This document discusses using repeat single nucleotide polymorphisms (rSNPs) to study evolution in yeast ribosomal DNA. Specifically, it will cover how rSNP data can be obtained from shotgun DNA databases, improved with quality scores, and used to infer recombination dynamics by analyzing rSNP statistics. The yeast rDNA consists of about 150 identical copies of a 9.1 kbp sequence that undergo mutation individually, while recombination serves to homogenize the repeats by duplicating or eliminating neutral mutations over time.

1. rSNP's:
Evolution Caught in the Act
Michael J.T. O'Kelly
6.085 Final Project Presentation
In this talk:
●First, some background science: yeast ribosomal DNA and
repeat Single Nucleotide Polymorphism model
●How to get rSNP data from a shotgun DNA database
●Improving the data with quality scores
●Inferring recombination dynamics from rSNP statistics