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The safety of massage therapy
E. Ernst
Objectives. After many years out of the limelight, massage therapy is now
experiencing a revival. The aim of this systematic review is to evaluate its potential
for harm.
Methods. Computerized literature searches were carried out in four databases. All
articles reporting adverse effects of any type of massage therapy were retrieved.
Adverse effects relating to massage oil or ice were excluded. No language
restrictions were applied. Data were extracted and evaluated according to
predefined criteria.
Results. Sixteen case reports of adverse effects and four case series were found.
The majority of adverse effects were associated with exotic types of manual
massage or massage delivered by laymen, while massage therapists were rarely
implicated. The reported adverse events include cerebrovascular accidents, displace-
ment of a ureteral stent, embolization of a kidney, haematoma, leg ulcers, nerve
damage, posterior interosseous syndrome, pseudoaneurism, pulmonary embolism,
ruptured uterus, strangulation of neck, thyrotoxicosis and various pain syndromes.
In the majority of these instances, there can be little doubt about a cause–effect
relationship. Serious adverse effects were associated mostly with massage
techniques other than ‘Swedish’ massage.
Conclusion. Massage is not entirely risk free. However, serious adverse events are
probably true rarities.
KEY WORDS: Complementary and alternative medicine, Massage, Adverse effects, Safety, Risk.
Massage can be defined as the systematic manipulation
of soft tissues of the body for pain reduction or other
therapeutic purposes. Manual palpation involved can
also be used for diagnostic purposes. ‘Classic’ (‘Swedish’)
massage comprises effleurage (stroking and gliding),
petrissage (kneading), and tapotement (percussion) w1x.
Various forms of massage originate from different parts
of the world (Table 1).
Until the early parts of the twentieth century, massage
was widely accepted in Europe and elsewhere as an
effective treatment for a range of conditions w2x. Even
though most of its indications are still not backed up by
convincing evidence we.g. 3, 4x, massage is making a
comeback. Between 1990 and 1997, the 1-year preva-
lence of use of massage by the US general population
increased from 6 to 12% w5x and massage belongs to the
three most popular complementary therapies, both in the
US w6x and in the UK w7x. The majority of physicians
(83%) feel that massage provides a useful adjunct to their
own practice and many (71%) refer patients to massage
therapists w8–10x.
The aim of this systematic review is to evaluate all
published data about adverse effects of massage therapy.
Methods
Computerized literature searches were carried out using
Medline, Embase, The Cochrane Library and AMED (January
1995 to December 2001). The search terms used were adverse
events, complications, lymph drainage, manual therapy,
massage, risk, Rolfing, safety and shiatsu. In addition, my
own files were searched, and other experts (n=21) as well as
professional organizations of massage therapy (n=18) were
consulted. The bibliographies of articles thus located were
also searched.
All reports (irrespective of language of publication) with
original data on adverse effects following any type of massage
therapy were included. Treatments not typically carried out
by a massage therapist were excluded, for example cardiac
Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK.
Submitted 2 May 2002; revised version accepted 5 February 2003.
Correspondence to: E. Ernst. E-mail: Edzard.Ernst@pms.ac.uk
Rheumatology 2003;42:1101–1106
doi:10.1093/rheumatology/keg306, available online at www.rheumatology.oupjournals.org
Advance Access publication 30 May 2003
1101
Rheumatology 42 ß British Society for Rheumatology 2003; all rights reserved
Rheumatology 2003;42:1101–1106
doi:10.1093/rheumatology/keg306, available online at www.rheumatology.oupjournals.org
Advance Access publication 30 May 2003
atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
massage, prostatic massage or carotid sinus massage. Adverse
events related to massage oils, such as allergies to aroma-
therapy oils, or to the use of ice in conjunction with massage
were also excluded we.g. 11, 12x. All articles were evaluated and
validated by the present author according to predefined criteria
(see headings of Table 2).
Results
Thirty-one relevant articles were located w13–43x. All
adverse effects are summarized in Table 2; exemplary
reports are also detailed below.
Massage by professionals
A 45-yr-old American man presented with acute exten-
sor paralysis of the metacarpophalangeal joints and
inability to abduct the thumb radially w25x. The problems
had occurred 15–20 min after deep tissue massage of the
forearm on the affected side. The massage included
direct pressure applied laterally with the elbow of the
therapist. The patient was diagnosed to suffer from
posterior interosseous syndrome. The cause was deemed
to be the direct and persistent pressure applied laterally,
compressing the posterior interosseous nerve against the
interosseous membrane causing neuropraxia.
A 39-yr-old healthy woman, who had no relevant
medical history and was taking no medication, had a
deep tissue massage that included the abdomen w26x.
Within 24 h, she experienced abdominal discomfort,
shoulder pain and nausea. Seventy-two hours after the
massage, she was admitted to hospital. On admission,
she was anaemic (haematocrit=23 lul), and an abdomi-
nal CT scan showed a large (14 cm318 cm) haematoma
in the right hepatic lobe. There was no evidence of
haemangioma, adenoma or other intrahepatic lesions.
A diagnosis of hepatic haematoma was made and the
most likely cause was thought to be the forceful abdo-
minal massage. Over the subsequent 6 months, the
patient received 2 units of packed red cells, lost 10.4 kg
of body weight due to persistent nausea, and developed
a low-grade fever. Eventually she made a full recovery.
German otolaryngologists published a series of four
patients with adverse reactions to conventional massage
therapy w32x. These individuals all suffered from neck
pain and were prescribed massage therapy. Subsequently
they noted an acute deterioration of hearing, which
was verified audiographically in all cases. The authors
feel that the time sequence of events renders a causal
relationship likely and report that they have seen ‘several
more cases’ of this type.
Clinical trials of massage therapy we.g. 33–35x rarely
mention adverse effects. A laudable exception is a study
of premature infant massage w36x. The authors observed
a small temperature drop after massage and noted that
‘the technique may expose the infant to a slight heat loss’.
Six normal volunteers and two patients with post-
thrombotic venous oedema were treated with manual
lymph massage with an external pressure of 70–100 mmHg
w37x. Subsequently biopsies were taken of the lymphatic
vessels. After a 10-min massage, damage of lymphatics
TABLE1.Briefexplanationsofdifferentformsofmanualmassagetherapy
Name
Countryof
originuoriginator
Description
oftechniqueTherapeuticaimPostulatedmechanism
Frictionmassage
orconnective
tissuemassage
(German:Bindegewebs
massage)
GermanyuDickeStrongandoftenpainful
mobilizationofsubcutaneous
tissuesbyspecialstrokingof
subcutaneoustissuesofthe
torsoandtheextremities
‘Neurotherapeutic’
methodaimedatloosening
adhesionsandinfluencing
distantorgans
Stimulationof
nerveendings
oftheautonomic
nervoussystem
LymphdrainageGermanyuFo¨ldiGentlestrokingtechniquealonglymph
vesselsandoverlymphnodes
IncreaselymphflowPassivemovement
oflymph
RolfingUSuRolfDeepandsometimespainful
manipulationofsofttissuestobreak
downabnormalconnectivetissue
Loosenupand
realignbody
Supportbody’s
ownenergyfield
ShiatsuJapanun.a.Massagewithstrongdigitalpressure
overacupuncturepoints
Restoreenergeticbalance
ofthebody
Stimulateenergy
flowaccordingtothe
conceptsofacupuncture
Swedishmassage
(classicmuscularmassage)
Europeun.a.Effleurage(stroking),petrissage
(kneading),tapotement
(vibrationandshaking),friction
(rubbing)
Decreasemuscletone,
increasebloodflow,
reducepain
Washoutlocalpainmediators,
reducemuscularspasm,
reducecentralpainperception
UrutMalaysiaun.a.Forcefulmassagetechniqueusedby
Malaytraditionalhealers
NotknownNotknown
n.a.,notapplicable.
1102 E. Ernst1102 E. Ernst
atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
TABLE 2. Reports of adverse events associated with massage therapy
First author
(year) Patient Type of massage Therapist Site of massage Indication Adverse event Causalityd
Outcome
Thambua
(1971) 30-yr-old Malay
pregnant woman
Urut Traditional
Malay healer
Abdomen Pregnancy Ruptured uterus Certain Surgery and
subsequent full
recovery
Warrena
(1978) 72-yr-old woman Vigorous massage
for ;10 min
Relative Calf muscle Leg pain Pulmonary embolism Likely Not mentioned
Tachia
(1990) 57-yr-old woman with
Hashimoto’s disease
Vigorous manual
massage
Not mentioned Neck Muscle pain
and stiffness
Transient destructive
thyrotoxicosis
Possible Full recovery after
6 months
Herskovitza
(1992)
61-yr-old man Shiatsu massage with
strong digital
pressure
Shiatsu therapist Base of his
palm and
thenar muscles
Not mentioned Painless weakness of
left thumb without
sensory symptoms
Certain Full recovery over
next 2 months
Sorensena
(1993)
38-yr-old diabetic man
with peripheral
neuropathy
Vacuum boot foot
massage with
mechanical device
‘Alternative
therapist’
Feet Peripheral
vascular
disease
Ulceration and infection Certain Amputation of leg
Liua
(1993) 52-yr-old man Self-massage with
‘massage balls’
Self-treatment Neck Chronic neck
pain
Tapered stenosis of the
extracranial
internal carotid artery
Possible Not mentioned
Mumma
(1993) 64-yr-old woman Shiatsu Shiatsu therapist Not mentioned Not mentioned Pain in left pericervical
and suprascapular areas
Possible Not mentioned
Rama
(1994) 1-day-old neonate ‘Traditional’ with
sand bag
Relative Testes Hydrocele Large haematoma Likely Full recovery
after surgical
intervention
Yeoa
(1994) 62-yr-old
anticoagulated
patient
Manual massagec
Relative Back Back pain Large haematoma,
slight anaemia
Likely Full recovery
within 2 weeks
Kalingaa
(1996) 16-yr-old boy with
exostosis on femur
Traditional Chinese
massagec
,
5 sessions
Practitioner of
traditional
Chinese medicine
Right thigh Pain in right
thigh
Pseudoaneurysm of
popliteal artery
Likely Full recovery
after arterial
reconstruction
Kerra
(1997) 51-yr-old women with
ureteral stent
Deep body massage
using Rolfing
technique
Rolfing therapist Abdomen,
pelvis, lower
back
Not mentioned Displacement of
ureteral
stent, a pin
Likely Full recovery after
repositioning
of stent
Mikhaila
(1997) 59-yr-old man with
aortofemoral bypass
Back massage including
walking on back
Relative Back Back pain Embolization of
the left kidney
Likely Full recovery with
anticoagulation and new
aortofemoral bypass
Giesea
(1998) 45-yr-old man Deep tissue massage
including
pressure applied with
elbow
Massage therapist Forearm Pain in
right forearm
Posterior interosseous
syndrome
Likely Near full recovery
after 3 weeks
Trottera
(1999) 39-yr-old woman Deep tissue massage Not mentioned Abdomen Not mentioned Large hepatic
haematoma
Likely Full recovery after
6 months
Safetyofmassagetherapy1103Safetyofmassagetherapy1103
atNanjingUniversityonMarch30,2012 http://rheumatology.oxfordjournals.org/ Downloadedfrom
was verified by electron microscopy. It affected initially
the endothelial lining and subsequently also lymphatic
collectors. The pressures applied were in excess of those
used in manual lymphatic drainage w38x.
Massage by laymen
A 72-yr-old woman was admitted to hospital with
thrombosis of the right middle cerebral artery w14x. She
later complained of discomfort in the left calf and a
diagnosis of deep-vein thrombophlebitis was made. The
leg was raised and intravenous heparin was started. The
patient’s husband massaged her leg vigorously for about
10 min in an attempt to relieve her discomfort. Sub-
sequently, the patient became short of breath and a
pulmonary embolus was diagnosed.
A 62-yr-old Chinese male on warfarin with stable INR
readings was admitted for an acute swelling over his left
back w21x. His wife had given him a vigorous manual
back massage for musculoskeletal pain in that area
2 days before. The patient was diagnosed to suffer from
a large (20 cm312 cm) haematoma, orthostatic hypo-
tension and slight anaemia. Both INR and platelet count
were normal. The patient’s warfarin medication was
temporarily reduced and a blood transfusion was admini-
stered. The haematoma gradually resolved over the next
2 weeks and the patient made a full recovery. The most
likely cause for the haematoma was the vigorous manual
massage combined with the warfarin-induced bleeding
tendency.
A 59-yr-old man with an aortobifemoral bypass was
admitted after his wife had treated him for back pain
with a manual massage, which included walking on his
back w24x. The patient subsequently experienced severe
left loin pain. The bypass had been performed
18 months previously; it had initially been successful
but had occluded later. The massage had dislodged the
thrombus in the graft into the left kidney. The patient
was anticoagulated, and later a new aortobifemoral graft
was implanted. A further abdominal CT scan 4 months
postoperatively showed no defect in the left kidney.
Massage using apparatus
A 38-yr-old man was treated by an ‘alternative therapist’
with a mechanical leg massage (vacuum boot) for peri-
pheral vascular disease in the presence of peripheral
diabetic neuropathy w17x. The patient subsequently
developed an infected leg ulcer. The leg became gan-
grenous and had to be amputated. The authors warn
that ‘patients of this kind wshould notx receive treatment
from any person without medical experience’.
A 56-yr-old woman placed an electric roller massage
device on her bed under her head to treat her neck pain
before retiring for the evening w27x. Later, when her
husband went to bed he noted that she was in the supine
position and the device was apparently functioning nor-
mally. The husband was awoken early next morning by a
clicking noise and found his wife in the same position.
Her blouse had become entangled in the roller of the
massage device and was constricted around her neck.
The husband called the paramedics who verified her death.
Deidikera
(1999)56-yr-oldwomenElectricalrollermassage
devise
Self-treatmentNeckNeckpainStrangulationofneckCertainDeath
Tsuboia
(2001)80-yr-oldmanShiatsuShiatsu
practitioner
UpperneckNeckand
shoulderpain,
headache
Retinalartery
embolismwith
subsequentpartial
lossofvision
andlefthemiparesis
LikelyPermanentocular
effects
Unknownb
(1980)
167lactatingwomenTraditionalRussian
breastmassage
TraditionalhealersBreastsLactationmastitisDeteriorationof
mastitisabscesses
CertainNotmentioned
Rahmanb
(1987)3MalaywomenUrut
(traditionalmassage)
TraditionalhealersAbdomenAbdominalpainColonruptureCertainFullrecovery
aftersurgery
Becroftb
(1989)48infantsTraditionalmassageTraditionalhealersAbdomen
ofmother
PregnancyCranialhaemorrhage
infetus
ProbableNotmentioned
Bru¨gelb
(1991)4patientsSwedishmassageTrainedmassage
therapist
NeckNeckpainDeteriorationof
hearing
ProbableNotmentioned
a
Casereport.
b
Caseseries.
c
Nofurtherdetailsprovided.
d
Asestimatedbythepresentauthor.
TABLE2.Continued
Firstauthor
(year)PatientTypeofmassageTherapistSiteofmassageIndicationAdverseeventCausalityd
Outcome
1104 E. Ernst1104 E. Ernst
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Exotic forms of manual massage
A 61-yr-old man received a shiatsu massage from a
trained therapist with strong digital pressure in the region
of the base of his palm and the thenar muscles w16x. The
procedure was accompanied with ‘notable transient pain’.
The next day he noticed a weakness of the left thumb
without sensory symptoms. On examination, he exhibited
moderate isolated weakness of the abductor policis brevis
muscle without atrophy or sensory dysfunction. Tinel’s
and Phalen’s signs were negative and nerve conduction
studies yielded normal findings. Mild active denervation
and reduced motor unit recruitment were noticed
electromyographically. The authors diagnosed a mono-
neuropathy caused by the manual compression of the
recurrent motor branch of the median nerve. The patient
made an uneventful recovery over the next few months.
Hawaiian authors report the case of a 64-yr-old woman
admitted to hospital for suspected myocardial infarction
w19x. She complained of increasing pain in the peri-
cervical and suprascapular areas. Myocardial infarc-
tion was not confirmed but the pain increased. A typical
rash along the left eighth cervical dermatome led to the
diagnosis of herpes zoster, confirmed through antibody
titres. The patient revealed that she had been treated with
‘an overtly vigorous shiatsu massage’ 3 days before the
onset of pain. The authors speculate that ‘zoster resulted
from either direct trauma to the nerve or nerve root during
the massage, or to subsequent tissue inflammation causing
swelling or immunological injury to the nerve’.
A 51-yr-old American woman had undergone place-
ment of a left ureteral double-J stent to relieve flank pain
associated with ureteral stricture w23x. Six days later she
consulted a ‘Rolfer’ and received a deep body massage
according to the Rolfing technique, which she had
enjoyed previously on a regular basis. The massage was
applied to the abdomen, pelvis and lower back. Towards
the end of the session, the patient experienced severe
flank pain and urinary incontinence. She was admitted
to hospital where a visible protrusion of the tip of the
stent was noted 1 cm beyond the ureteral orifice. Distal
migration of the stent was confirmed by radiographic
examination. The patient’s stent was repositioned, and
she subsequently made a full recovery.
An 80-yr-old Japanese man with a history of transient
ischaemic attacks and anticoagulant therapy received a
shiatsu massage on the neck in prone position to treat a
mild headache w28x. Immediately after rising, the nasal
half of his right visual field was impaired. He also
showed slight left hemiparesis dominant in the upper
extremity. Further investigations showed multiple branch
occlusions of the central artery and multiple small
infarctions in the right frontal lobe. The patient was
treated with urikinase for 7 days. Subsequently there
was full recovery of the hemiparesis but only minimal
improvement of ocular symptoms.
Reviews
US authors reviewed the question of whether back
massages are contraindicated after an acute myocardial
infarction w39x. They found elevation of blood pressure
and decrease of heart rate following back massage in
normal volunteers. Thus they caution that ‘heart rate
and blood pressure should be monitored before and after
the procedure to identify patients at risk for sympathetic
stimulation’. Other reviews of massage therapy for
specific indications w40–42x fail to address any safety
aspects. A recent Cochrane review of massage therapy
for pre-term infants states that ‘no adverse effects of
touch or massage were reported in any study’ w43x.
Discussion
Sixteen case reports and four case series (Table 2) of
adverse events after massage therapy were found. Massage
was frequently used for rheumatological conditions. In
the majority of these cases causality is established con-
vincingly, for instance, through the sequence or nature of
events. Some of the adverse effects relate to serious
complications.
Considering the popularity of massage therapy, the
number of reported adverse events seems minute. How-
ever, this could be due to under-reporting. In a related
area (spinal manipulation) we have, for instance, shown
that under-reporting of serious adverse events is close to
100% w44x.
Clearly, one should differentiate between various
approaches. The above findings suggest that massage
by non-professional and forceful techniques like shiatsu,
urut and Rolfing are relatively often associated with
adverse events. The reports reviewed above are often
incomplete. For instance, the background of the ther-
apist and the type of massage therapy are not always
described. This further limits the conclusiveness of the
evidence.
Several systematic reviews of controlled clinical trials
testing the effectiveness of massage therapies have been
published and have arrived at cautiously positive con-
clusions we.g. 45–47x. However, too few clinical trials of
massage therapy exist and many of its claims are not
backed up by evidence w3, 4x. Thus adequate risk–benefit
evaluations are not feasible.
In conclusion, massage therapies are not totally devoid
of risks. The incidence of adverse events is unknown,
but probably low.
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The safety of massage

  • 1. The safety of massage therapy E. Ernst Objectives. After many years out of the limelight, massage therapy is now experiencing a revival. The aim of this systematic review is to evaluate its potential for harm. Methods. Computerized literature searches were carried out in four databases. All articles reporting adverse effects of any type of massage therapy were retrieved. Adverse effects relating to massage oil or ice were excluded. No language restrictions were applied. Data were extracted and evaluated according to predefined criteria. Results. Sixteen case reports of adverse effects and four case series were found. The majority of adverse effects were associated with exotic types of manual massage or massage delivered by laymen, while massage therapists were rarely implicated. The reported adverse events include cerebrovascular accidents, displace- ment of a ureteral stent, embolization of a kidney, haematoma, leg ulcers, nerve damage, posterior interosseous syndrome, pseudoaneurism, pulmonary embolism, ruptured uterus, strangulation of neck, thyrotoxicosis and various pain syndromes. In the majority of these instances, there can be little doubt about a cause–effect relationship. Serious adverse effects were associated mostly with massage techniques other than ‘Swedish’ massage. Conclusion. Massage is not entirely risk free. However, serious adverse events are probably true rarities. KEY WORDS: Complementary and alternative medicine, Massage, Adverse effects, Safety, Risk. Massage can be defined as the systematic manipulation of soft tissues of the body for pain reduction or other therapeutic purposes. Manual palpation involved can also be used for diagnostic purposes. ‘Classic’ (‘Swedish’) massage comprises effleurage (stroking and gliding), petrissage (kneading), and tapotement (percussion) w1x. Various forms of massage originate from different parts of the world (Table 1). Until the early parts of the twentieth century, massage was widely accepted in Europe and elsewhere as an effective treatment for a range of conditions w2x. Even though most of its indications are still not backed up by convincing evidence we.g. 3, 4x, massage is making a comeback. Between 1990 and 1997, the 1-year preva- lence of use of massage by the US general population increased from 6 to 12% w5x and massage belongs to the three most popular complementary therapies, both in the US w6x and in the UK w7x. The majority of physicians (83%) feel that massage provides a useful adjunct to their own practice and many (71%) refer patients to massage therapists w8–10x. The aim of this systematic review is to evaluate all published data about adverse effects of massage therapy. Methods Computerized literature searches were carried out using Medline, Embase, The Cochrane Library and AMED (January 1995 to December 2001). The search terms used were adverse events, complications, lymph drainage, manual therapy, massage, risk, Rolfing, safety and shiatsu. In addition, my own files were searched, and other experts (n=21) as well as professional organizations of massage therapy (n=18) were consulted. The bibliographies of articles thus located were also searched. All reports (irrespective of language of publication) with original data on adverse effects following any type of massage therapy were included. Treatments not typically carried out by a massage therapist were excluded, for example cardiac Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK. Submitted 2 May 2002; revised version accepted 5 February 2003. Correspondence to: E. Ernst. E-mail: Edzard.Ernst@pms.ac.uk Rheumatology 2003;42:1101–1106 doi:10.1093/rheumatology/keg306, available online at www.rheumatology.oupjournals.org Advance Access publication 30 May 2003 1101 Rheumatology 42 ß British Society for Rheumatology 2003; all rights reserved Rheumatology 2003;42:1101–1106 doi:10.1093/rheumatology/keg306, available online at www.rheumatology.oupjournals.org Advance Access publication 30 May 2003 atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
  • 2. massage, prostatic massage or carotid sinus massage. Adverse events related to massage oils, such as allergies to aroma- therapy oils, or to the use of ice in conjunction with massage were also excluded we.g. 11, 12x. All articles were evaluated and validated by the present author according to predefined criteria (see headings of Table 2). Results Thirty-one relevant articles were located w13–43x. All adverse effects are summarized in Table 2; exemplary reports are also detailed below. Massage by professionals A 45-yr-old American man presented with acute exten- sor paralysis of the metacarpophalangeal joints and inability to abduct the thumb radially w25x. The problems had occurred 15–20 min after deep tissue massage of the forearm on the affected side. The massage included direct pressure applied laterally with the elbow of the therapist. The patient was diagnosed to suffer from posterior interosseous syndrome. The cause was deemed to be the direct and persistent pressure applied laterally, compressing the posterior interosseous nerve against the interosseous membrane causing neuropraxia. A 39-yr-old healthy woman, who had no relevant medical history and was taking no medication, had a deep tissue massage that included the abdomen w26x. Within 24 h, she experienced abdominal discomfort, shoulder pain and nausea. Seventy-two hours after the massage, she was admitted to hospital. On admission, she was anaemic (haematocrit=23 lul), and an abdomi- nal CT scan showed a large (14 cm318 cm) haematoma in the right hepatic lobe. There was no evidence of haemangioma, adenoma or other intrahepatic lesions. A diagnosis of hepatic haematoma was made and the most likely cause was thought to be the forceful abdo- minal massage. Over the subsequent 6 months, the patient received 2 units of packed red cells, lost 10.4 kg of body weight due to persistent nausea, and developed a low-grade fever. Eventually she made a full recovery. German otolaryngologists published a series of four patients with adverse reactions to conventional massage therapy w32x. These individuals all suffered from neck pain and were prescribed massage therapy. Subsequently they noted an acute deterioration of hearing, which was verified audiographically in all cases. The authors feel that the time sequence of events renders a causal relationship likely and report that they have seen ‘several more cases’ of this type. Clinical trials of massage therapy we.g. 33–35x rarely mention adverse effects. A laudable exception is a study of premature infant massage w36x. The authors observed a small temperature drop after massage and noted that ‘the technique may expose the infant to a slight heat loss’. Six normal volunteers and two patients with post- thrombotic venous oedema were treated with manual lymph massage with an external pressure of 70–100 mmHg w37x. Subsequently biopsies were taken of the lymphatic vessels. After a 10-min massage, damage of lymphatics TABLE1.Briefexplanationsofdifferentformsofmanualmassagetherapy Name Countryof originuoriginator Description oftechniqueTherapeuticaimPostulatedmechanism Frictionmassage orconnective tissuemassage (German:Bindegewebs massage) GermanyuDickeStrongandoftenpainful mobilizationofsubcutaneous tissuesbyspecialstrokingof subcutaneoustissuesofthe torsoandtheextremities ‘Neurotherapeutic’ methodaimedatloosening adhesionsandinfluencing distantorgans Stimulationof nerveendings oftheautonomic nervoussystem LymphdrainageGermanyuFo¨ldiGentlestrokingtechniquealonglymph vesselsandoverlymphnodes IncreaselymphflowPassivemovement oflymph RolfingUSuRolfDeepandsometimespainful manipulationofsofttissuestobreak downabnormalconnectivetissue Loosenupand realignbody Supportbody’s ownenergyfield ShiatsuJapanun.a.Massagewithstrongdigitalpressure overacupuncturepoints Restoreenergeticbalance ofthebody Stimulateenergy flowaccordingtothe conceptsofacupuncture Swedishmassage (classicmuscularmassage) Europeun.a.Effleurage(stroking),petrissage (kneading),tapotement (vibrationandshaking),friction (rubbing) Decreasemuscletone, increasebloodflow, reducepain Washoutlocalpainmediators, reducemuscularspasm, reducecentralpainperception UrutMalaysiaun.a.Forcefulmassagetechniqueusedby Malaytraditionalhealers NotknownNotknown n.a.,notapplicable. 1102 E. Ernst1102 E. Ernst atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
  • 3. TABLE 2. Reports of adverse events associated with massage therapy First author (year) Patient Type of massage Therapist Site of massage Indication Adverse event Causalityd Outcome Thambua (1971) 30-yr-old Malay pregnant woman Urut Traditional Malay healer Abdomen Pregnancy Ruptured uterus Certain Surgery and subsequent full recovery Warrena (1978) 72-yr-old woman Vigorous massage for ;10 min Relative Calf muscle Leg pain Pulmonary embolism Likely Not mentioned Tachia (1990) 57-yr-old woman with Hashimoto’s disease Vigorous manual massage Not mentioned Neck Muscle pain and stiffness Transient destructive thyrotoxicosis Possible Full recovery after 6 months Herskovitza (1992) 61-yr-old man Shiatsu massage with strong digital pressure Shiatsu therapist Base of his palm and thenar muscles Not mentioned Painless weakness of left thumb without sensory symptoms Certain Full recovery over next 2 months Sorensena (1993) 38-yr-old diabetic man with peripheral neuropathy Vacuum boot foot massage with mechanical device ‘Alternative therapist’ Feet Peripheral vascular disease Ulceration and infection Certain Amputation of leg Liua (1993) 52-yr-old man Self-massage with ‘massage balls’ Self-treatment Neck Chronic neck pain Tapered stenosis of the extracranial internal carotid artery Possible Not mentioned Mumma (1993) 64-yr-old woman Shiatsu Shiatsu therapist Not mentioned Not mentioned Pain in left pericervical and suprascapular areas Possible Not mentioned Rama (1994) 1-day-old neonate ‘Traditional’ with sand bag Relative Testes Hydrocele Large haematoma Likely Full recovery after surgical intervention Yeoa (1994) 62-yr-old anticoagulated patient Manual massagec Relative Back Back pain Large haematoma, slight anaemia Likely Full recovery within 2 weeks Kalingaa (1996) 16-yr-old boy with exostosis on femur Traditional Chinese massagec , 5 sessions Practitioner of traditional Chinese medicine Right thigh Pain in right thigh Pseudoaneurysm of popliteal artery Likely Full recovery after arterial reconstruction Kerra (1997) 51-yr-old women with ureteral stent Deep body massage using Rolfing technique Rolfing therapist Abdomen, pelvis, lower back Not mentioned Displacement of ureteral stent, a pin Likely Full recovery after repositioning of stent Mikhaila (1997) 59-yr-old man with aortofemoral bypass Back massage including walking on back Relative Back Back pain Embolization of the left kidney Likely Full recovery with anticoagulation and new aortofemoral bypass Giesea (1998) 45-yr-old man Deep tissue massage including pressure applied with elbow Massage therapist Forearm Pain in right forearm Posterior interosseous syndrome Likely Near full recovery after 3 weeks Trottera (1999) 39-yr-old woman Deep tissue massage Not mentioned Abdomen Not mentioned Large hepatic haematoma Likely Full recovery after 6 months Safetyofmassagetherapy1103Safetyofmassagetherapy1103 atNanjingUniversityonMarch30,2012 http://rheumatology.oxfordjournals.org/ Downloadedfrom
  • 4. was verified by electron microscopy. It affected initially the endothelial lining and subsequently also lymphatic collectors. The pressures applied were in excess of those used in manual lymphatic drainage w38x. Massage by laymen A 72-yr-old woman was admitted to hospital with thrombosis of the right middle cerebral artery w14x. She later complained of discomfort in the left calf and a diagnosis of deep-vein thrombophlebitis was made. The leg was raised and intravenous heparin was started. The patient’s husband massaged her leg vigorously for about 10 min in an attempt to relieve her discomfort. Sub- sequently, the patient became short of breath and a pulmonary embolus was diagnosed. A 62-yr-old Chinese male on warfarin with stable INR readings was admitted for an acute swelling over his left back w21x. His wife had given him a vigorous manual back massage for musculoskeletal pain in that area 2 days before. The patient was diagnosed to suffer from a large (20 cm312 cm) haematoma, orthostatic hypo- tension and slight anaemia. Both INR and platelet count were normal. The patient’s warfarin medication was temporarily reduced and a blood transfusion was admini- stered. The haematoma gradually resolved over the next 2 weeks and the patient made a full recovery. The most likely cause for the haematoma was the vigorous manual massage combined with the warfarin-induced bleeding tendency. A 59-yr-old man with an aortobifemoral bypass was admitted after his wife had treated him for back pain with a manual massage, which included walking on his back w24x. The patient subsequently experienced severe left loin pain. The bypass had been performed 18 months previously; it had initially been successful but had occluded later. The massage had dislodged the thrombus in the graft into the left kidney. The patient was anticoagulated, and later a new aortobifemoral graft was implanted. A further abdominal CT scan 4 months postoperatively showed no defect in the left kidney. Massage using apparatus A 38-yr-old man was treated by an ‘alternative therapist’ with a mechanical leg massage (vacuum boot) for peri- pheral vascular disease in the presence of peripheral diabetic neuropathy w17x. The patient subsequently developed an infected leg ulcer. The leg became gan- grenous and had to be amputated. The authors warn that ‘patients of this kind wshould notx receive treatment from any person without medical experience’. A 56-yr-old woman placed an electric roller massage device on her bed under her head to treat her neck pain before retiring for the evening w27x. Later, when her husband went to bed he noted that she was in the supine position and the device was apparently functioning nor- mally. The husband was awoken early next morning by a clicking noise and found his wife in the same position. Her blouse had become entangled in the roller of the massage device and was constricted around her neck. The husband called the paramedics who verified her death. Deidikera (1999)56-yr-oldwomenElectricalrollermassage devise Self-treatmentNeckNeckpainStrangulationofneckCertainDeath Tsuboia (2001)80-yr-oldmanShiatsuShiatsu practitioner UpperneckNeckand shoulderpain, headache Retinalartery embolismwith subsequentpartial lossofvision andlefthemiparesis LikelyPermanentocular effects Unknownb (1980) 167lactatingwomenTraditionalRussian breastmassage TraditionalhealersBreastsLactationmastitisDeteriorationof mastitisabscesses CertainNotmentioned Rahmanb (1987)3MalaywomenUrut (traditionalmassage) TraditionalhealersAbdomenAbdominalpainColonruptureCertainFullrecovery aftersurgery Becroftb (1989)48infantsTraditionalmassageTraditionalhealersAbdomen ofmother PregnancyCranialhaemorrhage infetus ProbableNotmentioned Bru¨gelb (1991)4patientsSwedishmassageTrainedmassage therapist NeckNeckpainDeteriorationof hearing ProbableNotmentioned a Casereport. b Caseseries. c Nofurtherdetailsprovided. d Asestimatedbythepresentauthor. TABLE2.Continued Firstauthor (year)PatientTypeofmassageTherapistSiteofmassageIndicationAdverseeventCausalityd Outcome 1104 E. Ernst1104 E. Ernst atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
  • 5. Exotic forms of manual massage A 61-yr-old man received a shiatsu massage from a trained therapist with strong digital pressure in the region of the base of his palm and the thenar muscles w16x. The procedure was accompanied with ‘notable transient pain’. The next day he noticed a weakness of the left thumb without sensory symptoms. On examination, he exhibited moderate isolated weakness of the abductor policis brevis muscle without atrophy or sensory dysfunction. Tinel’s and Phalen’s signs were negative and nerve conduction studies yielded normal findings. Mild active denervation and reduced motor unit recruitment were noticed electromyographically. The authors diagnosed a mono- neuropathy caused by the manual compression of the recurrent motor branch of the median nerve. The patient made an uneventful recovery over the next few months. Hawaiian authors report the case of a 64-yr-old woman admitted to hospital for suspected myocardial infarction w19x. She complained of increasing pain in the peri- cervical and suprascapular areas. Myocardial infarc- tion was not confirmed but the pain increased. A typical rash along the left eighth cervical dermatome led to the diagnosis of herpes zoster, confirmed through antibody titres. The patient revealed that she had been treated with ‘an overtly vigorous shiatsu massage’ 3 days before the onset of pain. The authors speculate that ‘zoster resulted from either direct trauma to the nerve or nerve root during the massage, or to subsequent tissue inflammation causing swelling or immunological injury to the nerve’. A 51-yr-old American woman had undergone place- ment of a left ureteral double-J stent to relieve flank pain associated with ureteral stricture w23x. Six days later she consulted a ‘Rolfer’ and received a deep body massage according to the Rolfing technique, which she had enjoyed previously on a regular basis. The massage was applied to the abdomen, pelvis and lower back. Towards the end of the session, the patient experienced severe flank pain and urinary incontinence. She was admitted to hospital where a visible protrusion of the tip of the stent was noted 1 cm beyond the ureteral orifice. Distal migration of the stent was confirmed by radiographic examination. The patient’s stent was repositioned, and she subsequently made a full recovery. An 80-yr-old Japanese man with a history of transient ischaemic attacks and anticoagulant therapy received a shiatsu massage on the neck in prone position to treat a mild headache w28x. Immediately after rising, the nasal half of his right visual field was impaired. He also showed slight left hemiparesis dominant in the upper extremity. Further investigations showed multiple branch occlusions of the central artery and multiple small infarctions in the right frontal lobe. The patient was treated with urikinase for 7 days. Subsequently there was full recovery of the hemiparesis but only minimal improvement of ocular symptoms. Reviews US authors reviewed the question of whether back massages are contraindicated after an acute myocardial infarction w39x. They found elevation of blood pressure and decrease of heart rate following back massage in normal volunteers. Thus they caution that ‘heart rate and blood pressure should be monitored before and after the procedure to identify patients at risk for sympathetic stimulation’. Other reviews of massage therapy for specific indications w40–42x fail to address any safety aspects. A recent Cochrane review of massage therapy for pre-term infants states that ‘no adverse effects of touch or massage were reported in any study’ w43x. Discussion Sixteen case reports and four case series (Table 2) of adverse events after massage therapy were found. Massage was frequently used for rheumatological conditions. In the majority of these cases causality is established con- vincingly, for instance, through the sequence or nature of events. Some of the adverse effects relate to serious complications. Considering the popularity of massage therapy, the number of reported adverse events seems minute. How- ever, this could be due to under-reporting. In a related area (spinal manipulation) we have, for instance, shown that under-reporting of serious adverse events is close to 100% w44x. Clearly, one should differentiate between various approaches. The above findings suggest that massage by non-professional and forceful techniques like shiatsu, urut and Rolfing are relatively often associated with adverse events. The reports reviewed above are often incomplete. For instance, the background of the ther- apist and the type of massage therapy are not always described. This further limits the conclusiveness of the evidence. Several systematic reviews of controlled clinical trials testing the effectiveness of massage therapies have been published and have arrived at cautiously positive con- clusions we.g. 45–47x. However, too few clinical trials of massage therapy exist and many of its claims are not backed up by evidence w3, 4x. Thus adequate risk–benefit evaluations are not feasible. In conclusion, massage therapies are not totally devoid of risks. The incidence of adverse events is unknown, but probably low. References 1. Geiringer SR, deLateur BJ. Physiatric therapeutics. 3. Traction, manipulation, and massage. Arch Phys Med Rehabil 1990;71:S264–6. 2. Westhof S, Ernst E. Geschichte der Massage. Dtsch Med Wochenschr 1992;117:150–3. 3. Ernst E, Fialka V. The clinical effectiveness of massage therapy—a critical review. Forsch Komplementa¨rmed 1994;1:226–32. 4. Vickers A. Yes, but how do we know it’s true? Knowledge claims in massage and aromatherapy. Complement Ther Nurs Midwifery 1997;3:63–5. Safety of massage therapy 1105Safety of massage therapy 1105 atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom
  • 6. 5. Eisenberg D, David RB, Ettner SL et al. Trends in alternative medicine use in the United States, 1990–1997. J Am Med Assoc 1998;280:1569–75. 6. Morris KT, Johnson N, Homer L, Walts D. A comparison of complementary therapy use between breast cancer patients and patients with other primary tumor sites. Am J Surg 2000;179:407–11. 7. Rees RW, Feigel I, Vickers A, Zollman C, McGurk R, Smith C. Prevalence of complementary therapy use by women with breast cancer: a population-based survey. Eur J Cancer 2000;36:1359–64. 8. Verhoef MJ. Physicians perspectives on massage therapy. Can Fam Physician 1998;44:1018. 9. Boutin PD, Buchwald D, Robinson L, Collier AC. Use of and attitudes about alternative and complementary ther- apies among outpatients and physicians at a municipal hospital. J Altern Complement Med 2000;6:335–43. 10. Wiesinger GF, Quittan M, Ebenbichler G, Kaider A, Fialka V. Benefit and costs of passive modalities in back pain outpatients: a descriptive study. Eur J Phys Med Rehabil 1997;7:182–6. 11. Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol 2000;143:923–9. 12. Day MJ. Hypersensitive response to ice massage. Phys Ther 1974;54:592–3. 13. Thambu JAM. Rupture of the uterus: treatment by suturing the tear. Med J Malaya 1971;25:293–4. 14. Warren SE. Pulmonary embolus originating below knee. Lancet 1978;ii:272–3. 15. Tachi J, Amino N, Miyai K. Massage therapy on neck: a contributing factor for destructive thyrotoxicosis? Thyroidology 1990;2:25–7. 16. Herskovitz S, Strauch G. Shiatsu massage-induced injury of themedianrecurrentmotorbranch.MuscleNerve1992;15:1215. 17. Sorensen L, Ibsen KE. Purulent myofasciitis in a patient with diabetes treated with a vacuum boot by a zone therapist. Ugeskr Laeger 1993;155:2150–2. 18. Liu JS, Tsai TC, Chang YY. Extracranial internal carotid artery dissection secondary to neck massage: visualisation of mural haematoma by MRI. Kao Hsiung I Hsueh Tsa Chih 1993;9:322–7. 19. Mumm AH, Morens DM, Elm JL, Diwan AR. Zoster after shiatsu massage. Lancet 1993;341:447. 20. Ram SP, Kyaw K, Noor AR. Haematoma testes due to traditional massage in neonate. Trop Doct 1994;24:81–2. 21. Yeo TC, Choo MHH, Tay MBE. Massive haematoma from digital massage in an anticoagulated patient: a case report. Singapore Med J 1994;35:319–20. 22. Kalinga MJ, Lo NN, Tan SK. Popliteal artery pseudo- aneurysm caused by an osteochondroma—a traditional medicine massage sequelae. Singapore Med J 1996;37:443–5. 23. Kerr HD. Ureteral stent displacement associated with deep massage. Wisconsin Med J 1997;12:57–8. 24. Mikhail A, Reidy JF, Taylor PR, Scoble JE. Renal artery embolization after back massage in a patient with aortic occlusion. Nephrol Dial Transplant 1997;12:797–8. 25. Giese S, Hentz VR. Posterior interosseous syndrome resulting from deep tissue massage. Plast Reconstr Surg 1998;102:1778–9. 26. Trotter JF. Hepatic haematoma after deep tissue massage. N Engl J Med 1999;341:2019–20. 27. Deidiker RD. Accidental ligature strangulation due to a roller-type massage device. Am J Forensic Med Pathol 1999;20:354–6. 28. Tsuboi K. Retinal and central artery embolism after ‘shiatsu’ on the neck. Stroke 2001;32:2441. 29. Anon. Breast massage. Klin Khir 1980;1:30–31. 30. Rahman MNG, McALll G, Chai KG. Massage-related perforation of the sigmoid colon in kelantan. Med J Malaysia 1987;42:56–7. 31. Becroft DMO, Gunn TR. Prenatal cranial haemorrhages in 47 Pacific Islander infants: is traditional massage the cause? N Z Med J 1989;102:207–10. 32. Bru¨gel FJ, Schorn K. Zervikaler Tinnitus nach HWS- Behandlung. Laryngorhinootologie 1991;70:321–5. 33. Hernandez-Reif M, Martinez A, Field T, Quintero O, Hart S, Burman I. Premenstrual symptoms are relieved by massage therapy. J Psychosom Obstet Gynaecol 2000;21:9–15. 34. Birk TJ, McGrady A, MacArthur RD, Khuder S. The effects of massage therapy alone and in combination with other complementary therapies on immune system mea- sures and quality of life in human immunodeficiency virus. J Altern Complement Med 2000;6:405–14. 35. Preyde M. Effectiveness of massage therapy for subacute low-back pain: a randomized controlled trial. CMAJ 2000; 162:1815–20. 36. White-Traut RC, Goldman MBC. Premature infant massage: is it safe? Pediatr Nurs 1988;14:285–9. 37. Eliska O, Eliskova M. Are peripheral lymphatics damaged by high pressure manual massage? Lymphology 1995; 28:21–30. 38. Fo¨ldi E. Massage and damage to lymphatics. Lymphology 1995;28:1–3. 39. Dunbar S, Redick E. Should patients with acute myocar- dial infarctions receive back massage? Focus Crit Care 1986;13:42–6. 40. Callaghan MJ. The role of massage in the management of the athlete: a review. Br J Sports Med 1993;27:28–33. 41. Buss IC, Halfens RJG, Abu-Saad HH. The effectiveness of massage in preventing pressure sores: a literature review. Rehabil Nurs 1997;22:229–42. 42. Tiidus PM. Manual massage and recovery of muscle function following exercise: a literature review. J Orthop Sports Phys Ther 1997;25:107–12. 43. Vickers A, Ohlsson A, Lacy JB, Horsley A. Massage therapy for preterm anduor low birth-weight infants. Cochrane Library 2000;1:1–23. 44. Stevinson C, Honan W, Cooke B, Ernst E. Neurological complications of cervical spine manipulation. J R Soc Med 2001;94:107–10. 45. Ernst E. Abdominal massage therapy for chronic con- stipation: a systematic review of controlled clinical trials. Forsch Komplementa¨rmed 1999;6:149–151. 46. Ernst E. Massage therapy for low back pain. A systematic review. J Pain Symptom Manage 1999;17:65–9. 47. Ernst E. Does post-exercise massage treatment reduce delayed onset muscle soreness? A systematic review. Br J Sports Med 1998;32:212–4. 1106 E. Ernst1106 E. Ernst atNanjingUniversityonMarch30,2012http://rheumatology.oxfordjournals.org/Downloadedfrom