	
  	
  As	
  an	
  angel	
  
investor,	
   Mr.	
   Lykos	
   has	
   made	
   minority	
   investments	
   in	
   various	
   private	
   companies	
   and	
   has	
   served	
   on	
   their	
   Board	
   of	
  
Directors.	
  
	
  
	
  
29	
  
BOD	
  &	
  Strategic	
  Advisors	
  
MAHMOUD	
  A.	
  ELSOHLY,	
  PHD	
  	
  
ScienNfic	
  Advisor	
  
World’s	
  foremost	
  expert	
  on	
  the	
  science	
  
of	
  cannabinoids.	
  	
  300+	
  	
  scien-fic	
  
publica-ons	
  .	
  	
  Research	
  professor	
  at	
  The	
  
University	
  of	
  Mississippi.	
  
JERRY	
  MCLAUGHLIN,	
  MBA	
  	
  
Strategic	
  Advisor,	
  	
  
Board	
  of	
  Directors	
  -­‐	
  Member	
  
CEO	
  of	
  AgeneBio;	
  25	
  year	
  veteran	
  
execu-ve	
  in	
  pharmaceu-cal	
  medical	
  
device	
  and	
  healthcare	
  related	
  industries	
  
(Endo	
  Pharma,	
  Merck,	
  MBA-­‐	
  Villanova	
  
University,BA-­‐	
  Dickinson	
  College).	
  
TOM	
  GEORGE	
  
Board	
  of	
  Directors	
  –	
  Chairman	
  of	
  Audit	
  
Commitee	
  
30	
  year	
  senior	
  execu-ve	
  in	
  corporate	
  
finance	
  and	
  accoun-ng;	
  CFO	
  of	
  Deckers	
  
Brands	
  (	
  Ophthonix,	
  Oakley,	
  Coopers	
  &	
  
Lybrand).	
  Graduate	
  of	
  University	
  of	
  
Southern	
  California.	
  
DOUGLAS	
  S.	
  INGRAM,	
  ESQ	
  
Board	
  of	
  Directors	
  –	
  Vice	
  Chairman,	
  
Chairman	
  of	
  CompensaNon	
  Commitee	
  
25	
  year	
  senior	
  execu-ve	
  in	
  healthcare,	
  
Past	
  President	
  of	
  Allergan,	
  former	
  
AGorney	
  at	
  Gibson,	
  Dunn	
  &	
  Crutcher,	
  
LLP.	
  Summa	
  cum	
  laude	
  and	
  Order	
  of	
  the	
  
Coif	
  graduate	
  of	
  the	
  Univ.	
  of	
  Arizona	
  
school	
  of	
  law.	
  
ROBERT	
  N.	
  WEINREB,	
  M.D.	
  	
  
ScienNfic	
  Advisor	
  
Chair,	
  Ophthalmology	
  Advisory	
  Board	
  
Globally	
  recognized	
  expert	
  on	
  glaucoma	
  
and	
  eye	
  diseases.	
  	
  1000+	
  	
  scien-fic	
  
publica-ons.	
  Dis-nguished	
  Professor	
  of	
  
Ophthalmology;	
  University	
  of	
  California	
  
San	
  Diego.	
  
	
  
DONALD	
  I.	
  ABRAMS,	
  M.D.	
  	
  
ScienNfic	
  Advisor	
  
Chief,	
  Hematology/Oncology	
  at	
  UCSF	
  
Cancer	
  and	
  Integra-ve	
  Medicine	
  
specialist	
  with	
  research	
  interests	
  in	
  the	
  
development	
  of	
  an--­‐cancer	
  therapeu-cs	
  
and	
  pallia-ve	
  care	
  medicines.	
  
30	
  
Contact	
  
	
  
650	
  Town	
  Center	
  Drive,	
  Suite	
  1770	
  
Costa	
  Mesa,	
  CA	
  92626	
  
949-­‐396-­‐0330	
  
hello@nemusbio.com	
  
www.nemusbioscience.com	
  	
  
Investor	
  RelaNons:	
  
Adam	
  Holdsworth	
  
PCG	
  Advisory	
  Group	
  
Tel:	
  646-­‐862-­‐4607	
  
adamh@pcgadvisory.com	
  	
  
Company:	
  
Brian	
  Murphy,	
  MD,	
  MPH,	
  MBA	
  
CEO	
  -­‐	
  CMO	
  
Tel:	
  949-­‐355-­‐1140	
  
brian@nemusbio.com	
  
	
  

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NEMUS Bioscience Roth Conference Presentation Highlights Progress and Pipeline

  • 1. Roth  Conference   March  16,  2016   NEMUS  Bioscience   OTCQB:  NMUS  
  • 2. 2   Forward  Looking  Statement   This  presenta-on  contains  “forward-­‐looking  statements”  within  the  meaning  of  the  “safe  harbor”  provisions  of   the  Private  Securi-es  Li-ga-on  Reform  Act  of  1995.  All  of  the  statements  in  this  presenta-on,  whether  wriGen  or   oral,   that   refer   to   expected   or   an-cipated   future   ac-ons   and   results   of   NEMUS   Bioscience,   Inc.   (NEMUS)   are   forward-­‐looking   statements.   These   forward-­‐looking   statements   reflect   the   beliefs   and   expecta-ons   of   the   management  of  NEMUS  as  of  the  date  of  this  presenta-on.  NEMUS  cannot  give  any  assurance  that  such  forward-­‐ looking  statements  will  prove  to  be  correct.  The  reader  is  cau-oned  not  to  place  undue  reliance  on  these  forward-­‐ looking  statements.         The  informa-on  provided  in  this  presenta-on  does  not  iden-fy  or  include  any  risk  or  exposures,  of  NEMUS  that   would   materially   adversely   affect   the   performance   or   risk   of   the   company.   For   a   descrip-on   of   the   risks   and   uncertain-es  related  to  the  business  of  NEMUS,  see  our  Annual  Report  on  Form  10-­‐K    filed  with  the  Securi-es  and   Exchange  Commission    and  our  subsequent  periodic  reports  filed  with  the  Securi-es  and  Exchange  Commission.         All  informa-on  contained  in  this  presenta-on  is  provided  as  of  the  date  of  the  presenta-on  and  is  subject  to   change   without   no-ce.   Neither   NEMUS,   nor   any   other   person   undertakes   any   obliga-on   to   update   or   revise   publicly  any  of  the  forward-­‐looking  statements  set  out  herein,  whether  as  a  result  of  new  informa-on,  future   events  or  otherwise,  except  as  required  by  law.  This  presenta-on  does  not  convey  an  offer  of  any  type  and  is  not   intended   to   be,   and   should   not   be   construed   as,   an   offer   to   sell,   or   the   solicita-on   of   an   offer   to   buy,   any   securi-es  of  NEMUS.  
  • 3. 3   OTCQB   NMUS   Price  (3/15/16)   $0.785   Market  Cap  (3/15/16)   $15.6  M   Shares  Outstanding   19.9  M  common  &  4500  PS,   25.5  M  if  100%  converted   %  Ownership  by  Directors  &   Employees   31.4%  shares   1.2  M  op-ons     Warrants  Outstanding   10.9  M  (Avg.  Strike  @  $1.15)   Founded   2012   Base  of  Opera-ons   Costa  Mesa,  California     &  Oxford,  Mississippi   Company  Overview   NEMUS  Bioscience  is  a  publicly  traded,  life-­‐science  biotech  company,  focused   on  developing  regulatory-­‐approved,  cannabinoid-­‐based  therapies,  for  a   spectrum  of  diseases,  especially  those  of  unmet  medical  need  
  • 4. 4   NEMUS  Value  ProposiNon   •  NEMUS  is  focused  on  developing  cannabinoid  molecules  for  the  treatment  and   management  of  acute  and  chronic  diseases,  especially  those  of  unmet  medical  need   •  NEMUS  is  the  sole  development  and  commercializaNon  partner  of  the  University  of   Mississippi,  drawing  on  47  years  of  intellectual  capital  in  cannabinoid  chemistry  and   physiology  from  the  only  enNty  with  a  Federal  license  to  directly  study  cannabinoids   •  NEMUS  is  advancing  therapeuNcs  for  medical  applicaNons  in  global  mulN-­‐billion  dollar   markets  including:   ü   A  cannabinoid  franchise  in  ophthalmology  in  glaucoma  and  re6nal  diseases     ü  Pallia6ve  care  in  oncology  (CINV  and  CIPN)     ü  An6-­‐infec6ves,  especially  in  strains  developing  resistance  to  an6bio6cs  (MRSA)   •  Proprietary  product  pipeline  led  by  a  pro-­‐drug  of  tetrahydrocannibinol  (THC)  and  novel   deriva-ves  of  cannabidiol  (CBD)   •  NEMUS  management  team  has  proven  track-­‐record  in  drug  research,  pharmaceu-cal  &   biotech  development,  and  public  company  experience  on  a  global  scale  
  • 5. 5   Recent  Milestones   •  August,  2015:  Comple-on  of  Series  B  $5  million  financing  round   •  September,  2015:  globally-­‐recognized  glaucoma  expert  Dr.  Robert  N.  Weinreb  joins  NEMUS   Scien-fic  Advisory  Board   •  October,  2015:  Patent  issued  in  Japan  for  NB1111  (THC  prodrug)   •  December,  2015:  NEMUS  in-­‐licenses  CBD  deriva-ves  from  UM  and  ini-ates  research  into   chemotherapy  induced  periphernal  neuropathy  (CIPN)   •  January,  2016:  interna-onally  recognized  cancer  expert  Dr.  Donald  I.  Abrams  joins  NEMUS  Scien-fic   Advisory  Board     •  January,  2016:  NEMUS  announces  valida-on  of  NB1111  data  in  glaucoma  with  45%  decline  in  IOP   •  January,  2016:  NEMUS  announces  ini-a-on  of  development  program  for  chemotherapy-­‐induced   nausea  and  vomi-ng  (CINV)  and  expects  to  request  a  pre-­‐IND  mee-ng  with  FDA  in  H1’16   •  February,  2016:  NEMUS  signs  agreement  with  AMRI  to  manufacture  proprietary  API  for  glaucoma   (NB1111)  and  CINV  (NB1222)  programs  
  • 6. 6   NEMUS  Cannabinoid  Prodrug  Programs     Hold  CompeNNve  Advantages   Orally  administered  cannabinoids  (both  pill  and  spray  delivery  mechanisms)  hold  a   variety  of  disadvantages  for  paNents:   •  Poor  bioavailability  vs  other  routes  of  administraNon   •  Irregular  pharmacokineNcs  secondary  to  GI  absorpNon   •  SuscepNble  to  significant  first-­‐pass  metabolism  by  the  liver     –  “Due  to  extensive  first-­‐pass  metabolism  and  high  lipid   solubility,  a  frac-on  of  the  drug  reaches  the  circula-on”1       –  “The  pharmacologic  effects  of  Marinol  are  dose-­‐related   and  subject  to  considerable  inter-­‐pa-ent  variability”1   –  “Intoxica-on  type  reac-ons  appear  dose-­‐related  due  to   great  inter-­‐pa-ent  drug  level  variability”  2     –  “The  pharmacokine-c  data  show  great  inter-­‐subject   variability”3   1) Marinol  Summary  Basis  of  Approval   2) Sa6vex  Product  Labelling  -­‐  Black  Box  Warning   3) Sa6vex  Product  Labelling   NEMUS  prodrug  technology   designed  to  capitalize  on  the   use  of  proprietary   formulaNons  that  could   allow  for  alternaNve  delivery   methods  miNgaNng  risk  of   unpredictable  plasma  levels   that  can  compromise  safety   and  efficacy  
  • 7. 7   InnovaNve  Cannabinoid  FormulaNons     Designed  for  Improved  Drug  Delivery   -­‐     •  Ocular  delivery:        Glaucoma  &  re-nal  diseases       •  Transmucosal  delivery:      CINV  &  CIPN  (suppository  &              buccal  patch)   •  Transmembranous  delivery:    An--­‐infec-ves  (An--­‐MRSA)        (nasal/transdermal)   All  NEMUS  licensed  delivery  opNons  opNmize  our  prodrug   cannabinoid  technology  by  enhancing  bioavailability  through   avoiding  first-­‐pass  liver  metabolism  and  offering  more   predictable  pharmacokineNcs  
  • 8. 8   •  The  University  of  Mississippi  (UM)  is  the  only  enNty  in  the  US  authorized  by  NIDA  and  the   DEA  to  cul-vate  cannabis  on  behalf  of  the  federal  government   •  The  University  of  Mississippi  has  a  con-nuous  45+  year  regulatory  history  in  dealing  with   FDA,  DEA,  NIDA,  NIH,  etc.     •  NEMUS  has  exclusive,  perpetual,  worldwide  exclusivity  for  all  compounds  and  targets  we   are  working  on  with  UM  for  key  fields  of  delivery   •  NEMUS  has:   •  Recurring  op6on  agreements  for  unique  THC  and  CBD  deriva6ve  molecules  including   patent  8,809,261  issued  August,  2014  covering  NCE  of  cannabinoid  prodrug  esters   •  Mul6ple  method  of  delivery  agreements  including  ocular,  transmembranous,   transmucosal   •  Mul6ple  research  agreements  including  CIPN  and  MRSA   The  Only  Federally-­‐Approved  Source  of     Cannabis-­‐Derived  Compounds  
  • 9. 9   Development  Pipeline:  OpNmizing  THC  and  CBD   Delivery  Through  Unique  FormulaNons   Drug  Name   Target   Delivery   Research   Pre-­‐clinical   Phase  1   Phase   2/3   NB1222   (THC-­‐based)   Chemotherapy-­‐ induced  nausea  &   vomiNng  (CINV)   Suppository  &   Buccal  Patch   NB1111   (THC-­‐based)   Glaucoma/ Ophthalmology   Targets   Sustained   Ocular   ID  pending   (CBD-­‐based)   Chemotherapy-­‐ induced  peripheral   neuropathy  (CIPN)   Trans-­‐ membranous   ID  pending     Methicillin-­‐Resistant   Staph  Aureus  (MRSA)     Topical  &   Transdermal   Target  indicaNons  are  mulN-­‐billion  dollar  global  markets  of  urgent  medical  need  
  • 10. 10     NB1222   Treatment  of     Chemotherapy-­‐Induced     Nausea  and  Vomi-ng  (CINV)        
  • 11. 11   NB1222:  Chemotherapy-­‐Induced     Nausea  and  VomiNng  (CINV)   •  There  are  an  es-mated  15  million  cancer  cases  globally  according  to  the   Interna-onal  Agency  for  Research  on  Cancer   •  25%-­‐30%  of  pa-ents  receive  chemotherapy;  of  the  chemotherapy  recipients,   70%-­‐80%  experience  CINV   •  The  global  CINV  market  exceeds  $1.3  B   •  Dronabinol  is  an  orally  administered  synthe-c  version  of  THC  approved  for   cachexia  in  HIV  and  nausea/vomi-ng  in  CINV  with  annual  sales  for  CINV  in   excess  of  $110  MM  (Source:  IMS  Health)   •  NEMUS  plans  to  develop  a  suppository  version  of  our  proprietary  prodrug  of   THC,  NB  1222,  for  use  in  CINV  by  filing  an  NDA  via  the  expedited  regulatory   pathway  of  505(b)(2)  
  • 12. 12   NB1222  Advantages  Versus  Dronabinol  in  CINV   -­‐1   4   9   PD   1   3   5   7   9   11   13   15   17   19   21   23   Plasma  ConcentraNons  (ng/ ml)   Timepoint  (h)   A  Comparison  of  THC  Plasma  ConcentraNons  From     ProDrug  THC  Suppository*  vs.  dronabinol  in  Humans   Dronabinol  10  mg   THC  10  mgEg   •  Bioavailability:  Dronabinol  has  been  found  to  have  a  bioavailability  of  6%-­‐15%  while  a   prodrug  of  THC  administered  via  suppository  yielded  a  bioavailability  of  roughly  70%*   •  AbsorpNon:  Orally  administered  dronabinol  can  have  erra-c  absorp-on  from  the  gut   coupled  to  varying  plasma  levels  due  to  first-­‐pass  metabolism  in  the  liver;  a  suppository   avoids  the  upper  GI  tract  and  thereby  de-­‐risks  the  nega-ve  effect  of  first-­‐pass   metabolism  on  the  drug  pharmacokine-cs   •  Adverse  Events:  Oral  dronabinol  has  been  associated  with  nausea  and  vomi-ng  adverse   events;  a  suppository  route  of  administra-on  mi-gates  that  side  effect   •  PharmacokineNcs:  THC  prodrug  dosing  using  a  suppository  allows  greater  drug   exposure  (graph  above)  and  maintenance  within  the  therapeu-c  window  versus  peak/ trough  PK  with  oral  dosing     Source:    NEMUS  Internal  Data    
  • 13. 13   NB1111   For  the  Treatment  of     Glaucoma  
  • 14. 14   Visual  Field  Defect  in  Glaucoma  How  the  World  is  Seen  With  Glaucoma  
  • 15. 15   The  Glaucoma  Market   •  $8  billion  globally  and  growing  with  aging  popula-ons   •  A  leading  cause  of  blindness  in  the  US   •  $2.3  billion  US  market  (32  MM  Rx)   •  Regulatory  pathway  well-­‐defined   •  Regulatory  strategy:  Poten-al  for  “urgent  medical  need”  and   “breakthrough  therapy”  FDA  designa-ons;     •  Glaucoma  as  a  “Non-­‐responder”  market  presents  greater  opportuni-es;   >50%  of  pa*ents  on  2  or  more  Rx   •  Cannabinoids  have  shown  neuroprotec-ve  quali-es  in  vitro  and  in  vivo   (mul-ple  animal  species)   •  Licensing  and  acquisiNons  in  the  glaucoma  market  occur  predominantly   earlier  in  development  (pre-­‐clin,  phase  1)  
  • 16. 16   NB1111  (Glaucoma/Ophthalmology)   Sustained  release  treatment  with  a  proprietary  THC  prodrug  could  bring  a  new   therapeuNc  class  directly  to  the  target  organ,  avoiding  systemic  exposure   OCULAR  FEATURES  OF  NB1111   •  Penetrates  all  chambers  of  the  eye   •  Produces  a  45%  reduc-on  in  Intra-­‐Ocular  Pressure  (IOP)   in  glaucoma  animal  model  (THC  has  been  shown  to   lower  IOP  in  previous  human  tes-ng)   •  ReducNon  of  IOP  is  the  only  proven  method  to  treat   glaucoma     •  Sustained  release  via  implantable  delivery  vehicle   enhance  compliance   •  PotenNally  first  medicaNon  to  exert  direct   neuroprotec-on  of  the  op-c  nerve  (re-nal  ganglion   cells;  RGCs)  by  inhibi-ng  apoptosis  pathway     •  NeuroprotecNon  is  the  “holy  grail”  of  glaucoma   The  proprietary   formulaNon  allows   THC  to  be  absorbed   across  membranes   that  are  normally   barriers  to  absorpNon    
  • 17. 17   THC  Lowers  IOP  in  Humans;  PredicNve  Animal  Model   Consistent  with  Human  Experience     •  The  acNve  moiety  of  NB1111,  THC,  has    been  shown  to  lower  IOP  in   mul-ple  human  studies     •  THC  delivered  by  inhala-on  (smoking)  or  edible  lowered  IOP  40%  to  65%  but   compromises  blood  flow  to  re-na  via  systemic  vasodila-on  and  dosing   complicated  by  short  half-­‐life   •  The  NEMUS  prodrug  NB1111  achieved  a  45%-­‐50%  reduc-on  in  IOP   in  validated  rabbit  glaucoma  model  tes-ng  conducted  at  UM     •  New  formulaNon  tesNng  of  NB1111  will  confront  the  compliance   issue  of  topical  drops  (eyedrops)  by  development  of  implantable   sustained  release  device   •  Next  stage  tesNng:   •  Canine/primate  studies  looking  at  IOP  lowering  effect  as  single  dose  and   mul--­‐dose  via  implantable  device   •  In  vitro  and  in  vivo  studies  assessing  neuroprotec-ve  biomarkers  
  • 18. 18   THC  Can  Address  MulNple  MOAs  in  Lowering  IOP  and   Preserving  ReNnal  Ganglion  Cells  (RGCs)   Therapy  Class           Mechanism  of   Ac-on  (MOA)     Increased  flow   trabecular  mesh   Increased  flow   uveoscleral   pathway     Decreased  fluid   produc-on   Direct   neuroprotec-ve   quali-es   Prostaglandins   (50%  mkt  share)   X   β-­‐  adrenergic   blockers  (30%)   X   α-­‐  adrenergic   agonists  (10%)   X   X   Carbonic   anhydrase   inhibitors  (<5%)     X   Cholinergic   agonists  (<5%)   X   Pro-­‐drug  THC   (NB1111)   X   X   X   X  
  • 19. 19   CHEMOTHERAPY-­‐INDUCED   PERIPHERAL  NEUROPATHY  (CIPN)     CBD  DERIVATIVES  
  • 20. 20   Chemotherapy-­‐Induced  Peripheral     Neuropathy  (CIPN):  Market  Data   •  CIPN  is  a  dose-­‐dependent  complica-on  associated  with  many  types  of     chemotherapeu-c  agents   •  In  addiNon  to  severe,  someNmes  unremimng  pain,  it  can  also  lead  to  premature   discon-nua-on  of  chemotherapy  which  in  turn  can  compromise  responses  to  cancer   treatment   •  No  agents  have  been  shown  to  prevent  CIPN  and  currently  there  is  a  significant  unmet   medical  need  for  therapies  that  can  mi-gate  the  pain  without  complica-ons  associated   with  addicNon  and  gastrointesNnal  obstrucNon   •  The  CIPN  market  in  the  United  States  exceeds  $500  MM  (LifeSci  Advisors,  2013)  and  the   parallel  opioid-­‐induced  cons-pa-on  market  is  es-mated  to  be  $600  MM  globally   (GlobalData,  2015)   •  NEMUS  has  signed  a  research  agreement  with  UM  to  test  CBD-­‐related  deriva-ves  in   validated  animal  models  of  CIPN   •  NEMUS  expects  to  complete  proof-­‐of-­‐concept  in  vivo  and  in  vitro  tesNng  in  2016  with   basic  science  data  presented  at  appropriate  scien-fic  mee-ngs  
  • 21. 21   METHICILLIN-­‐RESISTANT   STAPHYLOCOCCUS  AUREUS      MULTIPLE  CANNABINOID   DERIVATIVES  
  • 22. 22   MRSA  Has  Become  a  Global  Urgent  Health  Concern  
  • 23. 23   Methicillan-­‐Resistant  Staph  Aureus  (MRSA)   MRSA  FACTS  &  CURRENT  MEDICAL  LANDSCAPE   •  First  described  in  1961  now  a  pandemic   •  CDC:  prevalence  of  MRSA  in  ICU  sevng  approaching  60%   •  1960’s:  one  gene-c  MRSA  muta-on/clone;  currently  six  MRSA   gene-c  clones;  15  clones  in  China   •  2010  hospital  survey:  61.8%  of  pa-ents  admiGed  to  ICU  were   MRSA  colonized1   •  50%  of  screened  pa-ents  had  healthcare-­‐associated   infec-ons1   •  11,000  deaths  annually;  80,000  invasive  infec-ons/yr.2   •  Annual  costs  in  the  US:  $3.2  -­‐  $4  billion2     1)  Jarvis  WR  et  al;  Am  J  Infect  Control  2012;  40(3):  194-­‐200   2)  Pew  Trust  MRSA  Survey;  April  3,  2012  
  • 24. 24   Methicillan-­‐Resistant  Staph  Aureus  (MRSA)   NEMUS  is  Assessing  a  New  Class  of  AnN-­‐InfecNves   to  Combat  the  Threat  of  AnNbioNc  Resistance   CANNABINOID  EXPERIENCE  IN  MRSA1   •  Select  cannabinoids  have  been  known  to  possess  some  an-bacterial  proper-es  1     •  AnN-­‐bacterial  properNes  can  be  leveraged  to  address  newly  developed  strains   exhibi-ng  an-bio-c  resistance  to  current  meds     •  NEMUS  intends  to  seek  IP  protecNon  concerning  the  use  of  transmembrane   enhancing  formulaNons  of  cannabinoids  to  facilitate  bacteriocidal  ac-vity     •  A  spectrum  of  gram-­‐posi-ve  organisms  will  be  screened  in  addiNon  to  MRSA   1)  J  Nat  Prod.  2008  Aug;71(8):1427-­‐30.  doi:  10.1021/np8002673.  Epub  2008  Aug  6.     -­‐  An-bacterial  cannabinoids  from  Cannabis  sa-va:  a  structure-­‐ac-vity  study  
  • 25. 25   Upcoming  InflecNon  Point  Timelines     2016  Developmental  Goals   H1-­‐2016   •  Contract  API  manufacturer   for  THC-­‐val-­‐HS   •  Ini-ate  2yr  stability  study  API   •  Ini-ate  in  vivo  MRSA  studies   •  Ini-ate  CIPN  in  vivo  studies   •  Complete  ini-al  canine/ primate  study   •  Hold  FDA  pre-­‐IND  mee-ng:   NB1222  (CINV)   H2-­‐2016   •  Hold  FDA  pre-­‐IND  mee-ng:  NB1111   (Glaucoma)   •  Ini-ate  primate  sustained  release   glaucoma  study:  NB1111   •  Ini-ate  IND  enabling  studies:  NB1111   •  Complete  MRSA  in  vivo  studies   •  Ini-ate  MRSA  tox  studies   •  Ini-ate  CINV  tox  bridging  studies:   NB1222   •  Ini-ate  human  BA-­‐PK  study  in  CINV   •  Ini-ate  formula-on  work  on  new  CBD   formula-on  for  CIPN  
  • 26. 26   NEMUS  Bioscience,  Inc.  (OTCQB:  NMUS)   •  NEMUS  is  focused  on  developing  cannabinoid  molecules  for  the  treatment  and   management  of  acute  and  chronic  diseases,  especially  those  of  unmet  medical  need   •  NEMUS  cannabinoid  molecules  are  engineered  to  enhance  trans-­‐membrane  transport   resulNng  in:   ü  Enhanced  bioavailability   ü  Permits  routes  of  administra6on  that  avoid  first-­‐pass  metabolism  by  the  liver   ü  Resul6ng  in  more  predictable  pharmacokine6cs   ü  Patent  issued  in  August,  2014  allows  long  IP  runway  with  broad  claims  and  reach  for   the  delivery  of  molecules  and  condi6ons  that  can  be  treated   •  NEMUS  is  the  sole  development  and  commercializaNon  partner  of  the  University  of   Mississippi,  drawing  on  47  years  of  intellectual  capital  in  cannabinoid  chemistry  and   physiology   •  NEMUS  is  advancing  therapeuNcs  for  medical  applica-ons  in  global  mul--­‐billion  dollar   markets  including  a  cannabinoid  franchise  in  ophthalmology,  palliaNve  care  in  oncology,   and  anN-­‐infecNve  medicines,  especially  in  strains  developing  resistance  to  an-bio-cs  
  • 27. 27   Management   BRIAN  MURPHY,  MD,  MPH,  MBA  –  Chief  ExecuNve  Officer;  Chief  Medical  Officer,  Director   Dr.  Murphy  has  almost  two  decades  of  experience  in  drug  development  and  evalua-on,  both  from  the  academic  and  industry   perspec-ve.   He   most   recently   served   as   the   CMO   of   Eiger   Biosciences.   Previously,   Dr.   Murphy   was   CMO   at   Valeant   Pharmaceu-cals   Interna-onal   (VRX)   where   his   responsibili-es   also   included   oversight   of   Global   Medical   Affairs   and   Pharmacovigilance.  Dr.  Murphy  also  served  as  Medical  Director,  then  VP  of  Marke-ng  and  Commercial  Strategy  of  Hepatology   for  InterMune,  Inc.  (ITMN).  Prior  to  InterMune,  Dr.  Murphy  was  Medical  Director  of  North  America  for  An-virals/Interferons  at   Hoffmann-­‐LaRoche.  Murphy  is  board-­‐cer-fied  in  internal  medicine  and  completed  his  residency  at  Tuws-­‐New  England  Medical   Center.  He  went  on  to  complete  parallel  fellowship  tracts  at  Harvard  Medical  School  and  the  MassachuseGs  General  Hospital.   Dr.  Murphy  earned  his  MD,  MPH  (general  public  health),  and  MS  (pharmacology)  degrees  from  New  York  Medical  College  and   is   a   graduate   of   the   Harvard   School   of   Public   Health   (MPH   in   Health   Policy   and   Management).   He   earned   his   MBA   at   the   Columbia  University  Graduate  School  of  Business.         LIZ  BERECZ,  MA,  CPA  -­‐  Chief  Financial  Officer   Elizabeth  Berecz  is  a  seasoned  financial  execu-ve  with  over  20  years  of  experience  holding  senior  level  posi-ons  in  both  private   and   public   companies.   She   has   proven   success   in   leading   strategic   planning,   financial   repor-ng,   and   global   system   implementa-ons  for  companies  of  various  sizes.  Liz  started  her  career  at  Price  Waterhouse  Silicon  Valley  where  she  spent  five   years  audi-ng  several  high  profile  public  companies  in  the  technology  industry.  She  then  spent  10  years  holding  key  leadership   posi-ons   in   various   publicly   held   Companies   including   Quantum   Corpora-on   (Corporate   Controller),   Business   Objects   (VP   Finance  and  Administra-on),  and  Excite  (VP  Finance),  followed  by  10  years  of  key  leadership  roles  in  privately  held  Companies   including   CFO   posi-ons   with   Op-cal   Shop   Interna-onal,   StarTrac   Inc.,   Power   Balance   Technologies,   Inc.   and   most   recently   Bentley   Mills,   Inc.   She   also   serves   as   an   Adjunct   Professor   of   Accoun-ng   and   Finance   at   the   University   of   San   Francisco.   Elizabeth   received   her   BA   in   Economics   from   Stanford   University   and   a   MA   in   Sports   Management   from   University   of   San   Francisco.    
  • 28. 28   Management   COSMAS  N.  LYKOS,  ESQ  –  Co-­‐founder,  Officer  &  Board  Member  –  ExecuNve  Chairman       Cosmas  Lykos  co-­‐founded  NEMUS  in  2012  and  has  served  as  its  Chairman  of  the  Board  of  Directors  since  August  2014.     Awer  gradua-ng  with  Honors  from  Duke  University  School  of  Law  in  1993,  Mr.  Lykos  began  his  career  at  Gibson  Dunn  &   Crutcher,  LLP,  an  interna-onal  full-­‐service  law  firm,  as  a  corporate  associate  un-l  1998.    From  1998  to  2004,  Mr.  Lykos   served  as  Vice  President  of  Business  Affairs,  General  Counsel,  Secretary  and  Chief  Compliance  Officer  of  RemedyTemp,   Inc.,  a  NASDAQ  publicly-­‐traded  temporary  staffing  firm  with  over  250  directly-­‐owned  and  franchised  offices  na-onwide.     From  2004  un-l  2008,  Mr.  Lykos  served  as  Vice  President  of  Business  Development,  Chief  Legal  Officer,  Secretary  and  Chief   Compliance  Officer  of  Oakley,  Inc.,  a  NYSE  publicly-­‐traded  sports  and  technical  eyewear,  apparel,  accessories  and  retail   company.     In   January   of   2008,   he   became   Co-­‐owner   and   President   of   the   Op-cal   Shop   Interna-onal,   a   designer   and   distributor   of   licensed   eyewear   brands,   including   Chrome   Hearts   and   Blinde,   through   two   wholly-­‐owned   foreign   subsidiaries  with  a  direct  and  distributor  sales  network  in  over  60  countries  around  the  world.    Primary  responsibili-es   included  developing  and  implemen-ng  OSI’s  vision  and  strategies  and  the  management  of  its  foreign  subsidiaries,  sales,   legal,  human  resources,  finance  and  administra-ve  func-ons.    In  2011,  Mr.  Lykos  nego-ated  and  consummated  the  sale  of   OSI  to  its  primary  licensor,  Chrome  Hearts  LLC  and  con-nues  to  provide  consul-ng  services.    Mr.  Lykos  has  extensive  public   and  private  company  board  of  directors  experience.    As  Chief  Compliance  and  Legal  Officer  and  Secretary  of  both  Oakley,   Inc.  and  RemedyTemp,  Inc.,  Mr.  Lykos  aGended  all  board  of  director  mee-ngs  and  board  commiGee  mee-ngs.    As  an  angel   investor,   Mr.   Lykos   has   made   minority   investments   in   various   private   companies   and   has   served   on   their   Board   of   Directors.      
  • 29. 29   BOD  &  Strategic  Advisors   MAHMOUD  A.  ELSOHLY,  PHD     ScienNfic  Advisor   World’s  foremost  expert  on  the  science   of  cannabinoids.    300+    scien-fic   publica-ons  .    Research  professor  at  The   University  of  Mississippi.   JERRY  MCLAUGHLIN,  MBA     Strategic  Advisor,     Board  of  Directors  -­‐  Member   CEO  of  AgeneBio;  25  year  veteran   execu-ve  in  pharmaceu-cal  medical   device  and  healthcare  related  industries   (Endo  Pharma,  Merck,  MBA-­‐  Villanova   University,BA-­‐  Dickinson  College).   TOM  GEORGE   Board  of  Directors  –  Chairman  of  Audit   Commitee   30  year  senior  execu-ve  in  corporate   finance  and  accoun-ng;  CFO  of  Deckers   Brands  (  Ophthonix,  Oakley,  Coopers  &   Lybrand).  Graduate  of  University  of   Southern  California.   DOUGLAS  S.  INGRAM,  ESQ   Board  of  Directors  –  Vice  Chairman,   Chairman  of  CompensaNon  Commitee   25  year  senior  execu-ve  in  healthcare,   Past  President  of  Allergan,  former   AGorney  at  Gibson,  Dunn  &  Crutcher,   LLP.  Summa  cum  laude  and  Order  of  the   Coif  graduate  of  the  Univ.  of  Arizona   school  of  law.   ROBERT  N.  WEINREB,  M.D.     ScienNfic  Advisor   Chair,  Ophthalmology  Advisory  Board   Globally  recognized  expert  on  glaucoma   and  eye  diseases.    1000+    scien-fic   publica-ons.  Dis-nguished  Professor  of   Ophthalmology;  University  of  California   San  Diego.     DONALD  I.  ABRAMS,  M.D.     ScienNfic  Advisor   Chief,  Hematology/Oncology  at  UCSF   Cancer  and  Integra-ve  Medicine   specialist  with  research  interests  in  the   development  of  an--­‐cancer  therapeu-cs   and  pallia-ve  care  medicines.  
  • 30. 30   Contact     650  Town  Center  Drive,  Suite  1770   Costa  Mesa,  CA  92626   949-­‐396-­‐0330   hello@nemusbio.com   www.nemusbioscience.com     Investor  RelaNons:   Adam  Holdsworth   PCG  Advisory  Group   Tel:  646-­‐862-­‐4607   adamh@pcgadvisory.com     Company:   Brian  Murphy,  MD,  MPH,  MBA   CEO  -­‐  CMO   Tel:  949-­‐355-­‐1140   brian@nemusbio.com